DE464475C - Process for the production of nutrients and medicinal products suitable for acting on the intestines - Google Patents
Process for the production of nutrients and medicinal products suitable for acting on the intestinesInfo
- Publication number
- DE464475C DE464475C DER54222D DER0054222D DE464475C DE 464475 C DE464475 C DE 464475C DE R54222 D DER54222 D DE R54222D DE R0054222 D DER0054222 D DE R0054222D DE 464475 C DE464475 C DE 464475C
- Authority
- DE
- Germany
- Prior art keywords
- nutrients
- balls
- bacteria
- intestines
- bran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Botany (AREA)
- Zoology (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
Verfahren zur Herstellung von zur Einwirkung auf den Darm geeigneten Nähr- und Heilmitteln Die medizinische Wirkung von Pillen, Tabletten oder Kapseln- kann durch gewisse säurefeste Schutzhüllen auf annähernd bekannte Stellen im Darm gerichtet werden, wobei jedoch sehr oft der Erfolg ausbleibt, weil die gewollte Stelle nicht getroffen wird. Andererseits kann man auf diese Weise keine starken ätzenden Säuren einführen, da-die Säure sich auf eine kleine Stelle im Darm ergießen und tödliche Verbrennungen hervorrufen würde, während die Verabreichung solcher Säuren in festem Zustande das gewünschte Ergebnis nicht geben kann.Process for the preparation of substances suitable for acting on the intestine Nutrients and remedies The medicinal effects of pills, tablets or capsules- can reach approximately known places in the intestine through certain acid-resistant protective covers be judged, but very often the success fails because the wanted one Body is not hit. On the other hand, you can't be strong this way Introduce corrosive acids as the acid will pour onto a small spot in the intestine and would cause fatal burns while administering such Solid acids cannot give the desired result.
Die vorliegende Erfindung beseitigt alle diese Mängel und bringt außerdem noch sonstige große Vorteile. Sie besteht darin, daß man flüssige Nährstoffe, Chemikalien, ferner Bakterien o. dgl. in feste, im Darm unverändert bleibende poröse Körper hineinpreßt und je nach Bedarf trocknet oder flüssig läßt und jeden einzelnen Körper je nach Bedarf mit einer oder mehreren Schutzhüllen überzieht oder auch den gefüllten Körper ohne Schutzhülle läßt.The present invention overcomes and achieves all of these deficiencies other great advantages. It consists of getting liquid nutrients, chemicals, also press bacteria or the like into solid porous bodies that remain unchanged in the intestine and dries or runny as required and leaves each individual body depending on If necessary, cover with one or more protective covers or the filled body leaves without a protective cover.
Poröse Körper, die sich hierzu eignen, sind: Kleie, Holzkörner, Holzkohlekugeln, Filtermassagekugeln oder -würfel, poröse Glas- oder Quarzsandkugeln, gebrannte Tonkugeln und überhaupt poröse Körper aus Materialien, die die oben angeführten Eigenschaften besitzen. Die Vorteile dieses neuen Verfahrens sind folgende i. Die porösen Körper geben ihren Inhalt nur ganz allmählich ab, die Wirkung ist daher eine dauernde.Porous bodies that are suitable for this are: bran, wood grains, charcoal balls, Filter massage balls or cubes, porous glass or quartz sand balls, burnt clay balls and generally porous bodies made of materials that have the properties listed above own. The advantages of this new process are as follows: i. The porous body give off their content only very gradually, the effect is therefore permanent.
z. Bei Verabreichung von säuregefüllten porösen Körpern liegt der Vorteil darin, daß die Säuren, ehe sie mit der Darmschleimhaut in Berührung kommen, von den alkalischen -Säften nach und nach ausgelaugt werden- und so keinen Schaden verursachen trotz des Eindringens der festen Körper in die Darmschleimhaut.z. When administering acid-filled porous bodies, the The advantage is that the acids, before they come into contact with the intestinal mucosa, are gradually leached out by the alkaline juices and so no damage cause despite the penetration of the solid body into the intestinal mucosa.
Beispiel i.Example i.
