DE29612466U1 - Arrangement to avoid motion blur in confocal biomicroscopic imaging of corneal structures in the human eye - Google Patents
Arrangement to avoid motion blur in confocal biomicroscopic imaging of corneal structures in the human eyeInfo
- Publication number
- DE29612466U1 DE29612466U1 DE29612466U DE29612466U DE29612466U1 DE 29612466 U1 DE29612466 U1 DE 29612466U1 DE 29612466 U DE29612466 U DE 29612466U DE 29612466 U DE29612466 U DE 29612466U DE 29612466 U1 DE29612466 U1 DE 29612466U1
- Authority
- DE
- Germany
- Prior art keywords
- cornea
- objective
- confocal
- biomicroscopic
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000003384 imaging method Methods 0.000 title claims description 6
- 210000004087 cornea Anatomy 0.000 claims description 18
- 210000000981 epithelium Anatomy 0.000 claims description 5
- 238000006073 displacement reaction Methods 0.000 claims description 4
- 210000003038 endothelium Anatomy 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 238000004364 calculation method Methods 0.000 claims 1
- 238000004590 computer program Methods 0.000 claims 1
- 230000006641 stabilisation Effects 0.000 claims 1
- 238000011105 stabilization Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 210000000270 basal cell Anatomy 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 201000001891 corneal deposit Diseases 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000013532 laser treatment Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000012805 post-processing Methods 0.000 description 1
- 230000004461 rapid eye movement Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/1005—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for measuring distances inside the eye, e.g. thickness of the cornea
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microscoopes, Condenser (AREA)
Description
Erfinder/Anmelder:
Prof.Dr.rer.nat. Joachim Stave
Parkstr. 27
18119 Ostseebad WarnemündeInventor/Applicant:
Prof.Dr.rer.nat. Joachim Stave
Parkstr. 27
18119 Warnemünde
ANORDNIMG ZUR VERMEIDUNG VON BEWEGUNGSUNSCHARFEN BEI DER KONFOKALEN BIOMIKROSKOPISCHEN ABBILDUNG VON HORNHAUTSTRUKTUREN DES MENSCHLICHEN AUGESARRANGEMENT TO AVOID MOTION BLURRING IN CONFOCAL BIOMICROSCOPIC IMAGING OF CORNEAL STRUCTURES OF THE HUMAN EYE
Die Erfindung betrifft eine Anordnung zur Vermeidung von Bewegungsunschärfen bei der konfokalen biomikroskopischen Abbildung von Hornhautstrukturen des menschlichen Auges nach dem Oberbegriff des Schutzanspruches 1.The invention relates to an arrangement for avoiding motion blur in the confocal biomicroscopic imaging of corneal structures of the human eye according to the preamble of claim 1.
Die Erfindung wird zur Stabilisierung der konfokaJen biomikroskopischen Untersuchung und meßtechnischen Bildauswertung zur Erfassung von Normwerten der Zellstruktur des lebenden Auges bei Patienten mit Wundheilungsprozessen nach Verletzung oder Operation im Hornhautbereich, mit medikamentös bedingten Hornhauteinlagerungen oder nach EXIMER-Laserbehandlung z.B. zur Refraktionskorrektur angewendet. Letzlich ist diese Anordnung geeignet, individuelle Therapieerfolge besser im Sinne einer Optimierung zu erfassen und zu dokumentieren. Eine Histologie oder Elektronenmikroskopie ist in-vivo nicht möglich, da dazu das Gewebe abgetötet werden muß.The invention is used to stabilize the confocal biomicroscopic examination and metrological image evaluation to record standard values of the cell structure of the living eye in patients with wound healing processes after injury or surgery in the cornea area, with medication-induced corneal deposits or after EXIMER laser treatment, e.g. for refraction correction. Ultimately, this arrangement is suitable for better recording and documenting individual therapy successes in the sense of optimization. Histology or electron microscopy is not possible in vivo because the tissue must be killed for this.
Durch die Entwicklung von konfokalen Lichtspalt - und Laserscannern für die vorderen Augenabschnitte gelingt die Abbildung praktische aller Hornhautstrukturen am lebenden Auge.The development of confocal light slit and laser scanners for the anterior eye sections makes it possible to image practically all corneal structures on the living eye.
Das Problem bei diesen Geräten ist aber die teilweise erhebliche Bewegungsunschärfe und Verzerrung in den Einzelbildern einer Videosequenz durch die schnellen Augenbewegungen des Patieneten, die eine 2D- bzw. 3D-dimensionale Bildauswertung verhindert. Der Patient ist bei diesen Untersuchungen nur über eine flüssige optische Kontaktbrücke mit dem Mikroskop verbunden, wodurch eine seitliche und axiale Lageänderung ständig möglich ist.The problem with these devices, however, is the sometimes considerable motion blur and distortion in the individual images of a video sequence caused by the patient's rapid eye movements, which prevents 2D or 3D image analysis. During these examinations, the patient is only connected to the microscope via a liquid optical contact bridge, which means that lateral and axial position changes are constantly possible.
[Lund, E.; Waubke Th.: "Bildgebende Verfahren in der Augenheilkunde" Ferninand Euke-Verlag Stuttgart (1994)3[Lund, E.; Waubke Th.: "Imaging techniques in ophthalmology" Ferninand Euke-Verlag Stuttgart (1994)3
Eine vergleichbare technische Lösung im Sinne der Schutzansprüche 1 bis 3 ist nicht bekannt.A comparable technical solution within the meaning of claims 1 to 3 is not known.
Der im Schutzanspmch 1 angegebenen Erfindung liegt das Problem zugrunde, eine Anordnung zur bewegungsfreien konfokalen biomikroskopischen Abbildung des Epithels, der Basalzellen, der Keratocyten ,der Nerven und der Endothelzellen der Hornhaut in Verbindung mit einem konfokalen Licht- oder Laserscanner zu schaffen, mit der ein durch ein Niedervakuum Saugschalensystem vor dem Objektiv des Biomikroskops eine sichere Fixierung des Auges gelingt und damit eine Ausschaltung aller Bewegungsfreiheitsgrade des Auges relativ zum Gerät ermöglicht.The invention specified in claim 1 is based on the problem of creating an arrangement for motion-free confocal biomicroscopic imaging of the epithelium, basal cells, keratocytes, nerves and endothelial cells of the cornea in conjunction with a confocal light or laser scanner, with which a low-vacuum suction cup system in front of the objective of the biomicroscope enables secure fixation of the eye and thus enables elimination of all degrees of freedom of movement of the eye relative to the device.
Erfindungsgemäß wird das Problem mit den im Schutzanspmch 1 aufgeführten kennzeichnenden Merkmalen gelöst. Weitere vorteilhafte Merkmale beinhalten die Unteransprüche.According to the invention, the problem is solved with the characterizing features listed in claim 1. Further advantageous features are contained in the subclaims.
Mit der Erfindung wird erreicht, daß das Objektiv des konfokalen Biomikroskops von diesem getrennt auf einem Träger eines unter dem Gerät montierten Mikrometerantriebes befestigt wird, so daß das Objektiv mit seiner festen Fokalebene relativ zur konfokalen Bildblende und einer Niedervakuum-Saugschale am Mikroskop im Tubus miteis eines vom PC 9 angesteuerten Schrittschaltmotors am Mikrotrieb und damit in der Hornhaut des vakuumfixierten Auges verschoben werden kann.The invention ensures that the objective of the confocal biomicroscope is mounted separately on a carrier of a micrometer drive mounted under the device, so that the objective with its fixed focal plane can be moved relative to the confocal image diaphragm and a low-vacuum suction cup on the microscope in the tube using a stepper motor controlled by the PC 9 on the microdrive and thus in the cornea of the vacuum-fixed eye.
Dadurch, daß gleichzeitig über eine digitale Präzissionsmeßuhr an dem Mikrometertrieb mit dem Objektiv die Verschiebung der Fokalebene bei gleichzeitiger Lagekontrolle in der Hornhaut vom Epithel bis zum Endothel des Auges meßtechnisch erfaßt wird, kann das Biomikroskop gleichzeitig als Pachymeter zur kontaktlosen Homhautdickenmessung eingesetzt werden, (vergl. Fig. 2)Because the displacement of the focal plane is measured simultaneously using a digital precision dial gauge on the micrometer drive with the lens, while simultaneously controlling the position in the cornea from the epithelium to the endothelium of the eye, the biomicroscope can also be used as a pachymeter for contactless corneal thickness measurement (see Fig. 2).
Ein Ausfuhrungsbeispiel der Erfindung wird anhand der Figuren 1 und 2 erläutert. Es zeigen.An embodiment of the invention is explained with reference to Figures 1 and 2. They show.
Fig. 1: den prinzipiellen Aufbau der AnordnungFig. 1: the basic structure of the arrangement
Fig. 2: den Schnitt durch den Strahlengang des adaptierten PachymetervorsatzesFig. 2: the section through the beam path of the adapted pachymeter attachment
Nach Figur 1 ist das Objektiv 12 des konfokalen Lichtspalt- oder Laserscanning-Biomikroskops 1 von diesem getrennt auf einem Träger 2 eines unter dem Biomikroskop 1 montierten Mikrometerantriebes 10 befestigt, so daß das Objektiv 12 mit seiner festen Fokalebene relativ zur konfokalen BUdblende 5 und einer mit einer Vakuumpumpe 7 verbundenen Niedervakuum-Saugschale 3 für die Hornhaut 14 am Biomikroskop 1 im Biomikroskoptubus 6 mittels eines vom Steuercomputer 9 angesteuerten Schrittschaltmotors 13 am Mikrometerantrieb 10 und damit in der Hornhaut 14 des saugfixierten Auges 4 verschoben wird.According to Figure 1, the objective 12 of the confocal light slit or laser scanning biomicroscope 1 is mounted separately from the latter on a carrier 2 of a micrometer drive 10 mounted under the biomicroscope 1, so that the objective 12 with its fixed focal plane relative to the confocal diaphragm 5 and a low-vacuum suction cup 3 for the cornea 14 connected to a vacuum pump 7 on the biomicroscope 1 in the biomicroscope tube 6 by means of a stepping motor 13 controlled by the control computer 9 on the micrometer drive 10 and thus in the cornea 14 of the suction-fixed eye 4.
Die Bildfolge einer computergesteuerten axialen Hornhautabtastung wird nach digitaler Speicherung und Büdnachbearbeitung im Steuercomputer 9 anschließend zu einem 3D-Abbild der Strukturen der Hornhaut 14 verrechnet und meßtechnisch ausgewertet.The image sequence of a computer-controlled axial corneal scan is, after digital storage and image post-processing in the control computer 9, then calculated into a 3D image of the structures of the cornea 14 and evaluated using measurement technology.
Nach Fig. 2 ist es gleichzeitig möglich, über eine digitale Präzissionsmeßuhr 11 an dem Mikrometerantrieb 10 mit dem Objektiv 12 die Verschiebung der Objektiv-Fokalebene 16 bei gleichzeitiger Lagekontrolle in der Hornhaut 14 vom Epithel bis zum Endothel des Auges 4 meßtechnisch zu erfassen. Dadurch kann das Biomikroskop 1 gleichzeitig als Pachymeter zur kontaktlosen Homhautdickenmessung oder mittels einerdünnen Aplanationsscheibe 15 zwischen der Hornhaut 14 und dem Objektiv 12 zur Homhautdickenmessung im Kontaktverfahren eingesetzt werden.According to Fig. 2, it is simultaneously possible to measure the displacement of the objective focal plane 16 using a digital precision dial gauge 11 on the micrometer drive 10 with the objective 12 while simultaneously controlling the position in the cornea 14 from the epithelium to the endothelium of the eye 4. This means that the biomicroscope 1 can be used simultaneously as a pachymeter for contactless corneal thickness measurement or, by means of a thin aplanation disk 15 between the cornea 14 and the objective 12, for corneal thickness measurement using the contact method.
Liste der BezugszeichenList of reference symbols
1 konfokales Lichtspalt- oder Laserscanning-Biomokroskop1 confocal light slit or laser scanning biomicroscope
2 Objektivträger2 lens carriers
3 Niedervakuum-Saugschale3 Low vacuum suction cup
4 menschliches Auge4 human eye
5 konfokale Blende5 confocal aperture
6 Mikroskoptubus6 Microscope tube
7 Vakuumpumpe7 Vacuum pump
8 opt. Kontaktmittel8 opt. contact means
9 Steuercomputer9 Control computer
10 Mikrometerantrieb10 Micrometer drive
11 digitale Meßuhr11 digital dial gauge
12 Objektiv12 Lens
13 Schrittschaltmotor13 Stepper motor
14 Hornhaut14 Cornea
15 Acryl-Aplanationsscheibe15 Acrylic aplanation disc
16 Objektiv-Fokalebene16 Lens focal plane
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29612466U DE29612466U1 (en) | 1996-07-18 | 1996-07-18 | Arrangement to avoid motion blur in confocal biomicroscopic imaging of corneal structures in the human eye |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE29612466U DE29612466U1 (en) | 1996-07-18 | 1996-07-18 | Arrangement to avoid motion blur in confocal biomicroscopic imaging of corneal structures in the human eye |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE29612466U1 true DE29612466U1 (en) | 1996-10-10 |
Family
ID=8026643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE29612466U Expired - Lifetime DE29612466U1 (en) | 1996-07-18 | 1996-07-18 | Arrangement to avoid motion blur in confocal biomicroscopic imaging of corneal structures in the human eye |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE29612466U1 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002080760A1 (en) * | 2001-04-09 | 2002-10-17 | Sis Ag Surgical Instrument Systems | Method and device for determining the cornea thickness of an eye |
| DE10217263A1 (en) * | 2002-04-18 | 2003-11-06 | Albert Sturm | Positioning aid for placing diagnostic device onto sclera for checking cell structure of endothelium of cornea |
