DE3879803T2 - Reinigung von faktor viii:c durch phospholipid-affinitaet. - Google Patents

Reinigung von faktor viii:c durch phospholipid-affinitaet.

Info

Publication number
DE3879803T2
DE3879803T2 DE8888111301T DE3879803T DE3879803T2 DE 3879803 T2 DE3879803 T2 DE 3879803T2 DE 8888111301 T DE8888111301 T DE 8888111301T DE 3879803 T DE3879803 T DE 3879803T DE 3879803 T2 DE3879803 T2 DE 3879803T2
Authority
DE
Germany
Prior art keywords
factor viii
purification
phospholipid
phospholipid affinity
factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888111301T
Other languages
English (en)
Other versions
DE3879803D1 (de
Inventor
James E Brown
Cynthia A Cowgill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Inc filed Critical Miles Inc
Application granted granted Critical
Publication of DE3879803D1 publication Critical patent/DE3879803D1/de
Publication of DE3879803T2 publication Critical patent/DE3879803T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE8888111301T 1987-07-16 1988-07-14 Reinigung von faktor viii:c durch phospholipid-affinitaet. Expired - Fee Related DE3879803T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/074,123 US4795806A (en) 1987-07-16 1987-07-16 Phospholipid affinity purification of Factor VIII:C

Publications (2)

Publication Number Publication Date
DE3879803D1 DE3879803D1 (de) 1993-05-06
DE3879803T2 true DE3879803T2 (de) 1993-07-08

Family

ID=22117866

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888111301T Expired - Fee Related DE3879803T2 (de) 1987-07-16 1988-07-14 Reinigung von faktor viii:c durch phospholipid-affinitaet.

Country Status (6)

Country Link
US (1) US4795806A (de)
EP (1) EP0303064B1 (de)
AT (1) ATE87632T1 (de)
DE (1) DE3879803T2 (de)
ES (1) ES2053631T3 (de)
GR (1) GR3007541T3 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5930890A (en) * 1989-06-20 1991-01-08 Scripps Clinic And Research Foundation The phospholipid binding domain of factor viii
US5110907A (en) * 1989-08-01 1992-05-05 Alpha Therapeutic Corporation Factor viii complex purification using heparin affinity chromatography
WO1995003332A1 (en) * 1993-07-23 1995-02-02 Baxter International Inc. Activated human factor viii and method of preparation
US5576291A (en) * 1993-09-13 1996-11-19 Baxter International Inc. Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
DE4337573C1 (de) * 1993-11-04 1995-05-18 Octapharma Ag Verfahren zur Herstellung einer virusinaktivierten Faktor VIII enthaltenden Fraktion mittels chromatographischer Methoden
CA2276091A1 (en) * 1996-12-27 1998-07-09 Mochida Pharmaceutical Co., Ltd. Cell membrane-directed drugs
CA2634663C (en) 1999-02-22 2009-08-25 University Of Connecticut Novel albumin-free factor viii formulations
US8110218B2 (en) * 2000-11-30 2012-02-07 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein-lipid complexes
US7351688B2 (en) * 2003-02-05 2008-04-01 The Research Foundation Of State University Of New York Compositions and methods for less immunogenic protein formulations
US20050069578A1 (en) * 2003-08-05 2005-03-31 Balasubramanian Sathyamangalam V. Reconstitution medium for protein and peptide formulations
BRPI0612843A2 (pt) * 2005-06-29 2010-11-30 Univ New York State Res Found composição farmacêutica, métodos para fabricar a composição, e, uso de uma formulação
EP1915176A4 (de) * 2005-07-15 2008-12-03 Univ Vermont Hochsensitive immunassays und antikörper zum nachweis von blutfaktor viii
US7662405B2 (en) * 2005-08-09 2010-02-16 The Research Foundation Of State University Of New York Compositions and methods of preparation of liposomal microparticulate IL-12
US7875288B2 (en) * 2006-03-30 2011-01-25 The Research Foundation Of State University Of New York Method for treating blood coagulation disorders
EP2007357B1 (de) * 2006-03-30 2016-11-09 The Research Foundation Of State University Of New York Zusammensetzungen aus weniger immunogenen und langzirkulierenden protein-lipid-komplexen
WO2008102469A1 (ja) * 2007-02-23 2008-08-28 Kwansei Gakuin Educational Foundation 蛋白質結晶化剤および蛋白質結晶化剤を用いた蛋白質結晶化方法
JP5779780B2 (ja) 2008-11-07 2015-09-16 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 第ｖｉｉｉ因子製剤
US20130345403A1 (en) * 2010-12-16 2013-12-26 Novo Nordisk A/S Aqueous factor viii solution

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022758A (en) * 1973-06-19 1977-05-10 Ab Kabi Isolation of coagulation factors I and VIII from biological material
DE3101752A1 (de) * 1981-01-21 1982-08-26 Behringwerke Ag, 3550 Marburg "verfahren zur reinigung der blutgerinnungsfaktoren ii, vii, ix und/oder x und danach hergestellte praeparationen"
US4461833A (en) * 1982-06-23 1984-07-24 University Patents, Inc. Chromatographically purifying proteolytic procoagulant enzyme from animal tissue extract
US4397841A (en) * 1982-06-28 1983-08-09 Monsanto Company Production of blood coagulation factor VIII:C
US4508709A (en) * 1983-12-05 1985-04-02 Armour Pharmaceutical Company Process for purifying factor VIII:C
GB8403473D0 (en) * 1984-02-09 1984-03-14 Special Trustees For St Thomas Purification of factor viii
US4675385A (en) * 1985-03-27 1987-06-23 Alpha Therapeutic Corporation Isolation of human plasma procoagulant protein factor VIII from biological factors

Also Published As

Publication number Publication date
EP0303064B1 (de) 1993-03-31
US4795806A (en) 1989-01-03
ATE87632T1 (de) 1993-04-15
EP0303064A2 (de) 1989-02-15
EP0303064A3 (en) 1990-05-16
DE3879803D1 (de) 1993-05-06
GR3007541T3 (de) 1993-08-31
ES2053631T3 (es) 1994-08-01

Similar Documents

Publication Publication Date Title
DE3879803T2 (de) Reinigung von faktor viii:c durch phospholipid-affinitaet.
AU6733487A (en) Mammalian interleukin-4
FI873796A (fi) Foerbaettrad metod foer produktion av proteiner av faktor viii:c-typ.
EP1245678A3 (de) Rekombinante Proteine von mit Lymphadenopathiesyndrom und/oder erworbenem Immunschwächesyndrom assoziierten Viren
GR3030595T3 (en) Platelet activating factor antagonists.
FI91160B (fi) Menetelmä modifioidun ihmisen t-PA-proteiinin valmistamiseksi
EP0771871A3 (de) Expression von menschlichem Serumalbin in methylotrophischen Hefen
AU4971385A (en) A process for the cleavage of peptides and proteins at the methionyl bond
AU3473489A (en) Expression of hepatisis b s and pres2proteins in methylotrophic yeasts
DE68914316D1 (de) Polypeptide aus Vipergift und deren Genexpression.
EP0642507A4 (en) Catalytic antibodies against cocaine and methods of using and producing same.
ATE311447T1 (de) Herstellung von rekombinantem faktor viii in gegenwart von liposom-ähnliche verbindung- zusammensetzungen
AU2851389A (en) Synthetic peptides and mixtures thereof for detecting hiv antibodies
EP0395653A4 (en) Synovial phospholipases
DE69014300D1 (de) Radioaktive markierung von proteinen.
AU1321988A (en) The cloning of malaria-specific dna sequences: isolation of the gene for the 140 kd protein
ATE91303T1 (de) Verfahren zur herstellung von peptiden durch spezifische spaltung von gentechnisch gewonnenen fusionsproteinen mit collagenasen.
SU1538846A1 (ru) Лазерный материал

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee