DE212015000096U1 - Pinch valve and automatic analyzer with a pinch valve - Google Patents

Abstract

Pinch valve, characterized in that it is formed with a holding element for holding a hose, which allows the passage of a fluid, a pusher surface whose surface, which comes into contact with the held by the holding element crimping tube from a curved surface, a pinch, which is provided opposite the interposition of the crimp tube of the pusher surface, the shape of the crimping tube coming into contact with the part of the crimping rod is formed with the substantially same shape and substantially the same diameter as the pusher surface and wherein the width d of the shape of in Is substantially 1.5 times greater than the thickness of the squeeze tube, and drive means which are driven so that the distance between the pusher surface and the squeeze bar is variable to close the squeeze tube or open, is provided.

Description

[TECHNICAL FIELD]

The present invention relates to a pinch valve for shutting off a flow channel and an automatic analysis device, at the flow channel of the pinch valve is provided.

[STATE OF THE ART]

Patent Literature 1 discloses an automatic analyzer for measuring biological samples originating from blood, urine, etc. in the field of clinical laboratories, which is provided with a valve for controlling the flow channel for the measurement in order to control the shut-off and opening of the flow channel. As a valve for flow channel control mainly a pinch valve is present.

A pinch valve is closed by operating a pinch rod through a spool and crimping a pinch tube through the pinch bar and a pusher face. This pinch valve is not clogged when switching the flow channel against particles containing fluids and air and therefore, for example, if necessary, for use as a drain channel switching for discharging the samples after the completion of the measurement.

[LITERATURE OF THE PRIOR ART]

[Patent Literature]

• Patent Literature 1: JP H10-300752 A

[OVERVIEW OF THE INVENTION]

[TASK TO BE SOLVED BY THE INVENTION]

If the pinch valve is used to close and open the flow channel on an automatic analyzer, such as in a clinical laboratory where many samples need to be continuously treated, it is likely that the peripheral surface of the pinch valve and pusher pressure surface will be in Comes in contact with the crimping hose after a certain period of maintenance due to fatigue cracks. This squeeze tube is a regularly exchanged part, so that in the device equipped with the pinch valve regular maintenance work is required. During the performance of the maintenance work, the user of the device can not carry out an analysis with the likelihood of decreasing the test treatment efficiency.

In consideration of the above object, the invention aims to prevent the fatigue of the squeeze tube and to increase the maintainability of the device.

[MEANS OF SOLVING THE TASK]

Taking into account the above object, the invention has the following structure.

The invention is namely characterized in that it with
a holding element for holding a hose, which allows the passage of a fluid,
a pusher surface whose surface, which comes into contact with the squeeze tube held by the holding element, is formed of a curved surface,
a squeeze bar, which is provided opposite the interposition of the squeeze tube of the pusher surface, wherein the shape of the coming into contact with the squeeze tube part of the squeeze bar is formed with the substantially same shape and substantially the same diameter as the pusher surface and wherein the width d of Form of the contacting part is substantially 1.5 times greater than the thickness of the crimp tube, and
Drive means which are driven such that the distance between the pusher surface and the squeeze bar is variable in order to close or open the squeeze tube,
is provided.

[EFFECTS OF THE INVENTION]

According to the present invention, by the above-mentioned structure, a pinch valve which can surely control the closing and opening of the flow channel while reducing the fatigue of the pinch tube and an automatic analysis device with the pinch valve can be provided.

[BRIEF EXPLANATION OF THE DRAWINGS]

Show it

[ 1 ] a view of an example of an automatic analyzer;

[ 2 ] a view of the flow channel structure, comprising a flow cell detector with the pinch valve according to the invention;

[ 3 a view of the structure of a pinch valve;

[ 4 ] An enlarged view of a squeeze tube at the periphery of the pusher surface in an open pinch valve according to the prior art.

[ 5 ] An enlarged view of a squeeze tube at the periphery of the pusher surface in a closed pinch valve according to the prior art.

[ 6A ] An enlarged view of a closed pinch valve with a contact surface having a curved surface shape.

[ 6B ] An enlarged view of a closed pinch valve with a contact surface having a curved surface shape.

[ 7 ] is a schematic diagram illustrating the relationship between the shape of the contact surface and the deformation amount of the maximum deformed position of the squeeze tube;

[ 8A ] an enlarged view of a closed pinch valve in three variations of the curved surface form R at the contact surface;

[ 8B ] an enlarged view of a closed pinch valve in three variations of the curved surface form R at the contact surface;

[ 8C ] an enlarged view of a closed pinch valve in three variations of the curved surface form R at the contact surface;

[ 9 ] is a graph showing the relationship between the width d of the contact surface in the form of a curved surface and the deformation amount of the maximum deformed position of the squeeze tube.

[ 10 ] is a graph showing the relationship between the thickness t of the squeeze tube and the width d 'of the pusher surface in the case where the maximum amount of deformation of the squeeze tube surface is minimum;

[ 11A ] An enlarged view of the closed pinch valve in the case that the surface shape of the pinch bar and the pusher surface have the same curved surface shape, and in the case that they do not have the same shape.

[ 11B ] An enlarged view of the closed pinch valve in the case that the surface shape of the pinch bar and the pusher surface have the same curved surface shape, and in the case that they do not have the same shape.

[ 12 ] an enlarged view of the closed pinch valve;

[ 13 ] is a diagram illustrating the relationship between the squish amount of the squeeze tube and the pressure applied to the inner surface of the hose when the squeeze valve is closed.

EMBODIMENT OF THE INVENTION

Based on 1 An automatic analyzer will be explained.

In the automatic analyzer according to this embodiment are in racks 101 the analyzer 100 sample container 102 to hold samples and are passed through a rack transport line 117 except for a sample delivery point near a sample dispensing nozzle 103 postponed.

On an incubator disc 104 are several reaction vessels 105 installable, in which the rotational movement for the displacement of each installed in the circumferential direction reaction vessel 105 is possible in each case to a predetermined position.

A transport mechanism 106 for sample delivery chips and reaction vessel is movable in three directions of the X, Y and Z axis and is in the range of a holding element 107 for sample delivery chips and reaction containers, a stirring mechanism 108 for reaction vessels, one disposal well 109 for sample delivery chips and reaction vessels, a mounting location 110 for sample delivery chips and a predetermined location of the incubator disc 104 moved to perform the transport of sample delivery chips and reaction vessels.

On the holding element 107 for sample delivery chips and reaction vessels, several unused reaction vessels and sample delivery chips are provided. The transport mechanism 106 for sample dispensing chips and reaction vessel moves to the position above the holding element 107 for sample delivery chips and Reaction vessel, goes down there, takes an unused reaction vessel, then rises, further moves to the position above a certain point of the incubator 104 and then goes down to provide the reaction vessel.

Subsequently, the transport mechanism moves 106 for sample dispensing chips and reaction containers to the position above the holding element 107 for sample delivery chips and reaction containers, go down there, pick up an unused sample delivery chip, then rise, and move to the position above the attachment point 110 for sample delivery chips and then go down to provide the sample delivery chip.

The sample dispensing nozzle 103 is rotatable and movable up and down. It will be up to the position above the attachment point 110 Turned for trial delivery chips and then goes down, placing in the front end of the sample dispensing nozzle 103 the sample delivery chip is attached by press-fitting. The sample dispensing nozzle 103 with the attached sample delivery chip moves up to the position above the transport rack 101 opened sample container 102 , then go down and suck a predetermined amount of the in the sample container 102 held sample. The sample dispensing nozzle 103 with the aspirated sample moves to the position above the incubator 104 , then go down and bump into the incubator disc 104 held, unused reaction vessel 105 the sample out. When the ejection of the sample is stopped, the sample dispensing nozzle moves 103 to the position above the disposal hole 109 for sample delivery chips and reaction vessels to clear the spent sample delivery chip through the removal well.

