DE202005009189U1 - Arrangement for conducting con-focal laser-scanning contact endoscopy in larger cavity of body, using water immersion lens - Google Patents
Arrangement for conducting con-focal laser-scanning contact endoscopy in larger cavity of body, using water immersion lens Download PDFInfo
- Publication number
- DE202005009189U1 DE202005009189U1 DE202005009189U DE202005009189U DE202005009189U1 DE 202005009189 U1 DE202005009189 U1 DE 202005009189U1 DE 202005009189 U DE202005009189 U DE 202005009189U DE 202005009189 U DE202005009189 U DE 202005009189U DE 202005009189 U1 DE202005009189 U1 DE 202005009189U1
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- Prior art keywords
- arrangement
- water immersion
- contact
- arrangement according
- lens
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00163—Optical arrangements
- A61B1/00188—Optical arrangements with focusing or zooming features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/267—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the respiratory tract, e.g. laryngoscopes, bronchoscopes
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0028—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders specially adapted for specific applications, e.g. for endoscopes, ophthalmoscopes, attachments to conventional microscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/00064—Constructional details of the endoscope body
- A61B1/00071—Insertion part of the endoscope body
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Otolaryngology (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Microscoopes, Condenser (AREA)
Abstract
Description
Die Erfindung betrifft eine Anordnung zur Konfokalen Laser Scanning Kontakt-Endoskopie zur hochauflösenden in-vivo-Abbildung von oberfächennahen Gewebestrukturen in engen und tiefen Öffnungen des menschlichen Körpres Mit dieser Anordnug gelingt eine Aussage über mikroskopische Zellstrukturen besonders im Bereich der oberflächennahen Schleimhäute sowie mögliche Zellveränderungen (Tumoren) in diesen. Dazu werden konfokale Abbildungen mit hoher Tiefenauflösung angefertigt. Wichtige Parameter sind dabei z.B. die Zelldichte, tumoröse Zellveränderungen, exakte Tiefenlage zur Oberfläche, Transparenz und Reflektionsverhalten.The The invention relates to an arrangement for confocal laser scanning Contact endoscopy to the high-resolution in vivo imaging of superficial Tissue structures in narrow and deep openings of the human body This arrangement makes a statement about microscopic cell structures especially in the area of near-surface mucous membranes as well possible Cell changes (tumors) in these. Confocal images with high depth resolution are made for this purpose. Important parameters are e.g. the cell density, tumorous cell changes, exact depth to the surface, Transparency and reflection behavior.
Es ist bekannt, dass es mit den herkömmlichen konfokalen Licht- und Laser Scanning Mikroskopen bekannter Hersteller gelingt, die Haut (Körperoberfläche einschließlich Hornhaut des Auges) in Vergrößerungsbereichen der Zellstruktur abzubilden. Aufgrund der Größe der Geräte ist diese Technik der konfokalen Mikroskopie in tieferen Körperhöhlen bisher verschlossen geblieben.It is known to be compatible with conventional confocal light sources. and laser scanning microscopes from well-known manufacturers succeed, the Skin (body surface including cornea of the eye) in magnification areas to map the cell structure. Due to the size of the devices, this technique is the confocal Microscopy in deeper body cavities so far remained closed.
Normale Kontakt-Endoskope erreichen aufgrund des hohen Streulichtanteils der Beleuchtung nicht die gewünschte Tiefenauflösung und sind in der Regel auf eine Oberflächenfärbung (Methylen-Blau) angewiesen.normal Contact endoscopes reach due to the high level of scattered light the lighting is not the desired one depth resolution and are usually dependent on surface staining (methylene blue).
