DE3687532T2 - CYCLIC HEXAPEPTID LHRH ANTAGONISTS. - Google Patents

CYCLIC HEXAPEPTID LHRH ANTAGONISTS.

Info

Publication number
DE3687532T2
DE3687532T2 DE8686300859T DE3687532T DE3687532T2 DE 3687532 T2 DE3687532 T2 DE 3687532T2 DE 8686300859 T DE8686300859 T DE 8686300859T DE 3687532 T DE3687532 T DE 3687532T DE 3687532 T2 DE3687532 T2 DE 3687532T2
Authority
DE
Germany
Prior art keywords
hexapeptid
cyclic
lhrh antagonists
lhrh
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686300859T
Other languages
German (de)
Other versions
DE3687532D1 (en
Inventor
Daniel F Veber
Roger M Freidinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3687532D1 publication Critical patent/DE3687532D1/en
Publication of DE3687532T2 publication Critical patent/DE3687532T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein
DE8686300859T 1985-02-08 1986-02-07 CYCLIC HEXAPEPTID LHRH ANTAGONISTS. Expired - Fee Related DE3687532T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/699,778 US4659691A (en) 1985-02-08 1985-02-08 Novel cyclic Hexapeptide LHRH antagonists

Publications (2)

Publication Number Publication Date
DE3687532D1 DE3687532D1 (en) 1993-03-04
DE3687532T2 true DE3687532T2 (en) 1993-05-27

Family

ID=24810879

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686300859T Expired - Fee Related DE3687532T2 (en) 1985-02-08 1986-02-07 CYCLIC HEXAPEPTID LHRH ANTAGONISTS.

Country Status (4)

Country Link
US (1) US4659691A (en)
EP (1) EP0190946B1 (en)
JP (1) JPS61191698A (en)
DE (1) DE3687532T2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5064939A (en) * 1990-02-06 1991-11-12 The Salk Institute For Biological Studies Cyclic gnrh antagonists
US5811512A (en) * 1991-08-22 1998-09-22 The Trustees Of The University Of Pennsylvania Non-peptide peptidomimetics and related cyclic hexapeptides
US6008058A (en) * 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
US5521156A (en) * 1994-02-03 1996-05-28 Merrell Pharmaceuticals Inc. Cyclic neurokinin A antagonists
US6048863A (en) * 1994-04-19 2000-04-11 Takeda Chemical Industries, Ltd. Condensed-ring thiophene derivatives and thienopyrimidine derivatives, their production and use
DE4444260A1 (en) * 1994-12-13 1996-06-20 Hoechst Ag Cyclohexapeptides and their mixtures, process for their preparation and their use
WO1996034012A1 (en) * 1995-04-28 1996-10-31 Takeda Chemical Industries, Ltd. Cyclic pentapeptide lh-rh receptor antagonists
US5843901A (en) * 1995-06-07 1998-12-01 Advanced Research & Technology Institute LHRH antagonist peptides
EP0862573A1 (en) * 1995-10-19 1998-09-09 Takeda Chemical Industries, Ltd. Thienopyridine derivatives as gonadotropin releasing hormone antagonists
EP0876349B1 (en) * 1995-10-19 2002-09-11 Takeda Chemical Industries, Ltd. Quinoline derivatives as gnrh antagonists
US6080719A (en) * 1996-02-23 2000-06-27 Hoechst Aktiengesellschaft Cyclohexapeptides and their mixtures, a process for preparing them, and their use
US5828149A (en) * 1996-07-18 1998-10-27 Baker Hughes Incorported Lubricant inducer pump for electrical motor
US6583153B2 (en) 2000-12-12 2003-06-24 Ortho-Mcneil Pharmaceutical, Inc. 7-heterocyclyl quinoline and thieno[2,3-b]yridine derivatives useful as antagonists of gonadotropin releasing hormone
EP1479684A4 (en) 2002-01-30 2006-01-04 Takeda Pharmaceutical Thienopyrimidines, process for preparing the same and use thereof
WO2016046397A1 (en) * 2014-09-25 2016-03-31 Servicio Andaluz De Salud Cyclic peptides against the outer membrane protein a (ompa) for the treatment of infections caused by gram negative pathogens

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4162248A (en) * 1976-10-14 1979-07-24 Merck & Co., Inc. Somatostatin analogs
US4140767A (en) * 1977-12-01 1979-02-20 Merck & Co., Inc. Somatostatin analogs
US4377515A (en) * 1979-10-01 1983-03-22 Merck & Co., Inc. Long lasting agonists and antagonists of LH-RH
US4235886A (en) * 1979-10-31 1980-11-25 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4310518A (en) * 1979-10-31 1982-01-12 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs
US4522813A (en) * 1983-10-27 1985-06-11 Merck & Co., Inc. Cyclic hexapeptide somatostatin analogs

Also Published As

Publication number Publication date
US4659691A (en) 1987-04-21
EP0190946B1 (en) 1993-01-20
EP0190946A3 (en) 1988-09-14
EP0190946A2 (en) 1986-08-13
DE3687532D1 (en) 1993-03-04
JPS61191698A (en) 1986-08-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee