DE3750434D1 - Verwendung eines detektierbaren, markierten, Immunoglobulins oder eines Fragmentes davon zur Herstellung eines Mittels für den Nachweis eines Entzündungsherdes in vivo. - Google Patents
Verwendung eines detektierbaren, markierten, Immunoglobulins oder eines Fragmentes davon zur Herstellung eines Mittels für den Nachweis eines Entzündungsherdes in vivo.Info
- Publication number
- DE3750434D1 DE3750434D1 DE3750434T DE3750434T DE3750434D1 DE 3750434 D1 DE3750434 D1 DE 3750434D1 DE 3750434 T DE3750434 T DE 3750434T DE 3750434 T DE3750434 T DE 3750434T DE 3750434 D1 DE3750434 D1 DE 3750434D1
- Authority
- DE
- Germany
- Prior art keywords
- immunoglobulin
- fragment
- agent
- preparation
- detectable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- External Artificial Organs (AREA)
- Chemical Treatment Of Metals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81958586A | 1986-01-16 | 1986-01-16 | |
PCT/US1987/000079 WO1987004351A1 (en) | 1986-01-16 | 1987-01-12 | Method for the diagnosis and treatment of inflammation |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3750434D1 true DE3750434D1 (de) | 1994-10-06 |
DE3750434T2 DE3750434T2 (de) | 1995-03-23 |
DE3750434T3 DE3750434T3 (de) | 1999-04-08 |
Family
ID=25228549
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0577225T Pending DE577225T1 (de) | 1986-01-16 | 1987-01-16 | Diagnose und Behandlung von Entzündung. |
DE3750434T Expired - Fee Related DE3750434T3 (de) | 1986-01-16 | 1987-01-16 | Verwendung eines detektierbaren, markierten, Immunoglobulins oder eines Fragmentes davon zur Herstellung eines Mittels für den Nachweis eines Entzündungsherdes in vivo. |
DE3752380T Expired - Fee Related DE3752380T2 (de) | 1986-01-16 | 1987-01-16 | Diagnose und Behandlung von Entzündung |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE0577225T Pending DE577225T1 (de) | 1986-01-16 | 1987-01-16 | Diagnose und Behandlung von Entzündung. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3752380T Expired - Fee Related DE3752380T2 (de) | 1986-01-16 | 1987-01-16 | Diagnose und Behandlung von Entzündung |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP0577225B9 (de) |
JP (1) | JP2515357B2 (de) |
AT (2) | ATE110572T1 (de) |
AU (1) | AU597032B2 (de) |
CA (1) | CA1288688C (de) |
DE (3) | DE577225T1 (de) |
ES (2) | ES2053403T3 (de) |
GR (1) | GR940300027T1 (de) |
WO (1) | WO1987004351A1 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1987004351A1 (en) * | 1986-01-16 | 1987-07-30 | The General Hospital Corporation | Method for the diagnosis and treatment of inflammation |
FR2639231A1 (fr) * | 1988-11-23 | 1990-05-25 | Merieux Inst | Utilisation de fragments fc d'immunoglobulines g humaines, de peptides analogues du fragment fc, ou d'immunoglobulines g humaines dans l'obtention d'un medicament preparatoire a l'administration chez l'homme, dans un but therapeutique ou de diagnostic, d'anticorps monoclonaux |
US5792444A (en) * | 1989-05-09 | 1998-08-11 | The General Hospital Corporation | Labeled chemotactic peptides to image focal sites of infection or inflammation |
CA2016235C (en) * | 1989-05-09 | 2002-03-12 | Alan J. Fischman | Labeled chemotactic peptides to image focal sites of infection or inflammation |
EP0485664A1 (de) * | 1990-11-13 | 1992-05-20 | Mallinckrodt Diagnostica (Holland) B.V. | Verfahren zur Herstellung von einem diagnostischen Mittel zur Feststellung von Entzündungen |
ATE175976T1 (de) * | 1993-10-22 | 1999-02-15 | Nihon Mediphysics Co Ltd | Peptide mit affinität für entzündungen und deren radiomarkierte, diagnostische zusammensetzungen |
DE19514088A1 (de) * | 1995-04-13 | 1996-10-17 | Deutsches Krebsforsch | Konjugat zur Behandlung von Entzünduns-, Infektions- und/oder Hauterkrankungen |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2004464B (en) * | 1977-06-30 | 1982-01-13 | Cehovic G | Method of testing inflammation |
US4315906A (en) * | 1979-05-21 | 1982-02-16 | New England Nuclear Corporation | Cold insoluble globulin, its purification and use |
US4472371A (en) * | 1979-10-29 | 1984-09-18 | Summa Medical Corporation | Radiolabeled antibody to anti-tumor associated antigen and process |
US4444744A (en) * | 1980-03-03 | 1984-04-24 | Goldenberg Milton David | Tumor localization and therapy with labeled antibodies to cell surface antigens |
GB2101407A (en) * | 1981-05-14 | 1983-01-12 | Bulpitt And Sons Limited | Automatic electric kettle |
US4522918A (en) * | 1981-12-15 | 1985-06-11 | Jeffery Schlom | Process for producing monoclonal antibodies reactive with human breast cancer |
US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
GR850552B (de) * | 1984-03-07 | 1985-07-05 | Du Pont | |
US4636380A (en) * | 1984-04-23 | 1987-01-13 | Wong Dennis W | Novel physiologic chemical method of labeling protein substances with the radionuclides of indium |
US4634586A (en) * | 1984-05-21 | 1987-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Reagent and method for radioimaging leukocytes |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
GB8426470D0 (en) * | 1984-10-19 | 1984-11-28 | Technology Licence Co Ltd | Monoclonal antibodies |
AU597877B2 (en) * | 1984-12-26 | 1990-06-14 | Teijin Limited | Anti-pseudomonas aeruginosa human monoclonal antibody |
WO1987004351A1 (en) * | 1986-01-16 | 1987-07-30 | The General Hospital Corporation | Method for the diagnosis and treatment of inflammation |
GB8610202D0 (en) * | 1986-04-25 | 1986-05-29 | Technology Licence Co Ltd | Monoclonal antibodies |
GB8621910D0 (en) * | 1986-09-11 | 1986-10-15 | Technology Licence Co Ltd | Monoclonal antibodies |
-
1987
- 1987-01-12 WO PCT/US1987/000079 patent/WO1987004351A1/en unknown
- 1987-01-12 AU AU69377/87A patent/AU597032B2/en not_active Ceased
- 1987-01-12 JP JP62501013A patent/JP2515357B2/ja not_active Expired - Fee Related
- 1987-01-15 CA CA000527403A patent/CA1288688C/en not_active Expired - Lifetime
- 1987-01-16 ES ES93202324T patent/ES2053403T3/es not_active Expired - Lifetime
- 1987-01-16 DE DE0577225T patent/DE577225T1/de active Pending
- 1987-01-16 ES ES87300395T patent/ES2056812T5/es not_active Expired - Lifetime
- 1987-01-16 DE DE3750434T patent/DE3750434T3/de not_active Expired - Fee Related
- 1987-01-16 EP EP93202324A patent/EP0577225B9/de not_active Expired - Lifetime
- 1987-01-16 EP EP87300395A patent/EP0241106B2/de not_active Expired - Lifetime
- 1987-01-16 AT AT87300395T patent/ATE110572T1/de not_active IP Right Cessation
- 1987-01-16 AT AT93202324T patent/ATE283710T1/de not_active IP Right Cessation
- 1987-01-16 DE DE3752380T patent/DE3752380T2/de not_active Expired - Fee Related
-
1994
- 1994-05-31 GR GR940300027T patent/GR940300027T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2053403T1 (es) | 1994-08-01 |
WO1987004351A1 (en) | 1987-07-30 |
ATE283710T1 (de) | 2004-12-15 |
EP0241106A2 (de) | 1987-10-14 |
AU597032B2 (en) | 1990-05-24 |
DE3750434T2 (de) | 1995-03-23 |
ES2053403T3 (es) | 2005-06-01 |
ES2056812T5 (es) | 1998-11-16 |
DE3752380T2 (de) | 2005-11-03 |
JPS63502280A (ja) | 1988-09-01 |
EP0577225B1 (de) | 2004-12-01 |
CA1288688C (en) | 1991-09-10 |
JP2515357B2 (ja) | 1996-07-10 |
DE3750434T3 (de) | 1999-04-08 |
EP0241106B1 (de) | 1994-08-31 |
EP0241106B2 (de) | 1998-07-08 |
GR940300027T1 (en) | 1994-05-31 |
ES2056812T3 (es) | 1994-10-16 |
EP0577225A1 (de) | 1994-01-05 |
DE577225T1 (de) | 1994-09-22 |
AU6937787A (en) | 1987-08-14 |
EP0577225B9 (de) | 2005-03-02 |
EP0241106A3 (en) | 1989-02-08 |
DE3752380D1 (de) | 2005-01-05 |
ATE110572T1 (de) | 1994-09-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3382767D1 (de) | Ein Verfahren zur Herstellung eines Antikörpers, der zur Bestimmung der Anwesenheit eines menschlichen Oncogens befähigt ist. | |
ES513992A0 (es) | "un metodo para detectar sangre humana oculta en muestras de deposicion humana". | |
DE69633973D1 (de) | Antikörper gegen die alpha-kette von humanem interleukin 5 rezeptor | |
ATE145285T1 (de) | Nachweis einer neurologischen krankheit oder einer funktionsstörung | |
ES2132272T3 (es) | Procedimiento para la determinacion de aductos de hemoglobina. | |
NO954897L (no) | Fremgangsmåte for å bestemme et individs inflammasjonsindeks fra hele blodfibrinogen og hematokrit eller hemoglobinmålinger | |
DE3750434D1 (de) | Verwendung eines detektierbaren, markierten, Immunoglobulins oder eines Fragmentes davon zur Herstellung eines Mittels für den Nachweis eines Entzündungsherdes in vivo. | |
ATE329265T1 (de) | Verfahren zur instrumentellen bestimmung einer sich zeitabhängig ändernden messgrösse | |
DE3587542D1 (de) | Verfahren zur Diagnose in vitro von menschlichen Cytomegalovirusinfektionen und Anwendung von monoklonalen Antikörpern gegen Cytomegaloviren, die mit einer cytomegalovirusinduzierten Proteinkinase reagieren. | |
ATE349703T1 (de) | Kombination von crp und d-dimer zur diagnose von tiefer venenthrombose | |
DE3650635D1 (de) | Monoklonale Antikörper | |
DE69424974T2 (de) | Überwachung von Patienten mit Dickdarmkrebs durch Messung von NCA 50/90 im Blut | |
EP0621480A3 (de) | Diagnose und Überwachung von Patienten mit Lungenkrebs durch Messung von NCA 50/90 im Blut. | |
SE9401457L (sv) | Mätning av blodgaser | |
DE122478T1 (de) | Verfahren zur herstellung eines monoklonalen antikoerpers mit spezifizitaet fuer vernetzte fibrinderivate und ein testverfahren mittels dieses antikoerpers. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent | ||
8366 | Restricted maintained after opposition proceedings | ||
8339 | Ceased/non-payment of the annual fee |