DE2323954C3 - Feed - Google Patents

Description

example 1

Conventionally kept feed additive according to the invention served as test animals Sprague Dawley rats. Separate experiments were carried out for the male animals and 45 for the male animals. An increase of 12.86% and one for the females the tests relating to 2,4-dioxo-6-methyl-l, 2,3,4- increased increase of 9.06% compared to the respective tetrahydropyrimidine was the number of animals for the control groups.

male group of 30 test animals and 30 animals. In addition, the general condition was very good troll animals, 25 test animals per 50 test animals for the female group. Appearance and vitality animals and 25 control animals. In the comparison tests as well as the condition of the fur of the animals were in relation Aureomycin was the number of animals for the same with the controls clearly as better male group each 14 test animals and 14 con-judges.

Troll animals, for the female group each 15 test animals. For comparison, comparison animals and 15 control animals were used in an analogous manner. 55 experiments were carried out, instead of 2,4-dioxo-

The animals received commercially available pellets as feed and 6-methyl-l, 2,3,4-tetrahydropyrimidine as feed additive

ground, under the 2,4-dioxo-6-methyl-l, 2,3,4-tetra- the antibiotic aureomycin was used. It

hydropyrimidine in an amount of 200 ppm - 200 ppm aureomycin were added to the feed

was mixed. The control animals were beaten with and the test animal group was also given a

Letters pellets fed without additives. Food and water 60 control groups fed at the same time that do not have any

were available ad libitum. The attitude received feed additive was compared. The results are

was carried out in wire cages sprinkled with wood shavings - also shown in Table 1. A comparison

gen. the increase in growth shows that the percentage

The duration of the experiment was 14 days. Change in growth rate compared to the

The test results are the following table 65 control animals with the addition of 2,4-Dioxo «6-methyl-

see atie 1. The results could be obtained with the 1,2,3,4-tetrahydropyrimidine according to the invention ([12,8

t-test can be statistically verified (/> <0.01 or or 9.0%) is higher than when the antibiotic

*> <O, O125). cumulative according to the state of the art (11.5 and 6.8%).

Tabel

Start of experiment Laboratory animal End of trial Laboratory animal Increase <g) Laboratory animal modification (gffier) (g / animal) opposite to
of control control control control (%) With 2,4-dioxo-6-methyl- 1,2,3,4-tetrahydro- 43,700 116.850 75,250 pyrimidine male group of animals .. 43,433 43.880 108,300 101.720 64,900 57.840 + 12.865 ρ < 0.01 female group of animals .. 43,920 95.120 51.200 +9,062 ρ < 0.0125 For comparison with 48.785 119.785 71.714 Aureomycin 45.468 108.968 63,500 male group of animals .. 48.178 112.464 64.2857 + 11,557 female group of animals .. 44.875 104.312 59.437 +6.835

Example 2
Pig fattening trial

Four groups of 10 animals each were exactly comparable over a period of 16 weeks Conditions fattened.

Male and female pigs from the same litter were distributed among the groups in fully air-conditioned Held in cages and fed with a standardized fattening feed, which in each case before the Feeding was weighed and reweighed after the limited feeding time so that the actual Feed consumption could be determined exactly. The animals had an initial weight of about 30 kg and were kept up to a slaughter weight of about 100 kg. Only the fourth group (group D) already had an initial weight of about 38 kg per animal, so that the test duration here was only 14 weeks fraud. Group A served as a control, group B received an addition of 50 ppm 2,4-dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine, Group C has 100 ppm, group D 200 ppm 2,4-dioxo-6-methyl-l, 2,3,4-tetrahydropyrimidine addition, based on the amount of dry feed.

Table 2 shows the test results obtained in the most important parameters. Dk also during For the sake of clarity, the data determined over the entire duration of the experiment are not included. The for The figures given for 1 animal are in each case the mean values of the group. Weights in kg.

The table shows that the increased weight gain in groups C and D (100 and 200 ppm feed additive) is 5.33 or 5.07% (p <0.05) compared to the control group.

Taking into account the shortened fattening time in group D even an increase in weight is calculated of almost 7%.

The feed conversion was in group D with 3.8% and in group C with 4.3% compared to the

4 »control animal group can be significantly improved.

The two partial effects that add up result in a growth-promoting effect of about 10%.

group

A (control)

B.

C.

D.

At first
weight animal End
weight animal Table 2 Weight
increase
Animal day Feed
consumption/
animal 2,4-dioxo- 30.90 95.55 0.577 260.35 6-itiethy! -
1.2.3,4-telrahydro-
pyrimidine
additive / dry
fuucr 32.50 97.06 Weight
increase animal 0.576 259.58 31.10 99.20 64.65 0.608 262.70 50 37.80 97.80 64.55 0.612 232.83 100 68.10 200 60.00

Fullcr-

consumption,

Animal day

2,326
2,318
2,346
2.376

Cutter conversion. animal

1: 4.030
1: 4.021
1: 3.858
1: 3.880

The exploitation of the invention can be made by statutory provisions, in particular by the feed law, be limited.

Claims (1)

gung the regulation of growth, Verlag Paul Claim: Parey, Perlin, 1966) likely to make one anabolic, d. H. growth-promoting effect, the Feed, characterized by is based on the fact that an intervention in the metabolism a range of 50 to 500 ppm, based on the 5 of the cells. The enzymatic regulation Amount of dry food, of 2,4-dioxo-6-methyl-l, 2, the breakdown of protein is prevented by inhibiting the 3,4-tetrabydropyrimidine. L-amino acid oxidase so influenced that a slowing down of miiochondrial degradation with an increased activity of cell protein build-up io takes place in the cytoplasm, resulting in increased Weight gain of the correspondingly fed animal leads. The serious disadvantage of using it of antibiotics consists in the fact that there is more is and form more resistant bacterial strains and the Medicinal effect of antibiotics, especially in The invention relates to a feed that human medicine is questioned, is characterized by a content of 50 to The 2,4-dioxo to be used according to the invention 500 ppm, based on the amount of dry feed, of 6-methyl-1,2,3,4-tetrahydropyrimidine has none 2,4-Dioxo-6-methyl-1,2,3,4-tetrahydropyrimidine. 20 antibiotic properties and shows this evidence It is known in animal nutrition not to use the feed. Its growth-promoting effectiveness means various substances, such as above all anti- is in the same order of magnitude as that of antibiotics, but also hormones, psychotropic substances, biotica and is probably based on the same thyreostatica and other additions, with the mechanism of optimizing the cell metabolism Purpose to increase the effectiveness of feeding. The 25 position was due to the inhibition of L-amino acid oxidase.
Use of the last-mentioned substances is viewed by Das2,4-Dioxo-6-methyl-l, 2,3,4-tetrahydropyrimidine from the veterinary or food-chemical side as an easily accessible and therefore inexpensive questionable, so that a general use is a compound, their Use is therefore also out of the question because of the feared or proven side-step with regard to the economic viability of the effects. On the other hand, there is 30 animal feeding. It is widely used as an additive for feeding antibiotics. medium, especially for pigs, ruminants and The mode of action of the antibiotics is a poultry. twofold: once they develop a bacteriostatic In two carried out on rats and pigs Effectiveness and thus improve the general series of tests, which in the following two health status of the animals, on the other hand, they possess, 35 games are described, is evidence of the as more recent studies (J. S c h o 1 e: theory of the anabolic effectiveness of 2,4-dioxo-6-methy 1-1,2,3,4- Metabolic regulation provided with particular consideration given to tetrahydropyrimidine.