DE3161869D1 - A pharmaceutical composition for treating hypertension containing l-alpha-methyl-3,4-dihydroxyphenylalanine and salicylamide - Google Patents

A pharmaceutical composition for treating hypertension containing l-alpha-methyl-3,4-dihydroxyphenylalanine and salicylamide

Info

Publication number
DE3161869D1
DE3161869D1 DE8181102809T DE3161869T DE3161869D1 DE 3161869 D1 DE3161869 D1 DE 3161869D1 DE 8181102809 T DE8181102809 T DE 8181102809T DE 3161869 T DE3161869 T DE 3161869T DE 3161869 D1 DE3161869 D1 DE 3161869D1
Authority
DE
Germany
Prior art keywords
dihydroxyphenylalanine
salicylamide
alpha
methyl
pharmaceutical composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181102809T
Other languages
English (en)
Inventor
Stanley Vickers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3161869D1 publication Critical patent/DE3161869D1/de
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/618—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate
    • A61K31/621—Salicylic acid; Derivatives thereof having the carboxyl group in position 1 esterified, e.g. salsalate having the hydroxy group in position 2 esterified, e.g. benorylate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE8181102809T 1980-04-14 1981-04-13 A pharmaceutical composition for treating hypertension containing l-alpha-methyl-3,4-dihydroxyphenylalanine and salicylamide Expired DE3161869D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/139,913 US4321264A (en) 1980-04-14 1980-04-14 α-methyldopa compositions

Publications (1)

Publication Number Publication Date
DE3161869D1 true DE3161869D1 (en) 1984-02-16

Family

ID=22488861

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181102809T Expired DE3161869D1 (en) 1980-04-14 1981-04-13 A pharmaceutical composition for treating hypertension containing l-alpha-methyl-3,4-dihydroxyphenylalanine and salicylamide

Country Status (8)

Country Link
US (1) US4321264A (de)
EP (1) EP0038060B1 (de)
JP (1) JPS56161326A (de)
AT (1) ATE5796T1 (de)
DE (1) DE3161869D1 (de)
GR (1) GR74873B (de)
IE (1) IE51805B1 (de)
PT (1) PT72802B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6021570B2 (ja) * 1978-07-04 1985-05-28 三共株式会社 ド−パ類の高濃度製剤の製法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE602325A (de) * 1960-04-08
US3526698A (en) * 1968-04-11 1970-09-01 Merck & Co Inc Stabilization of levo-3-(3,4-dihydroxyphenyl)-2-methylalanine with sodium bisulfite and sorbitol
US3574834A (en) * 1969-04-30 1971-04-13 Merck & Co Inc Medicinal soporific composition
IL40597A (en) * 1971-11-11 1976-06-30 Ciba Geigy Ag Drug treatment of active antihypertensive agents containing active amino acid against high blood pressure and inhibitory B-hydroxylase
IE49218B1 (en) * 1978-12-01 1985-08-21 Merck & Co Inc Methyldopa composition

Also Published As

Publication number Publication date
PT72802A (en) 1981-05-01
PT72802B (en) 1983-03-29
JPS56161326A (en) 1981-12-11
IE810819L (en) 1981-10-14
ATE5796T1 (de) 1984-01-15
GR74873B (de) 1984-07-12
EP0038060B1 (de) 1984-01-11
IE51805B1 (en) 1987-04-01
US4321264A (en) 1982-03-23
EP0038060A1 (de) 1981-10-21

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Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee