DE4341114A1 - Emulsions comprising non-aqueous phase dispersed in oil phase - Google Patents

Emulsions comprising non-aqueous phase dispersed in oil phase

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Publication number
DE4341114A1
DE4341114A1 DE4341114A DE4341114A DE4341114A1 DE 4341114 A1 DE4341114 A1 DE 4341114A1 DE 4341114 A DE4341114 A DE 4341114A DE 4341114 A DE4341114 A DE 4341114A DE 4341114 A1 DE4341114 A1 DE 4341114A1
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Prior art keywords
oil
phase
aqueous
emulsifier
emulsion
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DE4341114A
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German (de)
Inventor
Gerd H Dahms
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Ifac Institut fur Angewandte Colloidtechnologie G
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IFAC GmbH and Co KG
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Priority to DE4341114A priority Critical patent/DE4341114A1/en
Publication of DE4341114A1 publication Critical patent/DE4341114A1/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
    • C11D3/3734—Cyclic silicones
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/34—Higher-molecular-weight carboxylic acid esters
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/064—Water-in-oil emulsions, e.g. Water-in-silicone emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/09—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in organic liquids
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/54—Silicon compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0004—Non aqueous liquid compositions comprising insoluble particles
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/18—Hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2041—Dihydric alcohols
    • C11D3/2044—Dihydric alcohols linear
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/373—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds containing silicones
    • C11D3/3738—Alkoxylated silicones
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2003—Alcohols; Phenols
    • C11D3/2065—Polyhydric alcohols

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Abstract

Stable X/O emulsions comprise an oil-immiscible non-aqueous phase (X phase), an oil phase, and an emulsifier which has an HLB of up to 6 and/or is a W/O emulsifier. Also claimed is a process for producing an emulsion as above.

Description

Die vorliegende Erfindung betrifft eine X/O-Emulsion aus einer nichtwäßrigen, mit Öl nicht mischbaren Phase und einer Ölphase. Die nichtwäßrige X-Phase stellt darin die disperse, die Ölphase die kontinuierliche Phase dar.The present invention relates to an X / O emulsion a non-aqueous, oil-immiscible phase and a Oil phase. The nonaqueous X phase represents the disperse in it, the oil phase is the continuous phase.

Solche Emulsionen sind nach dem Stand der Technik nur unter Schwierigkeiten herstellbar, insbesondere, wenn die Ölphase aus einem Siliconöl besteht. Selbst die Emulsionen dieser Art, die hergestellt werden konnten, genügen oft nicht den Anforde­ rungen, die zu ihrer Anwendung an ihre Stabilität gestellt werden.Such emulsions are in the prior art only below Difficulty to produce, especially if the oil phase consists of a silicone oil. Even the emulsions of this kind, which could be produced, often do not meet the requirement their application to their stability become.

Dementsprechend besteht die Aufgabe der Erfindung darin, eine stabile X/O-Emulsion der eingangs genannten Art zu schaf­ fen, die auf einfache Weise hergestellt werden kann und hin­ sichtlich ihrer Stabilität und ihrer Anwendbarkeit gegenüber bekannten Emulsionen dieser Art erheblich verbessert ist.Accordingly, the object of the invention is to a stable X / O emulsion of the type mentioned sheep fen, which can be easily manufactured and visibly of their stability and their applicability known emulsions of this type is significantly improved.

Insbesondere soll diese Emulsion auch die Aufnahme von Feststoffen ermöglichen.In particular, this emulsion is also the inclusion of Allow solids.

Zur Lösung dieser Aufgaben sieht die Erfindung vor, daß die stabile X/O-Emulsion mindestens einen Emulgator enthält, der einen HLB-Wert 6 hat und/oder ein W/O-Emulgator ist.To solve these problems, the invention provides that the stable X / O emulsion contains at least one emulsifier, the has an HLB value of 6 and / or is a W / O emulsifier.

Vorteilhafterweise ist der Emulgator aus der Gruppe Glyce­ rinester, Sorbitanester, Sorbitolester, Polyglycerinester, Fettalkohole, Propylenglycolester, Alkylglucosidester, Zucker­ ester, Lecithin, Siliconcopolymere und deren Mischungen oder Derivaten ausgewählt.Advantageously, the emulsifier is from the group Glyce esters, sorbitan esters, sorbitol esters, polyglycerol esters, Fatty alcohols, propylene glycol esters, alkylglucoside esters, sugars  ester, lecithin, silicone copolymers and mixtures thereof or Derivatives selected.

Die mit Hilfe mindestens eines dieser Emulgatoren herge­ stellten stabilen X/O-Emulsionen werden durch einen einfachen Mischvorgang unter Rühren erhalten, wobei die Stabilität die­ ser Emulsionen weder durch die eingetragene Rührwerksenergie, noch durch die Art des Rührwerkzeugs beeinflußt wird. Tatsäch­ lich kann zur Herstellung der erfindungsgemäßen Emulsion jedes geeignete handelsübliche Rührwerk eingesetzt werden.The herge with the help of at least one of these emulsifiers Stable X / O emulsions are made by a simple Stirring with stirring, the stability of the emulsions, neither by the listed agitator energy, is still affected by the nature of the stirring tool. Tatsäch Lich, for the preparation of the emulsion according to the invention each suitable commercial agitator can be used.

Die stabilen X/O-Emulsionen nach der Erfindung haben hohe Langzeitstabilität und erfüllen die üblichen Stabilitätsanfor­ derungen im Temperaturbereich von -5°C bis +45°C.The stable X / O emulsions according to the invention have high levels Long-term stability and meet the usual stability requirements temperature range from -5 ° C to + 45 ° C.

Zur näheren Erläuterung der Erfindung wird nachstehend le­ diglich beispielhaft eine erfindungsgemäße stabile X/O-Emulsi­ on beschrieben. Darin beziehen sich alle Prozentangaben auf Gewichtsprozente des jeweiligen Bestandteils, bezogen auf das Gesamtgewicht der Emulsion = 100. Die angegebenen Trivialnamen sind dem CTFA-Verzeichnis entnommen.For a more detailed explanation of the invention, le by way of example, a stable X / O emulsion according to the invention on. Therein all percentages refer to Weight percent of the respective component, based on the Total weight of the emulsion = 100. The trivial names given are taken from the CTFA directory.

Beispielexample

Eine Öl-Phase und eine nichtwäßrige, mit Öl nicht mischbare Phase wurden getrennt auf eine Temperatur im Bereich von 20°C bis 90°C, vorzugsweise 60°C bis 80°C, erwärmt und unter Rühren mit einem üblichen Rührwerk zusammengegeben. Nach ca. 1 Minute weiterer Rührzeit wird die hergestellte Emulsion auf Raumtem­ peratur abgekühlt oder abkühlen gelassen. Die Zusammensetzung betrugAn oil phase and a non-aqueous, oil-immiscible Phase were separated to a temperature in the range of 20 ° C to 90 ° C, preferably 60 ° C to 80 ° C, heated and with stirring combined with a standard agitator. After about 1 minute additional stirring time, the emulsion produced is Raumtem cooled or allowed to cool. The composition scam

Cyclomethicon + Dimethicon-Copolyol|15%Cyclomethicone + dimethicone copolyol | 15% Cyclomethiconcyclomethicone 30%30% (Ölphase) und @(Oil phase) and @ Propylenglycolpropylene glycol 55%55%

(nichtwäßrige, mit Öl nicht mischbare Phase). (non-aqueous, oil-immiscible phase).  

Gleiche Ergebnisse werden erhalten, wenn anstelle des Cy­ clomethicons andere Siliconöle oder Ölphasen wie Paraffinöle, Triglyceride, Fettalkohole, Esteröle oder deren Mischungen verwendet werden. Der Emulgator Dimethicon-Polyol kann durch andere Emulgatoren wie Glycerinester, Sorbitanester, Sorbitol­ ester, Polyglycerinester, Fettalkohol, Propylenglycolester, Alkylglucosidester, Zuckerester oder Lecithin oder deren Deri­ vate oder Mischungen ersetzt werden. Anstelle des Propylengly­ cols lassen sich mit gleichem Erfolg Butylenglycol, Polyalky­ lenglycol, Glycerin, Polyglycerin oder deren Mischungen ein­ setzen.Same results are obtained if instead of Cy clomethicons other silicone oils or oil phases such as paraffin oils, Triglycerides, fatty alcohols, ester oils or mixtures thereof be used. The emulsifier dimethicone polyol can by other emulsifiers such as glycerol esters, sorbitan esters, sorbitol ester, polyglycerol ester, fatty alcohol, propylene glycol ester, Alkylglucosidester, sugar esters or lecithin or their Deri vate or mixtures. Instead of propylene glycol cols can be equally successfully butylene glycol, polyalky glycol, glycerol, polyglycerol or mixtures thereof put.

Die stabilen X/O-Emulsionen dieser können in Abhängigkeit von der chemischen Zusammensetzung, vom Phasenvolumenverhält­ nis und dem gegebenenfalls vorhandenen Feststoffanteil als feste oder fließfähige Emulsionen hergestellt werden.The stable X / O emulsions of these can depend on of the chemical composition, the phase volume and the optionally present solid content as solid or flowable emulsions are produced.

Die vorgenannten stabilen X/O-Emulsionen sind wegen ihrer Stabilität und wegen der Beständigkeit der darin vorhandenen Tropfen in besonderem Maße als Träger für viele Arten von Wirkstoffen geeignet. Als einfacher Anwendungsfall sei im fol­ genden erwähnt, daß es wünschenswert ist, wenn Waschmittel für eine Waschmaschine in flüssiger Form vorliegen, weil flüssige Waschmittel leichter als feste Waschmittel dosiert werden kön­ nen. Weiterhin ist es wünschenswert, dem Waschmittel Enzyme wie Proteasen, Lipasen und Amylasen zuzusetzen. Üblicherweise sind diese Enzyme aber in wäßriger Lösung nicht langzeitbe­ ständig. Hier bietet eine X/O-Emulsion nach dem Beispiel eine geeignete Lösung für das Problem, ein flüssiges, enzymhaltiges Waschmittel zur Verfügung zu stellen:The aforementioned stable X / O emulsions are because of their Stability and because of the persistence of the existing ones Drops in particular as a carrier for many types of Suitable agents. As a simple application is in fol mentioned that it is desirable to use detergent for a washing machine in liquid form, because liquid Detergents are easier to dose than solid detergents NEN. Furthermore, it is desirable to the detergent enzymes such as proteases, lipases and amylases. Usually However, these enzymes are not long-term in aqueous solution constantly. Here is an X / O emulsion according to the example one appropriate solution to the problem, a liquid, enzyme-containing To provide detergent:

Die nichtwäßrige, mit Öl nicht mischbare Phase besteht in diesem Fall aus einem Polyol, nämlich Propylenglycol, in dem das Enzym gelöst und langzeitbeständig ist. Wird die so gebil­ dete Emulsion mit Detergentien versetzt, so erhält man ein flüssiges Waschmittel, in dem das innere der Tropfen, also die Polyollösung des Enzyms, durch den Emulgator vor Kontakt und Austausch geschützt ist. Das Enzym kann nur durch Zerstörung der Emulsion freigesetzt werden. Nach Wahl des Emulgators kann dies unmittelbar zu Beginn des Waschvorgangs entweder dadurch erreicht werden, daß die Emulsion durch die dabei herrschende Temperatur oder durch die gemeinsame Einwirkung der Temperatur und der beim Waschvorgang auftretenden Scherkräfte gebrochen wird.The non-aqueous, oil-immiscible phase consists in In this case, a polyol, namely propylene glycol, in which the enzyme is dissolved and long-term stable. Will the gebil dete emulsion with detergents, so you get one liquid detergent, in which the inner of the drops, so the Polyol solution of the enzyme, by the emulsifier before contact and  Exchange is protected. The enzyme can only be destroyed the emulsion are released. After choosing the emulsifier can this immediately at the beginning of the washing process either by it be achieved that the emulsion by the prevailing Temperature or by the joint action of the temperature and the shearing forces occurring during the washing process are broken becomes.

In Emulsionen nach dem vorstehend beschriebenen Beispiel können auch Feststoffe wie Pigmente, Mikrosphären oder Silica­ gel dispergiert werden. Pigmente wie Titandioxid oder Zinkoxid sind in der Kosmetik als Lichtschutzfilter gebräuchlich und lassen sich mittels einer solchen Emulsion besonders glatt und gleichmäßig auf die Haut auftragen. Mikrosphären oder Silica­ gel können als Träger für Wirkstoffe eingesetzt werden und Wachse können beispielsweise als Grundlage für Polituren verwendet werden.In emulsions according to the example described above may also contain solids such as pigments, microspheres or silica gel are dispersed. Pigments such as titanium dioxide or zinc oxide are used in cosmetics as sunscreen filters and can be particularly smooth and by means of such an emulsion Apply evenly to the skin. Microspheres or silica gel can be used as a carrier for active ingredients and For example, waxes can be used as a base for polishes be used.

In entsprechender Weise kann man auch Arzneimittel, die oral verabreicht werden, aber unter den im Magen herrschenden Bedingungen nicht stabil sind oder an anderen Orten des Ver­ dauungstraktes zur Einwirkung kommen sollen, mit einer X/O- Emulsion der vorgenannten Art an ihren Wirkungsort bringen. Diese Emulsion wird nämlich im Magen nicht gebrochen, so daß sie den Magen unverändert passiert. Ihr Wirkstoff wird viel mehr erst nachfolgend im Verdauungstrakt freigesetzt, nämlich dort, wo der Emulgator abgebaut oder aufgelöst wird. Die Aus­ wahl der Emulgatoren kann dabei ohne weiteres auf die an den Wirkorten bestehenden Bedingungen eingestellt werden.In a similar way one can also use medicines that be administered orally, but below those in the stomach Conditions are not stable or elsewhere in the United States should be used, with an X / O Bring emulsion of the aforementioned type to their place of action. This emulsion is not broken in the stomach, so that she passes the stomach unchanged. Your active ingredient will be much more released later in the digestive tract, namely where the emulsifier is broken down or dissolved. The off Choice of emulsifiers can readily on the on the Action sites existing conditions are set.

Selbstverständlich ist es bei der Herstellung von X/O-Emul­ sionen mit Wirkstoffen der vorgenannten Art ohne weiteres mög­ lich, diesen Emulsionen außer den Wirkstoffen selbst auch die sonstigen, nach dem Anwendungszweck jeweils erforderlichen Hilfs- und Zusatzstoffe hinzuzufügen.Of course, it is in the production of X / O Emul sions with active ingredients of the aforementioned type readily possible Lich, these emulsions in addition to the active ingredients themselves and the other, according to the application in each case required To add auxiliaries and additives.

Claims (12)

