DE4118710A1 - Prepn. of dry and viscous plant extracts - by distn. of ethanolic aq. fluid extracts, extn. of distillate with an immiscible liq. extractant and working up the distn. residue and extract - Google Patents
Prepn. of dry and viscous plant extracts - by distn. of ethanolic aq. fluid extracts, extn. of distillate with an immiscible liq. extractant and working up the distn. residue and extractInfo
- Publication number
- DE4118710A1 DE4118710A1 DE19914118710 DE4118710A DE4118710A1 DE 4118710 A1 DE4118710 A1 DE 4118710A1 DE 19914118710 DE19914118710 DE 19914118710 DE 4118710 A DE4118710 A DE 4118710A DE 4118710 A1 DE4118710 A1 DE 4118710A1
- Authority
- DE
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- Prior art keywords
- extract
- ethanolic
- extracts
- dry
- dick
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000284 extract Substances 0.000 title claims abstract description 71
- 239000012530 fluid Substances 0.000 title abstract description 4
- 239000000419 plant extract Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 claims abstract description 16
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000007788 liquid Substances 0.000 claims description 29
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 19
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 11
- 238000004821 distillation Methods 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- 235000001667 Vitex agnus castus Nutrition 0.000 claims description 6
- 244000063464 Vitex agnus-castus Species 0.000 claims description 6
- 235000009347 chasteberry Nutrition 0.000 claims description 6
- 239000000377 silicon dioxide Substances 0.000 claims description 6
- 235000012239 silicon dioxide Nutrition 0.000 claims description 6
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 5
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 150000005846 sugar alcohols Polymers 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 3
- 229920002678 cellulose Polymers 0.000 claims description 3
- 235000010980 cellulose Nutrition 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 229920000136 polysorbate Polymers 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- CTPDSKVQLSDPLC-UHFFFAOYSA-N 2-(oxolan-2-ylmethoxy)ethanol Chemical compound OCCOCC1CCCO1 CTPDSKVQLSDPLC-UHFFFAOYSA-N 0.000 claims description 2
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229920000858 Cyclodextrin Polymers 0.000 claims description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 229930195725 Mannitol Natural products 0.000 claims description 2
- 235000021360 Myristic acid Nutrition 0.000 claims description 2
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 235000021355 Stearic acid Nutrition 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims description 2
- 150000001735 carboxylic acids Chemical class 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229940097362 cyclodextrins Drugs 0.000 claims description 2
- 150000004665 fatty acids Chemical class 0.000 claims description 2
- 239000000321 herbal drug Substances 0.000 claims description 2
- 239000000594 mannitol Substances 0.000 claims description 2
- 235000010355 mannitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims description 2
- 229950008882 polysorbate Drugs 0.000 claims description 2
- 229960004063 propylene glycol Drugs 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- 235000010356 sorbitol Nutrition 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- 239000008117 stearic acid Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 235000000346 sugar Nutrition 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- 239000000811 xylitol Substances 0.000 claims description 2
- 235000010447 xylitol Nutrition 0.000 claims description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims description 2
- 229960002675 xylitol Drugs 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims 10
- -1 fatty acid esters Chemical class 0.000 claims 2
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 1
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 1
- 239000008186 active pharmaceutical agent Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 229960005168 croscarmellose Drugs 0.000 claims 1
- 229960000913 crospovidone Drugs 0.000 claims 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 235000013399 edible fruits Nutrition 0.000 claims 1
- 229940068965 polysorbates Drugs 0.000 claims 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 11
- 229940079593 drug Drugs 0.000 abstract description 9
- 239000007787 solid Substances 0.000 abstract description 5
- 239000002775 capsule Substances 0.000 abstract description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229940068977 polysorbate 20 Drugs 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Description
Für die pharmazeutische Verarbeitung von pflanzlichen Drogen werden hauptsächlich Flüssig-Extrakte (Fluid-Extrakte bzw. Tinkturen), Dickextrakte (Spissum-Extrakte) und Trockenextrakte (Siccum-Extrakte) verwendet.For the pharmaceutical processing of herbal drugs mainly liquid extracts (fluid extracts or Tinctures), thick extracts (spissum extracts) and dry extracts (Siccum extracts) used.
Wie in den meisten Arzneibüchern beschrieben, wird für die Herstellung von Flüssig-Extrakten in der Regel als Auszugs mittel eine wäßrig-äthanolische Mischung verwendet.As described in most pharmacopoeias, for Production of liquid extracts usually as an extract medium used an aqueous ethanol mixture.
Da viele Drogen medizinisch wirksame flüchtige Bestand teile enthalten, bestehen zwischen halbfesten bzw. Trocken- Extrakten und einem aus der gleichen Droge hergestellten Flüssig-Extrakt erhebliche Unterschiede in der phytoche mischen Zusammensetzung.Because many drugs are medically effective volatile parts included, exist between semi-solid or dry Extracts and one made from the same drug Liquid extract significant differences in phytoche mix composition.
Nach den herkömmlich angewandten Verfahren geht ein Großteil der flüchtigen Drogenbestandteile bei der Herstellung zu Trocken- bzw halbfesten Extrakten verloren. Somit sind klinisch-pharmakologische Aussagen, welche mit äthanolhal tigen Flüssig-Extrakten gewonnen wurden, nicht immer ohne weiteres auf Präparate von Trocken- bzw. Dick-Extrakten zu übertragen.The majority of the processes are based on the conventional methods of volatile drug components in manufacturing Dry or semi-solid extracts lost. So are clinical-pharmacological statements, which with ethanol liquid extracts, not always without further on preparations of dry or thick extracts transfer.
Daher ist ein Verfahren hocherwünscht, welches die Herstel lung von Dick- bzw. Trocken-Extrakten erlaubt, wo die flüchtigen Bestandteile praktisch nicht verloren gehen. Therefore, a method which the manufacturer Thick or dry extracts allowed where the volatile components are practically not lost.
Extrakte mit solchen Eigenschaften würden es erlauben, feste Arzneiformen, wie Tabletten, Kapseln (Hart- und Weichgelatine- Kapseln), Granulate, zu entwickeln, wo die klinisch-pharma kologische Wirksamkeit mit der einer äthanolhaltigen Flüssig- Extrakt-Arzneiform vergleichbar ist.Extracts with such properties would allow them to be solid Dosage forms, such as tablets, capsules (hard and soft gelatin Capsules), granules, develop where the clinical pharma ecological effectiveness with that of a liquid containing ethanol Extract drug form is comparable.
Feste Darreichungsformen haben insbesondere bei Drogen mit schlechtem Geschmack einen erheblichen Compliance-Vorteil gegenüber flüssigen Zubereitungen, da oft auf Grund der schlechten Compliance die Therapie vorzeitig vom Patienten abgebrochen wird. Außerdem sind diese Darreichungsformen im Gegensatz zu den Flüssig-Extrakt-Zubereitungen äthanolfrei, was insbesondere vorteilhaft ist für die Anwendung bei Alkoho likern und Kindern.Fixed dosage forms are particularly important for drugs bad taste has a significant compliance advantage compared to liquid preparations, because of the poor compliance the therapy prematurely from the patient is canceled. In addition, these dosage forms are in the In contrast to the liquid extract preparations, free of ethanol, which is particularly advantageous for use in alcohol likers and children.
Somit könnte den WHO-Empfehlungen voll entsprochen werden. Ein solcher Dick- oder Fest-Extrakt erlaubte es auch, durch Auflösung in einem äthanolfreien Lösungsmittel, äthanolfreie Flüssigextrakte herzustellen.The WHO recommendations could thus be fully complied with. Such a thick or solid extract also allowed through Dissolution in an ethanol-free solvent, ethanol-free To produce liquid extracts.
Der vorliegenden Erfindung liegt ein solches hocherwünschtes Verfahren zugrunde, welches die Herstellung von Dick- bzw. Trockenextrakten erlaubt, welche in ihren Inhaltsstoffzusam mensetzungen mit einem aus der gleichen Droge hergestellten wäßrig-äthanolischen Flüssig-Extrakt vergleichbar sind.The present invention has such a highly desirable one Process based on the production of thick or Dry extracts allowed, which together in their ingredients resolutions with one made from the same drug aqueous-ethanolic liquid extract are comparable.
Überraschenderweise wurde gefunden, daß durch Abdestillieren des Äthanol-Wasser-Gemisches aus Flüssig-Extrakten und anschließender Extraktion des Destillates mit einem geeigneten Extraktionsmittel die flüchtigen Drogen-Bestandteile aus der Äthanol-Wasser-Phase praktisch vollständig extrahiert werden können.Surprisingly, it was found that by distillation of the ethanol-water mixture of liquid extracts and subsequent extraction of the distillate with a suitable one Extractant the volatile drug components from the Ethanol-water phase can be extracted almost completely can.
Nach dem Abtrennen der Extraktionsphase und anschließender Vereinigung derselben mit dem Destillationsrückstand, erhält man ggf.durch Zugabe von geeigneten Hilfsstoffen einen Dick- bzw. Trocken-Extrakt, mit dem praktisch gleichen Inhaltsstoff- Spektrum, wie im ursprünglichen Flüssig-Extrakt.After separation of the extraction phase and subsequent Union of the same with the distillation residue if necessary, a thick- or dry extract, with practically the same ingredient Spectrum as in the original liquid extract.
Bedingt durch die Eigenschaften des Extraktionsmittels und Zugabe von ggf. Hilfsstoffen, wie z. B. hochdispersem Silicium dioxid, kann verhindert werden, daß die flüchtigen Bestand teile bei der späteren Weiterverarbeitung zu Pharmazeutika in relevantem Ausmaß entweichen.Due to the properties of the extractant and Addition of auxiliary materials, if necessary, such as B. highly disperse silicon dioxide, can be prevented from volatile parts in later processing into pharmaceuticals relevant dimensions escape.
Als Extraktionsmittel werden physiologisch unbedenkliche Ester von ein- oder mehrwertigen Carbonsäuren, wie z. B. Fettsäuren (z. B. Stearinsäure, Myristinsäure u. a.), Adipinsäure u. a. mit ein- oder mehrwertigen Alkoholen, z. B. Äthanol, Isopropanol, Glycerin u. a. verwendet, einzeln oder in Mischungen.Physiologically harmless esters are used as extractants of mono- or polyvalent carboxylic acids, such as. B. fatty acids (e.g. stearic acid, myristic acid and others), adipic acid u. a. with mono- or polyhydric alcohols, e.g. B. ethanol, Isopropanol, glycerin and the like a. used individually or in Mixtures.
Als Hilfsstoffe zur weiteren Verarbeitung werden ggf. pharma zeutisch übliche Hilfsstoffe, einzeln oder in Mischungen, wie hochdisperses Siliciumdioxid, Stärke und Derivate, Cellulose und Derivate (auch quervernetzt), Poly(1-vinyl-2-pyrrolidon) und Derivate (auch quervernetzt), Einfach- und Mehrfachzucker, wie z. B. Saccharose, Lactose, Zucker-Alkohole, wie z. B. Mannit, Xylit, Sorbit, Polyäthylenglycol, wie z. B. Polyäthylenglycol 4000, Cyclodextrine, Propylenglycol, Carbonsäureester, physio logisch verträgliche Tenside, wie z. B. Polysorbate u. a. zuge geben, besonders bevorzugt hochdisperses Siliciumdioxid. Pharmaceuticals may be used as auxiliary substances for further processing typical auxiliary substances, individually or in mixtures, such as highly disperse silicon dioxide, starch and derivatives, cellulose and derivatives (also cross-linked), poly (1-vinyl-2-pyrrolidone) and derivatives (also cross-linked), single and multiple sugars, such as B. sucrose, lactose, sugar alcohols, such as. B. mannitol, Xylitol, sorbitol, polyethylene glycol, such as. B. polyethylene glycol 4000, cyclodextrins, propylene glycol, carboxylic acid esters, physio logically compatible surfactants, such as. B. Polysorbate u. a. supplied give, particularly preferably highly disperse silicon dioxide.
200 g alkoholisch-wäßriger Flüssig-Extrakt aus Vitex Agnus Castus werden in einer Destillationsapparatur mit rotieren dem Kolben gegeben und destilliert.200 g alcoholic aqueous liquid extract from Vitex Agnus Castus will also rotate in a distillation apparatus given to the flask and distilled.
Anschließend wird das Destillat mit 20 g Isopropylmyristat und 120 ml gesättigter Kochsalzlösung versetzt und geschüttelt. Nach dem Absetzen der Isopropylmyristat-Phase wird diese abge trennt und mit dem Destillationsrückstand vereinigt. Den ver einigten Phasen werden 130 g Lactose, 23 g hochdisperses Sili ciumdioxid, 10 g Propylenglycol und 2 g Polysorbat 20 zugegeben.The distillate is then mixed with 20 g of isopropyl myristate and 120 ml of saturated sodium chloride solution and shaken. After the isopropyl myristate phase has settled, it is separated off and combined with the distillation residue. 130 g of lactose, 23 g of highly disperse silicon dioxide, 10 g of propylene glycol and 2 g of polysorbate 20 are added to the combined phases.
Nach intensivem Mischen entsteht ein Trockenextrakt, welcher zu festen Arzneiformen, wie Kapseln, Tabletten oder Granulate weiter verarbeitet werden kann.After intensive mixing, a dry extract is created, which to solid pharmaceutical forms, such as capsules, tablets or Granules can be processed further.
200 g alkoholisch-wäßriger Flüssig-Extrakt aus Vitex Agnus Castus werden in einer Destillationsapparatur mit rotierendem Kolben gegeben und destilliert.200 g alcoholic aqueous liquid extract from Vitex Agnus Castus are made in a still with rotating Added flask and distilled.
Anschließend wird das Destillat mit 20 g Isopropylmyristat und 120 ml gesättigter Kochsalzlösung versetzt und geschüttelt. Nach dem Absetzen der Isopropylmyristat-Phase wird diese abgetrennt und mit dem Destillationsrückstand vereinigt. Anschließend wird mit Glycofurol auf das ursprüngliche Volumen von 200 ml wieder aufgefüllt. Then the distillate with 20 g of isopropyl myristate and 120 ml of saturated saline solution and shaken. After the isopropyl myristate phase has settled, it becomes separated and combined with the distillation residue. Then the original is made with Glycofurol Volume of 200 ml replenished.
Gaschromatogramm von äthanolisch-wäßrigem Flüssig-Extrakt von Vitex Agnus Castus.Gas chromatogram of ethanolic aqueous liquid extract of Vitex Agnus Castus.
Gaschromatogramm eines erfindungsgemäß hergestellten Trocken-Extraktes, ausgehend von äthanolisch-wäßrigem Fluid-Extrakt aus Vitex Agnus Castus.Gas chromatogram of a produced according to the invention Dry extract, starting from watery ethanol Fluid extract from Vitex Agnus Castus.
Claims (10)
- - Destillation des äthanolisch-wäßrigen Flüssig-Extraktes.
- - Extraktion des Destillates mit einem nicht mischbaren toxikologisch unbedenklichen flüssigen Extraktionsmittel, ggf. unter Zugabe von zusätzlichem Wasser.
- - Abtrennung der Extraktionsphase von der Äthanol-Wasser-Phase.
- - Weiterverarbeitung von Extraktionsphase und Destillations rückstand zu Trockenextrakt oder Dickextrakt, unter Verwendung von ggf. geeigneten Hilfsstoffen,
- - oder separate Weiterverarbeitung von Extraktions phase und Destillationsrückstand und spätere Vereinigung dieser in der Pharmazeutika-Herstellung.
- - Distillation of the ethanolic-aqueous liquid extract.
- - Extraction of the distillate with an immiscible, toxicologically harmless liquid extractant, if necessary with the addition of additional water.
- - Separation of the extraction phase from the ethanol-water phase.
- - Further processing of the extraction phase and distillation residue into dry extract or thick extract, using suitable auxiliaries if necessary,
- - Or separate further processing of the extraction phase and distillation residue and later combining them in the pharmaceutical production.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19914118710 DE4118710A1 (en) | 1991-06-07 | 1991-06-07 | Prepn. of dry and viscous plant extracts - by distn. of ethanolic aq. fluid extracts, extn. of distillate with an immiscible liq. extractant and working up the distn. residue and extract |
| PCT/EP1992/001212 WO1992021357A1 (en) | 1991-06-07 | 1992-06-02 | Concentrated and/or dry plant extracts |
| AU18830/92A AU1883092A (en) | 1991-06-07 | 1992-06-02 | Concentrated and/or dry plant extracts |
| DE59207957T DE59207957D1 (en) | 1991-06-07 | 1992-06-02 | VEGETABLE THICK AND / OR DRY EXTRACTS |
| AT92911099T ATE147986T1 (en) | 1991-06-07 | 1992-06-02 | VEGETABLE THICK AND/OR DRY EXTRACTS |
| EP92911099A EP0589921B1 (en) | 1991-06-07 | 1992-06-02 | Concentrated and/or dry plant extracts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19914118710 DE4118710A1 (en) | 1991-06-07 | 1991-06-07 | Prepn. of dry and viscous plant extracts - by distn. of ethanolic aq. fluid extracts, extn. of distillate with an immiscible liq. extractant and working up the distn. residue and extract |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE4118710A1 true DE4118710A1 (en) | 1992-12-10 |
Family
ID=6433393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19914118710 Withdrawn DE4118710A1 (en) | 1991-06-07 | 1991-06-07 | Prepn. of dry and viscous plant extracts - by distn. of ethanolic aq. fluid extracts, extn. of distillate with an immiscible liq. extractant and working up the distn. residue and extract |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE4118710A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4344468A1 (en) * | 1993-12-22 | 1995-07-06 | Heilscher Karl Prof Dr Sc | Prodn. of powder prods. from fresh fruit and vegetables |
-
1991
- 1991-06-07 DE DE19914118710 patent/DE4118710A1/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4344468A1 (en) * | 1993-12-22 | 1995-07-06 | Heilscher Karl Prof Dr Sc | Prodn. of powder prods. from fresh fruit and vegetables |
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