DE282819C - - Google Patents
Info
- Publication number
- DE282819C DE282819C DENDAT282819D DE282819DA DE282819C DE 282819 C DE282819 C DE 282819C DE NDAT282819 D DENDAT282819 D DE NDAT282819D DE 282819D A DE282819D A DE 282819DA DE 282819 C DE282819 C DE 282819C
- Authority
- DE
- Germany
- Prior art keywords
- acid
- formic acid
- water
- sodium
- boric acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 12
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 8
- 239000004327 boric acid Substances 0.000 claims description 8
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 6
- 235000019253 formic acid Nutrition 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 5
- 150000001447 alkali salts Chemical class 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000011734 sodium Substances 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- XQCKCZWQCHDODF-UHFFFAOYSA-N OC=O.OB(O)O Chemical class OC=O.OB(O)O XQCKCZWQCHDODF-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 159000000000 sodium salts Chemical class 0.000 description 4
- 239000004280 Sodium formate Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 3
- 235000019254 sodium formate Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/022—Boron compounds without C-boron linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
PATENTSCHRIFTPATENT LETTERING
- JVe 282819 -KLASSE 12 o. GRUPPE - JVe 282819 - CLASS 12 or GROUP
Verfahren zur Darstellung von Salzen der Borämeisensäure.Process for the preparation of salts of borate formic acid.
Das vorliegende Verfahren betrifft die Darstellung von Alkalisalzen der Borämeisensäure; es besteht darin, daß man Borsäure und Ameisensäure, sei es in freiem Zustande oder in Form geeigneter Salze, in Gegenwart der salzbildenden Basen bzw. ihrer Carbonate aufeinander einwirken läßt.The present process relates to the preparation of alkali salts of boric formic acid; it consists in using boric acid and formic acid, be it in the free state or in the in the form of suitable salts, in the presence of the salt-forming bases or their carbonates on one another can act.
Zur Darstellung des Natriumboroformiats werden beispielsweise 431 g kristallisierte Soda und 575 g Borax in der Wärme mit 1250 ecm Wasser zur Lösung gebracht, und in die heiße Lösung werden 347 g 8oprozentige Ameisensäure langsam eingetragen. Hierbei tritt die Kohlensäureentwicklung so schnell und rasch auf, daß nach ganz kurzem Erhitzen der Überschuß derselben völlig verjagt ist. . Läßt man die Lösung nun erkalten, so scheidet sich bis zu 80 Prozent das gebildete Natriumsalz der Borämeisensäure aus.To prepare the sodium boroformate, for example, 431 g of crystallized soda are used and 575 g borax in the heat with 1250 ecm water to the solution, and in the hot Solution, 347 g of 8% formic acid are slowly introduced. This is where the Development of carbonic acid so rapidly and quickly that after a very short period of heating the Excess of the same is completely chased away. . If the solution is now allowed to cool down, it separates up to 80 percent of the sodium salt of boroformic acid formed.
Dasselbe Salz wird erhalten, wenn man 409,7 g Natriumformiat und 373,4 g Borsäure in Wasser löst und auskristallisieren läßt, sowie auch, wenn man 744,0 g Borsäure und 1716,0 g Soda in Wasser löst, 552,0 g Ameisensäure (wasserfrei) hinzufügt und kristallisieren läßt.The same salt is obtained if 409.7 g of sodium formate and 373.4 g of boric acid dissolves in water and allows to crystallize, as well as if you 744.0 g of boric acid and 1716.0 g of soda dissolved in water, 552.0 g of formic acid (anhydrous) is added and allowed to crystallize.
Ganz in derselben Weise kann das Kaliumsalz der Borämeisensäure erhalten werden, wenn man entsprechend den Wertigkeiten äquivalente Mengen der einzelnen Substanzen verwendet.The potassium salt of borate formic acid can be obtained in exactly the same way, if, according to the valencies, equivalent amounts of the individual substances are used used.
Das Natriumboroformiat bildet große Kristalle von der Zusammensetzung CBO7 H8Na bzw. CBO5 H4 Na + 2 H2O. Der Körper ist in Wasser und vor allem in heißem Wasser sehr leicht löslich, in kaltem Methylalkohol schwer, in Aceton sehr schwer löslich, in Äther und Ligroin unlöslich, löslich dagegen in heißem Methylalkohol. Der Schmelzpunkt des Körpers liegt konstant bei 110 bis 111° C.The sodium boroformate forms large crystals with the composition CBO 7 H 8 Na or CBO 5 H 4 Na + 2 H 2 O. The body is very easily soluble in water and especially in hot water, difficult in cold methyl alcohol and very difficult in acetone soluble, insoluble in ether and ligroin, but soluble in hot methyl alcohol. The melting point of the body is constant at 110 to 111 ° C.
Die Analyse der Verbindung ergab auf CBO7H8Na:Analysis of the compound for CBO 7 H 8 Na showed:
4040
4545
ΙΟΟ,ΟΟ. ■'■ΙΟΟ, ΟΟ. ■ '■
Das Molekulargewicht beträgt 166,11.The molecular weight is 166.11.
Daß hier nicht ein Gemisch, sondern eine homogene Verbindung vorliegt, ergibt sich aus folgendem. Sowohl Natriumformiat wie Borsäure kristallisieren für sich ohne Kristallwasser, das Natriumsalz der Borämeisensäure dagegen mit 2 Mol. Kristallwasser. Der Schmelzpunkt liegt auch nach wiederholtem Umkristallisieren stets konstant zwischen 110 und iii°. Das Natriumsalz der Borämeisensäure fällt aus allen Lösungen immer als derselbe Körper aus und stets mit 2 Mol. Kristallwasser. It turns out that this is not a mixture, but a homogeneous compound from the following. Both sodium formate and boric acid, the sodium salt of borate formic acid, crystallize on their own without water of crystallization on the other hand with 2 mol. of crystal water. The melting point is also after repeated Recrystallization always constant between 110 and iii °. The sodium salt of borate formic acid always precipitates out of all solutions as the same body and always with 2 mol. of crystal water.
Bei ioo° verliert die Verbindung 3 Mol. Wasser unter Bildung des Natriumsalzes derAt 100 ° the compound loses 3 moles of water with the formation of the sodium salt of
Metaborameisensäure C B O4 H2 Na. Die Konstitution des neuen Körpers läßt sich durch die FormelMetaboroformic acid CBO 4 H 2 Na. The constitution of the new body can be determined by the formula
- ; OH- ; OH
! OH-CH ! OH-CH
•\• \
0-B(OH)2 0-B (OH) 2
wiedergeben. Die freie Borameisensäure ist nicht beständig.reproduce. The free boroformic acid is not stable.
Bekannt ist bereits das Aluminiumborformiat (Hager, Handbuch der pharmaceutischen Praxis, neue Bearbeitung I [1905], S. 243).The aluminum boroformate is already known (Hager, Handbuch der pharmaceutischen Practice, new processing I [1905], p. 243).
• Dasselbe wird durch Eintragen von frisch gefälltem und gut ausgewaschenem Aluminiumhydroxyd in ein Gemisch von Ameisensäure und Borsäure, Filtrieren und Kristallisie-' renlassen unter Abdampfen erhalten.. Die Darstellung der bisher unbekannten Alkalisalze der Borameisensäure gestaltet sich wesentlich einfacher. Aus .der durch -Mischen der Lösungen von Natriumcarbonat und Borameisensäure oder von Natriumformiat und Borsäure erhaltenen Lösung scheidet sich das neue Salz bis zu 80 Prozent aus, so daß ein Abfiltrieren und Abdampfen fortfällt.• The same is done by entering freshly felled and well-washed aluminum hydroxide in a mixture of formic acid and boric acid, filtering and crystallizing to be left under evaporation .. The representation of the previously unknown alkali salts boroformic acid is much easier. From the mix the solutions of sodium carbonate and boroformic acid or of sodium formate and Boric acid obtained solution separates the new salt up to 80 percent, so that a There is no filtering and evaporation.
. Die Alkalisalze der Borameisensäure sollen medizinische Anwendung finden.. The alkali salts of boroformic acid are said to be used in medicine.
Claims (1)
Verfahren zur Darstellung von SalzenPatent-An saying:
Process for the preparation of salts
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE282819C true DE282819C (en) |
Family
ID=538439
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT282819D Active DE282819C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE282819C (en) |
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- DE DENDAT282819D patent/DE282819C/de active Active
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