DE2024425A1 - Process for the production of bis (N-methyl-carbamide) -esters from 2,6-pyridine-dimethanol - Google Patents

Process for the production of bis (N-methyl-carbamide) -esters from 2,6-pyridine-dimethanol

Info

Publication number
DE2024425A1
DE2024425A1 DE19702024425 DE2024425A DE2024425A1 DE 2024425 A1 DE2024425 A1 DE 2024425A1 DE 19702024425 DE19702024425 DE 19702024425 DE 2024425 A DE2024425 A DE 2024425A DE 2024425 A1 DE2024425 A1 DE 2024425A1
Authority
DE
Germany
Prior art keywords
bis
production
carbamide
dimethanol
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19702024425
Other languages
German (de)
Inventor
Antonio Barcelona Vila Casas (Spanien)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prodesfarma SA
Original Assignee
Prodes SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prodes SA filed Critical Prodes SA
Publication of DE2024425A1 publication Critical patent/DE2024425A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Description

Prodes S«A» Barcelona/SpanienProdes S «A» Barcelona / Spain

Verfahren zur Gewinnung von BIS-(H-KEfHXLCABBAKIB)-Ester aus 2,6-PXSIBIH-BIKEfHAHOLProcess for obtaining BIS- (H-KEfHXLCABBAKIB) -Ester from 2,6-PXSIBIH-BIKEfHAHOL

Die vorliegende Erfindung betrifft ein Verfahren sor Gewinnung τοη BIS-(H-MEfHXLCABBAKIB)-EStCr aus 2,6-PYBIDIBi-DIMHTHAIiOL und besteht darin» dass eine Reaktion 4es 2,6-PXRIBBfcBIKlSHAHOL ait PHEHXL-H-KEtBIL-CABBAXAf in Anwesen heit von Hatriua-Asetat nach der Formel ιThe present invention relates to a process for obtaining τοη BIS- (H-MEfHXLCABBAKIB) -EStCr from 2,6-PYBIDIBi-DIMHTHAIiOL and consists in the fact that a reaction 4es 2,6-PXRIBBfcBIKlSHAHOL ait PHEHXL-H-KEtBIL-CABBAXAf name of Hatriua acetate according to the formula ι

10984M192810984 M 1928

HOCH-O CH2OHHIGH - O CH 2 OH

fc n~ UOCBHOH 2 \ fc n ~ UOCBHOH 2 \

2024Λ252024-25

GHx GOOKa
7 GH x GOOKa
7th

[,HHCOOCH0 ft[, HHCOOCH 0 ft

erfolgt.he follows.

Bel dem vorgeschlagenen Verfahren werden feste Produkte verwendet, wodurch der Gebrauch von flüssigen oder gasförmigen, höchst giftigen Produkten, deren Handhabung sehr mühsam ist, vermieden wird. Die Reaktion kann organisch oder organisch/wässerig erfolgen«In the proposed process, solid products are made used, reducing the use of liquid or gaseous, highly toxic products, their handling very troublesome, is avoided. The reaction can be organic or organic / aqueous «

Das Verfahren kann gemäss dem nachfolgenden Beispiel durchgeführt werden, ist jedoch bezüglich Temperatur, Zeit, Konzentration, Lösungsmittel od. dgl. keineswegs an die angeführten Werte gebunden.The method can be carried out according to the following example are, however, regarding temperature, time, Concentration, solvent or the like in no way to the listed values are bound.

Beispielexample

Man erhitzt während drei Stunden bei eines Temperatur von 80 - 99C C eine Mischung, bestehend aus «* 47 gr EHENXL-N-METHXLOAHBAMAT, (Schmelzpunkt ca. C6° G) « 2 gr. Natrriaa-Azetat - 14- er. 2,6-PIHIDDr-DIMETHAliCL (Schiielspimkt 114 ~ 118° O) und - \5o mlThe mixture is heated for three hours at a temperature of 80-99 C C a mixture consisting of "* 47 gr EHENXL-N-METHXLOAHBAMAT, (melting point approx C6 ° G)" 2 gr Natrriaa acetate -. 14 he. 2,6-PIHIDDr-DIMETHAliCL (Schiielspimkt 114 ~ 118 ° E) and - \ 50 ml

Das LSsungeaittel wird anechließand durch destillation im IMi einer Te»p*ratur von 1ooo 0 entferntβ The LSsungeaittel is a Te "p * β temperature from 1oo o 0 anechließand by distillation in IMi

INSPECTEDINSPECTED

Der Reet wird alt einer Lösung von verdünnter Natronlauge und Chloroform behandelt, wobei der BIS-(H-METHyLCABBAHID)-Bster dem 2,6-PIHIDIN-DIItETHAHOL in der organischen Phase entzogen wird· Letzteres schallet, sobald es sieh «leder in Methanol surückkristalllslert hat, bei einer Temperatur von 13*° 0.The thatch becomes old with a solution of dilute caustic soda and chloroform, whereby the BIS- (H-METHyLCABBAHID) -ster is the 2,6-PIHIDINE-DIItETHAHOL in the organic phase is withdrawn. The latter resounds as soon as you see it has surückkristalllslert in methanol, at a temperature from 13 * ° 0.

109841/1928109841/1928

Claims (2)

PatestGodfather 1. Verfahren zur Gewinnung vom Ester aus Z t6-P 12IDnI-I)ISiFj1IIAHOL71 eine Reaktion dee 2, N-MiOTHXLCAEBAMAT genäse der For»els ait HDBRL-1. Process for the production of the ester from Z t 6-P 12IDnI-I) ISiFj 1 IIAHOL 71 a reaction dee 2, N-MiOTHXLCAEBAMAT according to the formula ait HDBRL- HOCH2 fjf CH2CH ♦HIGH 2 fjf CH 2 CH ♦ 2. ElS»(K-IIHIDIii~DIMlärHJ.L¥0L} Herfahren gemiiss die2. ElS »(K-IIHIDIii ~ DIMlärH J .L ¥ 0L} Approach according to the i hergestellt nach dem 1, g®k©Basei<sbn@t i produced according to the 1, g®k © Basei <sbn @ t 109841/1928109841/1928
DE19702024425 1970-03-21 1970-05-20 Process for the production of bis (N-methyl-carbamide) -esters from 2,6-pyridine-dimethanol Pending DE2024425A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES377775A ES377775A1 (en) 1970-03-21 1970-03-21 Procedure for the obtaining of ester bis- (N-meticarbamico) of 2,6-piridindimetanol. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
DE2024425A1 true DE2024425A1 (en) 1971-10-07

Family

ID=8455428

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19702024425 Pending DE2024425A1 (en) 1970-03-21 1970-05-20 Process for the production of bis (N-methyl-carbamide) -esters from 2,6-pyridine-dimethanol

Country Status (6)

Country Link
AT (1) AT299232B (en)
BE (1) BE753219A (en)
CH (1) CH553183A (en)
DE (1) DE2024425A1 (en)
ES (1) ES377775A1 (en)
FR (1) FR2083766A5 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU171664B (en) * 1976-01-24 1978-02-28 Richter Gedeon Vegyeszet Process for preparing 2,6-dihydroxymethyl-pyridine-bis/n-methyl-carbamate / in gamma 2 crystal form for direct tablet compression

Also Published As

Publication number Publication date
ES377775A1 (en) 1973-06-01
BE753219A (en) 1970-12-16
AT299232B (en) 1972-06-12
FR2083766A5 (en) 1971-12-17
CH553183A (en) 1974-08-30

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