DE3683859D1 - Produkte der avermectin-biotransformierung. - Google Patents

Produkte der avermectin-biotransformierung.

Info

Publication number
DE3683859D1
DE3683859D1 DE8686301494T DE3683859T DE3683859D1 DE 3683859 D1 DE3683859 D1 DE 3683859D1 DE 8686301494 T DE8686301494 T DE 8686301494T DE 3683859 T DE3683859 T DE 3683859T DE 3683859 D1 DE3683859 D1 DE 3683859D1
Authority
DE
Germany
Prior art keywords
biotransforming
avermectin
products
biotransforming products
avermectin biotransforming
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686301494T
Other languages
English (en)
Inventor
Robert T Goegelman
Raymond F White
Edward S Inamine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3683859D1 publication Critical patent/DE3683859D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/445—The saccharide radical is condensed with a heterocyclic radical, e.g. everninomycin, papulacandin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE8686301494T 1985-03-04 1986-03-03 Produkte der avermectin-biotransformierung. Expired - Fee Related DE3683859D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70819485A 1985-03-04 1985-03-04

Publications (1)

Publication Number Publication Date
DE3683859D1 true DE3683859D1 (de) 1992-03-26

Family

ID=24844765

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686301494T Expired - Fee Related DE3683859D1 (de) 1985-03-04 1986-03-03 Produkte der avermectin-biotransformierung.

Country Status (7)

Country Link
US (1) US4666937A (de)
EP (1) EP0194125B1 (de)
JP (1) JPS61233686A (de)
AU (1) AU582833B2 (de)
DE (1) DE3683859D1 (de)
NZ (1) NZ215349A (de)
ZA (1) ZA861553B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ216908A (en) * 1985-07-29 1989-06-28 Merck & Co Inc Avermectin derivatives
US4668696A (en) * 1985-07-29 1987-05-26 Merck & Co., Inc. Novel averonectin fermentation product of a microorganism with anthelmintic activity
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
US5183749A (en) * 1987-02-04 1993-02-02 Sankyo Company, Ltd. Microbial process for the preparation of milbemycin derivatives
DE3888936T2 (de) * 1987-11-03 1994-07-21 Beecham Group Plc Zwischenprodukte für die Herstellung makrolider Antibiotika mit anthelmintischer Wirkung.
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
GB8805978D0 (en) * 1988-03-14 1988-04-13 Glaxo Group Ltd Process
GB8809232D0 (en) * 1988-04-19 1988-05-25 Pfizer Ltd Antiparasitic agents
JP2629047B2 (ja) * 1988-05-10 1997-07-09 アメリカン・サイアナミツド・カンパニー マクロライド化合物
GB8813150D0 (en) * 1988-06-03 1988-07-06 American Cyanamid Co Chemical compounds
US5015662A (en) * 1988-10-18 1991-05-14 Merck & Co., Inc. Anthelmintic bioconversion products
NZ233043A (en) * 1989-03-30 1992-09-25 Merck & Co Inc Anthelmintic heterocyclic compounds prepared by action of cunninghamella blakesleeana on (dihydro)paraherquamide
US5225338A (en) * 1990-09-24 1993-07-06 Merck & Co., Inc. Microbial preparation of 13β-13-deoxy-22,23-dihydro avermectin-B1A/B1B aglycone
CA2052860A1 (en) * 1990-10-11 1992-04-12 Thomas L. Shih Avermectin degradation products and derivatives
US5250422A (en) * 1990-10-15 1993-10-05 Merck & Co., Inc. Biotransformation process for the production of invermectin derivatives
AU3809393A (en) * 1992-03-23 1993-10-21 Merck & Co., Inc. A strain of (streptomyces avermitilis) glycosylates avermectin compounds
US5478929A (en) * 1993-09-15 1995-12-26 Merck & Co., Inc. Bioconversion products of 27-hydroxy avermectin
DE10135550A1 (de) * 2001-07-20 2003-01-30 Bayer Cropscience Ag Verfahren zum Herstellen von neuen Spinosyn-Derivaten
WO2011075592A1 (en) 2009-12-17 2011-06-23 Merial Limited Compositions comprising macrocyclic lactone compounds and spirodioxepinoindoles
CN108018324B (zh) * 2016-10-28 2021-04-09 北大方正集团有限公司 一种生产多拉菌素的发酵培养基及其制备方法与应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4093629A (en) * 1977-04-11 1978-06-06 Merck & Co., Inc. Derivatives of antibiotic substance milbemycin and processes therefor
PH15982A (en) * 1977-10-03 1983-05-18 Merck & Co Inc Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4206205A (en) * 1977-10-03 1980-06-03 Merck & Co., Inc. Monosaccharide and aglycone derivatives of C-076
US4199569A (en) * 1977-10-03 1980-04-22 Merck & Co., Inc. Selective hydrogenation products of C-076 compounds and derivatives thereof
PH16612A (en) * 1977-12-19 1983-11-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds
JPS5632481A (en) * 1979-08-23 1981-04-01 Sankyo Co Ltd Antibiotic b-41d, its preparation, and acaricide and anthelminthic agent and repellent containing the same as active constituent
JPS57120589A (en) * 1981-01-20 1982-07-27 Sankyo Co Ltd 5-methoxy and 5-lower alkanoyloxy derivative, its preparation and acaricide and parasiticide
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
JPS5936682A (ja) * 1982-08-23 1984-02-28 Sankyo Co Ltd ミルペマイシンｄのヒドロキシ誘導体
US4469682A (en) * 1983-01-28 1984-09-04 Merck & Co., Inc. Avermectin and milbemycin phosphate esters, pharmaceutical compositions, and method of use
US4530921A (en) * 1983-10-03 1985-07-23 Merck & Co., Inc. Avermectin epoxide derivatives and method of use
US4582852A (en) * 1983-11-02 1986-04-15 Ciba-Geigy Corporation 14- and 15-hydroxy milbemycin derivatives for controlling plant and animal parasites

Also Published As

Publication number Publication date
AU582833B2 (en) 1989-04-13
US4666937A (en) 1987-05-19
EP0194125B1 (de) 1992-02-12
EP0194125A3 (en) 1986-10-29
NZ215349A (en) 1988-08-30
EP0194125A2 (de) 1986-09-10
ZA861553B (en) 1986-10-29
AU5426586A (en) 1986-09-11
JPS61233686A (ja) 1986-10-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee