DE3475199D1 - Macroporous polymers in beaded shape, process for their preparation and their use - Google Patents

Macroporous polymers in beaded shape, process for their preparation and their use

Info

Publication number
DE3475199D1
DE3475199D1 DE8484105909T DE3475199T DE3475199D1 DE 3475199 D1 DE3475199 D1 DE 3475199D1 DE 8484105909 T DE8484105909 T DE 8484105909T DE 3475199 T DE3475199 T DE 3475199T DE 3475199 D1 DE3475199 D1 DE 3475199D1
Authority
DE
Germany
Prior art keywords
esp
mole
units
monomer
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484105909T
Other languages
German (de)
Inventor
Siegfried Dr Noetzel
Otto Dr Mauz
Klaus Dr Sauber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25811132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3475199(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoechst AG filed Critical Hoechst AG
Priority to DE8484105909T priority Critical patent/DE3475199D1/en
Application granted granted Critical
Publication of DE3475199D1 publication Critical patent/DE3475199D1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
    • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
    • C08F20/52—Amides or imides
    • C08F20/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Graft Or Block Polymers (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Polymers (A) consist mainly of (1) units derived from monomers of formula (I) and (2) units derived from at least one other monomer. X = H or methyl; R = 1-12C aliphatic hydrocarbyl; Y = hydroxy or amino. The size of the polymer particles is 20-800 microns; they are practically spherical and have mean pore dia. 5-2000 (pref. 10-1000)nm. R = 1-6C aliphatic hydrocarbon, esp. methylene, and Y = hydroxy. A portion of Y may be replaced by spacer gps., esp. epoxy units at 0.1-20 mole % on total polymer. Pref. polymers contain 10-80 (esp. 15-60) mole % (I) units; 20-50 (esp. 30-50) mole % hydrophilic monomer units, and 1-50 (esp. 5-40) mole % crosslinking monomer. Opt. they also include 4-40 (8-20) mole % other non-hydrophilic, non-crosslinking monomers.
DE8484105909T 1983-05-28 1984-05-24 Macroporous polymers in beaded shape, process for their preparation and their use Expired DE3475199D1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE8484105909T DE3475199D1 (en) 1983-05-28 1984-05-24 Macroporous polymers in beaded shape, process for their preparation and their use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE3319506 1983-05-28
DE19843404021 DE3404021A1 (en) 1983-05-28 1984-02-06 MACROPOROUS PEARL POLYMERISATES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE8484105909T DE3475199D1 (en) 1983-05-28 1984-05-24 Macroporous polymers in beaded shape, process for their preparation and their use

Publications (1)

Publication Number Publication Date
DE3475199D1 true DE3475199D1 (en) 1988-12-22

Family

ID=25811132

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19843404021 Ceased DE3404021A1 (en) 1983-05-28 1984-02-06 MACROPOROUS PEARL POLYMERISATES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE8484105909T Expired DE3475199D1 (en) 1983-05-28 1984-05-24 Macroporous polymers in beaded shape, process for their preparation and their use

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE19843404021 Ceased DE3404021A1 (en) 1983-05-28 1984-02-06 MACROPOROUS PEARL POLYMERISATES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE

Country Status (17)

Country Link
US (1) US4568706A (en)
EP (1) EP0129719B1 (en)
AT (1) ATE38678T1 (en)
AU (1) AU564409B2 (en)
BR (1) BR8402533A (en)
CA (1) CA1251890A (en)
DE (2) DE3404021A1 (en)
DK (1) DK261084A (en)
ES (1) ES8502133A1 (en)
FI (1) FI73229C (en)
GR (1) GR81579B (en)
HU (1) HUT36151A (en)
IL (1) IL71946A (en)
NO (1) NO842097L (en)
NZ (1) NZ208287A (en)
PH (1) PH22516A (en)
PT (1) PT78643B (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3344912A1 (en) * 1983-12-13 1985-06-20 Hoechst Ag, 6230 Frankfurt CROSSLINKED POLYMERISATES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
DE3413904A1 (en) * 1984-04-13 1985-10-24 Hoechst Ag, 6230 Frankfurt POLYMERISATES BASED ON POLYVINYLENE CARBONATE AND / OR POLYHYDROXYMETHYLENE, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE
ATE71405T1 (en) * 1985-06-18 1992-01-15 Anawa Muenchen Ag SUPPORT FOR CULTIVATION OF HUMAN AND/OR ANIMAL CELLS IN A FERMENTATOR.
DE3521684A1 (en) * 1985-06-18 1986-12-18 Dr. Müller-Lierheim KG, Biologische Laboratorien, 8033 Planegg METHOD FOR COATING POLYMERS
US4691026A (en) * 1985-07-30 1987-09-01 Air Products And Chemicals, Inc. Self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers
US4788288A (en) * 1985-07-30 1988-11-29 Air Products And Chemicals, Inc. Self-and Hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers
US4663410A (en) * 1985-08-06 1987-05-05 Air Products And Chemicals, Inc. Polymers of self- and hydroxyl reactive formaldehyde-free cyclic hemiamidal and hemiamide ketal crosslinking monomers
GB8521192D0 (en) * 1985-08-23 1985-10-02 Courtaulds Plc Polymeric carrier materials
DE3537259A1 (en) * 1985-10-19 1987-04-23 Hoechst Ag COPOLYMERISAT, METHOD FOR THE PRODUCTION THEREOF AND ITS USE AS AN ENZYME CARRIER
US4698384A (en) * 1986-02-19 1987-10-06 Air Products And Chemicals, Inc. Nonwoven binder emulsions of vinyl acetate/ethylene copolymers having improved solvent resistance
US4745025A (en) * 1986-02-19 1988-05-17 Air Products And Chemicals, Inc. Nonwoven products bonded with binder emulsions of vinyl acetate/ethylene copolymers having improved solvent resistance
DE3629176A1 (en) * 1986-08-28 1988-03-17 Hoechst Ag CROSSLINKED POLYMERISATES WITH CARBONATE TER GROUPS AND METHOD FOR THE PRODUCTION THEREOF
CA2013023A1 (en) * 1989-04-17 1990-10-17 Milan F. Sojka Method of making highly adsorptive copolymers
US5100477A (en) * 1989-05-15 1992-03-31 Dow Corning Corporation Decontamination of toxic chemical agents
JPH0383914A (en) * 1989-08-18 1991-04-09 W R Grace & Co Drug carrier
TW198064B (en) * 1990-12-24 1993-01-11 Hoechst Ag
CN1039017C (en) * 1992-07-11 1998-07-08 南开大学 Method for synthesizing series plastics of macro-porous polyacrylamide
US6228340B1 (en) 1997-08-25 2001-05-08 The Regents Of The University Of California Method for the production of macroporous ceramics
DE19804518C2 (en) * 1998-02-05 2000-10-05 Roehm Gmbh Process for the production of pearl-shaped copolymers based on acrylate, carrier polymer materials produced thereafter and their use
US6464850B1 (en) * 1998-07-31 2002-10-15 Biowhittaker Molecular Applications, Inc. Method for producing hydrophilic monomers and uses thereof
SE0201623D0 (en) * 2002-05-30 2002-05-30 Amersham Biosciences Ab Macroporous cross-linked polymer particles
DE602004022395D1 (en) * 2003-04-16 2009-09-17 Sekisui Chemical Co Ltd METHOD FOR PRODUCING A PARTICLE WITH ITS INTEGRATED MAGNETIC MATERIAL
US7276283B2 (en) * 2004-03-24 2007-10-02 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of carbon-containing substrates
US8029902B2 (en) * 2006-12-11 2011-10-04 Wisconsin Alumni Research Foundation Plasma-enhanced functionalization of substrate surfaces with quaternary ammonium and quaternary phosphonium groups
CN114007737B (en) * 2019-07-03 2024-07-05 默克专利股份公司 Antibody drug conjugate purification

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594333A (en) * 1967-07-26 1971-07-20 Univ California Formylated aromatic polymers and method of making same
DE1795235C3 (en) * 1968-08-27 1974-06-06 Pharmacia Fine Chemicals Ab, Uppsala (Schweden) Separating agent for gel filtration
DE2237316C3 (en) * 1972-07-29 1985-08-29 Roehm Gmbh, 6100 Darmstadt Process for the production of bead-shaped, crosslinked, water-insoluble copolymers and their use
JPS52137482A (en) * 1976-05-14 1977-11-16 Kyoritsu Yuki Kogyo Kenkyusho:Kk Preparation of acrylamide polymer
DE2722751C2 (en) * 1977-05-20 1990-06-21 Röhm GmbH, 6100 Darmstadt Bead polymer with a particle diameter of 5 to 1000 μm and an internal cavity
JPS54160300A (en) * 1978-06-08 1979-12-18 Toyo Soda Mfg Co Ltd Hydrophilic separating carrier and making method thereof
US4266610A (en) * 1978-11-28 1981-05-12 Phillips Petroleum Company Sulfonate-cosurfactant mixtures for use in hard brines during oil recovery operations

Also Published As

Publication number Publication date
PH22516A (en) 1988-09-12
FI73229C (en) 1987-09-10
CA1251890A (en) 1989-03-28
US4568706A (en) 1986-02-04
DK261084A (en) 1984-11-29
IL71946A (en) 1987-11-30
PT78643A (en) 1984-06-01
AU2877084A (en) 1984-11-29
EP0129719A2 (en) 1985-01-02
DE3404021A1 (en) 1984-11-29
ES532831A0 (en) 1985-01-01
EP0129719A3 (en) 1986-02-12
IL71946A0 (en) 1984-09-30
ES8502133A1 (en) 1985-01-01
HUT36151A (en) 1985-08-28
EP0129719B1 (en) 1988-11-17
NO842097L (en) 1984-11-29
FI73229B (en) 1987-05-29
AU564409B2 (en) 1987-08-13
FI842078A0 (en) 1984-05-24
PT78643B (en) 1986-10-20
BR8402533A (en) 1985-04-02
DK261084D0 (en) 1984-05-25
ATE38678T1 (en) 1988-12-15
NZ208287A (en) 1986-10-08
FI842078A (en) 1984-11-29
GR81579B (en) 1984-12-11

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8365 Fully valid after opposition proceedings
8339 Ceased/non-payment of the annual fee