DE3842232A1 - Insect repellent, in particular tick repellent - Google Patents
Insect repellent, in particular tick repellentInfo
- Publication number
- DE3842232A1 DE3842232A1 DE19883842232 DE3842232A DE3842232A1 DE 3842232 A1 DE3842232 A1 DE 3842232A1 DE 19883842232 DE19883842232 DE 19883842232 DE 3842232 A DE3842232 A DE 3842232A DE 3842232 A1 DE3842232 A1 DE 3842232A1
- Authority
- DE
- Germany
- Prior art keywords
- weight
- repellent
- insect repellent
- insect
- diethyltoluamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/18—Vapour or smoke emitting compositions with delayed or sustained release
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Die Erfindung betrifft ein Insektenrepellent, insbesondere ein Zeckenrepellent.The invention relates to an insect repellent, in particular a tick repellent.
Es ist ein Insektenrepellent bekannt, das gegen Mücken und Bremsen wirkt und aus einer Lösung aus mehr als 30 Gew.-% Diethyltoluamid in Isopropanol besteht.An insect repellent that is known to fight mosquitoes and Brakes work and from a solution of more than 30% by weight Diethyltoluamide in isopropanol.
Ein weiteres bekanntes Insektenrepellent enthält Dimethyl phthalat in einer Menge von mehr als 90% in Isopropanol als Lösungsmittel.Another known insect repellent contains dimethyl phthalate in an amount greater than 90% in isopropanol than Solvent.
Ein weiteres bekanntes gegen Mücken und Bremsen wirkendes Insektenrepellent enthält als Wirkstoff eine Mischung aus einer Isopropanollösung von 30 Gew.-% m-Diethyltoluamid, 40 Gew.-% 2-Methyl-2,4-pentandiol und 30 Gew.-% Dimethylphthalat.Another well-known anti-mosquito and brake Insect repellent contains a mixture of active ingredients an isopropanol solution of 30% by weight of m-diethyltoluamide, 40% by weight of 2-methyl-2,4-pentanediol and 30% by weight of dimethyl phthalate.
Der Nachteil dieser bekannten Insektenrepellents besteht darin, daß sie einerseits den Wirkstoff in relativ hohen Konzentrationen enthalten müssen und andererseits keine zeckenabstoßende Wirkung besitzen.The disadvantage of these known insect repellents is in that on the one hand they contain the active ingredient in relatively high Must contain concentrations and on the other hand none have a repellent effect.
Die Erfindung hat sich die Aufgabe gestellt, ein Insekten repellent zu schaffen, das unter Einsatz einer relativ niedrigen Wirkstoffmenge formuliert werden kann und darüber hinaus im Gegensatz zu den bekannten Insektenrepellents auch eine zeckenabstoßende Wirkung besitzt.The invention has set itself the task of being an insect to create a repellent using a relative low amount of active ingredient can be formulated and above in addition to the known insect repellents too has a tick-repelling effect.
Diese Aufgabe wird durch das Insektenrepellent des Patentan spruchs 1 gelöst.This task is accomplished by the patent insect repellent spell 1 solved.
Die Erfindung beruht auf der überraschenden Feststellung, daß die Wirkung der bekannten Kombination aus m-Diethyl toluamid, 2-Methyl-2,4-pentandiol und einem niederen (C1-C4)-Alkylphthalsäureester dadurch in synergistischer Weise gesteigert werden kann, wobei darüber hinaus diese Kombination auch als Zeckenrepellent wirksam wird, wenn sie mit einem Gemisch aus Olivenöl und Lavendelöl vermischt wird.The invention is based on the surprising finding that the effect of the known combination of m-diethyl toluamide, 2-methyl-2,4-pentanediol and a lower (C 1 -C 4 ) -alkylphthalic acid ester can thereby be increased in a synergistic manner, whereby moreover, this combination also works as a tick repellent when mixed with a mixture of olive oil and lavender oil.
Der besondere Vorteil des erfindungsgemäßen Insektenre pellents beruht auf seinem zuverlässigen Schutz gegenüber Zeckenbiß, gegen dessen nachteilige Folgen bisher nur ein Schutz durch Impfen mit teuren Impfstoffen möglich war.The particular advantage of the insect according to the invention pellents relies on its reliable protection against Tick bite, against its adverse consequences so far only one Protection by vaccination with expensive vaccines was possible.
Insbesondere aufgrund der geringen Wirkstoffkonzentration zeigt das erfindungsgemäße Insektenrepellent darüber hinaus keine toxische, irritierende oder sensibilisierende Wirkung, ferner dringt es nicht in die Haut ein und entfaltet eine lange Wirkungsdauer von etwa 6 bis 8 Stunden, wobei es sparsam im Verbrauch, preiswert in der Herstellung sowie kinder- und umweltfreundlich und sehr lagerungsstabil ist.In particular due to the low concentration of active ingredients shows the insect repellent according to the invention beyond no toxic, irritating or sensitizing effects, furthermore, it does not penetrate the skin and unfolds one long duration of action of about 6 to 8 hours, taking it economical in consumption, inexpensive to manufacture as well is child and environmentally friendly and very stable in storage.
Vorzugsweise besteht der niedere C1C4-Alkylphthalsäureester aus Dimethylphthalat.The lower C 1 C 4 alkyl phthalic acid ester preferably consists of dimethyl phthalate.
Versuche haben ergeben, daß die orale Toxizität (LD50) von m-Diethyltoluamid an der Ratte 2000 mg/kg und diejenige von 2-Methyl-2,4-pentandiol an der Ratte 4,76 g/kg und am Kaninchen (24 Stunden auf der Haut) 8,56 ml/kg beträgt, wobei nach 90-tägiger Verfütterung von 0,31 g/kg pro Tag an Ratten keine nachteilige Reaktion festgestellt werden konnte.Experiments have shown that the oral toxicity (LD 50 ) of m-diethyltoluamide in the rat 2000 mg / kg and that of 2-methyl-2,4-pentanediol in the rat 4.76 g / kg and in the rabbit (24 hours on the skin) is 8.56 ml / kg, and after 90 days of feeding 0.31 g / kg per day in rats, no adverse reaction was found.
Die orale Toxizität (LD50) von Dimethylphthalat betrug an der Ratte 6,4 ml/kg, am Kaninchen 5,2 ml/kg und bei Mäusen 7,2 ml/kg, wobei darüber hinaus keine Symptome chronischer Toxizität bei einer Verabreichung von 20000 ppm an Ratten während einer Zeitspanne von 1 bis 2 Jahren feststellbar waren. The oral toxicity (LD 50 ) of dimethyl phthalate was 6.4 ml / kg in the rat, 5.2 ml / kg in the rabbit and 7.2 ml / kg in mice, with no further symptoms of chronic toxicity when administered at 20,000 ppm were found in rats over a period of 1 to 2 years.
Darüber hinaus haben klinische dermatologische Untersuchungen an 100 Probanden (epikutane Testunter suchungen) ergeben, daß gegen die Anwendung dieses Re pellents aus dermatologischer Sicht keine Bedenken be stehen, wobei hervorzuheben ist, daß sich unter den haut kranken Probanden zahlreiche Ekzematiker sowie solche mit Erkrankungen aus dem allergischen Formenkreis befanden.They also have clinical dermatological Examinations on 100 subjects (epicutaneous test sub searches) show that against the application of this Re pellents do not have any concerns from a dermatological point of view stand, it should be emphasized that under the skin subjects with numerous eczematists as well as those with Diseases from the allergic group.
m-Diethyltoluamid, 2-Methyl-2,4-pentandiol sowie die in dem erfindungsgemäßen Mittel eingesetzten niederen (C1 C4)-Alkylphthalsäureester, insbesondere Dimethylphthalat, sind bekannte im Handel erhältliche Substanzen.m-Diethyltoluamide, 2-methyl-2,4-pentanediol and the lower (C 1 C 4 ) -alkylphthalic acid esters used in the agent according to the invention, in particular dimethyl phthalate, are known commercially available substances.
Vorzugsweise entsprechen das in dem erfindungsgemäßen Insektenrepellent eingesetzte Olivenöl und Lavendelöl den Anforderungen des DAB-9.This preferably corresponds to that of the invention Olive oil and lavender oil used for insect repellent Requirements of the DAB-9.
Vorzugsweise besteht in dem erfindungsgemäßen Insekten repellent die Komponente A ausPreferably consists in the insects according to the invention repellent component A.
- a) 30 Gew.-% m-Diethyltoluamid,a) 30% by weight of m-diethyltoluamide,
- b) 40 Gew.-% 2-Methyl-2,4-pentandiol undb) 40% by weight of 2-methyl-2,4-pentanediol and
- c) 30 Gew.-% des niederen (C1-C4)-Alkylphthalsäure esters, insbesondere Dimethylphthalat, während die Komponente B) in einer Menge von 2 bis 5 Gew.-% und die Komponente C) in einer Menge von 0,1 bis 1 Gew.-% vorliegt.c) 30% by weight of the lower (C 1 -C 4 ) alkyl phthalic acid ester, in particular dimethyl phthalate, while component B) in an amount of 2 to 5% by weight and component C) in an amount of 0, 1 to 1 wt .-% is present.
Vorzugsweise wird das erfindungsgemäße Insektenrepellent als Lösung in einem pharmazeutisch verträglichen Lösungsmittel formuliert, wobei sich insbesondere Isopropanol als Lösungsmittel bewährt hat, vorzugsweise Isopropanol, das den Anforderungen des DAC (Deutscher Arzneimittel Codex) entspricht. Es kommen jedoch beliebige andere pharmazeutisch verträgliche Lösungsmittel in Frage, in denen die Komponenten A bis C sowie gegebenenfalls zusätzliche Additive, wie rückfettende Mittel und Aromastoffe, löslich sind. The insect repellent according to the invention is preferably used as Solution in a pharmaceutically acceptable solvent formulated, in particular isopropanol as Has proven solvent, preferably isopropanol, which the Requirements of the DAC (German Medicinal Codex) corresponds. However, any other pharmaceuticals come compatible solvents in question, in which the Components A to C and optionally additional ones Additives such as refatting agents and flavorings are soluble are.
Es ist jedoch auch möglich, das erfindungsgemäße Insekten repellent in üblicher Weise in Form eines Sprays, eines Gels oder eines Stiftes zu konfektionieren.However, it is also possible to insect the invention repellent in the usual way in the form of a spray, a gel or to assemble a pin.
Das folgende Beispiel erläutert die Erfindung.The following example illustrates the invention.
10 Gew.-% einer Mischung aus10 wt .-% of a mixture of
- a) 30 Gew.-% m-Diethyltoluamid,a) 30% by weight of m-diethyltoluamide,
- b) 40 Gew.-% 2-Methyl-2,4-pentandiol undb) 40% by weight of 2-methyl-2,4-pentanediol and
- c) 30 Gew.-% Dimethylphthalatc) 30% by weight of dimethyl phthalate
werden mit 2,5 Gew.-% Olivenöl und 0,2 Gew.-% Lavendelöl vermischt, worauf die Mischung mit Isopropanol ad 100 Gew.-% vermischt wird. Das erhaltene Produkt ist eine hellgelbe stabile Flüssigkeit, die leicht nach Lavendel riecht. Die Dichte beträgt 0,796 und der Brechungsindex n 1,383-1,384.are mixed with 2.5 wt .-% olive oil and 0.2 wt .-% lavender oil, whereupon the mixture is mixed with isopropanol ad 100 wt .-%. The product obtained is a light yellow stable liquid that smells slightly of lavender. The density is 0.796 and the refractive index n is 1.383-1.384.
Durch einfaches Einreiben der Haut läßt sich ein wirksamer Schutz gegenüber Insektenstichen und Zeckenbissen erzielen. Das Präparat zeigt keine Unverträglichkeiten und kann auch bei vorgeschädigter Haut sowie auch bei Kindern mit großem Erfolg eingesetzt werden. Obwohl sein Wirkstoffgehalt im Vergleich zu den bekannten Produkten relativ niedrig ist, ist seine insektenabstoßende Wirkung aufgrund der synergistischen Wirkung des Olivenöls und des Lavendel öls stark ausgeprägt, wobei es darüber hinaus in unerwar teter Weise auch eine zeckenabstoßende Wirkung ausübt. Ferner kann es zur wirksamen Behandlung von Insektenstichen verwendet werden.By simply rubbing in the skin, an effective one Get protection against insect bites and tick bites. The preparation shows no intolerance and can also for pre-damaged skin as well as in children with large Success. Although its active ingredient content in Is relatively low compared to the known products, is its insect repellent effect due to the synergistic effect of olive oil and lavender oil strongly pronounced, but it was also unheard of teter also has a tick-repellent effect. It can also be used to effectively treat insect bites be used.
Claims (6)
- A) 3 bis 20 Gew.-% einer Mischung aus
- a) 10 bis 40 Gew.-% m-Diethyltoluamid,
- b) 20 bis 50 Gew.-% 2-Methyl-2,4-pentandiol und
- c) 10 bis 40 Gew.-% eines niederen (C1-C4)-Alkyl phthalsäureesters,
- B) 1 bis 10 Gew.-% Olivenöl,
- C) 0,1 bis 5 Gew.-% Lavendelöl und
- D) Rest ad 100 Gew.-% eines pharmazeutisch verträglichen Lösungsmittels und/oder Trägers sowie gegebenenfalls weiterer Additive.
- A) 3 to 20 wt .-% of a mixture of
- a) 10 to 40% by weight of m-diethyltoluamide,
- b) 20 to 50 wt .-% 2-methyl-2,4-pentanediol and
- c) 10 to 40% by weight of a lower (C 1 -C 4 ) alkyl phthalic acid ester,
- B) 1 to 10% by weight of olive oil,
- C) 0.1 to 5% by weight of lavender oil and
- D) Remainder ad 100% by weight of a pharmaceutically acceptable solvent and / or carrier and, if appropriate, further additives.
- a) 30 Gew.-% m-Diethyltoluamid,
- b) 40 Gew.-% 2-Methyl-2,4-pentandiol und
- c) 30 Gew.-% des niederen (C1-C4)-Alkylphthalsäure esters besteht,
- a) 30% by weight of m-diethyltoluamide,
- b) 40% by weight of 2-methyl-2,4-pentanediol and
- c) 30% by weight of the lower (C 1 -C 4 ) alkylphthalic acid ester is present,
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19883842232 DE3842232A1 (en) | 1988-12-15 | 1988-12-15 | Insect repellent, in particular tick repellent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19883842232 DE3842232A1 (en) | 1988-12-15 | 1988-12-15 | Insect repellent, in particular tick repellent |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3842232A1 true DE3842232A1 (en) | 1990-06-21 |
Family
ID=6369236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19883842232 Withdrawn DE3842232A1 (en) | 1988-12-15 | 1988-12-15 | Insect repellent, in particular tick repellent |
Country Status (1)
Country | Link |
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DE (1) | DE3842232A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0583774A1 (en) * | 1992-08-18 | 1994-02-23 | The State Of Israel-Ministry Of Agriculture | An arthropod control composition for plant protection |
EP0630571A1 (en) * | 1993-06-24 | 1994-12-28 | Orphea S.A. | A liquid composition having a moth-repelling effect |
WO1997041728A1 (en) * | 1996-05-06 | 1997-11-13 | Bayer Aktiengesellschaft | Arthropod repellant |
WO2003055316A1 (en) * | 2001-12-24 | 2003-07-10 | Dragoco Gerberding & Co. Ag | Insect repellent composition comprising an extract of tarchonanthus camphoratus and repellency enhancer |
CN106236614A (en) * | 2016-09-28 | 2016-12-21 | 济南大学 | A kind of preparation method of composite natral plant mosquito-driving liquid |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2407205A (en) * | 1943-02-11 | 1946-09-03 | Carbide & Carbon Chem Corp | Insect repellents |
US2551891A (en) * | 1948-04-09 | 1951-05-08 | Geigy Ag J R | Diethyl-chlorobenzamide |
DE2823619A1 (en) * | 1977-05-31 | 1978-12-14 | Block Drug Co | MEANS FOR DISTRIBUTING ECTOPARASITES AND / OR KILLING THEIR EGGS |
US4164561A (en) * | 1976-04-29 | 1979-08-14 | Horst Hautmann | Insect repellent |
DE2925589A1 (en) * | 1979-06-25 | 1981-01-08 | Fichtel & Sachs Ag | INSECT REPELLENT |
DE3211632A1 (en) * | 1982-03-30 | 1983-10-06 | Bayer Ag | INSECT DRIVER |
DE3211633A1 (en) * | 1982-03-30 | 1983-10-13 | Bayer Ag, 5090 Leverkusen | INSECT DRIVER |
-
1988
- 1988-12-15 DE DE19883842232 patent/DE3842232A1/en not_active Withdrawn
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2407205A (en) * | 1943-02-11 | 1946-09-03 | Carbide & Carbon Chem Corp | Insect repellents |
US2551891A (en) * | 1948-04-09 | 1951-05-08 | Geigy Ag J R | Diethyl-chlorobenzamide |
US4164561A (en) * | 1976-04-29 | 1979-08-14 | Horst Hautmann | Insect repellent |
DE2823619A1 (en) * | 1977-05-31 | 1978-12-14 | Block Drug Co | MEANS FOR DISTRIBUTING ECTOPARASITES AND / OR KILLING THEIR EGGS |
DE2925589A1 (en) * | 1979-06-25 | 1981-01-08 | Fichtel & Sachs Ag | INSECT REPELLENT |
DE3211632A1 (en) * | 1982-03-30 | 1983-10-06 | Bayer Ag | INSECT DRIVER |
DE3211633A1 (en) * | 1982-03-30 | 1983-10-13 | Bayer Ag, 5090 Leverkusen | INSECT DRIVER |
Non-Patent Citations (5)
Title |
---|
- DE-Z: Chemie für Labor u. Betrieb-Forschung u. Technik, 35, 1984, 11, S. 566 * |
- DE-Z: Parfümerie u. Kosmetik, 59, 1978, S.367-371 * |
- US-Z: Chemical Abstracts: 103/118194Q * |
85/73373p * |
DE-Buch: WEGLER, R., Chemie der Pflanzen- schutz- u. Schädlingsbekämpfungsmittel, Bd. 1, 1970, S. 488 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0583774A1 (en) * | 1992-08-18 | 1994-02-23 | The State Of Israel-Ministry Of Agriculture | An arthropod control composition for plant protection |
EP0630571A1 (en) * | 1993-06-24 | 1994-12-28 | Orphea S.A. | A liquid composition having a moth-repelling effect |
WO1997041728A1 (en) * | 1996-05-06 | 1997-11-13 | Bayer Aktiengesellschaft | Arthropod repellant |
WO2003055316A1 (en) * | 2001-12-24 | 2003-07-10 | Dragoco Gerberding & Co. Ag | Insect repellent composition comprising an extract of tarchonanthus camphoratus and repellency enhancer |
CN106236614A (en) * | 2016-09-28 | 2016-12-21 | 济南大学 | A kind of preparation method of composite natral plant mosquito-driving liquid |
CN106236614B (en) * | 2016-09-28 | 2019-01-01 | 济南大学 | A kind of preparation method of composite natral plant mosquito repellent liquid |
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