DE3887292D1 - Antibiotic compounds called A / 16686 factors A'1, A'2 and A'3. - Google Patents

Antibiotic compounds called A / 16686 factors A'1, A'2 and A'3.

Info

Publication number
DE3887292D1
DE3887292D1 DE88116947T DE3887292T DE3887292D1 DE 3887292 D1 DE3887292 D1 DE 3887292D1 DE 88116947 T DE88116947 T DE 88116947T DE 3887292 T DE3887292 T DE 3887292T DE 3887292 D1 DE3887292 D1 DE 3887292D1
Authority
DE
Germany
Prior art keywords
factors
antibiotic
compounds
atcc
mutant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE88116947T
Other languages
German (de)
Other versions
DE3887292T2 (en
Inventor
Francesco Assi
Luciano Gastaldo
Maurizio Denaro
Romeo Ciabatti
Bruno Cavalleri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lepetit SpA filed Critical Lepetit SpA
Application granted granted Critical
Publication of DE3887292D1 publication Critical patent/DE3887292D1/en
Publication of DE3887292T2 publication Critical patent/DE3887292T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/001—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence having less than 12 amino acids and not being part of a ring structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to depsipeptidic compounds related to antibiotic A/16696 complex of formula I <CHEM> Said compounds are named antibiotic A/16686 factors A'1, A'2 and A'3, respectively and are produced by fermentation of the microorganism Actinoplanes sp ATCC 33076 or a natural or artifical mutant thereof under appropriate conditions or by contacting antibiotic A/16686 factors A1, A2 and A3 or a mixture thereof with the mycelium of Actinoplanes sp ATCC 33076 or a natural or articial mutant thereof. The compounds have antibacterial activity, in particular, against widely diffused gram-positive bacteria and are particularly useful for topical treating of wound infections and acne.
DE88116947T 1987-11-27 1988-10-13 Antibiotic compounds called A / 16686 factors A'1, A'2 and A'3. Expired - Fee Related DE3887292T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878727807A GB8727807D0 (en) 1987-11-27 1987-11-27 Novel antibiotic compounds named a/16686 factors a'1,a'2 and a'3

Publications (2)

Publication Number Publication Date
DE3887292D1 true DE3887292D1 (en) 1994-03-03
DE3887292T2 DE3887292T2 (en) 1994-05-05

Family

ID=10627634

Family Applications (1)

Application Number Title Priority Date Filing Date
DE88116947T Expired - Fee Related DE3887292T2 (en) 1987-11-27 1988-10-13 Antibiotic compounds called A / 16686 factors A'1, A'2 and A'3.

Country Status (9)

Country Link
EP (1) EP0318680B1 (en)
JP (1) JPH0791315B2 (en)
KR (1) KR890008168A (en)
AT (1) ATE100470T1 (en)
DE (1) DE3887292T2 (en)
DK (1) DK612188A (en)
ES (1) ES2061590T3 (en)
GB (1) GB8727807D0 (en)
IE (1) IE883451L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE110784T1 (en) * 1987-06-19 1994-09-15 Sandoz Ag CYCLIC PEPTOLIDES.
ES2072348T3 (en) * 1989-11-07 1995-07-16 Lepetit Spa ANTIBIOTIC RECOVERY PROCEDURE A / 16686.
EP0976394A1 (en) * 1998-07-30 2000-02-02 Biosearch Italia S.p.A. New injectable formulations
WO2003076460A1 (en) * 2002-03-08 2003-09-18 Vicuron Pharmaceuticals Inc. A process for the production of ramoplanin-like amide derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE7031T1 (en) * 1980-08-16 1984-04-15 Gruppo Lepetit S.P.A. ANTIBIOTIC A/16686 FACTOR A2, PROCESS FOR PRODUCTION THEREOF AND THE SIMULTANEOUSLY PREPARED ANTIBIOTIC A/16686 FACTORS A1 AND A3.

Also Published As

Publication number Publication date
ATE100470T1 (en) 1994-02-15
KR890008168A (en) 1989-07-10
EP0318680A3 (en) 1990-08-01
DK612188D0 (en) 1988-11-03
DK612188A (en) 1989-05-28
JPH0791315B2 (en) 1995-10-04
EP0318680B1 (en) 1994-01-19
IE883451L (en) 1989-05-27
GB8727807D0 (en) 1987-12-31
EP0318680A2 (en) 1989-06-07
JPH01168700A (en) 1989-07-04
DE3887292T2 (en) 1994-05-05
ES2061590T3 (en) 1994-12-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee