DE3382578T2 - Ester aus 3-(3-substituierten amino-2-hydroxypropoxy)-4-substituierten 2,5-thiadiazolabkoemmlingen. - Google Patents

Ester aus 3-(3-substituierten amino-2-hydroxypropoxy)-4-substituierten 2,5-thiadiazolabkoemmlingen.

Info

Publication number
DE3382578T2
DE3382578T2 DE8484900198T DE3382578T DE3382578T2 DE 3382578 T2 DE3382578 T2 DE 3382578T2 DE 8484900198 T DE8484900198 T DE 8484900198T DE 3382578 T DE3382578 T DE 3382578T DE 3382578 T2 DE3382578 T2 DE 3382578T2
Authority
DE
Germany
Prior art keywords
substituted
hydroxypropoxy
thiadiazole
combinations
ester made
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8484900198T
Other languages
English (en)
Other versions
DE3382578D1 (de
Inventor
L Matier
W Erhardt
Ghanshyam Patil
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of DE3382578D1 publication Critical patent/DE3382578D1/de
Application granted granted Critical
Publication of DE3382578T2 publication Critical patent/DE3382578T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8484900198T 1982-12-22 1983-11-22 Ester aus 3-(3-substituierten amino-2-hydroxypropoxy)-4-substituierten 2,5-thiadiazolabkoemmlingen. Expired - Fee Related DE3382578T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/452,280 US4508725A (en) 1982-12-22 1982-12-22 Esters of 3-(3-substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazole derivatives
PCT/US1983/001847 WO1984002525A1 (en) 1982-12-22 1983-11-22 Esters of 3-(3-substituted-amino-2-hydroxypropoxy)-4-substituted-1,2,5-thiadiazole derivatives

Publications (2)

Publication Number Publication Date
DE3382578D1 DE3382578D1 (de) 1992-07-16
DE3382578T2 true DE3382578T2 (de) 1993-03-25

Family

ID=23795857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484900198T Expired - Fee Related DE3382578T2 (de) 1982-12-22 1983-11-22 Ester aus 3-(3-substituierten amino-2-hydroxypropoxy)-4-substituierten 2,5-thiadiazolabkoemmlingen.

Country Status (14)

Country Link
US (1) US4508725A (de)
EP (1) EP0131006B1 (de)
JP (1) JPS60500288A (de)
AU (1) AU567908B2 (de)
CA (1) CA1230879A (de)
DE (1) DE3382578T2 (de)
ES (1) ES8504159A1 (de)
IE (1) IE59617B1 (de)
IT (1) IT1172381B (de)
MX (1) MX156097A (de)
NO (1) NO164095C (de)
NZ (1) NZ206385A (de)
WO (1) WO1984002525A1 (de)
ZA (1) ZA838829B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4623652A (en) 1981-11-12 1986-11-18 American Hospital Supply Corporation Esters of thiadiazole oxypropanolaine derivatives and pharmaceutical uses
US5320839A (en) * 1991-10-11 1994-06-14 Alcon Laboratories, Inc. Topical ophthalmic compositions comprising 4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazoles and methods for their use
WO1993006827A1 (en) * 1991-10-11 1993-04-15 Alcon Laboratories, Inc. Topical ophthalmic compositions comprising 4-(3-substituted amino-2-hydroxypropoxy)-1,2,5-thiadiazoles and methods for their use
US5929247A (en) * 1994-10-24 1999-07-27 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US6750238B1 (en) * 2000-05-12 2004-06-15 The University Of Toledo Aralkyl ester soft drugs
US6756047B2 (en) 2000-05-12 2004-06-29 The University Of Toledo Method and compositions for treating persistent pulmonary hypertension using aralkyl ester soft drugs
US7049326B2 (en) * 2000-05-12 2006-05-23 The University Of Toledo Method and compositions for temporarily incapacitating subjects
US20110092507A1 (en) * 2009-10-20 2011-04-21 Chin-Tsai Fan Process for preparing R-(+)-3-morpholino-4-(3- tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051144A (en) * 1968-05-22 1977-09-27 Charles E. Frosst & Co. Sinister-3,5-disubstituted oxozolidines their preparation and use
US3655663A (en) * 1969-04-21 1972-04-11 Burton K Wasson 4-(3-secondary amino-2-hydroxy-proxy) 1 2 5-thiadiazoles
FR2132570B1 (de) * 1971-04-09 1974-08-02 Lipha
US3729477A (en) * 1971-09-09 1973-04-24 Frosst & Co Charles E Certain 4-(3-amino-2-hydroxypropoxy)-1,2,5-thiadiazole-3-carboxamides
US4083992A (en) * 1972-12-15 1978-04-11 Imperial Chemical Industries Limited Alkanolamine derivatives
US3891639A (en) * 1973-04-19 1975-06-24 Merck Sharp & Dohme 4-{8 3-Amino-2-acyloxypropoxy{9 -1,2,5-thiadiazole compounds
US4011217A (en) * 1973-04-19 1977-03-08 Merck Sharp & Dohme (I.A.) Corporation 4-(3-amino-2-acyloxypropoxy)-1,2,5-thiadiazole compounds
AU509371B2 (en) * 1975-08-07 1980-05-08 F. Hoffmann-La Roche Ag Diazepine Derivatives
US4127674A (en) * 1977-03-21 1978-11-28 Allergan Pharmaceuticals, Inc. Method of treatment for glaucoma
US4387103A (en) * 1980-11-28 1983-06-07 American Hospital Supply Corporation Method for treatment or prophylaxis of cardiac disorders
ZA827646B (en) * 1981-11-12 1983-08-31 American Hospital Supply Corp Esters of aryloxypropanolamine derivatives

Also Published As

Publication number Publication date
NZ206385A (en) 1986-08-08
AU2334184A (en) 1984-07-17
ES528225A0 (es) 1985-04-16
NO164095B (no) 1990-05-21
IE832730L (en) 1984-06-22
EP0131006A1 (de) 1985-01-16
DE3382578D1 (de) 1992-07-16
NO843352L (no) 1984-08-22
IT1172381B (it) 1987-06-18
EP0131006B1 (de) 1992-06-10
JPS60500288A (ja) 1985-03-07
MX156097A (es) 1988-07-07
US4508725A (en) 1985-04-02
ES8504159A1 (es) 1985-04-16
CA1230879A (en) 1987-12-29
IT8349538A0 (it) 1983-12-19
WO1984002525A1 (en) 1984-07-05
ZA838829B (en) 1985-03-27
IE59617B1 (en) 1994-03-09
AU567908B2 (en) 1987-12-10
EP0131006A4 (de) 1985-06-06
NO164095C (no) 1990-09-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee