DE3145287A1 - Pyrrolo[2,3-d]pyrimidines, process for their preparation and their use as medicaments - Google Patents

Pyrrolo[2,3-d]pyrimidines, process for their preparation and their use as medicaments

Info

Publication number
DE3145287A1
DE3145287A1 DE19813145287 DE3145287A DE3145287A1 DE 3145287 A1 DE3145287 A1 DE 3145287A1 DE 19813145287 DE19813145287 DE 19813145287 DE 3145287 A DE3145287 A DE 3145287A DE 3145287 A1 DE3145287 A1 DE 3145287A1
Authority
DE
Germany
Prior art keywords
gt
lt
optionally substituted
alkyl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19813145287
Other languages
German (de)
Inventor
Kurt Dr Eger
Romanis Fruchtmann
Harald Dr Horstmann
Hairredin Dr Jacobi
Siegfried Dr Raddatz
Hermann Prof Dr Roth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troponwerke GmbH
Original Assignee
Troponwerke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troponwerke GmbH filed Critical Troponwerke GmbH
Priority to DE19813145287 priority Critical patent/DE3145287A1/en
Publication of DE3145287A1 publication Critical patent/DE3145287A1/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems

Abstract

Pyrrolo[2,3-d]pyrimidines of the general formula I <IMAGE> in which R represents hydrogen or preferably an optionally substituted alkyl group, R<1> represents hydrogen, mercapto, alkoxy, optionally substituted alkylmercapto, alkylamino, dialkylamino, optionally substituted arylamino, aralkylamino, pyrrolidinyl, piperidinyl, N-methylpiperazinyl, morpholinyl or pyrryl, or, if R is not hydrogen, but an optionally substituted alkyl group, represents hydroxyl, chloro or amino, R<2> and R<3> are identical or different and each represent alkyl or phenyl which is optionally substituted by halogen, trifluoromethyl, alkyl or alkoxy or together represent an alkylene chain having 2 to 5 carbon atoms, which is optionally substituted by alkyl, R<4> represents hydrogen, halogen, a nitro group, a lower alkyl or alkoxy group or a trifluoromethyl group, R<5> represents hydrogen, halogen or a lower alkyl or alkoxy group, their acid addition salts, a process for their preparation and their use as medicaments, in particular as anti-inflammatories and as agents for the treatment of diseases of the central nervous system.
DE19813145287 1981-11-14 1981-11-14 Pyrrolo[2,3-d]pyrimidines, process for their preparation and their use as medicaments Withdrawn DE3145287A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19813145287 DE3145287A1 (en) 1981-11-14 1981-11-14 Pyrrolo[2,3-d]pyrimidines, process for their preparation and their use as medicaments

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813145287 DE3145287A1 (en) 1981-11-14 1981-11-14 Pyrrolo[2,3-d]pyrimidines, process for their preparation and their use as medicaments

Publications (1)

Publication Number Publication Date
DE3145287A1 true DE3145287A1 (en) 1983-05-19

Family

ID=6146408

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19813145287 Withdrawn DE3145287A1 (en) 1981-11-14 1981-11-14 Pyrrolo[2,3-d]pyrimidines, process for their preparation and their use as medicaments

Country Status (1)

Country Link
DE (1) DE3145287A1 (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968686A (en) * 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
EP0482804A1 (en) * 1990-10-18 1992-04-29 Zeneca Limited Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1994013676A1 (en) * 1992-12-17 1994-06-23 Pfizer Inc. Pyrrolopyrimidines as crf antagonists
WO1995033750A1 (en) * 1994-06-08 1995-12-14 Pfizer Inc. Corticotropin releasing factor antagonists
EP0691128A1 (en) * 1994-06-15 1996-01-10 Pfizer Inc. Methods of administering CRF antagonists
EP0729758A2 (en) * 1995-03-02 1996-09-04 Pfizer Inc. Pyrazolopyrimidines and pyrrolopyrimidines for treatment of neuronal and other disorders
USRE36187E (en) * 1988-04-08 1999-04-06 The Regents Of The University Of Michigan Acyclic pyrrolo 2,3-d!pyrimidine analogs as antiviral agents
WO1999062518A1 (en) * 1998-06-02 1999-12-09 Osi Pharmaceuticals, Inc. PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE
US6051578A (en) * 1996-02-12 2000-04-18 Pfizer Inc. Pyrazolopyrimidines for treatment of CNS disorders
US6248753B1 (en) 1994-06-16 2001-06-19 Pfizer Inc Bicyclic compounds
WO2003055882A1 (en) * 2001-12-24 2003-07-10 Merck Patent Gmbh Pyrrolopyrimidines as phosphodiesterase vii inhibitors
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
WO2004056830A1 (en) * 2002-12-19 2004-07-08 Pfizer Products Inc. Pyrrolopyrimidine derivatives
US6833378B2 (en) 2000-01-18 2004-12-21 Pfizer Inc Corticotropin releasing factor antagonists
US6844351B1 (en) 1995-11-08 2005-01-18 Pfizer Inc. Corticotropin releasing factor antagonists
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6956047B1 (en) 1995-06-06 2005-10-18 Pfizer Inc. Corticotropin releasing factor antagonists
US7067664B1 (en) 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US7501407B2 (en) 2001-12-20 2009-03-10 Osi Pharmaceuticals, Inc. Pyrimidine A2B selective antagonist compounds, their synthesis and use
US7504407B2 (en) 2001-11-30 2009-03-17 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 and A3 receptors and uses thereof
US7645754B2 (en) 2001-12-20 2010-01-12 Osi Pharmaceuticals, Inc. Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use

