DE4122754A1 - Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function - Google Patents

Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function

Info

Publication number
DE4122754A1
DE4122754A1 DE4122754A DE4122754A DE4122754A1 DE 4122754 A1 DE4122754 A1 DE 4122754A1 DE 4122754 A DE4122754 A DE 4122754A DE 4122754 A DE4122754 A DE 4122754A DE 4122754 A1 DE4122754 A1 DE 4122754A1
Authority
DE
Germany
Prior art keywords
mmol
lactate
soln
substitute
glucose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4122754A
Other languages
German (de)
Inventor
Martin Prof Dr Med Vlaho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE4122754A priority Critical patent/DE4122754A1/en
Publication of DE4122754A1 publication Critical patent/DE4122754A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455Substitution fluids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/14Alkali metal chlorides; Alkaline earth metal chlorides

Abstract

The substitute soln. comprises Na (145 mmol/l), K (1-4 mmol/l according to need), Ca (1.5 mmol/l), magnesium (0.5 mmol/l), Cl ions (118 mmol/l), glucose 100 mg/dl), lactate (3.0 mmol/l) and bicarbonate (35 mmol/l). USE/ADVANTAGE - Used as a substitute soln. in haemofiltration in dialysis. The soln. is compatible with patients with severe liver diseases or acidosis, and is esp. compatible with small children whose undeveloped livers cannot convert the lactate used in prior art solns.

Description

Bei der von unserem Mandanten entwickelten Erfindung handelt es sich um eine chemische Substanz, welche als Substitu­ tionslösung für die Hämofiltration bei Dialyseverfahren geeignet ist. (Bikarbonat-Hämofiltration).Acting on the invention developed by our client it is a chemical substance, which as Substitu solution for hemofiltration in dialysis procedures suitable is. (Bicarbonate hemofiltration).

Unter patentfähigen Schutz gestellt werden soll die genaue Zusammensetzung und Herstellung der Bikarbonat-Substi­ tutionslösung, ebenso wie die gewerbliche Vermarktung. Die unter Schutz zu stellende Lösung setzt sich wie folgt zusammen:The exact protection is to be placed under patentable protection Composition and manufacture of bicarbonate substi solution as well as commercial marketing. The solution to be protected is set up as follows together:

Natrium 145 mmol/l, Kalium 1-4 mmol/l (nach Bedarf), Kalzium 1,5 mmol/l, Magnesium 0,5 mmol/l, Chlorid 118 mmol/l, Glukose 100 mg/dl, Laktat 3,0 mmol/l, Bikarbonat 35 mmol/l.Sodium 145 mmol / l, potassium 1-4 mmol / l (after Calcium) 1.5 mmol / l, magnesium 0.5 mmol / l, Chloride 118 mmol / l, glucose 100 mg / dl, lactate 3.0 mmol / l, Bicarbonate 35 mmol / l.

Zur adäquaten Verteilung der Inhaltsstoffe ist ein Verrüh­ ren, bzw. Schütteln der Substanz notwendig.To adequately distribute the ingredients, stir together Ren, or shaking the substance necessary.

Bei der von unserem Mandanten entwickelten Substitutions­ lösung handelt es sich um eine besonders gut verträgliche Substanz für die Bikarbonat-Hämofiltration, speziell ver­ wendbar bei schwerer Azidose. Besonders bei Kleinkindern ist die zur Anmeldung gebrachte Substitutionslösung schonend an­ wendbar. Die Lösung kann sowohl bei der maschinellen, als auch der kontinuierlichen atheriovinösen Hämo-Filtration zum Einsatz gebracht werden. Die Lösung stellt gegenüber der bisher üblicherweise verwendeten Laktatpuffersubstanz eine Weiterentwicklung dahingehend da, daß sie besonders gut verträglich ist bei Patienten die eine schwere Leberer­ krankung, bzw. Azidose (Speziel-Laktat-Azidose) aufweisen. Ebenso gut ist die Verträglichkeit bei Kleinkindern, die wegen ihrer noch unreifen Leber das früher verwendete Laktat nicht zu verstoffwechseln vermögen.In the substitution developed by our client solution is a particularly well tolerated Substance for bicarbonate hemofiltration, especially ver reversible in severe acidosis. Especially with toddlers the substitution solution submitted for registration reversible. The solution can be both in the machine, as also continuous atheriovinous hemofiltration for Be put into action. The solution faces the Lactate buffer substance commonly used up to now Further development in that they are particularly good a patient with a severe liver is tolerated disease or acidosis (special lactate acidosis). Tolerance in young children is just as good because of their still immature liver the lactate used earlier unable to metabolize.

Claims (1)

Bei der zum Patent angemeldeten Medizin handelt es sich um eine Substitutionslösung für die Hämofiltration bei Dialyseverfahren, dadurch gekennzeichnet, daß sich diese Lösung wie folgt zusammensetzt: Natrium 145 mmol/l, Kalium 1-4 mmol/l (nach Bedarf), Kalzium 1,5 mmol/l, Magnesium 0,5 mmol/l, Chlorid 118 mmol/l, Glukose 100 mg/dl, Laktat 3,0 mmol/l, Bikarbonat 35 mmol/l.The patent-pending medicine is a substitution solution for hemofiltration in dialysis procedures, characterized in that this solution is composed as follows: sodium 145 mmol / l, potassium 1-4 mmol / l (as required), calcium 1, 5 mmol / l, magnesium 0.5 mmol / l, chloride 118 mmol / l, glucose 100 mg / dl, lactate 3.0 mmol / l, bicarbonate 35 mmol / l.
DE4122754A 1991-07-10 1991-07-10 Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function Withdrawn DE4122754A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE4122754A DE4122754A1 (en) 1991-07-10 1991-07-10 Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4122754A DE4122754A1 (en) 1991-07-10 1991-07-10 Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function

Publications (1)

Publication Number Publication Date
DE4122754A1 true DE4122754A1 (en) 1993-01-21

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Family Applications (1)

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DE4122754A Withdrawn DE4122754A1 (en) 1991-07-10 1991-07-10 Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function

Country Status (1)

Country Link
DE (1) DE4122754A1 (en)

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277815B1 (en) * 1997-10-31 2001-08-21 Fresenius Medical Care Deutschland Gmbh Solution for peritoneal dialysis
NL1016235C2 (en) * 2000-09-21 2002-03-22 Adrianus Antonius Marcus Johan Liquid for haemofiltration.
US6689393B1 (en) 1999-03-22 2004-02-10 Fresenius Medical Care Deutschland Solution, in particular for hemodialysis or peritoneal dialysis and a method of preparing same
US6743191B1 (en) 1999-04-26 2004-06-01 Edwards Lifesciences Ag Substitution infusion fluid and citrate anticoagulation
US7186420B2 (en) 1999-04-26 2007-03-06 Edwards Lifesciences Corporation Multi-part substitution infusion fluids and matching anticoagulants
US7837666B2 (en) 2005-01-28 2010-11-23 Fresenius Medical Care North America Systems and methods for delivery of peritoneal dialysis (PD) solutions
US8038639B2 (en) 2004-11-04 2011-10-18 Baxter International Inc. Medical fluid system with flexible sheeting disposable unit
US8105258B2 (en) 1999-04-26 2012-01-31 Baxter International Inc. Citrate anticoagulation system for extracorporeal blood treatments
US8114276B2 (en) 2007-10-24 2012-02-14 Baxter International Inc. Personal hemodialysis system
US8858488B2 (en) 2003-11-05 2014-10-14 Baxter International Inc. Dialysis system including blood and dialysate cassette
US8920362B2 (en) 2007-07-05 2014-12-30 Baxter International Inc. Dialysis system having disposable cassette
US8992463B2 (en) 2007-11-09 2015-03-31 Baxter International Inc. Balanced flow dialysis machine
US9585810B2 (en) 2010-10-14 2017-03-07 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser
WO2017093553A1 (en) * 2015-12-04 2017-06-08 Fresenius Medical Care Deutschland Gmbh Hemofiltration solutions for the treatment of strokes
US9764074B1 (en) 2002-07-19 2017-09-19 Baxter International Inc. Systems and methods for performing dialysis
US10232103B1 (en) 2001-11-13 2019-03-19 Baxter International Inc. System, method, and composition for removing uremic toxins in dialysis processes
US10646634B2 (en) 2008-07-09 2020-05-12 Baxter International Inc. Dialysis system and disposable set
US11495334B2 (en) 2015-06-25 2022-11-08 Gambro Lundia Ab Medical device system and method having a distributed database
US11516183B2 (en) 2016-12-21 2022-11-29 Gambro Lundia Ab Medical device system including information technology infrastructure having secure cluster domain supporting external domain
US11918721B2 (en) 2022-04-22 2024-03-05 Baxter International Inc. Dialysis system having adaptive prescription management

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US3978212A (en) * 1973-12-19 1976-08-31 Chemo Drug Company Electrolyte solutions containing magnesium and free bicarbonate ions
EP0022922A1 (en) * 1979-07-24 1981-01-28 Gambro Dialysatoren K.G. Method of forming an aqueous dialysis solution
EP0034916A1 (en) * 1980-02-21 1981-09-02 Preston Leonard Veltman Compositions suitable for use in preparing dialysis solutions, and processes for producing such compositions
WO1981003180A1 (en) * 1980-05-09 1981-11-12 A Babb System for bicarbonate dialysate
EP0086553A1 (en) * 1982-01-29 1983-08-24 Preston Leonard Veltman Dialysis solutions containing bicarbonate ions
DE3224823A1 (en) * 1982-07-02 1984-01-05 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Process for the preparation of an electrolyte solution, which is optimised for the particular patient, for use in haemodialysis
EP0177614A1 (en) * 1984-02-13 1986-04-16 Tomita Pharmaceutical Corporation Limited Process for producing mixed electrolyte powder for use in bicarbonate dialysis
DE3917251A1 (en) * 1989-05-26 1990-11-29 Fresenius Ag Sodium biscarboxylate-containing concentrate and method for producing a dihydrogenation liquid
US4980374A (en) * 1988-04-15 1990-12-25 Fresenius Ag Dialysis and rinsing solution for intraperitoneal administration with antimicrobial activity
US5011826A (en) * 1988-04-15 1991-04-30 Fresenius Ag Aqueous dialysis and rinsing solution for intraperitoneal administration

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978212A (en) * 1973-12-19 1976-08-31 Chemo Drug Company Electrolyte solutions containing magnesium and free bicarbonate ions
EP0022922A1 (en) * 1979-07-24 1981-01-28 Gambro Dialysatoren K.G. Method of forming an aqueous dialysis solution
EP0034916A1 (en) * 1980-02-21 1981-09-02 Preston Leonard Veltman Compositions suitable for use in preparing dialysis solutions, and processes for producing such compositions
WO1981003180A1 (en) * 1980-05-09 1981-11-12 A Babb System for bicarbonate dialysate
EP0086553A1 (en) * 1982-01-29 1983-08-24 Preston Leonard Veltman Dialysis solutions containing bicarbonate ions
DE3224823A1 (en) * 1982-07-02 1984-01-05 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Process for the preparation of an electrolyte solution, which is optimised for the particular patient, for use in haemodialysis
EP0177614A1 (en) * 1984-02-13 1986-04-16 Tomita Pharmaceutical Corporation Limited Process for producing mixed electrolyte powder for use in bicarbonate dialysis
US4980374A (en) * 1988-04-15 1990-12-25 Fresenius Ag Dialysis and rinsing solution for intraperitoneal administration with antimicrobial activity
US5011826A (en) * 1988-04-15 1991-04-30 Fresenius Ag Aqueous dialysis and rinsing solution for intraperitoneal administration
DE3917251A1 (en) * 1989-05-26 1990-11-29 Fresenius Ag Sodium biscarboxylate-containing concentrate and method for producing a dihydrogenation liquid

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6277815B1 (en) * 1997-10-31 2001-08-21 Fresenius Medical Care Deutschland Gmbh Solution for peritoneal dialysis
US6689393B1 (en) 1999-03-22 2004-02-10 Fresenius Medical Care Deutschland Solution, in particular for hemodialysis or peritoneal dialysis and a method of preparing same
US8105258B2 (en) 1999-04-26 2012-01-31 Baxter International Inc. Citrate anticoagulation system for extracorporeal blood treatments
US8529486B2 (en) 1999-04-26 2013-09-10 Baxter International Inc. Citrate anticoagulation system for extracorporeal blood treatments
US6743191B1 (en) 1999-04-26 2004-06-01 Edwards Lifesciences Ag Substitution infusion fluid and citrate anticoagulation
US7186420B2 (en) 1999-04-26 2007-03-06 Edwards Lifesciences Corporation Multi-part substitution infusion fluids and matching anticoagulants
US7758900B2 (en) 1999-04-26 2010-07-20 Baxter International Inc. Multi-part substitution infusion fluids and matching anticoagulants
US8795517B2 (en) 1999-04-26 2014-08-05 Nikkiso Co., Ltd. Machine readable medium embodying instructions for citrate anticoagulation system for extracorporeal blood treatments
US8158157B2 (en) 1999-04-26 2012-04-17 Baxter International Inc. Multi-part substitution infusion fluids and matching anticoagulants
WO2002024209A1 (en) * 2000-09-21 2002-03-28 Hollander, Adrianus, Antonius, Marcus, Johannes Fluid for haemofiltration
NL1016235C2 (en) * 2000-09-21 2002-03-22 Adrianus Antonius Marcus Johan Liquid for haemofiltration.
US10232103B1 (en) 2001-11-13 2019-03-19 Baxter International Inc. System, method, and composition for removing uremic toxins in dialysis processes
US10980931B2 (en) 2001-11-13 2021-04-20 Baxter International Inc. System, method, and composition for removing uremic toxins in dialysis processes
US10363352B2 (en) 2002-07-19 2019-07-30 Baxter International Inc. Disposable set and system for dialysis
US10179200B2 (en) 2002-07-19 2019-01-15 Baxter International Inc. Disposable cassette and system for dialysis
US9764074B1 (en) 2002-07-19 2017-09-19 Baxter International Inc. Systems and methods for performing dialysis
US11235094B2 (en) 2002-07-19 2022-02-01 Baxter International Inc. System for peritoneal dialysis
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US10245370B2 (en) 2003-11-05 2019-04-02 Baxter International Inc. Renal failure therapy machines and methods including convective and diffusive clearance
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US9572919B2 (en) 2003-11-05 2017-02-21 Baxter International Inc. Dialysis system with cassette based balance chambers and volumetric pumps
US9872950B2 (en) 2003-11-05 2018-01-23 Baxter International Inc. Renal therapy system having pump reversing fluid control
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