DE3942114A1 - New isoquinoline:sulphonamide and naphthalene:sulphonamide cpds. - Google Patents

New isoquinoline:sulphonamide and naphthalene:sulphonamide cpds.

Info

Publication number
DE3942114A1
DE3942114A1 DE19893942114 DE3942114A DE3942114A1 DE 3942114 A1 DE3942114 A1 DE 3942114A1 DE 19893942114 DE19893942114 DE 19893942114 DE 3942114 A DE3942114 A DE 3942114A DE 3942114 A1 DE3942114 A1 DE 3942114A1
Authority
DE
Germany
Prior art keywords
substd
opt
lower alkyl
sulphonamide
hydroxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19893942114
Other languages
German (de)
Other versions
DE3942114C2 (en
Inventor
Hiroyoshi Hidaka
Tomohiko Ishikawa
Masatoshi Hagiwara
Tsutomu Inoue
Kenji Naitoh
Osamu Sakuma
Masayuki Yuasa
Tadashi Morita
Tadashi Toshioka
Isao Umezawa
Takashi Inaba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tobishi Pharmaceutical Co Ltd
Original Assignee
Tobishi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tobishi Pharmaceutical Co Ltd filed Critical Tobishi Pharmaceutical Co Ltd
Priority to DE3943678A priority Critical patent/DE3943678C2/en
Priority claimed from DE3943678A external-priority patent/DE3943678C2/en
Publication of DE3942114A1 publication Critical patent/DE3942114A1/en
Application granted granted Critical
Publication of DE3942114C2 publication Critical patent/DE3942114C2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/10—Quaternary compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Abstract

Bicyclic sulphonamides and their addn. and quat. salts are new: where Y = N, N-CH3 or CH; R1 = H, opt. substd. lower alkyl, formyl, halophenylpropargyl, opt. substd. aralkyl or opt. substd. phenyl; and R2 = -W-N(R3)-CH(R4)-(X)m-Ar(R5)(R6)(R7) (II) or (III); R3 = H, opt. substd. lower alkyl, formyl, halophenylpropargyl, opt. substd. aralkyl or opt. substd. phenyl or R3 + R1 = lower alkylene; R4 = H or lower alkyl; R5 = H, halogen, nitro, lower alkyl, opt. substd. hydroxyl, opt. N-substd. amino, opt. substd. carboxy, polyfluoro-lower alkyl, cyano, hydroxymethyl, methylthio, methylsulphinyl or methylsulphonyl; and R6 = H, halogen or lower alkoxy; or R5 + R6 = lower alkylenedioxy; R7 = H or lower alkoxy; X = vinylene or ethynylene; Ar = phenyl, naphthyl or heterocyclyl gp.; m = 1-3; W = lower alkylene, opt. substd. phenylene or opt. substd. phenylene-lower alkylene; R10 = H, nitro, opt. substd. amino, opt. substd. hydroxyl, lower alkyl or halogen or R10 + R1 = lower alkylene; R11 = H, hydroxyl or lower alkoxy; R12 = R13 = H or R12+R13 = oxo; n = 1-3; A = CR14R15 or NR14; R14 = H, opt. substd. hydroxyl, opt. substd. phenyl, acryl, substd. carbonyl, opt. substd. alkoxycarbonyl, substd. carbamoyl, opt. substd. amino, arylsulphonyl, aralkylsulphonyl, aralkyl or heterocyclyl gp.; and R15 = H or lower alkyl; or R14+R15 = alkylenedioxy or oxo.
DE19893942114 1988-12-26 1989-12-20 Compounds with an effect for a uniform vascular muscle relaxation and pharmaceutical composition containing them Expired - Fee Related DE3942114C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE3943678A DE3943678C2 (en) 1988-12-26 1989-12-20 New isoquinoline:sulphonamide and naphthalene:sulphonamide cpds.

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP32591088 1988-12-26
JP7641989 1989-03-30
JP8786889 1989-04-10
DE3943678A DE3943678C2 (en) 1988-12-26 1989-12-20 New isoquinoline:sulphonamide and naphthalene:sulphonamide cpds.

Publications (2)

Publication Number Publication Date
DE3942114A1 true DE3942114A1 (en) 1990-06-28
DE3942114C2 DE3942114C2 (en) 1997-09-04

Family

ID=27434830

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19893942114 Expired - Fee Related DE3942114C2 (en) 1988-12-26 1989-12-20 Compounds with an effect for a uniform vascular muscle relaxation and pharmaceutical composition containing them

Country Status (1)

Country Link
DE (1) DE3942114C2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244895A (en) * 1991-05-15 1993-09-14 Hiroyoshi Hidaka Anti-ulcer agent
WO1999004775A2 (en) * 1997-07-24 1999-02-04 Ontogeny, Inc. Method of treating dopaminergic and gaba-nergic disorders
WO1999010004A2 (en) * 1997-08-29 1999-03-04 Ontogeny, Inc. Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto
WO1999020298A1 (en) * 1997-10-20 1999-04-29 Ontogeny, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
EP2316830A3 (en) * 2003-05-16 2011-08-17 The Medicines Company (Leipzig) GmbH N-sulphonylated amino acid derivatives and their use as matriptase inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109023A1 (en) * 1982-11-18 1984-05-23 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonamide derivatives and process for the preparation thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0109023A1 (en) * 1982-11-18 1984-05-23 Asahi Kasei Kogyo Kabushiki Kaisha Isoquinolinesulfonamide derivatives and process for the preparation thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Chemical Abstracts, Bd. 101, 1984, 191715y *
Chemical Abstracts, Bd. 106, 1987, 32864u *
Chemical Abstracts, Bd. 108, 37665v *
Chemical Abstracts, Bd. 98, 1983, 71954y *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5244895A (en) * 1991-05-15 1993-09-14 Hiroyoshi Hidaka Anti-ulcer agent
WO1999004775A2 (en) * 1997-07-24 1999-02-04 Ontogeny, Inc. Method of treating dopaminergic and gaba-nergic disorders
WO1999004775A3 (en) * 1997-07-24 2000-11-23 Ontogeny Inc Method of treating dopaminergic and gaba-nergic disorders
US7144997B2 (en) 1997-07-24 2006-12-05 Curis, Inc. Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto
WO1999010004A2 (en) * 1997-08-29 1999-03-04 Ontogeny, Inc. Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto
WO1999010004A3 (en) * 1997-08-29 1999-05-27 Ontogeny Inc Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto
WO1999020298A1 (en) * 1997-10-20 1999-04-29 Ontogeny, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
US6639051B2 (en) 1997-10-20 2003-10-28 Curis, Inc. Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto
EP2316830A3 (en) * 2003-05-16 2011-08-17 The Medicines Company (Leipzig) GmbH N-sulphonylated amino acid derivatives and their use as matriptase inhibitors

Also Published As

Publication number Publication date
DE3942114C2 (en) 1997-09-04

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