On a reagent disk 111 are several reagent containers 118 Installed. At the upper part of the reagent disk 111 is a reagent disc blanket 112 provided so that the interior of the reagent disk 111 is kept at a predetermined temperature. At a part of the reagent disc cover 112 is an opening 113 provided the Reagenzscheibendecke. A reagent dispensing nozzle 114 is rotatable and movable up and down. It will be up to the position above the opening 113 the reagent disc blanket 112 rotated and then goes down, with the front end of the Reagenzabgabedüse 114 is immersed in a reagent in a particular reagent container and thus a predetermined amount of the reagent is aspirated. Subsequently, the Reagenzabgabedüse rises 114 is then up to the position above a certain point of the incubator 104 rotated and pushes into the reaction vessel 105 the reagent off.

The reaction vessel 105 into which the sample and the reagent have been expelled, is determined by the rotation of the incubator disc 104 moved to a predetermined location and then by the transport mechanism 106 for sample dispensing chips and reaction containers up to the stirring mechanism 108 transported for reaction vessels. When stirring mechanism 108 for reaction vessels, the reaction vessel is rotated to stir and mix the sample and reagent in the reaction vessel. The reaction vessel after completion of stirring is through the transport mechanism 106 for sample delivery chips and reaction vessels except for a specific location on the incubator disc 104 reset.

A reaction liquid suction nozzle 115 is rotatable and movable up and down. It moves to the position above the reaction vessel 105 in which stirring of the dispensed sample and reagent was stopped and that in the incubator disc 104 spent a predetermined reaction time, then goes down and then sucks the reaction liquid in the reaction vessel 105 at. The through the Reaktionsflüssigkeitssaugdüse 115 absorbed reaction liquid is in a detector unit 116 analyzed.

The reaction vessel 105 from which the reaction liquid was aspirated, is determined by the rotation of the incubator disc 104 moved to a certain point, by the transport mechanism 106 for sample dispensing chips and reaction containers from the incubator disc 105 to the position above the disposal hole 109 for sample delivery chips and reaction vessels moved and eliminated through the removal hole.

2 provides a view of the flow channel structure of the detector unit 116 with the pinch valve according to the invention.

A reaction liquid suction nozzle 201 for aspirating or expelling a liquid or air, a flow cell detector 202 for the detection of the object to be measured, a syringe 203 for generating the pressure difference for sucking or discharging the liquid or air and a drain box 204 for the expiration of the liquid or air are provided with a first channel 206 through which the nozzle connects to an input connection part 205 connected to the flow cell detector, a second channel 210 that of an output connection part 207 of the flow cell detector via a first valve 208 to a branching part 209 connected, a third channel 211 the one on the branching part 209 connected to the syringe, and a fourth channel 213 , the branching part 209 via a second valve 212 to the drain box 204 connected. By the upward and downward movement of the syringe 203 and the switching to open and close the first valve 208 and second valve 212 In this flow channel structure, the suction or ejection of the liquid or air takes place from the Reaktionsflüssigkeitssaugdüse 114 , According to the present structure of the flow channel is for the first valve 208 and the second valve 212 uses a pinch valve that can shut off a liquid and air containing particles.

3 FIG. 12 is a schematic view of the structure of a pinch valve. FIG.

The pinch valve 301 is from a pusher surface 302 , a coil part 303 a moving core driven by the coil 304 , a fixed core 305 to which the movable core is attracted, a squeeze bar functioning together with the movable core 306 and a crimp tube 307 educated. When the pinch valve, the movable core is operated by the coil member to the fixed core, thereby moving the squeeze bar towards the squeeze tube, the upper side 308 and the bottom side 309 of the squeeze tube as abzusperrender object each pressed by the pusher surface and the pinch rod and thereby the flow channel is closed in the squeeze tube.

4 shows an enlarged schematic view of the pinch valve 301 , the pinch bar 306 and the crimp tube 307 on the periphery of the pusher surface according to the prior art in the case that the valve is opened.

In 4 In order to observe the change in shape per unit area of the crimp tube, the upper side 308 and the bottom side 309 of the crimp tube in the thickness direction and longitudinal direction divided into equilateral zones. When the valve is open, no deformation of the squeeze tube is effected, so that all of the zones of the squeeze tube have the same surface area.

5 shows an enlarged schematic view of the pinch valve and the squeeze tube at the periphery of the pusher surface according to the prior art in the case that the valve is closed.

When the valve is closed, the pinch rod rises 306 so on, that the inner surface 501 the upper side 308 and the inner surface 502 the lower side 309 of the squeezing tube come into contact with each other to close the flow channel in the squeeze tube. This will shut off the flow channel.

At the top 501 and the bottom side 502 of the squeeze tube, the amount of deformation of the part in contact with the squeeze bar and the edge A of the pusher surface is maximum. According to the present embodiment, in the following with the edge A of the pusher surface 302 in contact standing equilateral zone of the upper side of the squeeze tube as the maximum deformed position a. The maximum deformed position a is given a large load at each repetition of the opening and closing of the pinch valve, so that it is likely that by repeated use of the pinch valve for a long period of time, the maximum deformed position a is broken due to fatigue cracks.

• (1) Form der Drückerfläche und Quetschstange;
• (2) Einwirkung durch Verformung weiterer Stellen;
• (3) Antriebsmenge der Quetschstange.

After thorough consideration of the inventors, it has been found that the amount of deformation of the maximum deformed point a of the squeeze tube is determined by the following three factors.

• (1) shape of the pusher surface and squeeze bar;
• (2) action by deformation of other sites;
• (3) Drive amount of the pinch bar.

According to the invention the above object is achieved in that the shape of the pusher surface and pinch rod and the drive amount of the pinch bar optimized with the valve closed and thus reduces the deformation amount at the maximum deformed point of the squeeze tube with the valve closed, reduces the load of fatigue cracks on the squeeze tube and thereby its life is extended.

First, the method for optimizing the shape of the pusher surface will be explained.

6A and 6B each show an enlargement of the periphery of the closed pinch valve in the event that the contact surface of the pusher surface coming into contact with the squeeze tube is a curved surface. 6A is a schematic view of the closed pinch valve, wherein in the contact area with the squeeze tube in contact surface of the pusher surface, a flat area 401 is present, wherein the edge R of the contact surface has a rounded shape (which is referred to below as an angular shape). 6B Fig. 12 is a schematic view of the closed pinch valve in which there is no flat area in the interface, the pusher surface as a whole being formed of a curved surface (hereinafter referred to as a curved surface shape).

In any case, will be at a part of the edge of the contact surface of the pusher surface 302 the maximum deformed point b, c formed in contact squish tube. At the maximum deformed point b, c, the arrow directions represent the deformation directions of the maximum deformed position and the length the deformation quantity. Here, the squeeze tube is normally deformed according to the contact surface, since its friction coefficient is large. Therefore, the deformation of the squeeze tube in the curved surface shape is milder than in the angular shape.

If a flat area 401 is present, the maximum deformed position b of the squeeze tube adjacent to the pusher surface is given not only the deformation corresponding to the contact surface, but also one with respect to the axis direction 601 of the crimp tube added from the center outward deformed. Therefore, the deformation amount of the maximum deformed point c becomes 6A in which the pusher surface has a curved surface shape in comparison with the deformation amount of the maximum deformed point b according to FIG 6B , in which the pusher surface has a polygonal shape, reduced.

7 shows a schematic view showing the relationship between the shape of the contact surface of the pusher surface 302 and the deformation amount of the maximum deformed site. In this case, it is specified that the thickness t of the hose and the width d of the pusher surface are constant. The larger the R formed at the edge of the pusher surface becomes, the milder becomes the deformation of the maximum deformed position of the squeeze tube formed by contact with the edge of the pusher surface, further, the flat portion which gives the squeeze tube an outwardly deforming deformation disappears that the amount of deformation of the surface of the squeeze tube can be reduced. When R 1 / 3d or more, the deformation pushing out the squeeze tube in the axis direction is small, so that the maximum amount of deformation of the surface of the squeeze tube is reduced. The maximum amount of deformation of the surface of the squeeze tube is minimal when R is 1 / 2d.

Subsequently, the method for optimizing the width d of the pusher surface 302 explained.

8A to 8C each represent an enlargement of the periphery of the pusher surface of the closed pinch valve, wherein the width d of the pusher surface is varied in three ways. The width d will be after the row of 8A to 8C greater.

In the case of 8C with the largest width d, the deformation point e of the squeeze tube adjacent to the pusher surface center is pushed out from the center outward with respect to the axis direction of the squeeze tube more than in the case of FIG 8A respectively. 8B , At this time, the maximum deformed position e of the squeeze tube adjacent to the curved pusher surface is not only given the deformation corresponding to the contact surface along the edge of the pusher face, but also a deformation expressed from the center outward with respect to the axis direction is further added, so that the deformation amount of the Surface of the crimp tube increases.

The relationship between the width d and the maximum amount of deformation in the case of the pusher face 302 with a curved surface shape is in 9 shown. Here, the material of the squeeze tube is a general silicone rubber whose hardness is about 50 to 70.

If the width d of the pusher surface is small compared to the thickness t of the squeeze tube (in the case of 8A ), the deformation of the squeeze tube along the edge of the pusher face is steep, whereby the maximum amount of deformation becomes large. On the other hand, if the width d of the pusher surface is large compared to the thickness t of the squeeze tube (in the case of 8C ), not only the deformation corresponding to the curved contact surface but also an axial direction is given 801 added from the center outward deformation, whereby the maximum deformation amount becomes large. As mentioned above, there is a width d of the pusher face that achieves the mildest deformation of the squeeze tube with respect to the thickness t of the squeeze tube and the minimization of further deformation with respect to the axis direction as well as a minimum amount of deformation of the maximum deformed position of the squeeze tube.

As a concrete example, the curved surface shape R when using a squeeze tube made of a silicone rubber material having a tube thickness t of 0.5 to 1.5 mm was examined. The amount of deformation (distortion amount) of the maximum deformed site of the squeeze tube was determined by performing the superelasticity simulation by the finite element method. As a result, at R 1.0 or less, a steep deformation of the pinch tube was obtained and the maximum deformation amount became large. In addition, when R = 5.0 or more, it was found that the deformation was forced out from the center to the outside in the axial direction and thus the maximum amount of deformation became large. Furthermore, it was found that at R = about 1.5, the amount of deformation of the maximum deformed position of the squeeze tube was minimal. At R = 1.5, as compared with the prior art pinch valve, the amount of deformation of the maximum deformed site of the squeeze tube can be reduced by about 0.5 times, to about half, and therefore the fatigue of the squeeze tube can be prevented.

After extensive research by the inventors, it has also been found that the thickness t of the squeeze tube and the width d 'of the pusher surface, which minimizes the maximum amount of deformation of the squeeze tube, are in proportional relationship to each other ( 10 ), wherein the deformation amount of the maximum deformed site of the squeeze tube can be reduced the most when the diameter of the curved surface R is greater than the thickness t of the squeeze tube by about 1.5 times.

Subsequently, the shape of the pinch bar is examined, which is arranged at the position opposite the pusher surface.

11A shows the closed pinch valve, where the pusher surface 302 a curved surface shape and the squeeze bar 306 has an angular shape. 11B shows the closed pinch valve, where the pusher surface 302 and the pinch bar 306 have the same curved surface shape.

If, as in 11A As shown, the surface shape of the pusher surface and the shape of the squeeze bar are different, the deformation amounts of the upper and lower sides of the squeeze tube on the side of the pusher surface and on the side of the squeeze bar are uneven, so that the upper side 201 of the squeeze tube is deformed extensively on the side of the pusher surface, wherein the deformation amount of the deformation point f increases on the inner wall of the squeeze tube. As a result, a deformation amount of the maximum deformed location g of the pinch tube is additionally given, so that the deformation amount of the surface of the pinch tube increases.