Man füllt unter dem Vakuum Kleie oder Körner aus Holz oder anderem Material von bis zur Schluckgrenze reichender Größe mit einer vor der Höchstentwicklung stehenden Kultur in Milch oder _ anderem Nährboden des Bacillus Bulgaricus, trocknet dann die Masse oder die Körner schnell durch Beimengen von Trockenmaterial und warme Ventilation, so daß die Weiterentwicklung der Bakterien unterbunden wird. Diese Präparate rönnen auch mit anderen Bakterien, z. B. Glyco-Bakterien oder Drogen oder Stoffen zusammengestellt werden. Für gewöhnliche Zwecke wird das Kleieprodukt mit Zucker gemischt und fein (für Säuglinge) oder grob (für Erwachsene) gemahlen oder im anderen Falle vorher noch mit Fruchtsäure haltendem Obstfleisch überzogen, während das Körnerprodukt entweder als solches genommen, wie es aus obigem Prozeß entsteht, oder je nach dem Falle vorher noch mit einer oder mehreren Schutzhüllen versehen wird, wovon die eine aus Fruchtsäure enthaltendem Obstfleisch bestehen kann.Bran or grains of wood or other things are filled under the vacuum Material of a size up to the limit of swallowing with a size before the maximum development Standing culture in milk or other medium of Bacillus Bulgaricus, dries then the mass or the grains quickly by adding dry material and warm Ventilation, so that the further development of the bacteria is prevented. These Preparations can also be used with other bacteria, e.g. B. Glyco-bacteria or drugs or Substances are put together. For common purposes, the bran product is made with Sugar mixed and finely ground (for infants) or coarsely (for adults) or in the other Trap with fruit pulp that holds fruit acid beforehand coated while the granular product is taken either as such, as it is from the above Process arises, or, depending on the case, beforehand with one or more protective covers is provided, one of which consists of fruit pulp containing fruit acid can.
Beispiel e.Example e.
Man füllt unter dem Vakuum oder sonstwie hochgradige Salzsäure öder - Milchsäure oder irgend sonst welche flüssige Drogen in poröse Glaskugeln oder poröse Tonfiltermasse-, Glas-, Schmirgel- oder sonstige geeignete Kugeln (Größe Schluckgrenze und aus einem gegen die einzufüllende Säure widerstandsfähigen Material), die man sofort auf der Stelle mit Wachs und Keratin ö. dglüberzieht, so daß die Füllung nicht auslaufen kann. Diese so überzogenen Pillen oder Tabletten kann man je nach dem gewünschten Zweck nochmals oder mehrmals überziehen.One fills under the vacuum or otherwise high-grade hydrochloric acid or empty - Lactic acid or any other liquid drug in porous glass balls or Porous clay filter paste, glass, emery or other suitable balls (size Swallowing limit and made of a material resistant to the acid to be filled), which are immediately coated with wax and keratin or the like on the spot, so that the The filling cannot leak. You can get these coated pills or tablets Overcoat again or several times depending on the desired purpose.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DER54222D DE464475C (en) | 1921-10-21 | 1921-10-21 | Process for the production of nutrients and medicinal products suitable for acting on the intestines |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DER54222D DE464475C (en) | 1921-10-21 | 1921-10-21 | Process for the production of nutrients and medicinal products suitable for acting on the intestines |
Publications (1)
Publication Number | Publication Date |
---|---|
DE464475C true DE464475C (en) | 1928-08-17 |
Family
ID=7409596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DER54222D Expired DE464475C (en) | 1921-10-21 | 1921-10-21 | Process for the production of nutrients and medicinal products suitable for acting on the intestines |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE464475C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1164813B (en) * | 1956-11-05 | 1964-03-05 | Commw Scient Ind Res Org | Process for the production of molded bodies, in particular pellets, for administration to ruminants |
-
1921
- 1921-10-21 DE DER54222D patent/DE464475C/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1164813B (en) * | 1956-11-05 | 1964-03-05 | Commw Scient Ind Res Org | Process for the production of molded bodies, in particular pellets, for administration to ruminants |
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