DE3440141A1 - Use of bistrichloromethyl carbonate as a proreagent for phosgene - Google Patents

Use of bistrichloromethyl carbonate as a proreagent for phosgene

Info

Publication number
DE3440141A1
DE3440141A1 DE19843440141 DE3440141A DE3440141A1 DE 3440141 A1 DE3440141 A1 DE 3440141A1 DE 19843440141 DE19843440141 DE 19843440141 DE 3440141 A DE3440141 A DE 3440141A DE 3440141 A1 DE3440141 A1 DE 3440141A1
Authority
DE
Germany
Prior art keywords
proreagent
phosgene
use
bistrichloromethyl carbonate
bistrichloromethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19843440141
Other languages
German (de)
Inventor
Heiner Dipl Chem Dr Eckert
Original Assignee
Eckert Heiner
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eckert Heiner filed Critical Eckert Heiner
Priority to DE19843440141 priority Critical patent/DE3440141A1/en
Publication of DE3440141A1 publication Critical patent/DE3440141A1/en
Application status is Ceased legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C68/00Preparation of esters of carbonic or haloformic acids
    • C07C68/06Preparation of esters of carbonic or haloformic acids from organic carbonates
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00Carbon; Compounds thereof
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B9/00General methods of preparing halides
    • C01B9/02Chlorides
    • CCHEMISTRY; METALLURGY
    • C01INORGANIC CHEMISTRY
    • C01FCOMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
    • C01F7/00Compounds of aluminium
    • C01F7/48Aluminium halides
    • C01F7/56Chlorides
    • C01F7/58Preparation of anhydrous aluminium chloride
    • C01F7/60Preparation of anhydrous aluminium chloride from oxygen-containing aluminium compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C263/00Preparation of derivatives of isocyanic acid
    • C07C263/10Preparation of derivatives of isocyanic acid by reaction of amines with carbonyl halides, e.g. with phosgene
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58Preparation of carboxylic acid halides
    • C07C51/60Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2.] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/20General preparatory processes
    • C08G64/30General preparatory processes using carbonates

Abstract

The use of bistrichloromethyl carbonate as a proreagent for phosgene and preferred application processes thereof are disclosed.
DE19843440141 1984-11-02 1984-11-02 Use of bistrichloromethyl carbonate as a proreagent for phosgene Ceased DE3440141A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19843440141 DE3440141A1 (en) 1984-11-02 1984-11-02 Use of bistrichloromethyl carbonate as a proreagent for phosgene

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843440141 DE3440141A1 (en) 1984-11-02 1984-11-02 Use of bistrichloromethyl carbonate as a proreagent for phosgene

Publications (1)

Publication Number Publication Date
DE3440141A1 true DE3440141A1 (en) 1986-05-07

Family

ID=6249383

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843440141 Ceased DE3440141A1 (en) 1984-11-02 1984-11-02 Use of bistrichloromethyl carbonate as a proreagent for phosgene

Country Status (1)

Country Link
DE (1) DE3440141A1 (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
EP0708129A1 (en) 1991-05-08 1996-04-24 Daicel Chemical Industries, Ltd. Process for producing polycarbonate
WO1996040792A1 (en) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
WO1996040791A1 (en) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
EP1097164A1 (en) * 1998-07-12 2001-05-09 Peptor Ltd Processes for coupling amino acids using bis-(trichloromethyl) carbonate
US6310189B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Nucleotides and analogs having photoremoveable protecting groups
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6344565B1 (en) 1999-08-27 2002-02-05 Roche Vitamins, Inc. Preparation of cycloacid
US6355432B1 (en) 1989-06-07 2002-03-12 Affymetrix Lnc. Products for detecting nucleic acids
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6420169B1 (en) 1989-06-07 2002-07-16 Affymetrix, Inc. Apparatus for forming polynucleotides or polypeptides
US6451536B1 (en) 1990-12-06 2002-09-17 Affymetrix Inc. Products for detecting nucleic acids
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6566495B1 (en) 1989-06-07 2003-05-20 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US7056666B2 (en) 1990-12-06 2006-06-06 Affymetrix, Inc. Analysis of surface immobilized polymers utilizing microfluorescence detection
EP1854799A1 (en) * 2006-05-12 2007-11-14 INDENA S.p.A. Process for the preparation of a taxane derivative
EP1867644A1 (en) 2003-07-24 2007-12-19 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
EP2033951A2 (en) 2002-02-01 2009-03-11 Euro-Celtique S.A. 2-Piperazine-pyridines useful for treating pain
EP2067776A1 (en) 2003-07-24 2009-06-10 Euro-Celtique S.A. Piperidine compounds and pharmaceutical compositions containing them
US7696208B2 (en) 2003-08-01 2010-04-13 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US7776861B2 (en) 2003-07-24 2010-08-17 Purdue Pharma L.P. Therapeutic agents useful for treating pain
CN102516126A (en) * 2011-11-29 2012-06-27 广州秀珀化工股份有限公司 Preparation method of alkyl substitution diphenylmethane diisocyanate
CN102617401A (en) * 2012-03-08 2012-08-01 象山志华新材料有限公司 Synthesis method for co-producing p-chloroaniline and p-chlorophenol isocyanate
EP2604598A1 (en) 2007-04-27 2013-06-19 Purdue Pharma L.P. TRPV1 antagonists and uses thereof

Cited By (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
US6747143B2 (en) 1989-06-07 2004-06-08 Affymetrix, Inc. Methods for polymer synthesis
US6646243B2 (en) 1989-06-07 2003-11-11 Affymetrix, Inc. Nucleic acid reading and analysis system
US6630308B2 (en) 1989-06-07 2003-10-07 Affymetrix, Inc. Methods of synthesizing a plurality of different polymers on a surface of a substrate
US6610482B1 (en) 1989-06-07 2003-08-26 Affymetrix, Inc. Support bound probes and methods of analysis using the same
US6261776B1 (en) 1989-06-07 2001-07-17 Affymetrix, Inc. Nucleic acid arrays
US6291183B1 (en) 1989-06-07 2001-09-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6310189B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Nucleotides and analogs having photoremoveable protecting groups
US6309822B1 (en) 1989-06-07 2001-10-30 Affymetrix, Inc. Method for comparing copy number of nucleic acid sequences
US6329143B1 (en) 1989-06-07 2001-12-11 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6600031B1 (en) 1989-06-07 2003-07-29 Affymetrix, Inc. Methods of making nucleic acid or oligonucleotide arrays
US6346413B1 (en) 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US6355432B1 (en) 1989-06-07 2002-03-12 Affymetrix Lnc. Products for detecting nucleic acids
US6379895B1 (en) 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6395491B1 (en) 1989-06-07 2002-05-28 Affymetrix, Inc. Method of information storage and recovery
US6403957B1 (en) 1989-06-07 2002-06-11 Affymetrix, Inc. Nucleic acid reading and analysis system
US6403320B1 (en) 1989-06-07 2002-06-11 Affymetrix, Inc. Support bound probes and methods of analysis using the same
US6406844B1 (en) 1989-06-07 2002-06-18 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6416952B1 (en) 1989-06-07 2002-07-09 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6420169B1 (en) 1989-06-07 2002-07-16 Affymetrix, Inc. Apparatus for forming polynucleotides or polypeptides
US6440667B1 (en) 1989-06-07 2002-08-27 Affymetrix Inc. Analysis of target molecules using an encoding system
US6566495B1 (en) 1989-06-07 2003-05-20 Affymetrix, Inc. Very large scale immobilized polymer synthesis
US6576424B2 (en) 1989-06-07 2003-06-10 Affymetrix Inc. Arrays and methods for detecting nucleic acids
US6491871B1 (en) 1989-06-07 2002-12-10 Affymetrix, Inc. System for determining receptor-ligand binding affinity
US6660234B2 (en) 1989-06-07 2003-12-09 Affymetrix, Inc. Apparatus for polymer synthesis
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6506558B1 (en) 1990-03-07 2003-01-14 Affymetrix Inc. Very large scale immobilized polymer synthesis
US6544739B1 (en) 1990-12-06 2003-04-08 Affymetrix, Inc. Method for marking samples
US7056666B2 (en) 1990-12-06 2006-06-06 Affymetrix, Inc. Analysis of surface immobilized polymers utilizing microfluorescence detection
US6451536B1 (en) 1990-12-06 2002-09-17 Affymetrix Inc. Products for detecting nucleic acids
EP0708129A1 (en) 1991-05-08 1996-04-24 Daicel Chemical Industries, Ltd. Process for producing polycarbonate
US6468740B1 (en) 1992-11-05 2002-10-22 Affymetrix, Inc. Cyclic and substituted immobilized molecular synthesis
WO1996040791A1 (en) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
WO1996040792A1 (en) * 1995-06-07 1996-12-19 Novo Nordisk A/S Modification of polypeptides
EP1097164A4 (en) * 1998-07-12 2005-05-25 Peptor Ltd Processes for coupling amino acids using bis-(trichloromethyl) carbonate
EP1097164A1 (en) * 1998-07-12 2001-05-09 Peptor Ltd Processes for coupling amino acids using bis-(trichloromethyl) carbonate
US6344565B1 (en) 1999-08-27 2002-02-05 Roche Vitamins, Inc. Preparation of cycloacid
EP2033951A2 (en) 2002-02-01 2009-03-11 Euro-Celtique S.A. 2-Piperazine-pyridines useful for treating pain
US8178560B2 (en) 2003-07-24 2012-05-15 Purdue Pharma L.P. Therapeutic agents useful for treating pain
EP1867644A1 (en) 2003-07-24 2007-12-19 Euro-Celtique S.A. Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain
US8637548B2 (en) 2003-07-24 2014-01-28 Purdue Pharma L.P. Therapeutic agents useful for treating pain
EP2067776A1 (en) 2003-07-24 2009-06-10 Euro-Celtique S.A. Piperidine compounds and pharmaceutical compositions containing them
US8349842B2 (en) 2003-07-24 2013-01-08 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
US7776861B2 (en) 2003-07-24 2010-08-17 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US9301953B2 (en) 2003-07-24 2016-04-05 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US7572812B2 (en) 2003-07-24 2009-08-11 Purdue Pharma, L.P., Usa Therapeutic agents useful for treating pain
US7696208B2 (en) 2003-08-01 2010-04-13 Purdue Pharma L.P. Therapeutic agents useful for treating pain
US8030310B2 (en) 2003-08-01 2011-10-04 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
CN101448839B (en) 2006-05-12 2011-09-21 因德纳有限公司 A process for the preparation of a taxane derivative
EP1854799A1 (en) * 2006-05-12 2007-11-14 INDENA S.p.A. Process for the preparation of a taxane derivative
WO2007131601A1 (en) * 2006-05-12 2007-11-22 Indena S.P.A. A process for the preparation of a taxane derivative
EP2604598A1 (en) 2007-04-27 2013-06-19 Purdue Pharma L.P. TRPV1 antagonists and uses thereof
EP2604599A1 (en) 2007-04-27 2013-06-19 Purdue Pharma LP TRPV1 antagonists and uses thereof
CN102516126A (en) * 2011-11-29 2012-06-27 广州秀珀化工股份有限公司 Preparation method of alkyl substitution diphenylmethane diisocyanate
CN102617401A (en) * 2012-03-08 2012-08-01 象山志华新材料有限公司 Synthesis method for co-producing p-chloroaniline and p-chlorophenol isocyanate

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Legal Events

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OP8 Request for examination as to paragraph 44 patent law
8131 Rejection