DE202008009113U1 - Measuring device with electrospray arrangement and device for optical analysis - Google Patents
Measuring device with electrospray arrangement and device for optical analysis Download PDFInfo
- Publication number
- DE202008009113U1 DE202008009113U1 DE202008009113U DE202008009113U DE202008009113U1 DE 202008009113 U1 DE202008009113 U1 DE 202008009113U1 DE 202008009113 U DE202008009113 U DE 202008009113U DE 202008009113 U DE202008009113 U DE 202008009113U DE 202008009113 U1 DE202008009113 U1 DE 202008009113U1
- Authority
- DE
- Germany
- Prior art keywords
- measuring device
- measuring
- supply line
- optical
- electrospray
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/165—Electrospray ionisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/08—Optical fibres; light guides
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- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Optics & Photonics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Messvorrichtung (1) zur Untersuchung von zu analysierenden Stoffen, mit einer Elektrospray-Anordnung sowie einer Zuleitung zum Zuführen des zu analysierenden Stoffes in die Elektrospray-Anordnung, dadurch gekennzeichnet, dass an der Elektrospray-Anordnung zusätzlich eine Vorrichtung zur optischen Analyse des in der Zuleitung befindlichen Stoffes angeordnet ist.measuring device (1) for the analysis of substances to be analyzed, with an electrospray assembly and a feed line for feeding the analyte Stoffes in the electrospray assembly, characterized in that on the electrospray assembly additionally a device for the optical analysis of the substance in the feed line is arranged.
Description
Die
Erfindung betrifft eine Messvorrichtung, die der Untersuchung von
zu analysierenden Stoffen mit einer Elektrospray-Anordnung dient.
Dabei zeigt die Elektrospray-Anordnung eine Zuleitung zum Zuführen
des zu analysierenden Stoffes. Derartige Elektrospray-Anordnungen
werden vorwiegend in der Massenspektrometrie eingesetzt; ein Beispiel
für eine derartige Elektrospray-Anordnung findet sich in der
deutschen Patentanmeldung
Oftmals ist es wünschenswert, neben den durch die Massenspektrometrie zugänglichen Informationen über den zu analysierenden Stoff weitere Erkenntnisse zur Zusammensetzung oder anderer Eigenschaften des Stoffes zu gewinnen.often it is desirable, besides that by mass spectrometry accessible information about the analyzer Substance further knowledge of the composition or other properties to gain the substance.
Aufgabe der vorliegenden Erfindung ist es, eine Vorrichtung anzugeben, welche die aus dem Stand der Technik bekannten Analysemöglichkeiten durch Elektrospray-Anordnungen ergänzt.task The present invention is to provide a device which by the known from the prior art analysis options Electrospray arrangements supplemented.
Diese Aufgabe wird gelöst durch die Messvorrichtung mit den in Patentanspruch 1 offenbarten Merkmalen. Die abhängigen Ansprüche 2 bis 6 betreffen vorteilhafte Varianten und Ausführungsformen der Erfindung.These Task is solved by the measuring device with the in Claim 1 disclosed features. The dependent ones Claims 2 to 6 relate to advantageous variants and Embodiments of the invention.
Die erfindungsgemäße Messvorrichtung zeigt eine Elektrosprayanordnung sowie eine Zuleitung, mit der der zu analysierende Stoff in die Elektrospray-Anordnung eingebracht werden kann. Dabei ist an der Elektrospray-Anordnung zusätzlich eine Vorrichtung zur optischen Analyse des in der Zuleitung befindlichen Stoffes angeordnet.The Measuring device according to the invention shows an electrospray arrangement and a supply line, with which the substance to be analyzed in the Electrospray arrangement can be introduced. It is at the Electrospray arrangement additionally a device for optical analysis of the substance located in the feed line arranged.
Zur optischen Analyse ist es vorteilhaft, wenn die Zuleitung ein Messfenster aufweist, das für die zur optischen Analyse verwendete optische Strahlung transparent ist. Die Zuleitung kann insbesondere als Kapillare ausgebildet sein, wodurch sich die Möglichkeit einer Stofftrennung durch Elektrophorese, insbesondere Kapillar-Elektrophorese, bietet.to Optical analysis, it is advantageous if the feed line a measuring window which was used for the optical analysis optical radiation is transparent. The supply line can in particular be designed as a capillary, thereby increasing the possibility a separation by electrophoresis, in particular capillary electrophoresis, offers.
Die Vorrichtung zur optischen Analyse kann in vorteilhafter Weise als Messzelle ausgebildet sein, die Anschlüsse für Lichtwellenleiter aufweist und in einer bevorzugten Ausführungsform der Erfindung mittels Stell- und Führungselementen entlang der Zuleitung bewegbar ist.The Device for optical analysis can be advantageously as Measuring cell be formed, the connections for Optical waveguide and in a preferred embodiment the invention by means of adjusting and guiding elements along the supply line is movable.
Zur Ermittlung der Fließgeschwindigkeit in der Zuleitung ist es vorteilhaft, zwei in geringem Abstand, beispielsweise von 1 bis 10 mm, angeordnete Leitfähigkeitssensoren in der Zuleitung zu verwenden, wodurch es möglich wird, die Leitfähigkeit der durch die Zuleitung fließende Lösung aufzunehmen und in eine Fließgeschwindigkeit umzurechnen.to Determining the flow rate in the supply line is it is advantageous to two at a small distance, for example from 1 to 10 mm, arranged conductivity sensors in the supply line whereby it becomes possible to use the conductivity to absorb the solution flowing through the supply line and to convert into a flow rate.
Die Erfindung ermöglicht es damit, optische Detektionsverfahren und/oder die Leitfähigkeitsdetektion mit der Massenspektroskopie bei Trennverfahren, wie beispielsweise der Kapillar-Elektrophorese, zu koppeln.The The invention thus makes it possible to use optical detection methods and / or conductivity detection with mass spectroscopy in separation processes, such as capillary electrophoresis, to pair.
Dies führt dazu, dass in der Kombination der genannten Messverfahren mittels der Massenspektrometrie eine einfache und zuverlässige Identifizierung von Analyten und weiteren Probenbestandteilen möglich ist. Die optische Detektion bietet die Möglichkeit, Hinweise zur Identifizierung der Bestandteile des Analyten zu gewinnen, bietet aber ferner auch die Chance, eine prä zise quantitative Bestimmung der interessierenden Probenbestandteile und Analyte vorzunehmen.This This leads to the fact that in the combination of the mentioned measuring methods By mass spectrometry a simple and reliable Identification of analytes and other sample components possible is. The optical detection offers the possibility of clues to identify the components of the analyte but also the chance, a precise quantitative Determination of the sample components and analytes of interest.
Die Tandemanordnung der Detektionsverfahren ermöglicht eine vereinfachte Methodenoptimierung und Identifizierung von Probenkomponenten, wobei die zusätzliche Leitfähigkeitsdetektion den Vorteil bietet, dass Fließgeschwindigkeiten bestimmt werden können.The Tandem arrangement of the detection method allows a simplified method optimization and identification of sample components, where the additional conductivity detection offers the advantage that flow rates are determined can.
Die Erfindung ermöglicht es, für eine nachfolgende Routineanalytik auf die Massenspektrometrie zu verzichten, die aufwändiger, schlechter routinefähig und weniger geeignet für quantitative Messungen ist.The Invention makes it possible for a subsequent Routine analysis to dispense with mass spectrometry, which is more complex, bad routable and less suitable for quantitative measurements is.
Die Kombination der genannten Detektionsverfahren mit der Massenspektrometrie in einem gemeinsamen Messkopf gewährleistet, dass die Detektionspunkte, an denen die Bestimmung der Probe vorgenommen wird, sehr nahe beieinander liegen, was dazu führt, dass aufgrund der damit annähernd gleichen Trennstrecke (Elektrophorese) eine Korrelation der beiden Detektionsspuren vereinfacht möglich ist.The Combination of said detection methods with mass spectrometry in a common measuring head ensures that the detection points, where the determination of the sample is made, very close to each other lie, which means that because of the approximately the same Separation path (electrophoresis) a correlation of the two detection tracks is possible in a simplified manner.
Anhand
der nachfolgenden
Es ist darüber hinaus denkbar, die Messzelle direkt in den Sprayerkopf zu integrieren, wodurch sich eine weitere Verringerung des Abstands der Messpunkte ergibt. Es ist daneben auch denkbar, alternative Sprayerköpfe anstatt des im Ausführungsbeispiel gezeigten Sprayerkopfes einzusetzen.It is also conceivable, the measuring cell directly into the Sprayer head to integrate, resulting in a further reduction the distance of the measuring points. It is also conceivable, alternative sprayer heads instead of in the embodiment use shown sprayer head.
ZITATE ENTHALTEN IN DER BESCHREIBUNGQUOTES INCLUDE IN THE DESCRIPTION
Diese Liste der vom Anmelder aufgeführten Dokumente wurde automatisiert erzeugt und ist ausschließlich zur besseren Information des Lesers aufgenommen. Die Liste ist nicht Bestandteil der deutschen Patent- bzw. Gebrauchsmusteranmeldung. Das DPMA übernimmt keinerlei Haftung für etwaige Fehler oder Auslassungen.This list The documents listed by the applicant have been automated generated and is solely for better information recorded by the reader. The list is not part of the German Patent or utility model application. The DPMA takes over no liability for any errors or omissions.
Zitierte PatentliteraturCited patent literature
- - DE 102007015714 A1 [0001] DE 102007015714 A1 [0001]
Claims (6)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE202008009113U DE202008009113U1 (en) | 2008-07-08 | 2008-07-08 | Measuring device with electrospray arrangement and device for optical analysis |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE202008009113U DE202008009113U1 (en) | 2008-07-08 | 2008-07-08 | Measuring device with electrospray arrangement and device for optical analysis |
Publications (1)
Publication Number | Publication Date |
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DE202008009113U1 true DE202008009113U1 (en) | 2008-11-13 |
Family
ID=39986537
Family Applications (1)
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DE202008009113U Expired - Lifetime DE202008009113U1 (en) | 2008-07-08 | 2008-07-08 | Measuring device with electrospray arrangement and device for optical analysis |
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DE (1) | DE202008009113U1 (en) |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007015714A1 (en) | 2006-04-07 | 2007-10-18 | Agilent Technologies, Inc. (n.d.Ges.d. Staates Delaware), Santa Clara | Sample e.g. aerosol, ionizing apparatus for mass spectrometer system, has concentric tube generating gaseous stream in path, where stream provides droplets with sufficient velocity to overcome repulsive force of electric field |
-
2008
- 2008-07-08 DE DE202008009113U patent/DE202008009113U1/en not_active Expired - Lifetime
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007015714A1 (en) | 2006-04-07 | 2007-10-18 | Agilent Technologies, Inc. (n.d.Ges.d. Staates Delaware), Santa Clara | Sample e.g. aerosol, ionizing apparatus for mass spectrometer system, has concentric tube generating gaseous stream in path, where stream provides droplets with sufficient velocity to overcome repulsive force of electric field |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
R207 | Utility model specification |
Effective date: 20081218 |
|
R081 | Change of applicant/patentee |
Owner name: J & M ANALYTIK AG, DE Free format text: FORMER OWNER: J & M ANALYTISCHE MESS- UND REGELTECHNIK GMBH, 73457 ESSINGEN, DE Effective date: 20090422 |
|
R150 | Term of protection extended to 6 years | ||
R150 | Term of protection extended to 6 years |
Effective date: 20111130 |
|
R151 | Term of protection extended to 8 years | ||
R151 | Term of protection extended to 8 years |
Effective date: 20140728 |
|
R152 | Term of protection extended to 10 years | ||
R071 | Expiry of right |