DE3409062A1 - Novel use of somatostatin - Google Patents

Novel use of somatostatin

Info

Publication number
DE3409062A1
DE3409062A1 DE19843409062 DE3409062A DE3409062A1 DE 3409062 A1 DE3409062 A1 DE 3409062A1 DE 19843409062 DE19843409062 DE 19843409062 DE 3409062 A DE3409062 A DE 3409062A DE 3409062 A1 DE3409062 A1 DE 3409062A1
Authority
DE
Germany
Prior art keywords
somatostatin
analgesic
peridural
novel use
application
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19843409062
Other languages
German (de)
Inventor
Joachim Dr.med. Chrubasik
geb. Hausmann Sigrun Dr.med. 7800 Freiburg Chrubasik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curamed Pharma GmbH
Original Assignee
Curamed Pharma GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curamed Pharma GmbH filed Critical Curamed Pharma GmbH
Priority to DE19843409062 priority Critical patent/DE3409062A1/en
Priority to EP19850102588 priority patent/EP0154940B1/en
Priority to DE8585102588T priority patent/DE3579479D1/en
Priority to US06/709,549 priority patent/US4670418A/en
Priority to JP60049201A priority patent/JPS60231619A/en
Publication of DE3409062A1 publication Critical patent/DE3409062A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Somatostatin can be used in the form of peridural injections and infusions as analgesic.

Description

Neue Verwendung von SomatostatinNew uses of somatostatin

Gegenstand der vorliegenden Erfindung ist eine neue Verwendung von Somatostatin.The present invention is a new use of Somatostatin.

Somatostatin ist ein synthetisches Peptid, das bisher gegen schwere akute gastroduodenale Ulkusblutungen, schwere akute Blutungen bei akuter erosiver bzw. hämorrhagischer Gastritis und Prophylaxe von postoperativen pankreatischen Komplikationen nach Pankreaschirurgie eingesetzt wurde. Somatostatin hemmt die Freisetzung von Wachstumshormon sowie anderen Hormonen, wie TSH, Insulin, Glucagon, Gastrin, Sekretin und Cholezystokinin.Somatostatin is a synthetic peptide that has so far been used against severe acute gastroduodenal ulcer bleeding, severe acute bleeding with acute erosive or hemorrhagic gastritis and prophylaxis of postoperative pancreatic Complications after pancreatic surgery was used. Somatostatin inhibits the release of growth hormone and other hormones such as TSH, insulin, glucagon, gastrin, Secretin and cholecystokinin.

Weiterhin wurde von M. Rezek et al., Can.J.Physiol.-Pharmakol. 56, 227-231, 1977 beschrieben, daß nach intrazerebroventrikulärer Infusion bei Ratten eine kurzfristige analgetische Wirkung gefunden wurde. Die Halbwertzeit von Somatostatin ist mit 2 - 4 Minuten außerordentlich kurz, jedoch ist in der Humanmedizin eine intrazerebroventrikuläre Dauerinfusion nicht durchführbar.Furthermore, M. Rezek et al., Can.J.Physiol.-Pharmakol. 56, 227-231, 1977 described that after intracerebroventricular infusion in rats a short-term analgesic effect was found. The half-life of somatostatin is extremely short at 2 - 4 minutes, but in human medicine there is one Continuous intracerebroventricular infusion not possible.

Es wurde jetzt überraschenderweise gefunden, daß Somatostatin nach periduraler Applikation rasch und in hohem Maße die Dura zu penetrieren vermag und in den Liquor gelangt. Damit kann Somatostatin zu den Opiatrezeptoren am Rückenmark gelangen und dort seine überraschend gute und bisher unbekannte analgetische Wirkung entwickeln.It has now surprisingly been found that somatostatin after peridural application is able to penetrate the dura quickly and to a high degree gets into the liquor. This allows somatostatin to reach the opiate receptors on the spinal cord and there its surprisingly good and previously unknown analgesic effect to develop.

Damit öffnen sich für Somatostatin völlig neue und hoch interessante Anwendungsgebiete, zumal die sonstigen Wirkungen und Nebenwirkungen von Somatostatin gut untersucht und bekannt sind.This opens up completely new and highly interesting ones for somatostatin Areas of application, especially the other effects and side effects of somatostatin well studied and known.

Gegenstand der vorliegenden Erfindung ist somit die Verwendung von Somatostatin in Form von periduralen Injektionen als Analgetikum. Weiterhin betrifft die Erfindung die Verwendung von Somatostatin zur Herstellung von periduralen Injektionslösungen als Analgetikum.The present invention thus relates to the use of Somatostatin in the form of peridural injections as an analgesic. Further concerns the invention the use of somatostatin for the preparation of peridural injection solutions as an analgesic.

Als peridurale Injektionslösungen können prinzipiell auch die bisher bekannten Lösungen zur Injektion und zur Infusion verwendet werden, die in isotonischer, steriler, pyrogenfreier Natriumchloridlösung vorliegen.As peridural injection solutions, the previously known solutions for injection and infusion are used, which are in isotonic, sterile, pyrogen-free sodium chloride solution.

Wegen der kurzen Halbwertzeit des Peptides muß die Applikationsform angepaßt werden. Dazu eignen sich beispielsweise kleine, extern anbringbare Dosiergeräte, die eine Dauerinfusion gestatten.Because of the short half-life of the peptide, the form of application must be adjusted. For example, small, externally attachable dosing devices are suitable, which allow continuous infusion.

Bei der Untersuchung von Hunden wurde festgestellt, daß die analgetische Wirksamkeit mehrere Wochen lang anhält.When examining dogs it was found that the analgesic Effectiveness lasts for several weeks.

Die Analgesieprüfung nach Cohen (J.Surg. 32, 32-37, 1982) ergab, daß alle Tiere eine 600C Wärmeplatte über die Dauer von 5 Sekunden tolerierten. Ein Pfund mit einem großen Dekubitus zeigte kein Zeichen von Schmerz. Die Hunde waren jedoch nicht sediert und zeigten eine ausgeglichene Verhaltensweise.Cohen's analgesia test (J.Surg. 32, 32-37, 1982) showed that all animals tolerated a 600C hotplate for 5 seconds. A Pounds with a large pressure ulcer showed no sign of pain. The dogs were however not sedated and exhibited a balanced behavior.

Die Versuche an den Hunden verliefen insgesamt nebenwirkungsfrei.The tests on the dogs were generally free of side effects.

Erste Humanversuche haben bestätigt, daß die peridurale Applikation von 125 ßg bzw. 250 ßg Stomatostatin analgetisch wirksam sind.First human experiments have confirmed that the peridural application of 125 ßg and 250 ßg stomatostatin are analgesic.

Claims (2)

Patentansprüche 1. Verwendung von Somatostatin in Form von periduralen Injektionen und Infusionen als Analgetikum. Claims 1. Use of somatostatin in the form of peridural Injections and infusions as an analgesic. 2. Verwendung von Somatostatin zur Herstellung von periduralen Injektions- und Infusionslösungen als Analgetikum.2. Use of somatostatin for the production of peridural injection and infusion solutions as an analgesic.
DE19843409062 1984-03-13 1984-03-13 Novel use of somatostatin Withdrawn DE3409062A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE19843409062 DE3409062A1 (en) 1984-03-13 1984-03-13 Novel use of somatostatin
EP19850102588 EP0154940B1 (en) 1984-03-13 1985-03-07 Use of somatostatin
DE8585102588T DE3579479D1 (en) 1984-03-13 1985-03-07 NEW USE OF SOMATOSTATIN.
US06/709,549 US4670418A (en) 1984-03-13 1985-03-08 Method of using somatostatin as an analgesic or an anesthetic
JP60049201A JPS60231619A (en) 1984-03-13 1985-03-11 Use of somatostatin as analgesic and anesthetic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843409062 DE3409062A1 (en) 1984-03-13 1984-03-13 Novel use of somatostatin

Publications (1)

Publication Number Publication Date
DE3409062A1 true DE3409062A1 (en) 1985-09-19

Family

ID=6230281

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19843409062 Withdrawn DE3409062A1 (en) 1984-03-13 1984-03-13 Novel use of somatostatin

Country Status (2)

Country Link
JP (1) JPS60231619A (en)
DE (1) DE3409062A1 (en)

Also Published As

Publication number Publication date
JPS60231619A (en) 1985-11-18

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