DE3228127A1 - Amino acid solutions for infusion - Google Patents

Amino acid solutions for infusion

Info

Publication number
DE3228127A1
DE3228127A1 DE19823228127 DE3228127A DE3228127A1 DE 3228127 A1 DE3228127 A1 DE 3228127A1 DE 19823228127 DE19823228127 DE 19823228127 DE 3228127 A DE3228127 A DE 3228127A DE 3228127 A1 DE3228127 A1 DE 3228127A1
Authority
DE
Germany
Prior art keywords
amino acid
infusion
acid solutions
electrolytes
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19823228127
Other languages
German (de)
Inventor
Des Erfinders Auf Nennung Verzicht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF SE
Original Assignee
BASF SE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BASF SE filed Critical BASF SE
Priority to DE19823228127 priority Critical patent/DE3228127A1/en
Publication of DE3228127A1 publication Critical patent/DE3228127A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention relates to novel amino acid solutions for infusion, for parenteral feeding, which contain arginine and valine in a ratio by weight of 1.9-2.0:1.

Description

Die Erfindung betrifft neue Aminosäure-Infusionslösungen zur parenteralen Ernährung.The invention relates to new amino acid infusion solutions for parenteral nutrition.

Es sind bereits Infusionslösungen für die parenterale Ernähung bekannt, vgl. Infusionstherapie II: Parenterale Ernährung, Springer Verlag, Berlin 1975.Infusion solutions for parenteral nutrition are already known, see Infusion Therapy II: Parenteral Nutrition, Springer Verlag, Berlin 1975.

Gegenstand der Erfindung sind Infusionslösungen, welche Aminosäuren und gegebenenfalls Kohlenhydrate und Elektrolyte enthalten, welche dadurch gekennzeichnet sind, daß sie Arginin und Valin im Gewichtsverhältnis von 1,9 bis 2,0 zu 1 enthalten.The invention relates to infusion solutions which contain amino acids and optionally carbohydrates and electrolytes, which are characterized in that they contain arginine and valine in a weight ratio of 1.9 to 2.0: 1.

Die Lösungen enthalten außer Arginin und Valin die weiteren essentiellen Aminosäuren Leucin, Isoleucin, Methionin, Threonin, Phenylalanin, Tryptophan, Histidin und Lysin. Anstelle von Lysin kann auch dessen Acetat und anstelle von Cystein N-Acetyl-L-cystein verwendet werden.In addition to arginine and valine, the solutions contain the other essential amino acids leucine, isoleucine, methionine, threonine, phenylalanine, tryptophan, histidine and lysine. Instead of lysine, its acetate can also be used, and instead of cysteine, N-acetyl-L-cysteine can be used.

Als Kohlenhydrate kommen Glucose, Fructose und insbesondere Sorbit und Xylit in Betracht. Als Elektrolyte eignen sich Natrium, Kalium, Calcium, Magnesium, Zink, Chlorid, Acetat, Glycerophosphat, Melat. Weiter können die Lösungen auch Spurenelemente und Vitamine enthalten.Glucose, fructose and, in particular, sorbitol and xylitol come into consideration as carbohydrates. Sodium, potassium, calcium, magnesium, zinc, chloride, acetate, glycerophosphate and melate are suitable as electrolytes. The solutions can also contain trace elements and vitamins.

Die erfindungsgemäßen Lösungen eignen sich für eine kontinuierliche qualitativ und quantitativ bilanzierte Ernährung bedrohlich erkrankter Patienten. Weiter eignen sie sich zur Korrektur bzw. Minimierung von Veränderungen des Postaggressionsstoffwechsels.The solutions according to the invention are suitable for continuous, qualitatively and quantitatively balanced nutrition of critically ill patients. They are also suitable for correcting or minimizing changes in post-aggression metabolism.

Die folgenden Beispiele erläutern die Erfindung.The following examples illustrate the invention.

Beispiel 1example 1

Aminosäuren-Lösung mit Kohlenhydraten und ElektrolytenAmino acid solution with carbohydrates and electrolytes

Beispiel 2Example 2

Aminosäuren-Lösung mit Kohlenhydraten und ElektrolytenAmino acid solution with carbohydrates and electrolytes

Beispiel 3Example 3

Aminosäuren-Lösung mit Kohlenhydraten und ElektrolytenAmino acid solution with carbohydrates and electrolytes

Beispiel 4Example 4

Aminosäuren-LösungAmino acid solution

Beispiel 5Example 5

Aminosäuren-Lösung mit ElektrolytenAmino acid solution with electrolytes

Beispiel 6Example 6

Aminosäuren-Lösung mit ElektrolytenAmino acid solution with electrolytes

Beispiel 7Example 7

Aminosäuren-Lösung mit Kohlenhydraten und ElektrolytenAmino acid solution with carbohydrates and electrolytes

Die Lösungen wurde mit verdünnter Kalilauge bzw. Äpfelsäure auf einen pH-Wert von 6,0 bis 6,8, vorzugsweise 6,2 bis 6,5 eingestellt.The solutions were adjusted to a pH of 6.0 to 6.8, preferably 6.2 to 6.5, with dilute potassium hydroxide solution or malic acid.

Claims (1)

Infusionslösungen, welche Aminosäuren und gegebenenfalls Kohlenhydrate und Elektrolyte enthalten, dadurch gekennzeichnet, daß sie Arginin und Valin im Gewichtsverhältnis von 1,9 bis 2,0 zu 1 enthalten.Infusion solutions which contain amino acids and optionally carbohydrates and electrolytes, characterized in that they contain arginine and valine in a weight ratio of 1.9 to 2.0 to 1.
DE19823228127 1982-07-28 1982-07-28 Amino acid solutions for infusion Withdrawn DE3228127A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19823228127 DE3228127A1 (en) 1982-07-28 1982-07-28 Amino acid solutions for infusion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19823228127 DE3228127A1 (en) 1982-07-28 1982-07-28 Amino acid solutions for infusion

Publications (1)

Publication Number Publication Date
DE3228127A1 true DE3228127A1 (en) 1984-02-02

Family

ID=6169495

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19823228127 Withdrawn DE3228127A1 (en) 1982-07-28 1982-07-28 Amino acid solutions for infusion

Country Status (1)

Country Link
DE (1) DE3228127A1 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001872A1 (en) * 1986-09-10 1988-03-24 Dudrick Medical Research Fund I, Ltd. Method and substrate composition for treating atherosclerosis
EP0483614A1 (en) * 1990-10-30 1992-05-06 Clintec Nutrition Company Use of amino acids for the protection of and metabolic recovery of ischemic cardiac tissue
EP0510687A2 (en) * 1991-04-26 1992-10-28 The Green Cross Corporation Infusion preparation
DE4134723C1 (en) * 1991-10-21 1993-02-11 Pfrimmer Kabi Gmbh & Co Kg, 8520 Erlangen, De
EP0740935A1 (en) * 1994-02-24 1996-11-06 Otsuka Pharmaceutical Factory, Inc. Analgesic activity enhancer
US5626880A (en) * 1991-04-26 1997-05-06 The Green Cross Corporation Infusion preparation

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988001872A1 (en) * 1986-09-10 1988-03-24 Dudrick Medical Research Fund I, Ltd. Method and substrate composition for treating atherosclerosis
EP0483614A1 (en) * 1990-10-30 1992-05-06 Clintec Nutrition Company Use of amino acids for the protection of and metabolic recovery of ischemic cardiac tissue
EP0671166A3 (en) * 1991-04-26 1998-01-07 The Green Cross Corporation Nutrient-supplying preparation
EP0510687A2 (en) * 1991-04-26 1992-10-28 The Green Cross Corporation Infusion preparation
EP0510687A3 (en) * 1991-04-26 1993-05-12 The Green Cross Corporation Infusion preparation
EP0671166A2 (en) * 1991-04-26 1995-09-13 The Green Cross Corporation Nutrient-supplying preparation
US5972367A (en) * 1991-04-26 1999-10-26 The Green Cross Corporation Infusion preparation
EP0752243A2 (en) * 1991-04-26 1997-01-08 The Green Cross Corporation Container filled with infusion liquids
US5626880A (en) * 1991-04-26 1997-05-06 The Green Cross Corporation Infusion preparation
US5674527A (en) * 1991-04-26 1997-10-07 The Green Cross Corporation Infusion preparation comprising phospholipid
EP0752243A3 (en) * 1991-04-26 1998-01-07 The Green Cross Corporation Container filled with infusion liquids
DE4134723C1 (en) * 1991-10-21 1993-02-11 Pfrimmer Kabi Gmbh & Co Kg, 8520 Erlangen, De
US5760005A (en) * 1991-10-21 1998-06-02 Pharmacia Gmbh Stabilized caloric nutrient solution and a multicompartmental system or multiple recipient for human parenteral nourishing
EP0740935A4 (en) * 1994-02-24 1999-06-16 Otsuka Pharma Co Ltd Analgesic activity enhancer
EP0740935A1 (en) * 1994-02-24 1996-11-06 Otsuka Pharmaceutical Factory, Inc. Analgesic activity enhancer

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Legal Events

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8130 Withdrawal