DE3067408D1 - Antibiotic pa-31088-iv, its salts with bases, a process for its manufacture, pharmaceutical compositions containing this antibiotic, streptomyces tokunonensis pa-31088 and its mutants - Google Patents

Antibiotic pa-31088-iv, its salts with bases, a process for its manufacture, pharmaceutical compositions containing this antibiotic, streptomyces tokunonensis pa-31088 and its mutants

Info

Publication number
DE3067408D1
DE3067408D1 DE8080101825T DE3067408T DE3067408D1 DE 3067408 D1 DE3067408 D1 DE 3067408D1 DE 8080101825 T DE8080101825 T DE 8080101825T DE 3067408 T DE3067408 T DE 3067408T DE 3067408 D1 DE3067408 D1 DE 3067408D1
Authority
DE
Germany
Prior art keywords
antibiotic
mutants
bases
salts
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080101825T
Other languages
German (de)
English (en)
Inventor
Kentaro Tanaka
Jun Ichi Shoji
Yoshimi Kawamura
Teruo Hattori
Eiji Kondo
Kouichi Matsumoto
Tadashi Yoshida
Naoki Tsuji
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Application granted granted Critical
Publication of DE3067408D1 publication Critical patent/DE3067408D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8080101825T 1979-04-06 1980-04-03 Antibiotic pa-31088-iv, its salts with bases, a process for its manufacture, pharmaceutical compositions containing this antibiotic, streptomyces tokunonensis pa-31088 and its mutants Expired DE3067408D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4234779A JPS55136282A (en) 1979-04-06 1979-04-06 Novel antibiotic pa-31088-4

Publications (1)

Publication Number Publication Date
DE3067408D1 true DE3067408D1 (en) 1984-05-17

Family

ID=12633486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080101825T Expired DE3067408D1 (en) 1979-04-06 1980-04-03 Antibiotic pa-31088-iv, its salts with bases, a process for its manufacture, pharmaceutical compositions containing this antibiotic, streptomyces tokunonensis pa-31088 and its mutants

Country Status (6)

Country Link
US (1) US4292241A (en, 2012)
EP (1) EP0017246B1 (en, 2012)
JP (1) JPS55136282A (en, 2012)
AU (1) AU528686B2 (en, 2012)
CA (1) CA1153968A (en, 2012)
DE (1) DE3067408D1 (en, 2012)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5683489A (en) * 1979-12-12 1981-07-08 Shionogi & Co Ltd New antibiotic pa-39504-x1 and it preparation
JPS5740485A (en) * 1980-08-25 1982-03-06 Shionogi & Co Ltd Novel antibiotic pa-39504-x3 and its preparation
JPS5764693A (en) * 1980-10-07 1982-04-19 Kowa Co Novel carbapenem compound and its preparation
US4468350A (en) * 1980-10-24 1984-08-28 Kowa Co., Ltd. KA-6643-Series antibiotics, process for producing same and medical composition containing same
JPS57176982A (en) * 1981-04-24 1982-10-30 Shionogi & Co Ltd Dioxolanylazetidinone compound, its preparation and use
DE3146190A1 (de) * 1981-11-21 1983-06-16 Hoechst Ag, 6230 Frankfurt Isolierung von chemisch instabilen antibiotika aus fermentationsloesungen
AR245221A1 (es) * 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
JPH01134170A (ja) * 1987-11-19 1989-05-26 Matsushita Electric Ind Co Ltd 冷凍サイクルの安全装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4172129A (en) * 1974-03-28 1979-10-23 Beecham Group Limited Antibiotics
GB1483142A (en) * 1975-03-15 1977-08-17 Beecham Group Ltd Streptomycetal antibiotic
NL7802826A (nl) * 1977-04-08 1978-10-10 Merck & Co Inc Thienamycinederivaat, werkwijze voor het bereiden daarvan, alsmede farmaceutische preparaten.
AU531084B2 (en) * 1977-10-19 1983-08-11 Merck & Co., Inc. Azetidine derivatives
DE2862419D1 (en) * 1977-11-12 1984-07-26 Beecham Group Plc Derivatives of 7-oxo-1-azabicyclo(3.2.0)-hept-2-ene-2-carboxylic acid, their preparation, pharmaceutical compositions containing them and intermediates
EP0005349A1 (en) * 1978-05-06 1979-11-14 Beecham Group Plc Alkylcarbapenems, their preparation, use in pharmaceutical compositions and intermediates

Also Published As

Publication number Publication date
CA1153968A (en) 1983-09-20
JPS6250471B2 (en, 2012) 1987-10-24
AU528686B2 (en) 1983-05-12
EP0017246A1 (en) 1980-10-15
US4292241A (en) 1981-09-29
AU5603780A (en) 1980-10-09
EP0017246B1 (en) 1984-04-11
JPS55136282A (en) 1980-10-23

Similar Documents

Publication Publication Date Title
DE3072004D1 (en) N-heterocyclyl thienamycins, process for preparing and antibiotic pharmaceutical composition containing the same
AU533951B2 (en) Antibiotic a/16686
DE3070269D1 (en) Beta-lactam antibiotics, their preparation, pharmaceutical compositions containing them and their preparation
GB2059415B (en) Antibiotic u-59,761 and its microbiological preparation
DE3063557D1 (en) Anthracycline derivatives, a process for their preparation and pharmaceutical compositions containing them
DE3067408D1 (en) Antibiotic pa-31088-iv, its salts with bases, a process for its manufacture, pharmaceutical compositions containing this antibiotic, streptomyces tokunonensis pa-31088 and its mutants
IL55738A (en) Deoxynarasin antibiotics,process for their preparation and a novel mutant of streptomyces aureofacins for use therein
DE3070264D1 (en) Diphenylalkanoether and diphenylalkanone oximeether derivatives, a process for their production, pharmaceutical compositions and their use
ZA806867B (en) Macrolide antibiotics,process for their production and pharmaceutical composition containing them
IL61437A0 (en) Macrolide antibiotics, process for their production and pharmaceutical compositions containing them
GB2066816B (en) Antibiotic substances and processes for production thereof
DE3068471D1 (en) Antibiotic pa-39504-x1 and its salts, process for its production and pharmaceutical compositions
DE3062572D1 (en) Penicillin derivatives, process for their preparation and pharmaceutical composition comprising them
GB2061946B (en) Macrolide antibiotic
YU43218B (en) Process for producing antibiotic compounds
AU538492B2 (en) Antibiotic substance
DE3065207D1 (en) 1,2,4-triazine derivatives, process for their production and pharmaceutical composition
IL61176A0 (en) 1,2,4-oxadiazine derivatives,process for their preparation and pharmaceutical compositions containing them
MY8500601A (en) Antibiotic crystalline epimer, its preparation and pharmaceutical composition containing it
GB2004271B (en) Antibiotic and a microbiological process for preparing antibiotics
GB2003145A (en) Process for the production of a 9,3"-di-acyl derivative of a macrolide antibiotic
DE3164438D1 (en) Antibiotic pa-39504-x3, process for its production and pharmaceutical compositions
PH13303A (en) Antibiotic,a process for its preparation and its a medicament
IL90250A0 (en) New antibiotic,aranorosin,a microbiological process for the preparation thereof and pharmaceutical compositions containing same
DE3065470D1 (en) An anthracycline antibiotic and a pharmaceutical composition containing the same

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee