DE3855122D1 - Artificial gene coding for human serum albumin, its use and process for its preparation - Google Patents

Artificial gene coding for human serum albumin, its use and process for its preparation

Info

Publication number
DE3855122D1
DE3855122D1 DE3855122T DE3855122T DE3855122D1 DE 3855122 D1 DE3855122 D1 DE 3855122D1 DE 3855122 T DE3855122 T DE 3855122T DE 3855122 T DE3855122 T DE 3855122T DE 3855122 D1 DE3855122 D1 DE 3855122D1
Authority
DE
Germany
Prior art keywords
serum albumin
human serum
disclosed
preparation
gene coding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3855122T
Other languages
German (de)
Other versions
DE3855122T2 (en
Inventor
Bertil Aberg
Andras Simoncsits
Miklos Kalman
Imre Cserpan
Gyoergy Bajszar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MTA SZEGEDI BIOLOGIAI KOEZPONTJA SZEGED HU
Vepex Contractor Ltd
Magyar Tudomanyos Akademia Szegedi Biologiai Kozpont
Skandigen AB
Original Assignee
MTA SZEGEDI BIOLOGIAI KOEZPONTJA SZEGED HU
Vepex Contractor Ltd
Magyar Tudomanyos Akademia Szegedi Biologiai Kozpont
Skandigen AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20369553&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3855122(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by MTA SZEGEDI BIOLOGIAI KOEZPONTJA SZEGED HU, Vepex Contractor Ltd, Magyar Tudomanyos Akademia Szegedi Biologiai Kozpont, Skandigen AB filed Critical MTA SZEGEDI BIOLOGIAI KOEZPONTJA SZEGED HU
Publication of DE3855122D1 publication Critical patent/DE3855122D1/en
Application granted granted Critical
Publication of DE3855122T2 publication Critical patent/DE3855122T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Abstract

A structural gene coding for authentic human serum albumin, - optionally supplemented by an upstream triplet coding for methionine and optionally extended by a synthetic prepro*-leader-coding sequence - , wherein the codons of the nucleotide sequence have been selected with regard to a non-human host, e.g. yeast, chosen for expression of authentic human serum albumin, is disclosed. Additionally there is disclosed a method of producing said gene. There are also disclosed a recombinant DNA molecule comprising said strucural gene inserted into a vector, and a host transformed with said recombinant DNA molecule. Furthermore there are disclosed a method of producing authentic human serum albumin, an authentic human serum albumin resulting from said method, and a pharmaceutical composition comprising said resulting human serum albumin.
DE3855122T 1987-09-14 1988-09-13 Artificial gene coding for human serum albumin, its use and process for its preparation Expired - Fee Related DE3855122T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8703539A SE459586B (en) 1987-09-14 1987-09-14 THE STRUCTURES CODING FOR AUTHENTIC HUMAN SERUM ALBUMIN AND PROCEDURES FOR ITS PREPARATION

Publications (2)

Publication Number Publication Date
DE3855122D1 true DE3855122D1 (en) 1996-04-25
DE3855122T2 DE3855122T2 (en) 1996-10-17

Family

ID=20369553

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3855122T Expired - Fee Related DE3855122T2 (en) 1987-09-14 1988-09-13 Artificial gene coding for human serum albumin, its use and process for its preparation

Country Status (12)

Country Link
EP (1) EP0308381B1 (en)
JP (1) JP2865683B2 (en)
AT (1) ATE135740T1 (en)
CA (1) CA1340650C (en)
DD (1) DD282473A5 (en)
DE (1) DE3855122T2 (en)
DK (1) DK163937C (en)
FI (1) FI901219A0 (en)
IL (1) IL87748A (en)
PL (1) PL274669A1 (en)
SE (1) SE459586B (en)
WO (1) WO1989002467A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2791418B2 (en) * 1987-12-02 1998-08-27 株式会社ミドリ十字 Method for producing heterologous protein, recombinant DNA, transformant
FR2649991B2 (en) * 1988-08-05 1994-03-04 Rhone Poulenc Sante USE OF STABLE DERIVATIVES OF PLASMID PKD1 FOR THE EXPRESSION AND SECRETION OF HETEROLOGOUS PROTEINS IN YEASTS OF THE GENUS KLUYVEROMYCES
US5759802A (en) * 1988-10-26 1998-06-02 Tonen Corporation Production of human serum alubumin A
US6406697B1 (en) 1989-02-23 2002-06-18 Genentech, Inc. Hybrid immunoglobulins
US5225538A (en) * 1989-02-23 1993-07-06 Genentech, Inc. Lymphocyte homing receptor/immunoglobulin fusion proteins
US5116964A (en) * 1989-02-23 1992-05-26 Genentech, Inc. Hybrid immunoglobulins
GB8909916D0 (en) * 1989-04-29 1989-06-14 Delta Biotechnology Ltd Polypeptides
ATE92107T1 (en) * 1989-04-29 1993-08-15 Delta Biotechnology Ltd N-TERMINAL FRAGMENTS OF HUMAN SERUM ALBUMIN-CONTAINING FUSION PROTEINS.
CA2017176A1 (en) * 1989-05-22 1990-11-22 Yoshitomi Pharmaceutical Industries Ltd. Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin
JPH0669365B2 (en) * 1989-05-22 1994-09-07 株式会社ミドリ十字 Albumin gene-containing plasmid, transformant, method for producing transformant, method for producing albumin
NL8901932A (en) * 1989-07-26 1991-02-18 Mogen Int PRODUCTION OF heterologous PROTEINS IN PLANTS OR PLANTS.
GB8923521D0 (en) * 1989-10-18 1989-12-06 Delta Biotechnology Ltd Yeast promoter
FR2686899B1 (en) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa NOVEL BIOLOGICALLY ACTIVE POLYPEPTIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
JPH07308199A (en) * 1994-05-18 1995-11-28 Green Cross Corp:The Production of human serum albumin
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
US5723125A (en) * 1995-12-28 1998-03-03 Tanox Biosystems, Inc. Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
CA2405709A1 (en) 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Albumin fusion proteins
US6946134B1 (en) 2000-04-12 2005-09-20 Human Genome Sciences, Inc. Albumin fusion proteins
CA2471363C (en) 2001-12-21 2014-02-11 Human Genome Sciences, Inc. Albumin fusion proteins
GB0217033D0 (en) 2002-07-23 2002-08-28 Delta Biotechnology Ltd Gene and polypeptide sequences

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL66614A (en) * 1981-08-28 1985-09-29 Genentech Inc Method of constructing a dna sequence encoding a polypeptide,microbial production of human serum albumin,and pharmaceutical compositions comprising it
EP0079739A3 (en) * 1981-11-12 1984-08-08 The Upjohn Company Albumin-based nucleotides, their replication and use, and plasmids for use therein
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
NZ207926A (en) * 1983-04-25 1988-04-29 Genentech Inc Use of yeast #a#-factor to assist in expression of proteins heterologus to yeast
JPS62500103A (en) * 1984-08-29 1987-01-16 チロン　コ−ポレイシヨン Expression of human connective tissue activators and related peptides
GB8427006D0 (en) * 1984-10-25 1984-11-28 Iq Bio Ltd Determination of chlamydia trachomatis
HU194308B (en) * 1984-11-23 1988-01-28 Mta Szbk Genetikai Intezete Process for preparing oligo- and polydeoxyribonucleotides
AU5890286A (en) * 1985-06-17 1986-12-24 Genex Corp. Cloned human serum albumin gene
US5451521A (en) * 1986-05-29 1995-09-19 Genetics Institute, Inc. Procoagulant proteins

Also Published As

Publication number Publication date
DD282473A5 (en) 1990-09-12
IL87748A0 (en) 1989-02-28
DK163937B (en) 1992-04-21
DK64990D0 (en) 1990-03-13
JPH03501323A (en) 1991-03-28
PL274669A1 (en) 1989-08-21
CA1340650C (en) 1999-07-13
SE8703539D0 (en) 1987-09-14
WO1989002467A1 (en) 1989-03-23
SE459586B (en) 1989-07-17
SE8703539L (en) 1989-03-15
DK64990A (en) 1990-05-14
ATE135740T1 (en) 1996-04-15
IL87748A (en) 1993-06-10
DE3855122T2 (en) 1996-10-17
JP2865683B2 (en) 1999-03-08
EP0308381A1 (en) 1989-03-22
DK163937C (en) 1992-09-14
FI901219A0 (en) 1990-03-12
EP0308381B1 (en) 1996-03-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee