DE3877136D1 - RECOMBINANT HISTIDINE PROTEIN OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE. - Google Patents

RECOMBINANT HISTIDINE PROTEIN OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE.

Info

Publication number
DE3877136D1
DE3877136D1 DE8888118043T DE3877136T DE3877136D1 DE 3877136 D1 DE3877136 D1 DE 3877136D1 DE 8888118043 T DE8888118043 T DE 8888118043T DE 3877136 T DE3877136 T DE 3877136T DE 3877136 D1 DE3877136 D1 DE 3877136D1
Authority
DE
Germany
Prior art keywords
antigens
plasmodium falciparum
production
fusion proteins
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888118043T
Other languages
German (de)
Inventor
Bernhard W- Marburg-Schr Knapp
Erika Dr Hundt
Burkhard Dr Enders
Hans Dr Kuepper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GSK Vaccines GmbH
Original Assignee
Behringwerke AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke AG filed Critical Behringwerke AG
Priority to DE8888118043T priority Critical patent/DE3877136D1/en
Application granted granted Critical
Publication of DE3877136D1 publication Critical patent/DE3877136D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/20—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans from protozoa
    • C07K16/205—Plasmodium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/6893—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for protozoa
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855—Proteins from animals other than mammals or birds

Abstract

The HRPII antigen of Plasmodium falciparum strain SGE2, with the indicated amino acid sequence, and antigenically active partial sequences thereof, are new. Also claimed are fusion proteins contg. these antigens; DNA and RNA coding for the antigens; vectors and DNA structures coding for the antigens or fusion proteins; host cells contg. such DNA or vectors; and antibodies to the antigens or fusion proteins.
DE8888118043T 1987-11-03 1988-10-29 RECOMBINANT HISTIDINE PROTEIN OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE. Expired - Fee Related DE3877136D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8888118043T DE3877136D1 (en) 1987-11-03 1988-10-29 RECOMBINANT HISTIDINE PROTEIN OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19873737238 DE3737238A1 (en) 1987-11-03 1987-11-03 RECOMBINANT HISTIDINE-PROTEIN (37 KD ANTIGEN) OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE
DE8888118043T DE3877136D1 (en) 1987-11-03 1988-10-29 RECOMBINANT HISTIDINE PROTEIN OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE.

Publications (1)

Publication Number Publication Date
DE3877136D1 true DE3877136D1 (en) 1993-02-11

Family

ID=6339664

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19873737238 Withdrawn DE3737238A1 (en) 1987-11-03 1987-11-03 RECOMBINANT HISTIDINE-PROTEIN (37 KD ANTIGEN) OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE
DE8888118043T Expired - Fee Related DE3877136D1 (en) 1987-11-03 1988-10-29 RECOMBINANT HISTIDINE PROTEIN OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19873737238 Withdrawn DE3737238A1 (en) 1987-11-03 1987-11-03 RECOMBINANT HISTIDINE-PROTEIN (37 KD ANTIGEN) OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE

Country Status (12)

Country Link
US (1) US5393523A (en)
EP (1) EP0315085B1 (en)
JP (1) JPH01165398A (en)
KR (1) KR970009346B1 (en)
AT (1) ATE83928T1 (en)
AU (1) AU618030B2 (en)
DE (2) DE3737238A1 (en)
DK (1) DK610588A (en)
ES (1) ES2037795T3 (en)
FI (1) FI97479C (en)
GR (1) GR3007476T3 (en)
PT (1) PT88915B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0474891A1 (en) * 1990-09-08 1992-03-18 BEHRINGWERKE Aktiengesellschaft Vectors for expression of malarial antigens on the surface of Salmonella vaccine strains
DE4041836A1 (en) * 1990-12-24 1992-06-25 Behringwerke Ag PROTECTIVE PLASMODIUM FALCIPARUM HYBRID PROTEINS COMPRISING PARTIAL SEQUENCES OF MALARIA ANTIGENE HRPII AND SERP, THEIR PREPARATION AND USE
AU670108B2 (en) * 1992-09-11 1996-07-04 Becton Dickinson & Company Improved antibodies to plasmodium falciparum
EP1754717A1 (en) 2005-08-19 2007-02-21 Université de Lausanne Antigenic peptides and their use
WO2009097159A1 (en) * 2008-02-02 2009-08-06 Tropical Health Systems Llc A blood purification method and appartus for the treatment of malaria

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE64957T1 (en) * 1984-02-22 1991-07-15 Wellcome Found CLONING DNA FOR PROTOZOA ANTIGENS.
AU5603786A (en) * 1985-04-11 1986-10-16 Walter And Eliza Hall Institute Of Medical Research, The Highly repetitive antigens - sharp-arp-mesa-plasmodium falciparum
US5130416A (en) * 1986-08-13 1992-07-14 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA clone containing a genomic fragment of PfHRP-II gene from plasmodium falciparum
US4721617A (en) * 1986-08-14 1988-01-26 Regents Of The University Of Minnesota Vaccine against lyme disease

Also Published As

Publication number Publication date
FI885023A0 (en) 1988-11-01
DK610588A (en) 1989-05-04
KR970009346B1 (en) 1997-06-10
EP0315085A2 (en) 1989-05-10
PT88915B (en) 1993-01-29
ES2037795T3 (en) 1993-07-01
FI97479C (en) 1996-12-27
FI885023A (en) 1989-05-04
KR890008318A (en) 1989-07-10
PT88915A (en) 1988-12-01
EP0315085B1 (en) 1992-12-30
ATE83928T1 (en) 1993-01-15
AU618030B2 (en) 1991-12-12
FI97479B (en) 1996-09-13
DE3737238A1 (en) 1989-05-18
GR3007476T3 (en) 1993-07-30
DK610588D0 (en) 1988-11-02
AU2459088A (en) 1989-05-25
JPH01165398A (en) 1989-06-29
EP0315085A3 (en) 1990-05-02
US5393523A (en) 1995-02-28

Similar Documents

Publication Publication Date Title
DE69636890D1 (en) NEW CTLA4 / CD28 LIGANDS AND THEIR APPLICATIONS
FI102075B1 (en) Method for preparing glycosylated or non-glycosylated polypeptide, recombinant nucleic acid and vectors
ATE90384T1 (en) RECOMBINANT VIRUS PROTEINS ACCOMPANYING LYMPHADENOPATHIC SYNDROME AND/OR ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS).
DE69934967D1 (en) METHOD FOR REDUCING IMMUNOGENICITY OF PROTEINS
DE3382837D1 (en) Production of functional human urokinase proteins
NO180239C (en) Expression vector encoding and expressing a polypeptide having the biological and immunological properties of EqIFN <gamma>, the host organism transformed therewith, and method for producing said polypeptide
HUP0002472A2 (en) Isolated dendritic cell membrane protein genes
ATE109830T1 (en) EXPRESSION OF VIRUS PROTEINS WITH IMMUNOLOGICAL ACTIVITY.
DK1246917T3 (en) Human Stra6 polypeptides
DE3881023D1 (en) PROTEINS, EXPRESSION VECTORS, CONTAINING DNA ENCODING SUCH PROTEINS, AND CELLS CONTAINING SUCH EXPRESSION VECTORS.
DE3877136D1 (en) RECOMBINANT HISTIDINE PROTEIN OF PLASMODIUM FALCIPARUM, ITS PRODUCTION AND USE.
ATE124420T1 (en) VACCINES AND TESTING KITS FOR HAEMOPHILUS INFLUENZAE.
SE8601940D0 (en) PREPARATION OF FUSED PROTEINS, ANTIBODIES AND PROCESSES THEREFOR
DK595187A (en) MINACTIVIN AND METHOD OF PRODUCING THEREOF
DE3876227D1 (en) MALARIA-SPECIFIC DNA SEQUENCES, THEIR EXPRESSION PRODUCTS AND THEIR USE.
DE69932644D1 (en) Human protein with in vitro antiproliferative activity.
FI870501A (en) A method for producing an antigenic cognate peptide or protein of the melanoma-associated p97 antigen, and recombinant viruses, recombinant vectors, and host cells useful therein
WO2002012475A3 (en) C1q-related factor, homologous polypeptides and therapeutic uses thereof
DK1241186T3 (en) Human growth arrest specifically gene-6 (gas-6) and nucleic acids encoding therefore
DK1241251T3 (en) Human prostasin-like protein and nucleic acids encoding the same
DK1241180T3 (en) Human A33 antigen-like protein and nucleic acids encoding this
DK1241184T3 (en) Human synaptogyrin-like protein and nucleic acids encoding this
ATE405590T1 (en) HUMAN HCAR-LIKE PROTEIN AND NUCLEIC ACID ENCODING THEREOF
DE69943058D1 (en) SOLUBLE PROTEIN 5 - UCP5
FI934079A (en) Method for preparing a fusion protein

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: CHIRON BEHRING GMBH & CO., 35039 MARBURG, DE

8339 Ceased/non-payment of the annual fee