DE3688137D1 - Ricin-antikoerper-konjugate. - Google Patents
Ricin-antikoerper-konjugate.Info
- Publication number
- DE3688137D1 DE3688137D1 DE8686906742T DE3688137T DE3688137D1 DE 3688137 D1 DE3688137 D1 DE 3688137D1 DE 8686906742 T DE8686906742 T DE 8686906742T DE 3688137 T DE3688137 T DE 3688137T DE 3688137 D1 DE3688137 D1 DE 3688137D1
- Authority
- DE
- Germany
- Prior art keywords
- ricin
- antibody conjugates
- ricin antibody
- derivative
- tumour cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6819—Plant toxins
- A61K47/6821—Plant heterodimeric toxins, e.g. abrin or modeccin
- A61K47/6823—Double chain ricin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Botany (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPH364785 | 1985-11-29 | ||
| PCT/AU1986/000370 WO1987003286A1 (en) | 1985-11-29 | 1986-12-01 | Ricin-antibody conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3688137D1 true DE3688137D1 (de) | 1993-04-29 |
Family
ID=3771392
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8686906742T Expired - Lifetime DE3688137D1 (de) | 1985-11-29 | 1986-12-01 | Ricin-antikoerper-konjugate. |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0248040B1 (de) |
| AT (1) | ATE87318T1 (de) |
| AU (1) | AU609380B2 (de) |
| DE (1) | DE3688137D1 (de) |
| NZ (1) | NZ218460A (de) |
| WO (1) | WO1987003286A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU585940B2 (en) * | 1984-09-25 | 1989-06-29 | Xoma Corporation | Lectin immunotoxins |
| US4714759A (en) * | 1985-12-02 | 1987-12-22 | Whitaker Jr Robert B | Immunotoxin therapy of allergy |
| US5395924A (en) * | 1986-03-20 | 1995-03-07 | Dana-Farber Cancer Institute, Inc. | Blocked lectins; methods and affinity support for making the same using affinity ligands; and method of killing selected cell populations having reduced non-selective cytotoxicity |
| US4808705A (en) * | 1986-12-19 | 1989-02-28 | Cetus Corporation | Stable formulations of ricin toxin a chain and of RTA-immunoconjugates and stabilizer screening methods therefor |
| AU619740B2 (en) * | 1987-02-24 | 1992-02-06 | Xoma Corporation | Immunosuppression in immunotoxin based human therapy |
| AU626087B2 (en) * | 1987-07-17 | 1992-07-23 | Xoma Corporation | Improved immunotoxin therapies utilizing purified ricin a-chain species |
| ZA89547B (en) * | 1988-02-02 | 1989-10-25 | Akzo Nv | Immunotoxins from barley toxin |
| WO1990014844A2 (en) * | 1989-06-06 | 1990-12-13 | Neorx Corporation | Sugars as cleavable linkers for the delivery and release of agents in native form |
| US5635384A (en) * | 1990-06-11 | 1997-06-03 | Dowelanco | Ribosome-inactivating proteins, inactive precursor forms thereof, a process for making and a method of using |
| US5248606A (en) * | 1990-06-11 | 1993-09-28 | Dowelanco | Dna encoding inactive precursor and active forms of maize ribosome inactivating protein |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5616418A (en) * | 1979-07-20 | 1981-02-17 | Teijin Ltd | Antitumor protein complex and its preparation |
| FR2466252A2 (fr) * | 1979-10-03 | 1981-04-10 | Clin Midy | Nouveaux produits ayant notamment des proprietes anticancereuses a base de chaine a de la ricine et d'une proteine |
| EP0044167A3 (de) * | 1980-07-14 | 1982-04-21 | The Regents Of The University Of California | Durch einen Antikörper gerichtetes zytotoxisches Mittel |
| FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| FR2516794B1 (fr) * | 1981-11-20 | 1985-10-25 | Sanofi Sa | Nouveaux medicaments anticancereux pour le traitement des leucemies t constitues de la chaine a de la ricine et d'un anticorps monoclonal specifique |
| US4664911A (en) * | 1983-06-21 | 1987-05-12 | Board Of Regents, University Of Texas System | Immunotoxin conjugates employing toxin B chain moieties |
| FR2566403B1 (fr) * | 1984-06-20 | 1986-11-07 | Sanofi Sa | Imidazolides, procede d'obtention et application a titre d'intermediaires de synthese de conjugues cytotoxiques |
| FR2591895B1 (fr) * | 1985-12-20 | 1988-08-26 | Sanofi Sa | Immunotoxines a longue duree d'action in vivo comportant la chaine a de ricine modifiee sur ses motifs polysaccharidiques |
-
1986
- 1986-12-01 AT AT86906742T patent/ATE87318T1/de not_active IP Right Cessation
- 1986-12-01 WO PCT/AU1986/000370 patent/WO1987003286A1/en active IP Right Grant
- 1986-12-01 EP EP86906742A patent/EP0248040B1/de not_active Expired - Lifetime
- 1986-12-01 AU AU66283/86A patent/AU609380B2/en not_active Ceased
- 1986-12-01 DE DE8686906742T patent/DE3688137D1/de not_active Expired - Lifetime
- 1986-12-01 NZ NZ218460A patent/NZ218460A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU609380B2 (en) | 1991-05-02 |
| EP0248040A4 (de) | 1988-01-07 |
| NZ218460A (en) | 1989-07-27 |
| AU6628386A (en) | 1987-07-01 |
| WO1987003286A1 (en) | 1987-06-04 |
| ATE87318T1 (de) | 1993-04-15 |
| EP0248040B1 (de) | 1993-03-24 |
| EP0248040A1 (de) | 1987-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |