DE2932923C2 - Cosmetic preparation for topical use to protect the skin against sunburn and to accelerate tanning - Google Patents

Description

65 Gluttuhion
Glycine

0.021 to 0.033%
rest

100%

Both components add up to 100.0%.

A particularly preferred agent of the invention, which is shown in the following examples of cosmetic products is used, has the following composition:

Tyrosine Arglnln Urocanate and Hlstldln Arglnln Urocanate together 13.6% with an analysis of the above compounds:

20th

The main self-protection mechanism of the skin against sunlight is melanogenesis, i. H. the Formation of the light protection pigment melanin in the melanocytes (specific cells) from colorless precursors, the premelamins. When exposed to sunlight finds an immediate pigmentation or a direct tanning effect through oxidation of the in the Epidermis existing premelamlne instead. This light and limited color scheme is called "tanning" called; it disappears quickly, followed by delayed or indirect pigmentation or melanogenesis, which is caused by the oxidation of other premelamines ■ formed after exposure to the sun will. This pigmentation begins 24 to 72 hours after exposure. Unfortunately the In is normal The amount of premelamine present in the skin is very limited, and after prolonged exposure to the sun it may burn and / or other skin damage occurs before the skin can form further premelamins, in particular with older skin, the much less premelamlin than younger skin contains.

The invention is based on the object of a means provide that when applied to the skin as Prämelamln works and stimulates the skin to a faster and stronger melamine formation.

For this purpose, the invention proposes the cosmetic means for accelerating the Tanning and to increase the protection of the skin, which contains a premelamine complex of tyrosine arginine urocanate, Hlstidln-Arglnln-Urocanat and GlyclnjGlutathlon contains.

A preferred composition of this agent contains tyrosine arglnin urocanate and halide arglnin urocanate In a total amount of 10 to 17% and 90 to 83% glycine glutathlon.

Analysis of the above compounds shows

Tyrosine 29.4% Arginine 33.2% Histidine 0.7% Urocanic acid 36.7%

100.0%

and Glycine Glutathlon 86.4% with an analysis of the above compound;

Glutathlon
Glycine

0.027%
rest

100.0%

Both components add up to 100.0%.

It is believed that the agent of the invention acts by the following two mechanisms:

1. It increases the concentration of premelanogeries in the epidermis before the first irradiation.

2. It promotes the passage of UV-A (315 to 390 nm) which induces tanning while the melanolytic UV-B (280 to 315 nm) is shielded. The urocanate of arginine and tyrosine acts as a Filter that allows UV-A at 315 to 390 nm to pass through as well as visible light. This jiiaturilche filter also stops UV-B with 280 bis 315 nm, the plaginalolytic effect of which has been demonstrated by immediate tanning, and limits also the erythematogenic effect of UV-B.

Usage examples:

The premelamine complex can be found in numerous skin treatment products and cosmetic agents can be used, such as. B. In face and body lotions, emulsions and creams, basic care products and make-up from liquid, emulsion and Cream type as well as gel type, numerous eye and face care substances, such as e.g. creamy and liquid shadows under the eyes and eyes, liquid and creamy eyelash and brow inks, "eyeliners", eye creams, lipsticks and lip balm, liquid and creamy leg and body make-up, such as. B. Basic leg care products, Hair products such as B. Shampoos, hair tonics and conditioning agents.

The only basic requirement is that the premelan complex of a conventional cosmetic Cream, lotion or emulsion, stick, powder (loose or compressed) or any other conventional one Carrier in concentrations between 1 and 10% (preferably 3 to 5%) is added, with none

special precautionary measures are required.

Specific examples of cosmetic products of the invention are given below. In any event, if desired, the product may also contain 0 to 10% of conventional UV light shielding agents, such as e.g. B. Derivatives of p-aminobenzoic acid (e.g. 2-EthyIhexyl-p- «2-methylamylnobenzoate), cinnamic acid (e.g. 2-Ethoxyethyl-p-methoxylnnamate), salicylic acid (e.g. Homomenthylsallcylate or 2-EthylhexyIsalicylate) or Benzophenone (e.g., 2,4-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, or 2,2'-dihydroxy-4,4'-dimethoxybenzophenone). Be; For each of the following means, the amount of premelamine can, if desired , be varied within the range from 1 to 5% , the added amount of deionized water being adjusted accordingly.

The following remedies are known according to

conventional process. Phases A and B are heated separately and they are hot Phases ,, are mixed, cooled and avoided

- borrowed phases staggered. '

cream

■ ·% by weight

continuation

Phase A hydrocarbon wax
Carnauba wax
cholesterol
Beeswax
lanolin

Isopropyl fatty acid ester
Perhydrosqualene
Sorbitan fatty acid ester
mineral oil

. Phase B methyl paraben

hydrolyzed animal protein
Premelanin
deionized water

Phase C perfume

emulsion

'»Eyeliner«

3,850

2.291

0.468

6,360 12,220 16,000

5,000

2,884 10,024

0.400 • 8.000

3,000 29,347

0.156

100,000

50

Wt%

55

Phase A silicone oil 2.00

Fettaikohoi 0.50

Polyoxyethylene fatty acid ester 1.25

Sorbitan fatty acid ester 0.30

Isopropyl fatty acid ester 5.00

Mineral oil 3.00

Silicone wax 2.00

higher alkyl fatty acid ester 7.50

2-ethylhexyl-p-dimethylamino-0.75 benzoate

lipstick

60 Phase A carnauba wax
Candelilla wax
Vegetable fat
Lanolin alcohols

⁶⁵ hydrocarbon wax

Fatty alcohol
Lanolin oil

Wt%

Phase B de-toned water 56.01 Propylene glycol! 5.00 Prärnelanin 3.00 Milk protein 2.00 Methyl paraben 0.40 Alkanoiamine 0.25 Cellulose derivative 0.50 Phase C. Perfume 0.30 Phase D. Carboxy vinyl polymer 10.00 Phase E. Red dye 0.24 (0.05% aqueous solution)

100.00

Weight "%

Phase a deionized water 60.95 Magnesium Aluminum Sililiaf! 0.60 Methyl paraben 0.40 hydrolyzed animal protein 0.10 Premelanin 3.00 Phase B volume 0.70 Phase C. Pigments ''' * '' ■ 6.00 Phase D. Propylene glycol 4.50 Cellulose derivative 1.00 Phase E. Pigments 8.00 Phase ^p Alkanoiamine 0.55 Phase G Carnauba wax 2.00 Glyceryl fatty acid ester 1.50 fatty acid 1.80 Fatty alcohol 0.30 Isopropyl ethanolin fatty acid ester 0.40 mineral oil 7.10 Sorbitan fatty acid ester 1.10 100.00

Wt%

3.60 4.30 8.20 7.00 7.50 6.00 21.00

continuation

lanolin
mineral oil

Preservative premelanin

Phase B clay gel
Phase C Pigments Phase D Perfume

Weight%

IO

15th

Liquid make-up

Phase A beeswax '\' ■ ' castor oil

! Phase B mineral spirit Phase C deionized water

Premelanin

Sodium borate

Preservative phase D pigments

Phenyl mercury acetate phase E deionized water

hydrolyzed protein

% By weight

25th

^: 'f Phase A *' deionized water 57.365 ^ cellulose derivative 0.100

Tropylene glycol 3,000

Methyl paraben 0.400

Alkanolamine 1,000

Borax 1,000

Magnesium aluminum silicate 0.250 ₃₀

Lecithin 0.500

Dioctyl sodium sulfosuccinate 0.050

Powder mix 13,000 premelanin 3,000 35

Phase B fatty acid 2,600

liquid absorption base 8,000 glyceryl fatty acid ester 3,000,

f 40

Propyl paraben 0.050

Vegetable oil 3,250

• mineral oil 3,250

Phase C perfume oil base 0.185 45

100,000

Eyelashes or browbones

Wt% ⁵⁰

26.84 0.52 52.945

6.94 3.00 0.65 0.40

7.50 0.005

1.00

0.20

100.00

65

Claims (3)

Patent claims: 1. Cosmetic for topical use to protect the fjut against sunburn and to accelerate tanning, characterized in that it is a premelanin complex from tyrosin-arglnln urocanate, hlstldln-arglnln urocanate and Glycln-Glutathlon. 2. Means according to claim 1, characterized in that that there is a total of 10 to 17% tyrosin-arglnln urocanate and histldln-arglnln urocanate and 90 contains up to 83% glycine glutathione 3. Composition according to claim 2, characterized in that it is tyrosin-arglnln urocanate / Hlstldln-arglnln urocanate together contains 13.6% and 86.4% Glycln-Glutathlon. The analysis of the Glycln-Glutathlon «Igt an: Tyrosine 24 up to 35% Arginine 27 up to 40% Histidine 0.5 up to 0.9% Urocanic acid 30th up to 43% 100% 60