DE3783933D1 - MACROLID CONNECTIONS. - Google Patents

MACROLID CONNECTIONS.

Info

Publication number
DE3783933D1
DE3783933D1 DE8787302095T DE3783933T DE3783933D1 DE 3783933 D1 DE3783933 D1 DE 3783933D1 DE 8787302095 T DE8787302095 T DE 8787302095T DE 3783933 T DE3783933 T DE 3783933T DE 3783933 D1 DE3783933 D1 DE 3783933D1
Authority
DE
Germany
Prior art keywords
macrolid
connections
carbon
compounds
oxygen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787302095T
Other languages
German (de)
Other versions
DE3783933T2 (en
Inventor
Derek R Sutherland
John B Ward
Neil Porter
Hazel M Noble
Richard A Fletton
David Noble
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Application granted granted Critical
Publication of DE3783933D1 publication Critical patent/DE3783933D1/en
Publication of DE3783933T2 publication Critical patent/DE3783933T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Plant Pathology (AREA)
  • Biotechnology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)

Abstract

Compounds are described of the formula <CHEM> and salts thereof, wherein R<1> is methyl, ethyl or isopropyl; R<2> is -H,-OH or substituted-OH and R<3> is-H, or R<2> and R<3> together with the carbon atom to which they are attached represent C=CH2, C=O or C=NOR<6> (where R<6> is-H, alkyl or alkenyl and the C=NOR<6> is in the E configuration); OR<4> is as defined above for OR<5> and one of the symbols X represents an epoxide oxygen atom and the other represents an epoxide oxygen atom or a carbon-carbon bond. These compounds may be used for controlling insect, acarine, nematode or other pests.
DE8787302095T 1986-03-12 1987-03-11 MACROLID CONNECTIONS. Expired - Fee Related DE3783933T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB868606108A GB8606108D0 (en) 1986-03-12 1986-03-12 Chemical compounds

Publications (2)

Publication Number Publication Date
DE3783933D1 true DE3783933D1 (en) 1993-03-18
DE3783933T2 DE3783933T2 (en) 1993-07-01

Family

ID=10594458

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787302095T Expired - Fee Related DE3783933T2 (en) 1986-03-12 1987-03-11 MACROLID CONNECTIONS.

Country Status (9)

Country Link
US (1) US4910219A (en)
EP (1) EP0241146B1 (en)
JP (1) JP2517721B2 (en)
AT (1) ATE85337T1 (en)
CA (1) CA1282064C (en)
DE (1) DE3783933T2 (en)
ES (1) ES2053529T3 (en)
GB (1) GB8606108D0 (en)
HK (1) HK39395A (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4876272A (en) * 1987-03-06 1989-10-24 American Cyanamid Company Mono- and diepoxide derivatives of LL-F28249 compounds
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
DE3888936T2 (en) * 1987-11-03 1994-07-21 Beecham Group Plc Intermediates for the production of macrolide antibiotics with an anthelmintic effect.
GB8809232D0 (en) * 1988-04-19 1988-05-25 Pfizer Ltd Antiparasitic agents
GB8811036D0 (en) * 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
JPH06505711A (en) * 1990-12-07 1994-06-30 テンプル　ユニバーシティ−オブ　ザ　コモンウェルス　システム　オブ　ハイヤー　エデュケーション Stabilized insect parasitic nematode composition
AU666750B2 (en) * 1992-09-01 1996-02-22 Novartis Animal Health K.K. Novel processes for the production of 13-ether derivatives of milbemycins, and novel intermediates therefor
US7671034B2 (en) * 2003-12-19 2010-03-02 Merial Limited Stabilized formulation of ivermectin feed premix with an extended shelf life
US8980896B2 (en) 2009-12-17 2015-03-17 Merial, Inc. Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
US20240141250A1 (en) 2022-10-18 2024-05-02 Infineum International Limited Lubricating Oil Compositions

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201861A (en) * 1977-10-03 1980-05-06 Merck & Co., Inc. Acyl derivatives of C-076 compounds
US4289760A (en) * 1980-05-02 1981-09-15 Merck & Co., Inc. 23-Keto derivatives of C-076 compounds
JPS57139080A (en) * 1981-02-23 1982-08-27 Sankyo Co Ltd 14,15-epoxy derivative of antibiotic substance b-41 and its preparation
US4423209A (en) * 1982-02-26 1983-12-27 Merck & Co., Inc. Processes for the interconversion of avermectin compounds
JPS5933288A (en) * 1982-08-19 1984-02-23 Sankyo Co Ltd 5-oxo derivative of milbemycin d
JPS5936681A (en) * 1982-08-23 1984-02-28 Sankyo Co Ltd Epoxy derivative of milbemycin d
JPS59108785A (en) * 1982-11-25 1984-06-23 Sankyo Co Ltd 5-oxime derivative of milbemycins
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
PT80577B (en) * 1984-06-05 1987-09-18 American Cyanamid Co PROCESS FOR THE PRODUCTION OF NEW MACROLID AGENTS LL-F28249 UTEIS IN THE TREATMENT OF HELMINTICAL INFECTIONS BY ECTOPARASITAS ARTHROPODES AND BY ACARIDEOS
US4579864A (en) * 1984-06-11 1986-04-01 Merck & Co., Inc. Avermectin and milbemycin 13-keto, 13-imino and 13-amino derivatives
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
AU596586B2 (en) * 1985-04-30 1990-05-10 American Cyanamid Company Chemical derivatives of antibiotics S541

Also Published As

Publication number Publication date
EP0241146A1 (en) 1987-10-14
JP2517721B2 (en) 1996-07-24
CA1282064C (en) 1991-03-26
ATE85337T1 (en) 1993-02-15
JPS62230787A (en) 1987-10-09
DE3783933T2 (en) 1993-07-01
EP0241146B1 (en) 1993-02-03
GB8606108D0 (en) 1986-04-16
ES2053529T3 (en) 1994-08-01
HK39395A (en) 1995-03-24
US4910219A (en) 1990-03-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee