DE3340872A1 - Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former - Google Patents
Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel formerInfo
- Publication number
- DE3340872A1 DE3340872A1 DE19833340872 DE3340872A DE3340872A1 DE 3340872 A1 DE3340872 A1 DE 3340872A1 DE 19833340872 DE19833340872 DE 19833340872 DE 3340872 A DE3340872 A DE 3340872A DE 3340872 A1 DE3340872 A1 DE 3340872A1
- Authority
- DE
- Germany
- Prior art keywords
- urea
- polyacrylic acid
- absorption
- production
- methacrylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Herstellunq von resorptionsfördernden waßrigen Salbengelen ausManufacture of absorption-promoting aqueous ointment gels
Polvacrylsäure oder Methacrylsäure-Mischpolymerisaten unter Verwendung von Harnstoff als Gelbildner Polvacrylsäure oder Mischpolymerisate von Methacrylsäure der unterschiedlichsten Kettenlänge (z.B. CarbopolR934, CarbopolR94O, EudispertR)1) werden vielfach zur Herstellung von hydrophilen Salbengelen verwendet. Die Herstellung erfolgt in der Weise, daß. Polyacrylsäure in Wasser dispergiert wird und die Dispersion mit organischen oder anorganischen Basen neutralisiert wird. Es bildet sich beim Rühren durch Salzbildung ein transparentes, streichfähiqes Gel, in das die verschiedenartigsten Arzneistoffe zur topischen Applikation eingearbeitet werden können.Polyacrylic acid or methacrylic acid copolymers using of urea as a gel-forming agent, polyacrylic acid or copolymers of methacrylic acid the most varied chain lengths (e.g. CarbopolR934, CarbopolR94O, EudispertR) 1) are widely used for the production of hydrophilic ointment gels. The production takes place in such a way that. Polyacrylic acid is dispersed in water and the dispersion is neutralized with organic or inorganic bases. It forms at the Stirring through salt formation a transparent, spreadable gel in which the most diverse Medicinal substances for topical application can be incorporated.
Es wurde nun gefunden, daß eine solche Gelbildung auch dann erfolgt, wenn in die wäßrige Dispersion von Polyacrylsäure neutrale Verbindungen, wie beispielsweise Harnstoff eingearbeitet werden.It has now been found that such a gel formation also takes place if in the aqueous dispersion of polyacrylic acid neutral compounds, such as Urea can be incorporated.
Die Konzentration an Polyacrylsäure oder Methacrylsäure-Mischpolymerisaten kann dabei zwischen 1% und 10% variieren, die Konzentration an Harnstoff zwischen 1% und 30%.The concentration of polyacrylic acid or methacrylic acid copolymers can vary between 1% and 10%, the concentration of urea between 1% and 30%.
Die entstehenden transparenten Gele sind vielseitig anwendbar.The resulting transparent gels can be used in many ways.
Zum einen ist der Harnstoff selbst eine Substanz mit dermatoloqischer Eiqenwirkung. Darüber hinaus besitzt der Harnstoff keratolytische Wirkung, die zu einer verstärkten Penetration zugesetzter Wirkstoffe führt. Weiterhin kann Harnstoff aufgrund 1) Hersteller: Carbopol R - BF Goodrich Chemical GmbH EudispertR - Röhm Pharma GmbH seiner solubilisierenden Eigenschaften dazu dienen, wasserunlösliche Wirkstoffe zu solubilisieren und auf diesem Wege besser resorbierbar zu machen. Oberraschenderweise sind mit Harnstoff hergestellte Gele auch im sauren Milieu stabil. Darüber hinaus erlaubt die Verwendung von Harnstoff die Einarbeitunq von l!irkstoffen, die entweder mit Polyacrylsäure unvertranlich sind, oder die nur im sauren Medium beständig sind. So eist beispielsweise ein unter Verwendung von Harnstoff hergestelltes Polvacrylsäure-Gel, das saurer gemacht wurde, noch die typischen Eigenschaften von Polyacrylsäure-Gelen auf.For one, the urea itself is a dermatological substance Own effect. In addition, the urea has keratolytic effects that lead to leads to an increased penetration of added active ingredients. Urea can also be used based on 1) Manufacturer: Carbopol R - BF Goodrich Chemical GmbH EudispertR - Röhm Pharma GmbH its solubilizing properties serve to Solubilize water-insoluble active ingredients and in this way make them more absorbable close. Surprisingly, gels made with urea are also acidic Stable milieu. In addition, the use of urea allows incorporation of active ingredients that are either incompatible with polyacrylic acid, or that are only are stable in the acidic medium. For example, a using Urea made polyacrylic acid gel made more acidic, still the typical ones Properties of polyacrylic acid gels.
Die folgenden Beispiele kennzeichnen die Erfindunn: Beispiel 1: Carbopol R934 2,0 Harnstoff 2,5 Wasser ad 50,0 Beispiel 2: CarbopolR940 3,0 Harnstoff 5,0 Wasser ad 50,0 Beispiel 3: CarbopolR940 4,0 Harnstoff 10,0 Milchsäure 4,0 Wasser ad 50,0 Beispiel 4: Carbopol R940 4,0 Harnstoff 10,0 TetracyclinHCl 0,5 Milchsäure 4,0 Wasser ad sn,oThe following examples characterize the invention: Example 1: Carbopol R934 2.0 urea 2.5 water ad 50.0 Example 2: Carbopol R940 3.0 urea 5.0 Water ad 50.0 Example 3: Carbopol R940 4.0 urea 10.0 lactic acid 4.0 water ad 50.0 Example 4: Carbopol R940 4.0 Urea 10.0 TetracyclineHCl 0.5 Lactic acid 4.0 water ad sn, o
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833340872 DE3340872A1 (en) | 1983-11-11 | 1983-11-11 | Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833340872 DE3340872A1 (en) | 1983-11-11 | 1983-11-11 | Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3340872A1 true DE3340872A1 (en) | 1985-05-23 |
Family
ID=6214111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19833340872 Withdrawn DE3340872A1 (en) | 1983-11-11 | 1983-11-11 | Production of absorption-promoting aqueous ointment gels from polyacrylic acid or methacrylic acid copolymers using urea as gel former |
Country Status (1)
Country | Link |
---|---|
DE (1) | DE3340872A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0355152A1 (en) * | 1988-01-15 | 1990-02-28 | Curatek Pharmaceuticals | Topical metronidazole formulations and therapeutic uses thereof. |
-
1983
- 1983-11-11 DE DE19833340872 patent/DE3340872A1/en not_active Withdrawn
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0355152A1 (en) * | 1988-01-15 | 1990-02-28 | Curatek Pharmaceuticals | Topical metronidazole formulations and therapeutic uses thereof. |
EP0355152A4 (en) * | 1988-01-15 | 1990-06-27 | Curatek Pharmaceuticals | Topical metronidazole formulations and therapeutic uses thereof. |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8139 | Disposal/non-payment of the annual fee |