DE3862426D1 - 2-SELENOMETHYL-1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. - Google Patents

2-SELENOMETHYL-1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.

Info

Publication number
DE3862426D1
DE3862426D1 DE8888108469T DE3862426T DE3862426D1 DE 3862426 D1 DE3862426 D1 DE 3862426D1 DE 8888108469 T DE8888108469 T DE 8888108469T DE 3862426 T DE3862426 T DE 3862426T DE 3862426 D1 DE3862426 D1 DE 3862426D1
Authority
DE
Germany
Prior art keywords
group
selenomethyl
dihydropyridine
production
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888108469T
Other languages
German (de)
Inventor
Marco Frigerio
Carmelo A Gandolfi
Odoardo Tofanetti
Sergio Tognella
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Italia SpA
Original Assignee
Boehringer Biochemia Robin SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Biochemia Robin SpA filed Critical Boehringer Biochemia Robin SpA
Application granted granted Critical
Publication of DE3862426D1 publication Critical patent/DE3862426D1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Compounds of formula I <CHEM> wherein: R1 is a cyano, nitro, acetyl, benzoyl or alkoxycarbonyl group; R2 is an optionally substituted phenyl or hetaryl group; R3 is an alkoxycarbonyl group; R4 is an alkyl group, optionally substituted by hydroxy, amino, phenyl, heterocyclic group; an optionally substituted phenyl group or an heterocyclic group. Compounds I are useful in human therapy as agents able to interact with Ca<+><+>-dependent systems and as anti-tumor agents.
DE8888108469T 1987-05-29 1988-05-27 2-SELENOMETHYL-1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. Expired - Fee Related DE3862426D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20728/87A IT1205114B (en) 1987-05-29 1987-05-29 2-SELENOMETHYL-1,4-DIHYDROPYRIDINE, PROCEDURE FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Publications (1)

Publication Number Publication Date
DE3862426D1 true DE3862426D1 (en) 1991-05-23

Family

ID=11171169

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888108469T Expired - Fee Related DE3862426D1 (en) 1987-05-29 1988-05-27 2-SELENOMETHYL-1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.

Country Status (7)

Country Link
US (1) US4988713A (en)
EP (1) EP0292981B1 (en)
AT (1) ATE62675T1 (en)
DE (1) DE3862426D1 (en)
ES (1) ES2031552T3 (en)
GR (1) GR3002560T3 (en)
IT (1) IT1205114B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863292A (en) * 1996-09-26 1999-01-26 Tosic; Aleksandar Articulated external orthopedic fixation system and method of use
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
CA2401336C (en) * 2000-02-29 2014-12-23 Integriderm, Inc. Inhibitors of melanocyte tyrosinase as topical skin lighteners

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
HU199796B (en) * 1985-08-06 1990-03-28 Boehringer Biochemia Srl Process for producing 2-thiomethyl-substituted-1,4-dihydropyridines and pharmaceutical compositions comprising such compounds

Also Published As

Publication number Publication date
EP0292981A2 (en) 1988-11-30
ATE62675T1 (en) 1991-05-15
IT1205114B (en) 1989-03-15
EP0292981B1 (en) 1991-04-17
US4988713A (en) 1991-01-29
ES2031552T3 (en) 1992-12-16
GR3002560T3 (en) 1993-01-25
EP0292981A3 (en) 1989-02-22
IT8720728A0 (en) 1987-05-29

Similar Documents

Publication Publication Date Title
DE69100079D1 (en) NAPHTHALINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
DE69030206D1 (en) Pyrazolopyridine compounds and process for their preparation
ATE124953T1 (en) BALE ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS THEREOF.
UY23404A1 (en) PREPARATION OF PYRIDYLIC COMPOUNDS THAT HAVE ANTIHISTAMINE ACTIVITY
ATE122042T1 (en) PYRAZOLOISOQUINOLINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME.
ATE18549T1 (en) 1-CARBOXYALKANOYLINDOLINE-2-CARBONIC ACID ESTER, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS, AND THEIR THERAPEUTIC USE.
DE3882277D1 (en) FLAVON-3-CARBONIC ACID COMPOUNDS AND METHOD, INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS.
FI103046B1 (en) A process for the preparation of pyrrolidinylthiocarbapenem derivatives useful as pharmaceuticals
ATE107298T1 (en) 3-AMINOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ATE172976T1 (en) 3-AMINOCHROMANE SPIRODERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
DE3862426D1 (en) 2-SELENOMETHYL-1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
DE3687385D1 (en) 2-SUBSTITUTED-1,4-DIHYDROPYRIDINE, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
ATE56707T1 (en) IMIDAZOLE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS.
DE69130266T2 (en) Optically active alkylenedioxybenzene derivatives and their use as medicines
ATE9584T1 (en) BETA-LACTAM ANTIBACTERIAL COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
ATE79870T1 (en) 2-THIOMETHYL-SUBSTITUTED PYRIDINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICALS CONTAINING THEM.
ATE7137T1 (en) NITROSOUREUM DERIVATIVES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE3775526D1 (en) BACTERICIDAL PYRIDOBENZOTHIAZINE DERIVATIVES WITH LONG DURATION OF EFFECT.
DE3770117D1 (en) NEW 1- / 3- (2-DIALKYLAMINOAETHOXY) -2-THIENYL / -3-PHENYL-1-PROPANONE AND THEIR ACID ADDITION SALTS AND METHOD FOR THE PRODUCTION THEREOF AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
ATE73775T1 (en) 2-DITHIOALKYL-DIHYDROPYRIDINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
DE69110570D1 (en) Medicament containing an N6-substituted adenosine derivative for the treatment of hyperlipidemia or hypertriglyceridemia.
DE3887611D1 (en) Butenic acid amides, their salts, pharmaceutical compositions containing them and processes for their preparation.
IT1229846B (en) ESTERS OF CATECOLAMINS.
DE3684536D1 (en) 1-DETHIA-2-THIACEPHALOSPORANCARBONSAEE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS MEDICINAL PRODUCTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME.
ATE44741T1 (en) 2-(N-SUBSTITUTED GUANIDINO)-4HETEROARYLTHIAZOLE AS ANTI-ULCER AGENTS.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee