DE20200220U1 - stent - Google Patents

stent

Info

Publication number
DE20200220U1
DE20200220U1 DE20200220U DE20200220U DE20200220U1 DE 20200220 U1 DE20200220 U1 DE 20200220U1 DE 20200220 U DE20200220 U DE 20200220U DE 20200220 U DE20200220 U DE 20200220U DE 20200220 U1 DE20200220 U1 DE 20200220U1
Authority
DE
Germany
Prior art keywords
stent
characterized
polymer
pores
diameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE20200220U
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Translumina GmbH
Original Assignee
Translumina GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Translumina GmbH filed Critical Translumina GmbH
Priority to DE20200220U priority Critical patent/DE20200220U1/en
Publication of DE20200220U1 publication Critical patent/DE20200220U1/en
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04Macromolecular materials
    • A61L31/06Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0023Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in porosity
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings

Description

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Der Beschreibungstext wurde nicht elektronisch erfaßt The description text has not been detected electronically

Claims (19)

1. Stent mit einer Verstrebungen aufweisenden Wandung, wobei in der Wandung und/oder in den Verstrebungen Bereiche zur Aufnahme eines oder mehrerer Medikamente vorgesehen sind, dadurch gekennzeichnet , daß die Bereiche in Form von die Wandung bzw. die Verstrebungen durchdringenden Poren ausgeführt sind. 1 with a stent struts having the wall, being provided in the wall and / or in the struts areas for receiving one or more medicaments, characterized in that the regions in the form of the wall and the struts are designed penetrating pores.
2. Stent nach Anspruch 1, dadurch gekennzeichnet, daß der Stent im wesentlichen zylindrisch ausgeführt ist und die Längsachse der Poren gegenüber der Längsachse des Stents vertikal oder schräg verläuft. 2. The stent of claim 1, characterized in that the stent is substantially cylindrical design and the longitudinal axis of the pores with respect to the longitudinal axis of the stent extends vertically or obliquely.
3. Stent nach Anspruch 1 oder 2, dadurch gekennzeichnet, daß die Poren durch Laseranwendung, durch Ätzen, durch Umformverfahren oder durch Abtragsverfahren oder durch Kombinationen dieser Verfahren gefertigt sind. 3. The stent of claim 1 or 2, characterized in that the pores by laser application, by etching, by forming processes or by ablation method, or by combinations of these methods are made.
4. Stent nach einem der Ansprüche 1 bis 3, dadurch gekennzeichnet, daß die Wandungen der Poren im Längsschnitt eine konvexe oder konkave Gestalt annehmen und/oder daß die Poren gerade oder konisch verlaufende Wandungen aufweisen. 4. The stent according to any one of claims 1 to 3, characterized in that the walls of the pores assume in longitudinal section, a convex or concave shape and / or that the pores have straight or tapered walls.
5. Stent nach einem der Ansprüche 1 bis 4, dadurch gekennzeichnet, daß in den Poren ein oder mehrere Medikamente aufgenommen sind und die Mündungen der Poren mittels eines Polymers verschlossen sind. 5. The stent according to any one of claims 1 to 4, characterized in that are received in the pores, one or more drugs and the mouths of the pores are closed by means of a polymer.
6. Stent nach einem der Ansprüche 1 bis 5, dadurch gekennzeichnet, daß in den Poren ein Schichtstruktur vorgesehen ist, deren einzelne Schichten abwechselnd aus einem oder mehren Medikamenten und aus Polymer bestehen. 6. The stent according to one of claims 1 to 5, characterized in that a layer structure is provided in the pores, the individual layers consist alternately from one or more drugs and polymer.
7. Stent nach Anspruch 6, dadurch gekennzeichnet, daß der Porenquerschnitt vollständig durch die Schichtstruktur ausgefüllt ist. 7. The stent of claim 6, characterized in that the pore cross section is completely filled by the layer structure.
8. Stent nach einem der Ansprüche 1 bis 7, dadurch gekennzeichnet, daß Kanäle vorgesehen sind, die die Poren miteinander verbinden. 8. A stent according to any one of claims 1 to 7, characterized in that channels are provided which connect the pores with each other.
9. Stent nach Anspruch 8, dadurch gekennzeichnet, daß die Kanäle mit einem oder mehreren Medikamenten gefüllt sind und daß die in die Poren mündenden Endbereiche der Kanäle mittels eines Polymers verschlossen sind. 9. The stent of claim 8, characterized in that the channels are filled with one or more medicaments and that the pores opening into the end regions of the channels are closed by means of a polymer.
10. Stent nach einem der Ansprüche 5 bis 9, dadurch gekennzeichnet, daß es sich bei den Polymeren um ein biokompatibles, biologisch zersetzbares Polymer, insbesondere um ein Polylactid handelt. 10. A stent according to any one of claims 5 to 9, characterized in that it is the polymers are biocompatible, biologically degradable polymer, especially a polylactide.
11. Stent nach einem der Ansprüche 1 bis 10, dadurch gekennzeichnet, daß wenigstens einige der Poren in ihrem Längsschnitt eine bauchförmige Gestalt aufweisen, die durch einen Mündungsbereich geringeren Durchmessers und einen ausbauchenden Bereich größeren Durchmessers gekennzeichnet ist. 11. The stent according to one of claims 1 to 10, characterized in that at least some of the pores have a bulbous shape in its longitudinal section, reduced by a mouth portion diameter, and a bulging region of larger diameter is indicated.
12. Stent nach Anspruch 11, dadurch gekennzeichnet, daß in den Poren Polymer und Medikament enthaltende Teilchen aufgenommen sind, deren äußere Schicht aus einem Polymer, vorzugsweise aus einem Polymer nach Anspruch 10, besteht und in deren Inneren ein oder mehrere Medikamente aufgenommen sind, wobei der kleinste Durchmesser der Teilchen über dem Durchmesser des Mündungsbereichs liegt. 12. The stent of claim 11, characterized in that the pores contained in the polymer and drug particles are added, the outer layer consists of a polymer, preferably a polymer of claim 10 and inside which one or more medicines are added, wherein the smallest diameter of the particles is greater than the diameter of the mouth portion.
13. Stent nach Anspruch 12, dadurch gekennzeichnet, daß im Inneren der Teilchen mehrere aufeinanderfolgende Schichten aus Polymer und Medikament angeordnet sind. 13. The stent of claim 12, characterized in that several consecutive layers of polymer and drug are located in the interior of the particles.
14. Stent nach einem der Ansprüche 1 bis 13, dadurch gekennzeichnet, daß die Poren in den Bereichen der Verstrebungen aufgenommen sind, die sich in Längsrichtung des Stents erstrecken. 14. A stent according to any one of claims 1 to 13, characterized in that the pores in the areas of the struts are accommodated, which extend in the longitudinal direction of the stent.
15. Stent nach einem der Ansprüche 1 bis 14, dadurch gekennzeichnet, daß die Poren in den Bereichen der Verstrebungen aufgenommen sind, die sich in Umfangsrichtung des Stents erstrecken. 15. A stent according to any one of claims 1 to 14, characterized in that the pores in the areas of the struts are accommodated, which extend in the circumferential direction of the stent.
16. Stent mit einer Verstrebungen aufweisenden Wandung, wobei in der Wandung und/oder in den Verstrebungen Bereiche zur Aufnahme von Medikamenten vorgesehen sind, dadurch gekennzeichnet, daß die Bereiche als Ausnehmungen ausgebildet sind, die einen Mündungsbereich geringeren Durchmessers und einen ausbauchenden Bereich größeren Durchmessers aufweisen. 16. stent with struts having the wall, being provided in the wall and / or in the struts portions for receiving medicament, characterized in that the regions are formed as recesses having a mouth region with a smaller diameter, and a bulging region of larger diameter ,
17. Stent nach Anspruch 16, dadurch gekennzeichnet, daß die Ausnehmungen durch eine Kombination aus Laseranwendung und Ätzen hergestellt sind und der Mündungsbereich abgerundete Kanten aufweist. 17. The stent of claim 16, characterized in that the recesses are produced by a combination of laser application and etching, and the mouth portion has rounded edges.
18. Stent nach Anspruch 16 oder 17, dadurch gekennzeichnet, daß in den Ausnehmungen Polymer und Medikament aufweisende Teilchen aufgenommen sind, deren äußere Schicht aus einem Polymer, vorzugsweise aus einem Polymer nach Anspruch 10 besteht und in deren Inneren ein oder mehrere Medikamente aufgenommen sind, wobei der kleinste Durchmesser der Teilchen über dem größten Durchmesser der Mündungen der Ausnehmungen liegt. 18. The stent of claim 16 or 17, characterized in that the recesses having in polymer and drug particles are added, the outer layer consists of a polymer, preferably a polymer of claim 10 and inside which one or more medicines are added, wherein the smallest diameter of the particles is greater than the largest diameter of the mouths of the recesses.
19. Stent nach Anspruch 16 oder 17, dadurch gekennzeichnet, daß in den Ausnehmungen Polymer und Medikament aufweisende Teilchen aufgenommen sind, wobei das Polymer vorzugsweise aus einem Polymer nach Anspruch 10 besteht, wobei das Medikament in einer Polymermatrix verteilt ist und wobei der kleinste Durchmesser der Teilchen über dem größten Durchmesser des Mündungsbereichs der Ausnehmungen liegt. 19. The stent of claim 16 or 17, characterized in that comprising in the recesses polymer and drug particles are added, wherein the polymer preferably consists of a polymer according to claim 10, wherein the medicament is dispersed in a polymer matrix, and wherein the smallest diameter of the particles is greater than the largest diameter of the mouth region of the recesses.
DE20200220U 2002-01-08 2002-01-08 stent Expired - Lifetime DE20200220U1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE20200220U DE20200220U1 (en) 2002-01-08 2002-01-08 stent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE20200220U DE20200220U1 (en) 2002-01-08 2002-01-08 stent

Publications (1)

Publication Number Publication Date
DE20200220U1 true DE20200220U1 (en) 2002-03-21

Family

ID=7966355

Family Applications (1)

Application Number Title Priority Date Filing Date
DE20200220U Expired - Lifetime DE20200220U1 (en) 2002-01-08 2002-01-08 stent

Country Status (1)

Country Link
DE (1) DE20200220U1 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003015664A1 (en) * 2001-08-20 2003-02-27 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
WO2004043510A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
WO2004087011A2 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
DE10320262A1 (en) * 2003-05-07 2004-12-02 Meko Laserstrahl-Materialbearbeitungen E.K. A process for producing a medical implant and an implant produced in this way
EP1604697A1 (en) * 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
EP1635893A2 (en) * 2003-06-05 2006-03-22 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
DE102007060497A1 (en) 2007-12-06 2009-06-10 Joline Gmbh & Co. Kg Implantable endoprosthesis
US7658758B2 (en) 2001-09-07 2010-02-09 Innovational Holdings, Llc Method and apparatus for loading a beneficial agent into an expandable medical device
US7758636B2 (en) 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
US7850728B2 (en) 2000-10-16 2010-12-14 Innovational Holdings Llc Expandable medical device for delivery of beneficial agent
US7896912B2 (en) 1998-03-30 2011-03-01 Innovational Holdings, Llc Expandable medical device with S-shaped bridging elements
EP2289571A1 (en) * 2003-03-28 2011-03-02 Conor Medsystems, Inc. Implantable medical device with beneficial agent concentration gradient
EP1402849B2 (en) 2002-09-20 2011-03-16 Abbott Laboratories Vascular Enterprises Limited Stent with rough surface and its manufacturing method
US8197881B2 (en) 2003-09-22 2012-06-12 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US8291854B2 (en) 2003-04-17 2012-10-23 Translumina Gmbh Device for applying active substances to surfaces of medical implants, in particular stents

Cited By (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206435B2 (en) 1998-03-30 2012-06-26 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US8052735B2 (en) 1998-03-30 2011-11-08 Innovational Holdings, Llc Expandable medical device with ductile hinges
US7896912B2 (en) 1998-03-30 2011-03-01 Innovational Holdings, Llc Expandable medical device with S-shaped bridging elements
US7850728B2 (en) 2000-10-16 2010-12-14 Innovational Holdings Llc Expandable medical device for delivery of beneficial agent
US8187321B2 (en) 2000-10-16 2012-05-29 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7850727B2 (en) 2001-08-20 2010-12-14 Innovational Holdings, Llc Expandable medical device for delivery of beneficial agent
US7842083B2 (en) 2001-08-20 2010-11-30 Innovational Holdings, Llc. Expandable medical device with improved spatial distribution
WO2003015664A1 (en) * 2001-08-20 2003-02-27 Conor Medsystems, Inc. Expandable medical device for delivery of beneficial agent
US7658758B2 (en) 2001-09-07 2010-02-09 Innovational Holdings, Llc Method and apparatus for loading a beneficial agent into an expandable medical device
EP1402849B2 (en) 2002-09-20 2011-03-16 Abbott Laboratories Vascular Enterprises Limited Stent with rough surface and its manufacturing method
US8349390B2 (en) 2002-09-20 2013-01-08 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
US7758636B2 (en) 2002-09-20 2010-07-20 Innovational Holdings Llc Expandable medical device with openings for delivery of multiple beneficial agents
US9254202B2 (en) 2002-09-20 2016-02-09 Innovational Holdings Llc Method and apparatus for loading a beneficial agent into an expandable medical device
WO2004043510A1 (en) * 2002-11-08 2004-05-27 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
EP2338538A1 (en) * 2002-11-08 2011-06-29 Conor Medsystems, Inc. Method and apparatus for reducing tissue damage after ischemic injury
EP2289572A3 (en) * 2003-03-28 2012-04-04 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
EP2289571A1 (en) * 2003-03-28 2011-03-02 Conor Medsystems, Inc. Implantable medical device with beneficial agent concentration gradient
US8449901B2 (en) 2003-03-28 2013-05-28 Innovational Holdings, Llc Implantable medical device with beneficial agent concentration gradient
WO2004087011A2 (en) * 2003-03-28 2004-10-14 Conor Medsystems, Inc. Therapeutic agent delivery device with controlled therapeutic agent release rates
WO2004087011A3 (en) * 2003-03-28 2004-12-16 Conor Medsystems Inc Therapeutic agent delivery device with controlled therapeutic agent release rates
US8291854B2 (en) 2003-04-17 2012-10-23 Translumina Gmbh Device for applying active substances to surfaces of medical implants, in particular stents
DE10320262A1 (en) * 2003-05-07 2004-12-02 Meko Laserstrahl-Materialbearbeitungen E.K. A process for producing a medical implant and an implant produced in this way
EP1635893A2 (en) * 2003-06-05 2006-03-22 Conor Medsystems, Inc. Drug delivery device and method for bi-directional drug delivery
EP1635893A4 (en) * 2003-06-05 2010-07-07 Conor Medsystems Inc Drug delivery device and method for bi-directional drug delivery
US8197881B2 (en) 2003-09-22 2012-06-12 Conor Medsystems, Inc. Method and apparatus for loading a beneficial agent into an expandable medical device
EP1604697A1 (en) * 2004-06-09 2005-12-14 J.A.C.C. GmbH Implantable device
WO2005120393A3 (en) * 2004-06-09 2006-06-08 J A C C Gmbh Implantable device for drug delivery and improved visibility
EP2364677A1 (en) 2007-12-06 2011-09-14 Translumina GmbH Implantable vessel support
DE102007060497A1 (en) 2007-12-06 2009-06-10 Joline Gmbh & Co. Kg Implantable endoprosthesis

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