Das Problem der Erfindung besteht in der Entwicklung einer Anordnung für ein starres / halbstarres Endoskop zur Kopplung an ein konfokales Laser Scanning Ohthalmoskop für eine mikroskopische Abbildung von Oberflächenstrukturen durch der Verlagerung der Laser-Fokusebene an das Ende eines dünnen, langen Objektivtubus (Endoskop) sowie der Einkopplung in das Gewebe durch ein stark vergrößerndes Objektiv mit hoher numerischer Apertur und eine PMMA-Kontaktkappe.The Problem of the invention is the development of an arrangement for a rigid / semi-rigid endoscope for coupling to a confocal laser Scanning Ohthalmoscope for a microscopic picture of surface structures through the displacement the laser focus plane to the end of a thin, long lens barrel (Endoscope) as well as the coupling into the tissue by a strongly enlarging High numerical aperture lens and a PMMA contact cap.
Der Erindung liegt die Aufgabe zugrunde, eine Anordnung zu schaffen, mit der es nach einer Kopplung an ein konfokales Laser-Scanning-Mikroskop gelingt, Zellstrukturen auch in tieferen Körperhöhlen des menschlichen Körpers zu analysieren und dass damit auch eine in vivo-kontrollierte Gewebeentnahme möglich wird.Of the Erindung is the object of the invention to provide an arrangement with it after coupling to a confocal laser scanning microscope succeeds in cell structures even in deeper body cavities of the human body analyze and thus also an in vivo-controlled tissue sampling possible becomes.
Erfindungsgemäß wird diese Aufgabe dadurch gelöst, dass ein Endoskop an ein konfokales Laser-Scanning-Opthalmoskop mit hoher Vergrößerung und numerischer Apertur gekoppelt wird, in dem durch eine Feldlinse und ein Projektiv die Bildebene (Zwischenbild / Fokalebene) des Mikroskops in die Dingebene eines am Ende des Endoskops befindlichen Miniaturobjektivs (Wasserimmersion) mit hoher Vergrößerung und numerischer Apertur verlagert wird. Zur exakten Bestimmung der Tiefenlage des abgebildeten Gewebes befindet sich am Ende des Endoskops eine kleine PMMA-Kontaktkappe, die den Abstand zum Gewebe stabilisiert. Durch eine Verschiebung des Projektivs relativ zum Kontakt-Objektiv kann jede beliebige Vergrößerung und Tiefenlage eingestellt bzw. ein mechnisch-elektronischer z-Scan mittels Schrittmotor durchgeführt werden. Mechanisch-optische Gelenke sollen eine gewisse Beweglichkeit (Rotation, Schwenk) beim Einführen in die Körperhöhlen ermöglichen.According to the invention this Task solved by that an endoscope connects to a confocal laser scanning opthalmoscope with high magnification and coupled numerical aperture, in which by a field lens and a projective the image plane (intermediate image / focal plane) of the Microscope in the plane of a person at the end of the endoscope Miniature lens (water immersion version) with high magnification and numerical aperture is shifted. For the exact determination of the depth of the imaged tissue is located at the end of the endoscope small PMMA contact cap which stabilizes the distance to the tissue. By shifting the projective relative to the contact lens can be any magnification and Set depth or a mechanical-electronic z-scan using Stepper motor performed become. Mechanical-optical joints are said to have a certain flexibility (Rotation, swivel) during insertion into the body cavities.
Die Original-Funktion des konfokalen Laser Mikroskops soll durch den Endoscopzusatz nicht eingeschränkt und in der Konzeption eines Baukastensystems aufgebaut werden.The Original function of the confocal laser microscope is intended by the Endoscopic additive not restricted and be built in the conception of a modular system.
Erreichte Vorteile der Erfindung gegenüber vergleichbaren Mikroskopen sind:
- 1. in vivo-Darstellung der Mikromorphologie von Zellstrukturen in tiefen Körperhöhlen,
- 2. Gezielte Gewebeentnahme bei Tumorverdacht und
- 3. In vivo-Nachkontrolle nach Operation
- 1. in vivo representation of the micromorphology of cell structures in deep body cavities,
- 2. Targeted tissue sampling in suspected tumors and
- 3. In vivo follow-up after surgery
Anhand
eines Ausführungsbeispiel
wird die Erfindung näher
erläutert
werden. Die beigefügte
Gemäß
- 11
- Strahlengang des scannenden Lasersbeam path of the scanning laser
- 22
- Konfokalen Laser Scanning Mikroskops HRT II / RCMconfocal Laser Scanning Microscope HRT II / RCM
- 33
- Feldlinse des RCMfield lens of the RCM
- 44
- Projektions-ObjektivProjection Lens
- 55
- Laser-FokusLaser Focus
- 66
- Wasser-ImmersionsobjektivWater-immersion objective
- 77
- Endoskoprohrendoscope tube
- 88th
- Optisches Gelenkoptical joint
- 99
- PMMA-KontaktkappePMMA contact cap
- 1010
- SpiegelprismenkappeMirror refractor
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE202005009189U DE202005009189U1 (en) | 2005-06-11 | 2005-06-11 | Arrangement for conducting con-focal laser-scanning contact endoscopy in larger cavity of body, using water immersion lens |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE202005009189U DE202005009189U1 (en) | 2005-06-11 | 2005-06-11 | Arrangement for conducting con-focal laser-scanning contact endoscopy in larger cavity of body, using water immersion lens |
Publications (1)
Publication Number | Publication Date |
---|---|
DE202005009189U1 true DE202005009189U1 (en) | 2005-09-22 |
Family
ID=35062661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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DE202005009189U Expired - Lifetime DE202005009189U1 (en) | 2005-06-11 | 2005-06-11 | Arrangement for conducting con-focal laser-scanning contact endoscopy in larger cavity of body, using water immersion lens |
Country Status (1)
Country | Link |
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DE (1) | DE202005009189U1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9198560B2 (en) | 2012-03-19 | 2015-12-01 | Welch Allyn, Inc. | Medical diagnostic instrument |
WO2016061315A1 (en) * | 2014-10-15 | 2016-04-21 | Smith & Nephew, Inc. | Endoscope with a multiple diameter working section |
DE102021214722A1 (en) | 2021-12-20 | 2023-06-22 | Universität Rostock, Körperschaft des öffentlichen Rechts | Method and device for generating images of an object |
-
2005
- 2005-06-11 DE DE202005009189U patent/DE202005009189U1/en not_active Expired - Lifetime
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9198560B2 (en) | 2012-03-19 | 2015-12-01 | Welch Allyn, Inc. | Medical diagnostic instrument |
WO2016061315A1 (en) * | 2014-10-15 | 2016-04-21 | Smith & Nephew, Inc. | Endoscope with a multiple diameter working section |
CN107072503A (en) * | 2014-10-15 | 2017-08-18 | 柯惠有限合伙公司 | Endoscope with many diameter work sections |
AU2015332475B2 (en) * | 2014-10-15 | 2020-06-25 | Covidien Lp | Endoscope with a multiple diameter working section |
US11096569B2 (en) | 2014-10-15 | 2021-08-24 | Covidien Lp | Endoscope with a multiple diameter working section |
DE102021214722A1 (en) | 2021-12-20 | 2023-06-22 | Universität Rostock, Körperschaft des öffentlichen Rechts | Method and device for generating images of an object |
WO2023134971A1 (en) | 2021-12-20 | 2023-07-20 | Universität Rostock | Method and apparatus for generating images of an object |
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Legal Events
Date | Code | Title | Description |
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R207 | Utility model specification |
Effective date: 20051027 |
|
R081 | Change of applicant/patentee |
Owner name: UNIVERSITAET ROSTOCK, DE Free format text: FORMER OWNER: STAVE, JOACHIM, PROF.DR.RER.NAT.HABIL., 18119 ROSTOCK, DE Effective date: 20071030 |
|
R150 | Term of protection extended to 6 years |
Effective date: 20080804 |
|
R157 | Lapse of ip right after 6 years |
Effective date: 20120103 |