DE3673300D1 - N-alkyl- und n-benzyl-adriamycinabkoemmlinge. - Google Patents

N-alkyl- und n-benzyl-adriamycinabkoemmlinge.

Info

Publication number
DE3673300D1
DE3673300D1 DE8686902258T DE3673300T DE3673300D1 DE 3673300 D1 DE3673300 D1 DE 3673300D1 DE 8686902258 T DE8686902258 T DE 8686902258T DE 3673300 T DE3673300 T DE 3673300T DE 3673300 D1 DE3673300 D1 DE 3673300D1
Authority
DE
Germany
Prior art keywords
adriamycinabkoemmlinge
benzyl
alkyl
benzyl adriamycinabkoemmlinge
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686902258T
Other languages
English (en)
Inventor
Mervyn Israel
Ramakrishnan Seshadri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tennessee Research Foundation
Original Assignee
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tennessee Research Foundation filed Critical University of Tennessee Research Foundation
Application granted granted Critical
Publication of DE3673300D1 publication Critical patent/DE3673300D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8686902258T 1985-04-08 1986-04-04 N-alkyl- und n-benzyl-adriamycinabkoemmlinge. Expired - Fee Related DE3673300D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/720,697 US4610977A (en) 1985-04-08 1985-04-08 N-alkyl and N-benzyl adriamycin derivatives
PCT/US1986/000690 WO1986005983A1 (en) 1985-04-08 1986-04-04 N-alkyl and n-benzyl adriamycin derivatives

Publications (1)

Publication Number Publication Date
DE3673300D1 true DE3673300D1 (de) 1990-09-13

Family

ID=24894956

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686902258T Expired - Fee Related DE3673300D1 (de) 1985-04-08 1986-04-04 N-alkyl- und n-benzyl-adriamycinabkoemmlinge.

Country Status (5)

Country Link
US (1) US4610977A (de)
EP (1) EP0216867B1 (de)
JP (1) JPH075625B2 (de)
DE (1) DE3673300D1 (de)
WO (1) WO1986005983A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3706175A1 (de) * 1987-02-26 1988-09-08 Behringwerke Ag Verwendung von lipophilen anthracyclinen zur behandlung "sekundaer" anthracyclin-resistenter tumoren, mittel enthaltend ein lipophiles anthracyclin und verfahren zu seiner herstellung
GB0307553D0 (en) * 2003-04-01 2003-05-07 Novartis Ag Organic compounds
SE0401066D0 (sv) * 2004-04-22 2004-04-22 Stefan Sjoeberg Chemical Derivatives
US7541342B2 (en) * 2005-03-04 2009-06-02 University Of Tennessee Research Foundation Use of PKC-activating compounds as cardioprotectants and as apoptosis-inducing anti-tumor agents
EP2456423A2 (de) 2009-07-17 2012-05-30 Valderm APS Behandlung von hyperproliferativen erkrankungen
WO2013026454A1 (en) 2011-08-22 2013-02-28 Valderm Aps Treatment of clinical conditions with anthracyclines
US11666589B2 (en) * 2020-03-02 2023-06-06 Paradox Pharmaceuticals, Inc. Pivarubicin and benzarubicin compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU33730B (en) * 1967-04-18 1978-02-28 Farmaceutici Italia Process for preparing a novel antibiotic substance and salts thereof
US3803124A (en) * 1968-04-12 1974-04-09 Farmaceutici It Soc Process for the preparation of adriamycin and adriamycinone and adriamycin derivatives
GB1368680A (en) * 1972-12-09 1974-10-02 Farmaceutici Italia Adriamycin derivatives
US4035566A (en) * 1975-09-25 1977-07-12 Sidney Farber Cancer Institute, Inc. N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
US4177264A (en) * 1977-10-17 1979-12-04 Sri International N-benzyl anthracyclines
US4250303A (en) * 1977-10-17 1981-02-10 Sri International N-Benzyl anthracyclines
US4299822A (en) * 1980-06-09 1981-11-10 Sidney Farber Cancer Institute, Inc. N-Trifluoroacetyladriamycin-14-O-hemiglutarate and -hemiadipate and therapeutic compositions containing same

Also Published As

Publication number Publication date
EP0216867A4 (de) 1987-04-28
EP0216867A1 (de) 1987-04-08
EP0216867B1 (de) 1990-08-08
JPS62502465A (ja) 1987-09-24
WO1986005983A1 (en) 1986-10-23
JPH075625B2 (ja) 1995-01-25
US4610977A (en) 1986-09-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee