DE3669507D1 - 1-benzyl-2-(n-substituierte)-carbamoyltetrahydroisochinoline und methode zur ihrer herstellung. - Google Patents

1-benzyl-2-(n-substituierte)-carbamoyltetrahydroisochinoline und methode zur ihrer herstellung.

Info

Publication number
DE3669507D1
DE3669507D1 DE8686300241T DE3669507T DE3669507D1 DE 3669507 D1 DE3669507 D1 DE 3669507D1 DE 8686300241 T DE8686300241 T DE 8686300241T DE 3669507 T DE3669507 T DE 3669507T DE 3669507 D1 DE3669507 D1 DE 3669507D1
Authority
DE
Germany
Prior art keywords
carbamoyltetrahydroisochinoline
benzyl
substituted
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686300241T
Other languages
English (en)
Inventor
Chavdar Borissov Ivanov
Donka Minkova Mondeshka
Nikolina Dimitrova Berova
Rossitza Stefanova Rakovska
Yordanka Tzolova Panova
Marko Tzonev Markov
Radi Georgiev Ovcharov
Petko Dimitrov Usunov
Orhideya Boncheva Zabunova
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmachim TPO
Original Assignee
Pharmachim TPO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmachim TPO filed Critical Pharmachim TPO
Application granted granted Critical
Publication of DE3669507D1 publication Critical patent/DE3669507D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE8686300241T 1986-01-15 1986-01-15 1-benzyl-2-(n-substituierte)-carbamoyltetrahydroisochinoline und methode zur ihrer herstellung. Expired - Lifetime DE3669507D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP86300241A EP0232569B1 (de) 1986-01-15 1986-01-15 1-Benzyl-2-(N-substituierte)-carbamoyltetrahydroisochinoline und Methode zur ihrer Herstellung

Publications (1)

Publication Number Publication Date
DE3669507D1 true DE3669507D1 (de) 1990-04-19

Family

ID=8195851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686300241T Expired - Lifetime DE3669507D1 (de) 1986-01-15 1986-01-15 1-benzyl-2-(n-substituierte)-carbamoyltetrahydroisochinoline und methode zur ihrer herstellung.

Country Status (5)

Country Link
US (1) US4678853A (de)
EP (1) EP0232569B1 (de)
JP (1) JPS62198666A (de)
DE (1) DE3669507D1 (de)
DK (1) DK8386A (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4956371A (en) * 1989-09-19 1990-09-11 Euroceltique, S.A. Substituted isoquinolines and methods of using same
US5087214A (en) * 1991-05-21 1992-02-11 United Technologies Automotive, Inc. Battery terminal connector
GB9127306D0 (en) * 1991-12-23 1992-02-19 Boots Co Plc Therapeutic agents
US6858147B2 (en) * 2001-08-03 2005-02-22 Dispersion Technology, Inc. Method for the removal of heavy metals from aqueous solution by means of silica as an adsorbent in counter-flow selective dialysis
US7470787B2 (en) 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
EP2526948A1 (de) 2006-09-20 2012-11-28 Aerie Pharmaceuticals, Inc. RHO-Kinase-Hemmer
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
EP3053913B1 (de) 2009-05-01 2018-03-07 Aerie Pharmaceuticals, Inc. Hemmer mit doppelmechanismus zur behandlung von erkrankungen
US20140275160A1 (en) 2013-03-15 2014-09-18 Aerie Pharmaceuticals, Inc. Combination therapy
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
AU2015414743B2 (en) 2015-11-17 2019-07-18 Alcon Inc. Process for the preparation of kinase inhibitors and intermediates thereof
JP6907319B2 (ja) 2016-08-31 2021-07-21 アエリエ ファーマシューティカルズ インコーポレイテッド 眼科用組成物
EP3609871A4 (de) 2017-03-31 2021-01-06 Aerie Pharmaceuticals, Inc. Aryl-cyclopropyl-amino-isochinolinyl-amidverbindungen
CA3112391A1 (en) 2018-09-14 2020-03-19 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3725388A (en) * 1970-06-25 1973-04-03 Boehringer Sohn Ingelheim N-acyl-7-(n{41 -cycloalkyl-ureido-n{40 -sulfonyl)-isoquinolines and -benzazepines and alkali metal salts thereof
US3875167A (en) * 1972-05-26 1975-04-01 Research Corp Synthesis of thalicarpine
US3905982A (en) * 1973-07-23 1975-09-16 Searle & Co 1-Aryl-n-dialkylaminoalkyl-3,4-dihydro-2(1H)-isoquinolinecarboxamides and related compounds

Also Published As

Publication number Publication date
DK8386D0 (da) 1986-01-08
EP0232569B1 (de) 1990-03-14
DK8386A (da) 1987-07-09
US4678853A (en) 1987-07-07
JPS62198666A (ja) 1987-09-02
EP0232569A1 (de) 1987-08-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee