DE2861361D1 - 1-n-acylated-4-o-glycosyl-6-o-glycosyl-1,3-diaminocyclitol derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents
1-n-acylated-4-o-glycosyl-6-o-glycosyl-1,3-diaminocyclitol derivatives, process for their preparation and pharmaceutical compositions containing themInfo
- Publication number
- DE2861361D1 DE2861361D1 DE7878100925T DE2861361T DE2861361D1 DE 2861361 D1 DE2861361 D1 DE 2861361D1 DE 7878100925 T DE7878100925 T DE 7878100925T DE 2861361 T DE2861361 T DE 2861361T DE 2861361 D1 DE2861361 D1 DE 2861361D1
- Authority
- DE
- Germany
- Prior art keywords
- glycosyl
- acylated
- preparation
- pharmaceutical compositions
- compositions containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11284077A JPS5446770A (en) | 1977-09-19 | 1977-09-19 | Novel aminoglycoside derivatives |
JP11417677A JPS5446785A (en) | 1977-09-22 | 1977-09-22 | Novel aminoglycoside derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2861361D1 true DE2861361D1 (en) | 1982-01-28 |
Family
ID=26451911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE7878100925T Expired DE2861361D1 (en) | 1977-09-19 | 1978-09-18 | 1-n-acylated-4-o-glycosyl-6-o-glycosyl-1,3-diaminocyclitol derivatives, process for their preparation and pharmaceutical compositions containing them |
Country Status (4)
Country | Link |
---|---|
US (1) | US4199570A (de) |
EP (1) | EP0001280B1 (de) |
CA (1) | CA1105455A (de) |
DE (1) | DE2861361D1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468512A (en) * | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
US4468513A (en) * | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 2'-N-Acylated and 2'-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
US4424344A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
US4424345A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
US4654325A (en) * | 1984-05-24 | 1987-03-31 | Selenke William M | Medicament for reducing nephrotoxicity caused by positively charged agents such as aminoglycosides and methods of use thereof |
GB8415614D0 (en) * | 1984-06-19 | 1984-07-25 | Shell Int Research | Azetidine derivatives |
US7794713B2 (en) * | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
US20080213274A1 (en) * | 2005-10-28 | 2008-09-04 | Sabbadini Roger A | Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye |
US20090074720A1 (en) * | 2005-10-28 | 2009-03-19 | Sabbadini Roger A | Methods for decreasing immune response and treating immune conditions |
US7862812B2 (en) * | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
AU2008326297B2 (en) * | 2007-11-21 | 2012-11-08 | Cipla USA, Inc. | Antibacterial aminoglycoside analogs |
WO2010132760A1 (en) * | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of tobramycin |
WO2010132757A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010132768A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of sisomicin |
WO2010132765A2 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
WO2010132759A1 (en) | 2009-05-15 | 2010-11-18 | Achaogen, Inc. | Antibacterial derivatives of dibekacin |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR205516A1 (es) * | 1972-03-08 | 1976-05-14 | Bristol Myers Co | Proceso para la preparacion de derivados de tobramicina |
JPS554118B2 (de) * | 1973-08-29 | 1980-01-29 | ||
US4051315A (en) * | 1974-11-13 | 1977-09-27 | Bristol-Myers Company | 6"-Deoxykanamycin B and 6"-deoxytobramycin |
JPS51127045A (en) * | 1975-04-24 | 1976-11-05 | Microbial Chem Res Found | A process for preparing 3'- deoxykanamycin a derivatives. |
JPS5356661A (en) * | 1976-10-28 | 1978-05-23 | Shionogi & Co Ltd | Novel amino glycoside antibiotics derivatives |
-
1978
- 1978-07-07 CA CA307,011A patent/CA1105455A/en not_active Expired
- 1978-08-17 US US05/934,595 patent/US4199570A/en not_active Expired - Lifetime
- 1978-09-18 DE DE7878100925T patent/DE2861361D1/de not_active Expired
- 1978-09-18 EP EP78100925A patent/EP0001280B1/de not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0001280B1 (de) | 1981-11-25 |
EP0001280A3 (en) | 1979-06-27 |
CA1105455A (en) | 1981-07-21 |
US4199570A (en) | 1980-04-22 |
EP0001280A2 (de) | 1979-04-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |