DE3280438D1 - Vitamin d glycoside. - Google Patents

Vitamin d glycoside.

Info

Publication number
DE3280438D1
DE3280438D1 DE8282902413T DE3280438T DE3280438D1 DE 3280438 D1 DE3280438 D1 DE 3280438D1 DE 8282902413 T DE8282902413 T DE 8282902413T DE 3280438 T DE3280438 T DE 3280438T DE 3280438 D1 DE3280438 D1 DE 3280438D1
Authority
DE
Germany
Prior art keywords
cpds
active
glycoside
vitamin
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8282902413T
Other languages
German (de)
Other versions
DE3280438T2 (en
Inventor
Sally Ann Holick
Michael Francis Holick
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
General Hospital Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp filed Critical General Hospital Corp
Priority claimed from EP82902413A external-priority patent/EP0112332B1/en
Publication of DE3280438D1 publication Critical patent/DE3280438D1/en
Application granted granted Critical
Publication of DE3280438T2 publication Critical patent/DE3280438T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/207—Cyclohexane rings not substituted by nitrogen atoms, e.g. kasugamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cpds. of formula (I) which are biologically active in maintaining Ca and P metabolism in animals are new. In (I) the broken bond is an opt. double bond; R2 is H, Me or Et, X is H or OR1; and R2 is H or straight- or branched chain glycoside residue contg. 1-20 glycosidic units per residue. Provided that at least 1 R1 is other than H. Cpds. (I) are synthetic water-soluble forms of vitamins D3 and D2 and hydroxylated metabolites, and they are hypocalcaemically active and they maintain Ca and P homeostasis. Unexpectedly (I) may promote Ca absorption through the intestine without mobilisation of bone Ca, and so serum Ca levels may be increased by stimulation of intestinal Ca transport. Dose is 0.1 microgram -1 mg/kg.
DE82902413T 1982-06-30 1982-06-30 VITAMIN D GLYCOSIDE. Expired - Lifetime DE3280438T2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP82902413A EP0112332B1 (en) 1982-06-30 1982-06-30 Vitamin d glycosides

Publications (2)

Publication Number Publication Date
DE3280438D1 true DE3280438D1 (en) 1993-07-22
DE3280438T2 DE3280438T2 (en) 1993-10-21

Family

ID=8190208

Family Applications (1)

Application Number Title Priority Date Filing Date
DE82902413T Expired - Lifetime DE3280438T2 (en) 1982-06-30 1982-06-30 VITAMIN D GLYCOSIDE.

Country Status (1)

Country Link
DE (1) DE3280438T2 (en)

Also Published As

Publication number Publication date
DE3280438T2 (en) 1993-10-21

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Legal Events

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8364 No opposition during term of opposition