If, on the other hand, as in 11B 1, the crimping bar and the pusher face have the same curved surface shape and the same width d, the upper side and the lower side of the crimping tube are deformed to the same extent, so that no place with an excessively increasing amount of deformation occurs on the inner surface of the crimping tube, thus causing the Deformation amount of the maximum deformed point f of the surface of the squeeze tube can be reduced.

Subsequently, the method for optimizing the drive amount of the squeeze bar (squeezing amount of the squeeze tube with the valve closed) will be explained.

The pinch valve normally has a structure in which, with the flow of a fluid, such as liquid or gas, in the squeeze tube, the distance between the squeeze bar and the pusher surface is narrowed to shut off the flow channel in the squeeze tube. Therefore, the inner surface of the squeeze tube must be given a sufficient barrier pressure against the internal pressure of the flow channel of the squeeze tube to shut it off by means of the pinch valve without leakage.

12 shows a schematic view of a state of the squeeze tube with the valve closed in the event that the pusher surface 302 and the pinch bar 306 have the same curved surface shape. When the valve is closed, the inner surface is where the upper side 501 and the bottom side 502 of the squeeze tube are in contact with each other, given a contact pressure p.

13 FIG. 15 is a graph showing the relationship between the squish amount h of the squeeze tube and the squeezing pressure p given to the tube inner surface in a state of the closed squeeze valve having the shape shown in FIG 12 represents. According to this diagram, the thickness t of the squeeze tube is constant.

If the squish amount h is increased to a certain extent, the contact pressure p becomes larger. For complete shut-off of the flow channel in the crimp tube is sufficient if the contact pressure p to a barrier pressure P1, which can withstand the internal pressure in the flow channel is set, the squish H1, which achieves the contact pressure p = P1, can be determined as the optimal squeezing. In this way, by determining the squish amount H1, it is possible to close the squish valve with a minimum amount of deformation without giving excessive pressure to the squish tube when closing the valve.

As a concrete example, the squeezing amount H1 when using a squeeze tube made of a silicone rubber material having a thickness t of 0.5 to 1.5 mm is examined. When the blocking pressure P1 required by the pinch valve is set to approximately 200 kPa when the flow channel is closed, the contact pressure p given to the inner surface of the pinch tube at the closed valve must be approximately 1.0 MPa or more in the case of the safety factor of 5. After carrying out the above-mentioned superelasticity simulation by means of the finite element method, it was found that with the squish amount H1 of about 1.7 to 2.0 mm, the contact pressure p was about 1.0 MPa, whereby the flow channel could be shut off completely , In comparison with the prior art shape and squish amount, the amount of deformation (distortion amount) can be made to be about 0.16 times, that is, 0.16 times. H. about one-tenth, so that it can be prevented that an excessive force is given concentric and thereby the squeeze tube is immediately put into a state of fatigue.

Among products to which the pinch valve of the present invention is applied are automatic analyzers having a flow channel mechanism including flow cell type detectors, but their detection principle and other device structures may be different from the embodiment of the present invention. For example, it may be a pinch valve provided on a flow passage for supplying a sample into an electrode membrane for an ion-selective electrode for measuring ion concentration such as Na, K, Cl in the sample. It may also be a pinch valve provided on a device for measuring a component contained in the gas to close and open the flow passage for the passage of the gas.

LIST OF REFERENCE NUMBERS

100

analyzer

101

frame

102

sample container

103

Probeabgabedüse

104

incubator

105

reaction vessel

106

Transport mechanism for sample delivery chips and reaction vessels

107

Holding elements for sample delivery chips and reaction containers

108

Stirring mechanism for reaction vessels

109

Disposal hole for sample delivery chips and reaction vessels

110

Location for trial delivery chips

111

reagent

112

Reagenzscheibendecke

113

Opening the reagent disk cover

114

reagent dispensing

115

Reaktionsflüssigkeitssaugdüse

116

detector unit

117

Rack transport line

118

reagent

201

detector part

202

Flow cell detector

203

syringe

204

Floor drain

205

Input connection part of the flow cell detector

206

first channel

207

Output connection part of the flow cell detector

208

first valve

209

branching part

210

second channel

211

third channel

212

second valve

213

fourth channel

301

pinch

302

pusher surface

303

Kitchen sink

304

movable core

305

fixed core

306

squeezee

307

squeeze tube

308

upper side of the crimp tube

309

lower side of the crimp tube

401

flat area

501

Inner surface of the upper side of the squeeze tube

502

Inner surface of the lower side of the squeeze tube

701

Axial direction of the squeeze tube

Claims (11)

Pinch valve, characterized in that it is formed with a holding element for holding a hose, which allows the passage of a fluid, a pusher surface whose surface, which comes into contact with the held by the holding element crimping tube from a curved surface, a pinch, which is provided opposite the interposition of the crimp tube of the pusher surface, wherein the shape of the crimping tube coming into contact with the part of the crimping rod is formed with the substantially same shape and substantially the same diameter as the pusher surface and wherein the width d of the shape of in Is substantially 1.5 times greater than the thickness of the squeeze tube, and drive means which are driven so that the distance between the pusher surface and the squeeze bar is variable to close the squeeze tube or open, is provided. Pinch valve according to claim 1, characterized in that the curvature R of coming into contact with the squeeze tube surface of the pusher surface and squeezing bar is about one-third or more of the width d of coming into contact with the squeeze tube surface of the pusher surface and pinch rod. A pinch valve according to claim 2, characterized in that R is approximately 1.5 when the squeeze tube is made of a silicone rubber material having a thickness t of 0.5 to 1.5 mm. Pinch valve according to claim 1, characterized in that in the pinch valve in a closed state, the drive means the distance between the pusher surface and the pinch rod such that the squish H1 is achieved, in which the contact pressure p is a barrier pressure P1, the internal pressure in the squeeze tube can resist. Pinch valve according to claim 4, characterized in that the squeezing amount H1 is approximately 1.7 to 2.0 mm when the squeeze tube a silicone rubber material having a thickness t of 0.5 to 1.5 mm. An automatic analyzer having an analyzing part for analyzing samples to be measured, a flow passage for passing a fluid for use for analysis, and a squeezing tube for opening and closing the flow passage according to the analysis process, characterized in that the pinch valve is provided with a holding member for holding the squeeze tube, a pusher surface, the surface of which comes into contact with the crimping tube held by the holding element, is formed of a curved surface, a crimping bar provided opposite the crimping tube of the pusher surface, the shape of the part coming into contact with the crimping tube the squeeze bar is formed in substantially the same shape and substantially the same diameter as the pusher face and wherein the width d of the shape of the contacting part is about 1.5 times larger than the thickness of the Quetsc is hschlauchs, and drive means which are driven so that the distance between the pusher surface and the squeeze bar is variable to close the squeeze tube or open, is provided. An automatic analyzer according to claim 6, characterized in that the analysis part comprises a flow cell detector part for quantitatively or qualitatively detecting a component contained in organisms derived samples, and that the pinch valve is provided on a flow passage for communicating the fluid with the flow cell detector part is provided. Automatic analysis device according to claim 6, characterized in that the curvature R of the surface of the pusher surface and squeeze bar coming into contact with the squeeze tube is approximately one third or more of the width d of the area of the pusher surface and squeeze bar coming into contact with the squeeze tube. An automatic analyzer according to claim 8, characterized in that R is approximately 1.5 when the squeeze tube is made of a silicone rubber material having a thickness t of 0.5 to 1.5 mm. Automatic analysis device according to claim 6, characterized in that in the pinch valve in a closed state, the drive means control the distance between the pusher surface and the squeeze bar such that the squeezing H1 is achieved, wherein the contact pressure p is a barrier pressure P1, the internal pressure in Can withstand crimping hose. An automatic analyzer according to claim 11, characterized in that the squish amount H1 is about 1.7 mm when the squish tube is made of a silicone rubber material having a thickness t of 0.5 to 1.5 mm.

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