1. Stabile X/O-Emulsion aus einer nichtwäßrigen, mit Öl nicht mischbaren Phase, einer Ölphase und mindestens einem Emul­ gator, dadurch gekennzeichnet, daß der Emulgator einen HLB-Wert 6 hat und/oder ein W/O-Emulgator ist.1. Stable X / O emulsion of a non-aqueous, oil-immiscible phase, an oil phase and at least one Emul gator, characterized in that the emulsifier has an HLB value 6 and / or is a W / O emulsifier. 2. Emulsion nach Anspruch 1, dadurch gekennzeichnet, daß die nichtwäßrige, mit Öl nicht mischbare Phase ein mit Wasser mischbares Polyol ist.2. Emulsion according to claim 1, characterized in that the non-aqueous, oil-immiscible phase with water is miscible polyol. 3. Emulsion nach Anspruch 2, dadurch gekennzeichnet, daß das Polyol aus der Gruppe Propylenglycol, Butylenglycol, Poly­ alkylenglykol, Glycerin, Polyglycerin oder deren Mischung ausgewählt ist.3. Emulsion according to claim 2, characterized in that the Polyol from the group propylene glycol, butylene glycol, poly alkylene glycol, glycerol, polyglycerol or mixtures thereof is selected. 4. Emulsion nach einem der Ansprüche 1 bis 3, dadurch gekenn­ zeichnet, daß die nichtwäßrige, mit Öl nicht mischbare Phase einen Wirkstoff enthält, der aus der Gruppe pharma­ zeutischer, kosmetischer, waschmitteltechnologischer, le­ bensmitteltechnologischer oder agrartechnologischer Wirk­ stoffe ausgewählt ist.4. Emulsion according to one of claims 1 to 3, characterized marked indicates that the non-aqueous, immiscible with oil Phase contains an active substance, which from the group pharma ceutical, cosmetic, detergent technology, le Food technological or agrotechnical Wirkwirk is selected. 5. Emulsion nach einem der vorstehenden Ansprüche, dadurch gekennzeichnet, daß die nichtwäßrige, mit Öl nicht misch­ bare Phase einen Feststoff enthält, der aus der Gruppe Pigmente, Mikrosphären, Silicagel ausgewählt ist.5. Emulsion according to any one of the preceding claims, characterized characterized in that the non-aqueous, not mixed with oil bare phase contains a solid that is from the group Pigments, microspheres, silica gel. 6. Emulsion nach einem der Ansprüche 1 bis 5, dadurch gekenn­ zeichnet, daß die Ölphase aus der Gruppe Siliconöle, Par­ affinöle, Triglyceride, Fettalkohole, Esteröle oder deren Mischung ausgewählt ist.6. Emulsion according to any one of claims 1 to 5, characterized marked characterized in that the oil phase from the group silicone oils, par affine oils, triglycerides, fatty alcohols, ester oils or theirs Mixture is selected. 7. Emulsion nach Anspruch 6, dadurch gekennzeichnet, daß die Ölphase einen Feststoff enthält, der aus der Gruppe Pig­ mente, Mikrosphären, Silicagel, Wachs ausgewählt ist. 7. Emulsion according to claim 6, characterized in that the Oil phase contains a solid selected from the group Pig mente, microspheres, silica gel, wax is selected.   8. Emulsion nach einem der Ansprüche 1 bis 8, dadurch gekenn­ zeichnet, daß der Emulgator aus der Gruppe Glycerinester, Sorbitanester, Sorbitolester, Polyglycerinester, Fettalko­ hole, Propylenglycolester, Alkylglucosidester, Zucker­ ester, Lecithin, Siliconcopolymere und deren Mischungen oder Derivaten ausgewählt ist.8. Emulsion according to one of claims 1 to 8, characterized marked characterized in that the emulsifier is selected from the group glycerol ester, Sorbitan esters, sorbitol esters, polyglycerol esters, fatty alcohols hole, propylene glycol ester, alkyl glucoside ester, sugar esters, lecithin, silicone copolymers and mixtures thereof or derivatives is selected. 9. Verfahren zur Herstellung einer stabilen X/O-Emulsion, die eine nichtwäßrige, mit Öl nicht mischbare Phase, eine Öl­ phase und mindestens einen Emulgator enthält, dadurch ge­ kennzeichnet, daß der Emulgator aus der Gruppe von Emulga­ toren mit einem HLB-Wert 6 ausgewählt wird und/oder ein W/O-Emulgator ist, daß die nichtwäßrige, mit Öl nicht mischbare Phase und die Ölphase getrennt auf eine Tempera­ tur im Bereich von 20°C bis 90°C erwärmt werden, daß die so vorerwärmte nichtwäßrige, mit Öl nicht mischbare Phase und die so vorerwärmte Ölphase unter Rühren zusammengege­ ben werden und die Mischung auf Raumtemperatur abgekühlt wird.9. A process for producing a stable X / O emulsion, the a non-aqueous, oil-immiscible phase, an oil phase and at least one emulsifier, thereby ge indicates that the emulsifier is from the group of Emulga is selected with an HLB value 6 and / or a W / O emulsifier is that non-aqueous, with no oil miscible phase and the oil phase separated to a tempera be heated in the range of 20 ° C to 90 ° C, that the so preheated non-aqueous, oil-immiscible phase and the thus preheated oil phase together under stirring ben and the mixture cooled to room temperature becomes. 10. Verfahren nach Anspruch 9, dadurch gekennzeichnet, daß die nichtwäßrige, mit Öl nicht mischbare Phase und die Ölphase getrennt auf eine Temperatur im Bereich von 60°C bis 80°C erwärmt werden.10. The method according to claim 9, characterized in that the non-aqueous, oil-immiscible phase and the oil phase separated to a temperature in the range of 60 ° C to 80 ° C to be heated. 11. Verwendung von mindestens einem Emulgator, der aus der Gruppe von Emulgatoren mit einem HLB-Wert 6 ausgewählt ist und/oder ein W/O-Emulgator ist, zur Herstellung einer stabilen X/O-Emulsion, die eine nichtwäßrige, mit Öl nicht mischbare Phase und eine Ölphase enthält.11. Use of at least one emulsifier derived from Group of emulsifiers with an HLB value 6 selected is and / or a W / O emulsifier, for producing a stable X / O emulsion, which is a non-aqueous, with no oil contains miscible phase and an oil phase. 12. Verwendung von mindestens einem Emulgator nach Anspruch 11 zur Herstellung einer Emulsion, bei der die nichtwäßrige, mit Öl nicht mischbare Phase einen pharmazeutischen, kos­ metischen, waschmitteltechnologischen, lebensmitteltechno­ logischen oder agrartechnologischen Wirkstoff enthält.12. Use of at least one emulsifier according to claim 11 for the preparation of an emulsion in which the non-aqueous, phase immiscible with oil a pharmaceutical, kos metic, detergent technology, food technology logical or agrotechnologically active ingredient.
DE4341114A 1993-12-02 1993-12-02 Emulsions comprising non-aqueous phase dispersed in oil phase Withdrawn DE4341114A1 (en)

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024325A1 (en) * 1995-02-06 1996-08-15 R.P. Scherer Corporation Improved topical application emulsions
FR2826292A1 (en) * 2001-06-22 2002-12-27 Rhodia Chimie Sa OIL OIL EMULSIONS COMPRISING SILICONE, DISPERSIONS OF SUCH EMULSIONS AND USE
EP1267946A2 (en) * 2000-02-28 2003-01-02 Genesegues, Inc. Nanocapsule encapsulation system and method
WO2003078039A1 (en) * 2002-03-18 2003-09-25 Clr- Chemisches Laboratorium Dr. Kurt Richter Gmbh P/o emulsions comprising aminofunctional polyols
US10987308B2 (en) 2014-09-03 2021-04-27 Genesegues, Inc. Therapeutic nanoparticles and related compositions, methods and systems

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996024325A1 (en) * 1995-02-06 1996-08-15 R.P. Scherer Corporation Improved topical application emulsions
EP1267946A2 (en) * 2000-02-28 2003-01-02 Genesegues, Inc. Nanocapsule encapsulation system and method
EP1267946A4 (en) * 2000-02-28 2008-07-02 Genesegues Inc Nanocapsule encapsulation system and method
FR2826292A1 (en) * 2001-06-22 2002-12-27 Rhodia Chimie Sa OIL OIL EMULSIONS COMPRISING SILICONE, DISPERSIONS OF SUCH EMULSIONS AND USE
WO2003000396A1 (en) * 2001-06-22 2003-01-03 Rhodia Chimie Oil-in-oil emulsions comprising a silicone, dispersions and use of said emulsions
WO2003078039A1 (en) * 2002-03-18 2003-09-25 Clr- Chemisches Laboratorium Dr. Kurt Richter Gmbh P/o emulsions comprising aminofunctional polyols
US10987308B2 (en) 2014-09-03 2021-04-27 Genesegues, Inc. Therapeutic nanoparticles and related compositions, methods and systems

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