Cited By (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968686A (en) * 1988-04-08 1990-11-06 The Regents Of The University Of Michigan Acyclic pyrrolo [2,3-d]pyrimidine analogs as antiviral agents
USRE36187E (en) * 1988-04-08 1999-04-06 The Regents Of The University Of Michigan Acyclic pyrrolo 2,3-d!pyrimidine analogs as antiviral agents
EP0482804A1 (en) * 1990-10-18 1992-04-29 Zeneca Limited Pyrrolo[2,3-d]pyrimidines with cardiovascular activity, process for their preparation and pharmaceutical compositions containing them
US5328910A (en) * 1990-10-18 1994-07-12 Imperial Chemical Industries Plc Sino-atrial node modulating pyrrolopyrimidines
US5705490A (en) * 1990-11-01 1998-01-06 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5360795A (en) * 1990-11-01 1994-11-01 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5712255A (en) * 1990-11-01 1998-01-27 The Regents Of The University Of Michigan Treatment of herpes infections with polysubstituted benzimidazoles
US6093698A (en) * 1990-11-01 2000-07-25 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
US5646125A (en) * 1990-11-01 1997-07-08 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5654283A (en) * 1990-11-01 1997-08-05 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5665709A (en) * 1990-11-01 1997-09-09 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
US6765008B1 (en) * 1992-12-17 2004-07-20 Pfizer Inc Pyrrolopyrimidines as CRF antagonists
WO1994013676A1 (en) * 1992-12-17 1994-06-23 Pfizer Inc. Pyrrolopyrimidines as crf antagonists
AU690090B2 (en) * 1992-12-17 1998-04-23 Pfizer Inc. Pyrrolopyrimidines as CRF antagonists
US5962479A (en) * 1994-06-08 1999-10-05 Pfizer Inc. Corticotropin releasing factor antagonists
WO1995033750A1 (en) * 1994-06-08 1995-12-14 Pfizer Inc. Corticotropin releasing factor antagonists
EP0691128A1 (en) * 1994-06-15 1996-01-10 Pfizer Inc. Methods of administering CRF antagonists
US6200979B1 (en) 1994-06-15 2001-03-13 Gene M. Bright Methods of administering CRF antagonists
US6248753B1 (en) 1994-06-16 2001-06-19 Pfizer Inc Bicyclic compounds
EP0729758A3 (en) * 1995-03-02 1997-10-29 Pfizer Pyrazolopyrimidines and pyrrolopyrimidines for treatment of neuronal and other disorders
EP0729758A2 (en) * 1995-03-02 1996-09-04 Pfizer Inc. Pyrazolopyrimidines and pyrrolopyrimidines for treatment of neuronal and other disorders
US6956047B1 (en) 1995-06-06 2005-10-18 Pfizer Inc. Corticotropin releasing factor antagonists
US7125880B1 (en) 1995-06-06 2006-10-24 Pfizer Inc. Corticotropin releasing factor antagonists
US7067664B1 (en) 1995-06-06 2006-06-27 Pfizer Inc. Corticotropin releasing factor antagonists
US6844351B1 (en) 1995-11-08 2005-01-18 Pfizer Inc. Corticotropin releasing factor antagonists
US6051578A (en) * 1996-02-12 2000-04-18 Pfizer Inc. Pyrazolopyrimidines for treatment of CNS disorders
CZ302486B6 (en) * 1998-06-02 2011-06-15 Osi Pharmaceuticals, Inc. N-6-Substituted-7-deazapurine, process for its preparation and pharmaceutical composition containing thereof
EP2011499A3 (en) * 1998-06-02 2010-10-20 OSI Pharmaceuticals, Inc. Pyrrolo[2,3d]Pyrimidine compositions and their use
US6686366B1 (en) 1998-06-02 2004-02-03 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
WO1999062518A1 (en) * 1998-06-02 1999-12-09 Osi Pharmaceuticals, Inc. PYRROLO[2,3d]PYRIMIDINE COMPOSITIONS AND THEIR USE
US6800633B2 (en) 1998-06-02 2004-10-05 Osi Pharmaceuticals, Inc. Pyrrolo[2,3d]pyrimidine compositions and their use
US7429574B2 (en) 1998-06-02 2008-09-30 Osi Pharmaceuticals, Inc. 4-heterocyclo-pyrrolo[2,3d] pyrimidine compositions and their use
JP2002516861A (en) * 1998-06-02 2002-06-11 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド Pyrrolo [2,3d] pyrimidine compositions and the use thereof
US6878716B1 (en) 1998-06-02 2005-04-12 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptor and uses thereof
US6664252B2 (en) 1999-12-02 2003-12-16 Osi Pharmaceuticals, Inc. 4-aminopyrrolo[2,3-d]pyrimidine compounds specific to adenosine A2a receptor and uses thereof
US7160890B2 (en) 1999-12-02 2007-01-09 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680322B2 (en) 1999-12-02 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US6833378B2 (en) 2000-01-18 2004-12-21 Pfizer Inc Corticotropin releasing factor antagonists
US6673802B2 (en) 2000-12-01 2004-01-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A3 receptor and uses thereof
US6680324B2 (en) 2000-12-01 2004-01-20 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 receptors and uses thereof
US7598252B2 (en) 2000-12-01 2009-10-06 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A, receptors and uses thereof
US7504407B2 (en) 2001-11-30 2009-03-17 Osi Pharmaceuticals, Inc. Compounds specific to adenosine A1 and A3 receptors and uses thereof
US7501407B2 (en) 2001-12-20 2009-03-10 Osi Pharmaceuticals, Inc. Pyrimidine A2B selective antagonist compounds, their synthesis and use
US7645754B2 (en) 2001-12-20 2010-01-12 Osi Pharmaceuticals, Inc. Pyrrolopyrimidine A2B selective antagonist compounds, their synthesis and use
WO2003055882A1 (en) * 2001-12-24 2003-07-10 Merck Patent Gmbh Pyrrolopyrimidines as phosphodiesterase vii inhibitors
US7498334B2 (en) * 2001-12-24 2009-03-03 Merck Patent Gmbh Pyrrolopyrimidines as phosphodiesterase VII inhibitors
US7271262B2 (en) 2002-12-19 2007-09-18 Pfizer Inc Pyrrolopyrimidine derivatives
NL1025068C2 (en) * 2002-12-19 2004-11-16 Pfizer Prod Inc Pyrrolopyrimidine derivatives.
WO2004056830A1 (en) * 2002-12-19 2004-07-08 Pfizer Products Inc. Pyrrolopyrimidine derivatives

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Legal Events

Date Code Title Description
8130 Withdrawal