DE2356653A1 - Anti-cancer medicaments contg. amygdalin - causing tumour regression, preventing further tumour growth and having analgesic effect - Google Patents

Anti-cancer medicaments contg. amygdalin - causing tumour regression, preventing further tumour growth and having analgesic effect

Info

Publication number
DE2356653A1
DE2356653A1 DE2356653A DE2356653A DE2356653A1 DE 2356653 A1 DE2356653 A1 DE 2356653A1 DE 2356653 A DE2356653 A DE 2356653A DE 2356653 A DE2356653 A DE 2356653A DE 2356653 A1 DE2356653 A1 DE 2356653A1
Authority
DE
Germany
Prior art keywords
amygdalin
combination
tumour
analgesic effect
preventing further
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2356653A
Other languages
German (de)
Inventor
Auf Nichtnennung Antrag
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SIDUS ARZNEIMITTEL GmbH
Original Assignee
SIDUS ARZNEIMITTEL GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SIDUS ARZNEIMITTEL GmbH filed Critical SIDUS ARZNEIMITTEL GmbH
Priority to DE2356653A priority Critical patent/DE2356653A1/en
Publication of DE2356653A1 publication Critical patent/DE2356653A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A novel medicament for treating cancer contains amygdalin (I) as active ingredient, opt in combination with thiamine (or its salts) Mo or Zn (or their cpds or salts) xanthine and/or Mg aspartate. Regression of the tumour is caused together with prevention of further tumour development. There is also simultaneous analgesic action.

Description

fp-i-~-i-η-τ» "°1.n-hr 2fp-i- ~ -i-η-τ »" ° 1.n-hr 2

PATENTANWÄLTEPATENT LAWYERS

DR. ERNST STURMDR. ERNST STURM

DR. HORST REINHARDDR. HORST REINHARD

DIPL.-ING. KARL-JÜRGEN KREUTZDIPL.-ING. KARL-JÜRGEN KREUTZ

8000 München 40, Leopoldsttaße 20/IV Telefon: (0811) 39 64518000 Munich 40, Leopoldsttaße 20 / IV Telephone: (0811) 39 6451

Draht: IsarpatentWire: Isarpatent

Bank: Deutsche Bank AG München 21/14171Bank: Deutsche Bank AG Munich 21/14171

Postscheck: München 9756-809Postal check: Munich 9756-809

ji r> τιo j τη x+rt e Tji r> τι o j τη x + rt e T

Datum 13. November 1?17?Date November 13th 1? 17 ?

~] τι η.π· yon ~] τι η.π · yon

>>^trifft ein Arzneimittel ?vr B^hand->> ^ hits a remedy ? vr B ^ hand-

a«?s a «? s

^inc? "bereits -v^rscaie^ne Verbin seien 3.ie Ver-nin^nngen^ inc? "already -v ^ rscaie ^ ne conn 3. let the shortcomings be

rW, C"ri-(/3 -rhloräthylrW, C "ri - (/ 3 -rhloroethyl

-s e_(f3-c-s e _ (f3-c

idi N,W-id i N, W-

äthyl)-phosptOfunidester, Triät^ylenmelamin, ^riatnyspnreajnW und 3i6-'Bia-propoxy-2, 5-bis-äthylenimino-77W=1" nnt.ethyl) -phosptofunidester, triet ^ ylenmelamine, ^ riatnyspnreajnW and 3 i 6-'Bia-propoxy-2,5-bis-ethylenimino-77W = 1 "nnt.

vonfrom

si.^^ als Chemotherapeutika -1^
Hs -bekannt. N-ben ί ,2-IsoOronyliden-6-äthylen-si. ^^ as chemotherapeutic agents - 1 ^
Hs - known. N-ben ί, 2-iso-oronylidene-6-ethylene-

ucontranosfi zeigt vor ellem das 1,6-Bis-(|i-oblorät-hylamino)-1 ,e-deso^-D-mannit-dihyArocnloria. einenucontranosfi mainly shows the 1,6-bis- (| i-oblorät-hylamino) -1 , e-deso ^ -D-mannit-dihyArocnloria. a

'509820/1183 BAD original _2_'509820/1183 BAD original _ 2 _

f ekt (^Tat^-rw. 42, 5R2 Pt9SBj ^ »f ect (^ Tat ^ -rw. 42, 5R2 Pt9SBj ^ »

",np Behandlung ^es Frebsop ha^on "bis", np treatment ^ es Frebsop ha ^ on" up

be"te prak+risc1'1» Bedentunn- erlangt. .Fach/teil ο Λρτ. >>'-.irarynt<->'" Αγ"τϊΐ<3ΐτπΐttpl hpsteh/^n insbesondere in Λ°τ> nnq-nori fiRr.'hen T-r"i"p-be "te prak + risc 1 ' 1 » Condition attained.. Subject / part ο Λρτ. >>' -. ir a rynt <->'"Α γ " τ ϊΐ <3 ΐτπΐttpl hpsteh / ^ n especially in Λ ° τ> nnq-nori fiRr.'hen T - r "i" p-

Eine Aiifpabe <?.<=*r vorliegenden Erfinrin.n^; ist ns, Q1n A^^.n^iinittel 7π schaffen, ^^ eirierP^itB eine RuckfHil^TTn.0* ^-R" ρ*??«=» sr τ op. ^ « zumindest abnr eine TTnt erb rech imp; der V^lter^ntW Geschwilst "bewirkt wnß. andererseits gleicr?eitipsehe WirkungAn Aiifpabe <?. <= * R present invention n ^; is n s, Q 1n A ^^. n ^ iinittel 7π create, ^^ eirierP ^ itB a RuckfHil ^ TTn. 0 * ^ - R "ρ * ??" = "sr τ op. ^" At least from n r a TT nt inherited imp; the elder ^ ntW Geschwilst "causes wnß. on the other hand, the same effect

"Diese Aiafgq"be wii0'1' ^rfindtings^emäß da^^rch.-crelÖRt, rl aß ^nP Arzneimittel al^ Wirkstoff Amygdalin enthält."These Aiafgq" be wii 0 ' 1 ' ^ rfindtings ^ emäß da ^^ rch.-crelÖRt, rl aß ^ nP medicament al ^ active ingredient contains amygdalin.

Amygdalin (Mpnc^elonitril-pGentiobiosid; Ό-mandelonitril-ß-D-glucosido-6-ß-D-glncosid) mit der Summenformel G2oH27^°11 ^2OH27^1-1 *^ H2^ flr3L(3-e"t:; sich besonders in den Kernen von bitte-J ren Mandeln, in Firschlorbeerblätt°rn νοηλ in ä^n Fernen vieler Pri.inusarten (Aprikosen, Kirschen, Pfirsichen). Jn ?ainnm ?<nstanri bildet Amygdalin ein w?ißr?Rt kristallisiertes P1TlVOr oder pilän^-ende, bitter' schmeckende "Rlattc^en, die in Wars°r sehr leicht, in Alkohol wen!^ löslich sind i.m'ü "hon 2Ί5 C schmelzen (Literatur Römp-o, Chemie Lexikon ^. Aufl^, V-*v* 1, Spalte 5«??).Amygdalin (Mpnc ^ elonitril-pGentiobiosid; Ό-mandelonitril-ß-D-glucosido-6-ß-D-glncosid) with the empirical formula G2o H 27 ^ ° 11 ^ 2O H 27 ^ 1-1 * ^ H 2 ^ flr3L ( 3 - e " t :; particularly in the kernels of please-J ren almonds, in bay laurel leaves νοηλ in a distance of many species of pri.inus (apricots, cherries, peaches). Jn ? A in n m ? <N stanri amygdaline forms a w? ISSR? Rt crystallized P 1 TlVOr or pilän ^ span, bitter 'tasting' Rlattc ^ s, very light, whom the Wars in ° r in alcohol! ^ are soluble i.m'ü "hon 2Ί5 C melt (Literature Römp-o, Chemie Lexikon ^. Aufl ^, V- * v * 1, column 5 «??).

Zur oralen Applikation ist erfind ■"m^s^emäß d«?s A.^v^cialln τη i folgenden Substanzen in Forobinption anwo"ndbar:For oral application, the invention is based on the A. ^ v ^ cialln τη i The following substances can be used in Forobinption:

50 9 8 20TTT8T BADOR.Q.NAL50 9 8 20TTT8T BADOR.Q.NAL

e FJaT "7 e FJaT " 7

Π-tT η+· i τη Π-tT η + i τη

nn. ä^ i-ind n n. ä ^ ii nd

un^.un ^.

Vorhin^ττπ.^θτιBefore ^ ττπ. ^ Θτι

SaIi70, irpbesondereSaIi 70 , in particular

^ ptm* mM.Ri"in ν.ηδ Feine Sal"-?, Molybdän ι in ^ af»i. 0 υη^ Vo^ini/nn^nr1, ^in1?: und sein? S=u.r?e und Tantnln zn? ^ ptm * m M.Ri "in ν.ηδ Feine Sal" - ?, Molybdenum ι in ^ af »i. 0 υη ^ Vo ^ ini / nn ^ nr 1 , ^ in 1 ?: And be? S = ur? E and aunties zn?

7T1T1 Tn.jeVtJo-n
Iiη entweder ai
Ά - 5»5 7 T 1 T 1 Tn.perVtJo-n
Iiη either ai
Ά - 5 »5

oder i.m.-Injection) 'krann Amy^da in Wasser o^e^ in saiirem Puffer bei einein m Puffer verwendet werden.or i.m.-Injection) 'krann Amy ^ da in water o ^ e ^ in safe buffer at one m buffer can be used.

-n-n

rvw. einrvw. a

ptte kann vorzugsweise ■ erfindungsgeaufweisen: ptte can preferably ■ have the following:

100 - 250
50 rap; Thiamin B100-250
50 rap; Thiamine B

1010

P,^ mg MoP, ^ mg Mo

Füllstoffe adFillers ad

5098 20Vii835098 20Vii83

erf In ^.erf In ^.

^T1cl'inson.'q?'"n ^ T1cl ' in son.' q ? '" n

Wii1!7"1 in ο· βτ».τ?_Λ1+"Wii 1 ! 7 " 1 in ο · βτ» .τ? _ Λ 1+ "

SAD ORiGINALSAD ORiGINAL

509820/1183509820/1183

Claims (1)

PatentansprücheClaims * mitte"1 "711T? ^ohan^l^in^; von Kr^ns,* middle " 1 " 711 T? ^ ohan ^ l ^ in ^; by Kr ^ ns, -qaß ^r ""1S WiT1Vsirrtf^f1 Ajiiy^daH in p- q aß ^ r "" 1 S WiT 1 Vsirrtf ^ f 1 Ajiiy ^ daH in p j p. A^rn^Tmxttel· nach Ans/nrnc1" 1., -ι p ^u.rchj p. A ^ rn ^ Tmxttel · after Ans / nrnc 1 "1., -ι p ^ u.rch ^bB ^s Amycdalin in Kombination mit HThiamin oder lessen ^ bB ^ s Amycdalin in combination with HThiamin or lessen Tn^imitt^i nach Anspruch 1. oder 2., 1^cIt gekennzeichnet,Tn ^ imitt ^ i according to claim 1. or 2., 1 ^ cIt characterized, ^pß es Amycrialin in Kambination mit Molybdän ofler dessen SaIr:en odev Vorbindungen enthält.includes en odev Vorbindungen: ^ there PSS Amycrialin in Kambination with molybdenum ofler its Sair. 4. Arzneimittel nach einem der Ansprüche 1. - 3· -> 4. Medicament according to one of claims 1. - 3 · -> daß es Any^dalin in Kombination mit Z-ink o^.er dessen iS-'il^en oder Vorhindnn^en enthält.that it is Any ^ dalin in combination with Z-ink o ^ .er of that iS-'il ^ en or Vorhindnnn ^ en contains. 5. Arzneimittel nach einem der Ansprüche 1. -4., dadurch Erel'"ennKeichn.et,
r*aß GB Amygdalin in Kombination mit Xanthin enthält.5. Medicament according to one of claims 1. -4., Characterized by Erel '"ennKeichn.et,
r * ate GB contains amygdalin in combination with xanthine. 50 98 20/1 183 SAi 50 98 20/1 183 SAi f>. Arzneimittel nach einem ^e^ Ansprüche 1.-5., ^ρdurch vekennzeichnet, daß «s Amy^au in in Komhination mit enthält. f>. Medicament according to one of the claims 1-5., ^ Ρ by ve indicates that "s contains Amy ^ au in combination with. 7· Arzneimittel nach Anspruch 1.,7 Medicines according to Claim 1, daß es ziit? Injektion Amygdalin in hernsteinsanrem Pnffer enthält.that it is time? Injection of amygdalin in hernsteinsanrem pepper contains. 8. Arrneimi.ttel nach einem d°r Ansprüche 1. — -l··, dadurch p-ekennneichnet, daß es Kur oralen Applikation pus 1OÖ - 250 mn; Amy^dalir-50 mg Thiamin "B, 10 mg ZnSOz1., 2, S top; Molybdän nnd Füllstoffen ad n.s. besteht.8. Arrneimi.ttel according to one d ° r claims 1. - -l · ·, characterized p-ekennneichnet that there is cure oral application pus 1OÖ - 250 mn; Amy ^ dalir-50 mg thiamine "B, 10 mg ZnSOz 1. , 2, S top; molybdenum and fillers ad ns consists. 509820/1183509820/1183
DE2356653A 1973-11-13 1973-11-13 Anti-cancer medicaments contg. amygdalin - causing tumour regression, preventing further tumour growth and having analgesic effect Pending DE2356653A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE2356653A DE2356653A1 (en) 1973-11-13 1973-11-13 Anti-cancer medicaments contg. amygdalin - causing tumour regression, preventing further tumour growth and having analgesic effect

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2356653A DE2356653A1 (en) 1973-11-13 1973-11-13 Anti-cancer medicaments contg. amygdalin - causing tumour regression, preventing further tumour growth and having analgesic effect

Publications (1)

Publication Number Publication Date
DE2356653A1 true DE2356653A1 (en) 1975-05-15

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ID=5897991

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DE2356653A Pending DE2356653A1 (en) 1973-11-13 1973-11-13 Anti-cancer medicaments contg. amygdalin - causing tumour regression, preventing further tumour growth and having analgesic effect

Country Status (1)

Country Link
DE (1) DE2356653A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702914A1 (en) * 1976-01-23 1977-09-15 Univ Missouri INJECTABLE STERILIZER FOR MALE ANIMALS FOR SELECTIVE CONTROL OF THE TEST FUNCTION
JPS5498339A (en) * 1978-01-18 1979-08-03 Rikagaku Kenkyusho Carcinostatic agent

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702914A1 (en) * 1976-01-23 1977-09-15 Univ Missouri INJECTABLE STERILIZER FOR MALE ANIMALS FOR SELECTIVE CONTROL OF THE TEST FUNCTION
JPS5498339A (en) * 1978-01-18 1979-08-03 Rikagaku Kenkyusho Carcinostatic agent
JPS5728694B2 (en) * 1978-01-18 1982-06-18

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