DE467246C - Process for the production of tuberculin - Google Patents

Process for the production of tuberculin

Info

Publication number
DE467246C
DE467246C DESCH73054D DESC073054D DE467246C DE 467246 C DE467246 C DE 467246C DE SCH73054 D DESCH73054 D DE SCH73054D DE SC073054 D DESC073054 D DE SC073054D DE 467246 C DE467246 C DE 467246C
Authority
DE
Germany
Prior art keywords
tuberculin
production
tubercle bacilli
yeast cells
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH73054D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
IGNAZ SCHILLER DR
Original Assignee
IGNAZ SCHILLER DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IGNAZ SCHILLER DR filed Critical IGNAZ SCHILLER DR
Priority to DESCH73054D priority Critical patent/DE467246C/en
Application granted granted Critical
Publication of DE467246C publication Critical patent/DE467246C/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Description

Verfahren zur Herstellung von Tuberkulin Bisher wurde das Tuberkulin in der Weise gewonnen, daß die Tuberkelbazillen auf einen I`Tährboden gebracht werden, der aus Bouillon o. dgl. und Glycerin besteht. Die Herstellung dieses Nährbodens erfordert verhältnismäßig viel Zeit und ist nicht billig.Process for the production of tuberculin So far the tuberculin was obtained in such a way that the tubercle bacilli are brought to a breeding ground, which consists of bouillon o. The like. And glycerin. The creation of this medium requires a relatively long time and is not cheap.

Nach der Erfindung wird der "-'Vährbotien durch Wasser gebildet, in welchem sich lebende Hefezellen (Bierhefezellen) befinden. Bei dem Kampf zwischen den Hefezellen und den Tuberkelbazillen werden die Zellen durch Verdauung vernichtet, und hierdurch gelangen die Tuberkelbazillen zur starken Entwicklung. Es bildet sich auf der Oberfläche des Wassers ein Schleier, wie bei den bekannten Verfahren, der durch die Tuberkelbazillen gebildet wird. Diese werden in bekannter Weise auf Tuberkulin verarbeitet.According to the invention, the "-'Vährbotien is formed by water, in which are living yeast cells (brewer's yeast cells). In the fight between the yeast cells and the tubercle bacilli are destroyed by digestion, and through this the tubercle bacilli develop strongly. It forms on the surface of the water a veil, as in the known processes, the is formed by the tubercle bacilli. These are known to act on tuberculin processed.

Der wesentlicheUnterschied des neuenVerfabrens gegenüber den bekannten besteht darin, daß das bisher hergestellte Tuberkulin ein einfaches Stoffwechselprodukt der Tuberkelbazillen ist, während gemäß der Erfindung das Tuberkulin ebenso wie in dem kranken Organismus im Kampf der Tuberkelbazillen mit lebenden Zellen gebildet wird. Durch das Zusammenbringen der beiden Zellenarten in dem stickstofffreien Wasser entsteht zwischen ihnen ein Kampf um die Nahrung, bei dem die lebende Hefe von den Bazillen verdaut wird. Diese werden so auf biologischem Wege gezwungen, Tuberkulin auszuscheiden.The main difference between the new process and the known consists in the fact that the tuberculin produced so far is a simple metabolic product of the tubercle bacilli, while according to the invention the tuberculin as well as formed in the diseased organism in the fight between the tubercle bacilli and living cells will. By bringing the two types of cells together in the nitrogen-free water a fight for food arises between them, in which the live yeast of the Bacilli is digested. These are forced in a biological way, tuberculin to be eliminated.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung von Tuberkulin, dadurch gekennzeichnet, daß Tuberkelbazillen in mit lebenden Hefezellen versetztes Wasser gebracht werden, worauf die nach Verdauung der Hefezellen sich in Form eines Schleiers auf der Oberfläche des Wassers entwickelnden Tuberkelbazillen in bekannter Weise auf Tuberkulin verarbeitet werden.PATENT CLAIM: Process for the production of tuberculin, thereby characterized in that tubercle bacilli in water mixed with living yeast cells are brought, whereupon the digestion of the yeast cells in the form of a veil tubercle bacilli developing on the surface of the water in a known manner processed on tuberculin.
DESCH73054D 1925-02-13 1925-02-13 Process for the production of tuberculin Expired DE467246C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH73054D DE467246C (en) 1925-02-13 1925-02-13 Process for the production of tuberculin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH73054D DE467246C (en) 1925-02-13 1925-02-13 Process for the production of tuberculin

Publications (1)

Publication Number Publication Date
DE467246C true DE467246C (en) 1928-10-22

Family

ID=7440595

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH73054D Expired DE467246C (en) 1925-02-13 1925-02-13 Process for the production of tuberculin

Country Status (1)

Country Link
DE (1) DE467246C (en)

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