| WO2010108764A1 (en) * | 2009-03-27 | 2010-09-30 | Thales | Active display imaging system provided with an additional lens |
-
1996
- 1996-07-18 DE DE29612466U patent/DE29612466U1/en not_active Expired - Lifetime
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002080760A1 (en) * | 2001-04-09 | 2002-10-17 | Sis Ag Surgical Instrument Systems | Method and device for determining the cornea thickness of an eye |
| US6588903B2 (en) | 2001-04-09 | 2003-07-08 | Sis Ag Surgical Instruments Systems | Method and device configuration for determining the corneal thickness of an eye |
| DE10217263A1 (en) * | 2002-04-18 | 2003-11-06 | Albert Sturm | Positioning aid for placing diagnostic device onto sclera for checking cell structure of endothelium of cornea |
| WO2010108764A1 (en) * | 2009-03-27 | 2010-09-30 | Thales | Active display imaging system provided with an additional lens |
| FR2943797A1 (en) * | 2009-03-27 | 2010-10-01 | Thales Sa | IMAGING SYSTEM WITH ACTIVE DISPLAY AND BONNETTE |
| CN102414598A (en) * | 2009-03-27 | 2012-04-11 | 泰勒斯公司 | Active display imaging system provided with an additional lens |
| US8632193B2 (en) | 2009-03-27 | 2014-01-21 | Thales | Active display imaging system provided with an eyecup |
| CN102414598B (en) * | 2009-03-27 | 2014-07-09 | 泰勒斯公司 | Active display imaging system provided with an additional lens |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3245939C2 (en) | Device for generating an image of the fundus | |
| DE102008000225B3 (en) | fundus | |
| EP1327412B1 (en) | Apparatus for illuminating the lens of a human eye | |
| DE19950792A1 (en) | Ophthalmic wavefront aberration diagnostic tool, has camera that aids in focusing aerial image from lenslet array, on wavefront sensor | |
| EP1596709B1 (en) | Arrangement for improving the image field in ophthalmological appliances | |
| DE69218957T2 (en) | DEVICE FOR IN VIVO OBSERVING THE MICROSCOPIC STRUCTURES OF THE SKIN OR SIMILAR TISSUE | |
| Masters et al. | Confocal microscopy of the human cornea in vivo | |
| DE102013106420A1 (en) | Method for aligning a system and system for detecting position data of at least one element in the front region of an eye | |
| DE60204178T2 (en) | Aberration-free illustration of the ocular fundus | |
| DE102005035870A1 (en) | Optical scan system for medical applications such as in eye treatment which produces a fixation beam from a source controlled in synchrony with a moveable reflector | |
| EP2194840B1 (en) | Device and method for examining the eye fundus, especially the photoreceptors | |
| EP1891890A1 (en) | Optical device, use of a an optical device according to the present invention and method for blocking light reflexes in the observation optical path of an optical device | |
| WO2019141750A1 (en) | Method for the continuous control of the fixation of a patient's eye during the detection of biometric measurement data of the patient's eye | |
| DE29612466U1 (en) | Arrangement to avoid motion blur in confocal biomicroscopic imaging of corneal structures in the human eye | |
| DE10254369A1 (en) | Ophthalmic device with eye tracker unit | |
| Furrer et al. | Review Confocal Microscopy as a Tool for the Investigation of the Anterior Part of the Eye | |
| EP1241976A1 (en) | Method and assembly for detecting multi-dimensional eye movements and a staining tincture therefor | |
| DE102020212084A1 (en) | Arrangement for laser processing of eye opacities | |
| DE102009006024A1 (en) | Contact glass for diagnosing optician for viewing entire eye, particularly fundus of eye, comprises transparent contact lens surface facing to cornea of eye | |
| DE102019106428A1 (en) | Method and device for the contactless recording of images of the cornea | |
| DE10025320A1 (en) | Unit to correct individual aberration in human eye; has one or more implantable or contact lenses, which are manufactured according to aberration measurement and implanted in eye or fitted on eye | |
| WO2006105941A2 (en) | Device and method for visually examining the human or animal body | |
| WO1998013665A1 (en) | Process and device for measuring a bump on a surface, in particular on the retina of the eye | |
| DE4210485C2 (en) | Device for determining the eye refraction and use therefor | |
| DE102021214722A1 (en) | Method and device for generating images of an object |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R207 | Utility model specification |
Effective date: 19961121 |
|
| R150 | Utility model maintained after payment of first maintenance fee after three years |
Effective date: 20000111 |
|
| R151 | Utility model maintained after payment of second maintenance fee after six years |
Effective date: 20030218 |
|
| R152 | Utility model maintained after payment of third maintenance fee after eight years |
Effective date: 20050131 |
|
| R071 | Expiry of right |