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Mallinckrodt Inc
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Mallinckrodt Inc
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Application filed by Mallinckrodt IncfiledCriticalMallinckrodt Inc
Priority claimed from EP85301604Aexternal-prioritypatent/EP0193671B1/en
Application grantedgrantedCritical
Publication of DE3563206D1publicationCriticalpatent/DE3563206D1/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
Sepn. of p-fluoroaniline (I) from a mixt. is carried out by (a) contacting the mixt. with a mineral acid in the presence of an org. solvent to form an insoluble salt and (b) isolating the salt. Pref. acids are HCl, H2SO4, H3PO4, HBr or HNO3. Suitable solvents are ethyl acetate, heptane, hexane and methylene chloride. The salt is pref. contacted with a base such as an aq. soln. of NaOH, KOH, Ca(OH)2, Na2CO3, K2CO3, CaO or BaO. Process (a) is carried out at 0-75, pref. 10-40 deg.C and 0-1000, pref. 0-50 psig. The salt is reacted with 1-1.5 mole of base per mole of salt at 0-60, pref. 10-24 deg.C and 0-5 psig.
DE8585301604T1985-03-081985-03-08Separation of aniline and p-fluoroaniline
ExpiredDE3563206D1
(en)