DE2225541A1 - Cosmetic/pharmaceutical compsn - improving skin complexion - Google Patents

Cosmetic/pharmaceutical compsn - improving skin complexion

Info

Publication number
DE2225541A1
DE2225541A1 DE19722225541 DE2225541A DE2225541A1 DE 2225541 A1 DE2225541 A1 DE 2225541A1 DE 19722225541 DE19722225541 DE 19722225541 DE 2225541 A DE2225541 A DE 2225541A DE 2225541 A1 DE2225541 A1 DE 2225541A1
Authority
DE
Germany
Prior art keywords
skin
diaminobutane
cosmetic
deriv
palmitate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19722225541
Other languages
German (de)
Inventor
Boris Dr Janistyn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to DE19722225541 priority Critical patent/DE2225541A1/en
Publication of DE2225541A1 publication Critical patent/DE2225541A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The compsn. contains are polyamine or deriv. thereof esp. 1,4-diaminobutane (putrescine). The amines improves the complexion of the skin since they stimulate cell growth. They diffuse through animal cell membranes and readily permeate the skin, but have very low lipid solubility. They improve the activity of oestrogenic and anabolic steroids so allow a reduction in the amount of these cpds. required. Amines may be used with conventional bases e.g. lanolin, vaseline, beeswax etc. A suitable deriv. is the palmitate. A skin cream is made by mixing 100g. base (15g. stearin, 5g. isopropyl palmitate, 2g. squalane, 1g. emulsifier, 3g. glycerol mono or di stearate, 5g. sorbitol soln. and 69g. distilled water contg. perfume and preservative) with 0.5-5 mg. 1,4-diaminobutane.

Description

Beschreibung 1 Kosmetische und pharmazeutische Zubereitungen Es ist bekannt,dass einige aliphatische Polyamine, wie s.B. Description 1 Cosmetic and pharmaceutical preparations It is known that some aliphatic polyamines, such as s.B.

Spermidin, Spermin, Cadaverin und Diaminoptopan das Zellwachstui von Hamsternierenzellen signifikant anregen(1).Spermidine, spermine, cadaverine and diaminoptopan are the cell growth cases of Significantly stimulate hamster kidney cells (1).

Ein aus den Zellkulturen isolierter höchst aktiver Zellwachstumfakter konnte als 1,4 -Diaminobutan(Putrescin)identifisiert werden. 1,4- Diaminobutan entfaltet seine maximale Zellwachstum fördernen Eigenschaften bereits bei einer Konzentration von 3.10-8 M.(2).A highly active cell growth factor isolated from cell cultures could be identified as 1,4-diaminobutane (putrescine). 1,4-diaminobutane unfolds its maximum cell growth properties promote even at one concentration from 3.10-8 sts (2).

Darüber hinaus konnte nunmehr gezeigt werden,dass auch für menschliche Fibroblastenkulturen 1,4-Diaminobutan einen mamimalen Wachstumsfaktor bei einer Konzentration von 2.10 7 M derstellt(3).In addition, it has now been shown that also for human Fibroblast cultures 1,4-diaminobutane have a mammimal growth factor in a Concentration of 2.10 7 M is established (3).

Dieser Befund konnte von verschiedenen Arbeitskreisen bestätigt werden und es konnte weiter gezeigt werden, dass 1,4-Diaminobutan in der Lage ist Serumzugaben zu den Medien verschiedener Zellkulturen zu ersetzem(4,5,6).This finding has been confirmed by various working groups and it could further be shown that 1,4-diaminobutane is capable of adding serum to replace the media of different cell cultures (4,5,6).

Kürzlich durchgeführte Versuche weisen darauf hin, das menschliche Fibroblastenkulturen selbst bei hohen Serumkonzentrationen im Wachstumsmedium nicht die optimale Wachstumsfaktorkonzentration des 1,4-Diaminpbutan erreichen, so dass Zusätze dieser Substans eine grössere Wachstumseffektivität ergeben(7,8).Recent experiments indicate the human Fibroblast cultures not even with high serum concentrations in the growth medium achieve the optimal growth factor concentration of 1,4-diamine-butane, so that Additions of these substances result in greater growth effectiveness (7,8).

Es ist bekannt, dass Verbindungen mit geringer Anzahl von Kohleastoffatomen un mit wenigstens 2 Aminogruppen gut wasserlöslic@ je@och sehr wenig löslich in Äthyläther sind. Im Gegensatz zu den Alkaloiden dringen sie sehr langsam in die Zelle ein.It is known that compounds with a low number of carbon atoms And with at least 2 amino groups, they are readily soluble in water, but are also very sparingly soluble in Are ethyl ether. In contrast to the alkaloids, they penetrate very slowly Cell one.

Es wurde num gefunden, dass die niedrigmolekalaren Polyamine dennoch durch tierische Membranen diffundieren und in die mensc@-liche Haut gut permeieren, obwchl die Lipidlöslichkeit schr gering ist.In Mischung mit bekannten kosmetischen und/oder pharmazeutischen Grundstoffen, wie z.B. Lanolin, Vaselime, Bienenwachs, Isopropanolfettsäuresster, Cetylalkohol, Fettsäuren, Polyäthylenylykole, Glycerin, glycerinfettsäursester usw. sind Lotionen und Emulsionen herstellbar,die gut 1,4-Dieminobutan und des sen Derivate, beispielsweise das Palmitat in die Haut einschleusen und eine deutliche Besserung des Turgors der Haut hervorrufen. Die Besserung des Turgors zeigt sich in einer Minderung der kleinen gesichtsfalten, der geriatrische Effekt @@@ deut-Lich. Die wirkung östrogener Stoffe und anabolischer Steroide wird deutlich abgehoben und man ist in der Lage die Mengen dieser Verbindungen zu beschränken,was als Vorteil zu bezeichnen ist. Die nicht zu erwartende perkutane Effektivität des 1,4- Diaminobutans in Form geeigneter Zubereitungen bringt Vorteile,die als beachtliche Neuerungen anzusprechen sind.In allen Zubereitungen ist die Dosierung des 1,4- Diaminobutans und seiner Derivate z*B. des Palmitates sehr gering.It was found that the low molecular weight polyamines nevertheless diffuse through animal membranes and permeate well into human skin, Although the lipid solubility is extremely low, in a mixture with known cosmetic products and / or pharmaceutical raw materials such as lanolin, vaselime, beeswax, Isopropanol fatty acid ester, cetyl alcohol, fatty acids, polyethylene glycol, glycerine, glycerol fatty acid esters, etc., lotions and emulsions can be produced which are good 1,4-dieminobutane and its derivatives, for example the palmitate smuggle into the skin and one cause significant improvement in the turgor of the skin. The improvement of the turgor shows itself in a reduction of the small facial wrinkles, the geriatric ones Effect @@@ German-Lich. The effects of estrogenic substances and anabolic steroids will be clearly lifted and you are able to limit the amounts of these compounds, what can be described as an advantage. The unexpected percutaneous effectiveness of the 1,4-diaminobutane in the form of suitable preparations brings advantages that are considered considerable Innovations are to be addressed. In all preparations, the dosage of 1,4-diaminobutane is and its derivatives z * B. of the palmitate very slight.

Beispiele: 1. Hautcrome@ 15,0 Stearin 5,0 Isopropylpalmitat 2,0 Squalan 1,0 Emulgator 3,0 Glycerinzono(di)stearat 5,0 Borbitlöaung 69,0 destilliertes Wesser(Parfümöl, Konservierungslittel) Je 300 g Hautcreie werden 0,5 -5 ig 1 ,4-Diaiinobutsn oder di.Examples: 1. Skin crome @ 15.0 stearin 5.0 isopropyl palmitate 2.0 squalane 1.0 Emulsifier 3.0 Glycerin mono (di) stearate 5.0 Borbitol solution 69.0 Distilled water (perfume oil, Preservative) For 300 g skin creams, 0.5-5 ig 1, 4-Diaiinobutsn or di.

entsprechend höhere Menge des Palmitaten zugesetzt.correspondingly higher amount of palmitate added.

2. Haarwasser: 0,5 Salicylsäure 0,5 Propylenglykol 0,1 Camphersäure 0,1 Hexachlorophen(Bydroxytrichlorphenylmethen) 0,2 Parfümöl 0,1 Polyvinylpyrrolidon k-30 96,5 Äthanol, 55%ig Je Liter Haarwasser werden 0,05 -10 mg 1,4- Dieminobutan sugesetzt.2. Hair lotion: 0.5 salicylic acid 0.5 propylene glycol 0.1 camphoric acid 0.1 hexachlorophene (hydroxytrichlorophenylmethene) 0.2 perfume oil 0.1 polyvinylpyrrolidone k-30 96.5 ethanol, 55% per liter of hair tonic 0.05-10 mg 1,4-dieminobutane sugesets.

Berangezogene Literatur: 1) Hem, R.g. , Biochem. biophys. Reß. Commun., 14, 34(1964) 2) Raina, A., Acta Physiol. Scand., 60, Suppl. 218,1 (1963) 3) Raina, A., and coben,S.S., Proc, US Nat.Acad.Sci., 55,1587(1966 4) Russell D., and Snyder S.H., Proc. US Nat. Acad. Sci., 60,1420 5) (1968) @) ina,A. and Jänne, J., Fed. Proc., 29, 1568(1970) 6) Caldarera, C.M., Barbiroli,B. and Morussi, G., Biochem.J.97, 84(1965) 7) Ham, R.G., Proc.US Nat.Sei.,53, 288(1965) 8) Nature New Biology Vol.235 (1972)Related literature: 1) Hem, R.g. , Biochem. biophys. Reß. Commun., 14, 34 (1964) 2) Raina, A., Acta Physiol. Scand., 60, Suppl. 218.1 (1963) 3) Raina, A., and coben, S.S., Proc, US Nat. Acad. Sci., 55.1587 (1966 4) Russell D., and Snyder S.H., Proc. US Nat. Acad. Sci., 60, 1420 5) (1968) @) ina, A. and Jänne, J., Fed. Proc., 29, 1568 (1970) 6) Caldarera, C.M., Barbiroli, B. and Morussi, G., Biochem. J.97, 84 (1965) 7) Ham, R.G., Proc.US Nat.Sei., 53, 288 (1965) 8) Nature New Biology Vol. 235 (1972)

Claims (1)

Patentanspruch Kesmetische und/ oder pharmazeutische Zubereitungen dadurch gekennzeichnet, dass ihnen Polyamine und deren Derivate insbesondere 1,4- Diaminobut@n bzw. dessen Derivate zugesetzt werden.Patent claim Kesmetic and / or pharmaceutical preparations characterized in that they polyamines and their derivatives, in particular 1,4- Diaminobut @ n or its derivatives are added.
DE19722225541 1972-05-26 1972-05-26 Cosmetic/pharmaceutical compsn - improving skin complexion Pending DE2225541A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19722225541 DE2225541A1 (en) 1972-05-26 1972-05-26 Cosmetic/pharmaceutical compsn - improving skin complexion

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19722225541 DE2225541A1 (en) 1972-05-26 1972-05-26 Cosmetic/pharmaceutical compsn - improving skin complexion

Publications (1)

Publication Number Publication Date
DE2225541A1 true DE2225541A1 (en) 1973-12-06

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Family Applications (1)

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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006048671A1 (en) * 2004-11-05 2006-05-11 Bioforskning As Polyamine compositions
EP3288520A4 (en) * 2015-05-01 2018-12-12 L'oreal Use of active agents during chemical treatments
WO2019014195A1 (en) * 2017-07-10 2019-01-17 Coty Inc. Nail hardening composition and method of use
US10441518B2 (en) 2015-11-24 2019-10-15 L'oreal Compositions for treating the hair
US11083675B2 (en) 2015-11-24 2021-08-10 L'oreal Compositions for altering the color of hair
US11090249B2 (en) 2018-10-31 2021-08-17 L'oreal Hair treatment compositions, methods, and kits for treating hair
US11135150B2 (en) 2016-11-21 2021-10-05 L'oreal Compositions and methods for improving the quality of chemically treated hair
US11213470B2 (en) 2015-11-24 2022-01-04 L'oreal Compositions for treating the hair
US11419809B2 (en) 2019-06-27 2022-08-23 L'oreal Hair treatment compositions and methods for treating hair
US11433011B2 (en) 2017-05-24 2022-09-06 L'oreal Methods for treating chemically relaxed hair
US11596588B2 (en) 2017-12-29 2023-03-07 L'oreal Compositions for altering the color of hair

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008519022A (en) * 2004-11-05 2008-06-05 バイオフォースクニング エーエス Polyamine composition
WO2006048671A1 (en) * 2004-11-05 2006-05-11 Bioforskning As Polyamine compositions
EP3288520A4 (en) * 2015-05-01 2018-12-12 L'oreal Use of active agents during chemical treatments
US10231915B2 (en) 2015-05-01 2019-03-19 L'oreal Compositions for altering the color of hair
RU2746990C2 (en) * 2015-05-01 2021-04-23 Л'Ореаль Active agents application in chemical treatment
US11191706B2 (en) 2015-11-24 2021-12-07 L'oreal Compositions for altering the color of hair
US12048759B2 (en) 2015-11-24 2024-07-30 L'oreal Compositions for treating the hair
US10441518B2 (en) 2015-11-24 2019-10-15 L'oreal Compositions for treating the hair
US10828244B2 (en) 2015-11-24 2020-11-10 L'oreal Compositions for treating the hair
US11083675B2 (en) 2015-11-24 2021-08-10 L'oreal Compositions for altering the color of hair
US11213470B2 (en) 2015-11-24 2022-01-04 L'oreal Compositions for treating the hair
US11135150B2 (en) 2016-11-21 2021-10-05 L'oreal Compositions and methods for improving the quality of chemically treated hair
US11433011B2 (en) 2017-05-24 2022-09-06 L'oreal Methods for treating chemically relaxed hair
US11628148B2 (en) 2017-07-10 2023-04-18 Wella Operations Us, Llc Nail hardening composition and method of use
US11890262B2 (en) 2017-07-10 2024-02-06 Wella Operations Us, Llc Nail hardening composition and method of use
WO2019014195A1 (en) * 2017-07-10 2019-01-17 Coty Inc. Nail hardening composition and method of use
US11596588B2 (en) 2017-12-29 2023-03-07 L'oreal Compositions for altering the color of hair
US11090249B2 (en) 2018-10-31 2021-08-17 L'oreal Hair treatment compositions, methods, and kits for treating hair
US11975092B2 (en) 2018-10-31 2024-05-07 L'oreal Hair treatment compositions, methods, and kits for treating hair
US11419809B2 (en) 2019-06-27 2022-08-23 L'oreal Hair treatment compositions and methods for treating hair

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