DE4122754A1 - Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function - Google Patents
Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver functionInfo
- Publication number
- DE4122754A1 DE4122754A1 DE4122754A DE4122754A DE4122754A1 DE 4122754 A1 DE4122754 A1 DE 4122754A1 DE 4122754 A DE4122754 A DE 4122754A DE 4122754 A DE4122754 A DE 4122754A DE 4122754 A1 DE4122754 A1 DE 4122754A1
- Authority
- DE
- Germany
- Prior art keywords
- mmol
- lactate
- soln
- substitute
- glucose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
Abstract
Description
Bei der von unserem Mandanten entwickelten Erfindung handelt es sich um eine chemische Substanz, welche als Substitu tionslösung für die Hämofiltration bei Dialyseverfahren geeignet ist. (Bikarbonat-Hämofiltration).Acting on the invention developed by our client it is a chemical substance, which as Substitu solution for hemofiltration in dialysis procedures suitable is. (Bicarbonate hemofiltration).
Unter patentfähigen Schutz gestellt werden soll die genaue Zusammensetzung und Herstellung der Bikarbonat-Substi tutionslösung, ebenso wie die gewerbliche Vermarktung. Die unter Schutz zu stellende Lösung setzt sich wie folgt zusammen:The exact protection is to be placed under patentable protection Composition and manufacture of bicarbonate substi solution as well as commercial marketing. The solution to be protected is set up as follows together:
Natrium 145 mmol/l, Kalium 1-4 mmol/l (nach Bedarf), Kalzium 1,5 mmol/l, Magnesium 0,5 mmol/l, Chlorid 118 mmol/l, Glukose 100 mg/dl, Laktat 3,0 mmol/l, Bikarbonat 35 mmol/l.Sodium 145 mmol / l, potassium 1-4 mmol / l (after Calcium) 1.5 mmol / l, magnesium 0.5 mmol / l, Chloride 118 mmol / l, glucose 100 mg / dl, lactate 3.0 mmol / l, Bicarbonate 35 mmol / l.
Zur adäquaten Verteilung der Inhaltsstoffe ist ein Verrüh ren, bzw. Schütteln der Substanz notwendig.To adequately distribute the ingredients, stir together Ren, or shaking the substance necessary.
Bei der von unserem Mandanten entwickelten Substitutions lösung handelt es sich um eine besonders gut verträgliche Substanz für die Bikarbonat-Hämofiltration, speziell ver wendbar bei schwerer Azidose. Besonders bei Kleinkindern ist die zur Anmeldung gebrachte Substitutionslösung schonend an wendbar. Die Lösung kann sowohl bei der maschinellen, als auch der kontinuierlichen atheriovinösen Hämo-Filtration zum Einsatz gebracht werden. Die Lösung stellt gegenüber der bisher üblicherweise verwendeten Laktatpuffersubstanz eine Weiterentwicklung dahingehend da, daß sie besonders gut verträglich ist bei Patienten die eine schwere Leberer krankung, bzw. Azidose (Speziel-Laktat-Azidose) aufweisen. Ebenso gut ist die Verträglichkeit bei Kleinkindern, die wegen ihrer noch unreifen Leber das früher verwendete Laktat nicht zu verstoffwechseln vermögen.In the substitution developed by our client solution is a particularly well tolerated Substance for bicarbonate hemofiltration, especially ver reversible in severe acidosis. Especially with toddlers the substitution solution submitted for registration reversible. The solution can be both in the machine, as also continuous atheriovinous hemofiltration for Be put into action. The solution faces the Lactate buffer substance commonly used up to now Further development in that they are particularly good a patient with a severe liver is tolerated disease or acidosis (special lactate acidosis). Tolerance in young children is just as good because of their still immature liver the lactate used earlier unable to metabolize.
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4122754A DE4122754A1 (en) | 1991-07-10 | 1991-07-10 | Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4122754A DE4122754A1 (en) | 1991-07-10 | 1991-07-10 | Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function |
Publications (1)
Publication Number | Publication Date |
---|---|
DE4122754A1 true DE4122754A1 (en) | 1993-01-21 |
Family
ID=6435788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE4122754A Withdrawn DE4122754A1 (en) | 1991-07-10 | 1991-07-10 | Substitute soln. for haemo-filtration in dialysing processes - contains sodium, potassium, calcium, magnesium, chloride ions, glucose, lactate and bi:carbonate, esp. for patients with weakened liver function |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE4122754A1 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6277815B1 (en) * | 1997-10-31 | 2001-08-21 | Fresenius Medical Care Deutschland Gmbh | Solution for peritoneal dialysis |
NL1016235C2 (en) * | 2000-09-21 | 2002-03-22 | Adrianus Antonius Marcus Johan | Liquid for haemofiltration. |
US6689393B1 (en) | 1999-03-22 | 2004-02-10 | Fresenius Medical Care Deutschland | Solution, in particular for hemodialysis or peritoneal dialysis and a method of preparing same |
US6743191B1 (en) | 1999-04-26 | 2004-06-01 | Edwards Lifesciences Ag | Substitution infusion fluid and citrate anticoagulation |
US7186420B2 (en) | 1999-04-26 | 2007-03-06 | Edwards Lifesciences Corporation | Multi-part substitution infusion fluids and matching anticoagulants |
US7837666B2 (en) | 2005-01-28 | 2010-11-23 | Fresenius Medical Care North America | Systems and methods for delivery of peritoneal dialysis (PD) solutions |
US8038639B2 (en) | 2004-11-04 | 2011-10-18 | Baxter International Inc. | Medical fluid system with flexible sheeting disposable unit |
US8105258B2 (en) | 1999-04-26 | 2012-01-31 | Baxter International Inc. | Citrate anticoagulation system for extracorporeal blood treatments |
US8114276B2 (en) | 2007-10-24 | 2012-02-14 | Baxter International Inc. | Personal hemodialysis system |
US8858488B2 (en) | 2003-11-05 | 2014-10-14 | Baxter International Inc. | Dialysis system including blood and dialysate cassette |
US8920362B2 (en) | 2007-07-05 | 2014-12-30 | Baxter International Inc. | Dialysis system having disposable cassette |
US8992463B2 (en) | 2007-11-09 | 2015-03-31 | Baxter International Inc. | Balanced flow dialysis machine |
US9585810B2 (en) | 2010-10-14 | 2017-03-07 | Fresenius Medical Care Holdings, Inc. | Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser |
WO2017093553A1 (en) * | 2015-12-04 | 2017-06-08 | Fresenius Medical Care Deutschland Gmbh | Hemofiltration solutions for the treatment of strokes |
US9764074B1 (en) | 2002-07-19 | 2017-09-19 | Baxter International Inc. | Systems and methods for performing dialysis |
US10232103B1 (en) | 2001-11-13 | 2019-03-19 | Baxter International Inc. | System, method, and composition for removing uremic toxins in dialysis processes |
US10646634B2 (en) | 2008-07-09 | 2020-05-12 | Baxter International Inc. | Dialysis system and disposable set |
US11495334B2 (en) | 2015-06-25 | 2022-11-08 | Gambro Lundia Ab | Medical device system and method having a distributed database |
US11516183B2 (en) | 2016-12-21 | 2022-11-29 | Gambro Lundia Ab | Medical device system including information technology infrastructure having secure cluster domain supporting external domain |
US11918721B2 (en) | 2022-04-22 | 2024-03-05 | Baxter International Inc. | Dialysis system having adaptive prescription management |
Citations (10)
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---|---|---|---|---|
US3978212A (en) * | 1973-12-19 | 1976-08-31 | Chemo Drug Company | Electrolyte solutions containing magnesium and free bicarbonate ions |
EP0022922A1 (en) * | 1979-07-24 | 1981-01-28 | Gambro Dialysatoren K.G. | Method of forming an aqueous dialysis solution |
EP0034916A1 (en) * | 1980-02-21 | 1981-09-02 | Preston Leonard Veltman | Compositions suitable for use in preparing dialysis solutions, and processes for producing such compositions |
WO1981003180A1 (en) * | 1980-05-09 | 1981-11-12 | A Babb | System for bicarbonate dialysate |
EP0086553A1 (en) * | 1982-01-29 | 1983-08-24 | Preston Leonard Veltman | Dialysis solutions containing bicarbonate ions |
DE3224823A1 (en) * | 1982-07-02 | 1984-01-05 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Process for the preparation of an electrolyte solution, which is optimised for the particular patient, for use in haemodialysis |
EP0177614A1 (en) * | 1984-02-13 | 1986-04-16 | Tomita Pharmaceutical Corporation Limited | Process for producing mixed electrolyte powder for use in bicarbonate dialysis |
DE3917251A1 (en) * | 1989-05-26 | 1990-11-29 | Fresenius Ag | Sodium biscarboxylate-containing concentrate and method for producing a dihydrogenation liquid |
US4980374A (en) * | 1988-04-15 | 1990-12-25 | Fresenius Ag | Dialysis and rinsing solution for intraperitoneal administration with antimicrobial activity |
US5011826A (en) * | 1988-04-15 | 1991-04-30 | Fresenius Ag | Aqueous dialysis and rinsing solution for intraperitoneal administration |
-
1991
- 1991-07-10 DE DE4122754A patent/DE4122754A1/en not_active Withdrawn
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3978212A (en) * | 1973-12-19 | 1976-08-31 | Chemo Drug Company | Electrolyte solutions containing magnesium and free bicarbonate ions |
EP0022922A1 (en) * | 1979-07-24 | 1981-01-28 | Gambro Dialysatoren K.G. | Method of forming an aqueous dialysis solution |
EP0034916A1 (en) * | 1980-02-21 | 1981-09-02 | Preston Leonard Veltman | Compositions suitable for use in preparing dialysis solutions, and processes for producing such compositions |
WO1981003180A1 (en) * | 1980-05-09 | 1981-11-12 | A Babb | System for bicarbonate dialysate |
EP0086553A1 (en) * | 1982-01-29 | 1983-08-24 | Preston Leonard Veltman | Dialysis solutions containing bicarbonate ions |
DE3224823A1 (en) * | 1982-07-02 | 1984-01-05 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Process for the preparation of an electrolyte solution, which is optimised for the particular patient, for use in haemodialysis |
EP0177614A1 (en) * | 1984-02-13 | 1986-04-16 | Tomita Pharmaceutical Corporation Limited | Process for producing mixed electrolyte powder for use in bicarbonate dialysis |
US4980374A (en) * | 1988-04-15 | 1990-12-25 | Fresenius Ag | Dialysis and rinsing solution for intraperitoneal administration with antimicrobial activity |
US5011826A (en) * | 1988-04-15 | 1991-04-30 | Fresenius Ag | Aqueous dialysis and rinsing solution for intraperitoneal administration |
DE3917251A1 (en) * | 1989-05-26 | 1990-11-29 | Fresenius Ag | Sodium biscarboxylate-containing concentrate and method for producing a dihydrogenation liquid |
Cited By (79)
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US6277815B1 (en) * | 1997-10-31 | 2001-08-21 | Fresenius Medical Care Deutschland Gmbh | Solution for peritoneal dialysis |
US6689393B1 (en) | 1999-03-22 | 2004-02-10 | Fresenius Medical Care Deutschland | Solution, in particular for hemodialysis or peritoneal dialysis and a method of preparing same |
US8105258B2 (en) | 1999-04-26 | 2012-01-31 | Baxter International Inc. | Citrate anticoagulation system for extracorporeal blood treatments |
US8529486B2 (en) | 1999-04-26 | 2013-09-10 | Baxter International Inc. | Citrate anticoagulation system for extracorporeal blood treatments |
US6743191B1 (en) | 1999-04-26 | 2004-06-01 | Edwards Lifesciences Ag | Substitution infusion fluid and citrate anticoagulation |
US7186420B2 (en) | 1999-04-26 | 2007-03-06 | Edwards Lifesciences Corporation | Multi-part substitution infusion fluids and matching anticoagulants |
US7758900B2 (en) | 1999-04-26 | 2010-07-20 | Baxter International Inc. | Multi-part substitution infusion fluids and matching anticoagulants |
US8795517B2 (en) | 1999-04-26 | 2014-08-05 | Nikkiso Co., Ltd. | Machine readable medium embodying instructions for citrate anticoagulation system for extracorporeal blood treatments |
US8158157B2 (en) | 1999-04-26 | 2012-04-17 | Baxter International Inc. | Multi-part substitution infusion fluids and matching anticoagulants |
WO2002024209A1 (en) * | 2000-09-21 | 2002-03-28 | Hollander, Adrianus, Antonius, Marcus, Johannes | Fluid for haemofiltration |
NL1016235C2 (en) * | 2000-09-21 | 2002-03-22 | Adrianus Antonius Marcus Johan | Liquid for haemofiltration. |
US10232103B1 (en) | 2001-11-13 | 2019-03-19 | Baxter International Inc. | System, method, and composition for removing uremic toxins in dialysis processes |
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US9764074B1 (en) | 2002-07-19 | 2017-09-19 | Baxter International Inc. | Systems and methods for performing dialysis |
US11235094B2 (en) | 2002-07-19 | 2022-02-01 | Baxter International Inc. | System for peritoneal dialysis |
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