DE19907305A1 - Products with three or more discrete and optically-distinguishable phases containing active substances, dyes and preservatives - Google Patents

Products with three or more discrete and optically-distinguishable phases containing active substances, dyes and preservatives

Info

Publication number
DE19907305A1
DE19907305A1 DE19907305A DE19907305A DE19907305A1 DE 19907305 A1 DE19907305 A1 DE 19907305A1 DE 19907305 A DE19907305 A DE 19907305A DE 19907305 A DE19907305 A DE 19907305A DE 19907305 A1 DE19907305 A1 DE 19907305A1
Authority
DE
Germany
Prior art keywords
phase
water
phases
soluble
fat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19907305A
Other languages
German (de)
Inventor
Reinhold A Brunke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NEW STANDARD GmbH
Original Assignee
NEW STANDARD GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NEW STANDARD GmbH filed Critical NEW STANDARD GmbH
Priority to DE19907305A priority Critical patent/DE19907305A1/en
Publication of DE19907305A1 publication Critical patent/DE19907305A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B61/00—Dyes of natural origin prepared from natural sources, e.g. vegetable sources
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Medicinal Preparation (AREA)

Abstract

Four-phase products and their production and use are claimed, phase 1 being of conventional oils, phase 2 of lipophilic components which are incompatible with phases 1 and 4 and which have specific wt. below 1, phase 3 of water and hydrophilic solvents such as propylene glycol or glycerol and phase 4 of lipophiles which are incompatible with phases 1 and 2 and which are of specific wt. above 1. The ratio phases 1 : 2 : 3 : 4 is 1 ; 0.001-1 : 0.001-10 : 0-1. The specified phase compositions are as follows : phase 1 - up to 100% oil components, 0-100% fat-soluble dyes, 0-100% fat-soluble actives and 0-100% preservatives; phase 2 - up to 100% components which are immiscible with phases 1 and 4 and 0-100% fat-soluble dyes; phase 3 - up to 100% water, 0-100% hydrophilic solvents, 0-100% water-soluble actives, 0-100% water-soluble dyes and 0-100% preservatives; and phase 4 - up to 100% components which are immiscible with phases 1 and 2 and 0-100% actives. NB. There are no claims relating specifically to production or use of the compositions.

Description

Stand der TechnikState of the art

Lösliche Wirkstoffe sind durch ihre Struktur bestimmt entweder hy­ drophil oder lipophil. Bisher ist es daher üblich und ausreichend, Produkte mit 2 Phasen, einer Fettphase und einer Wasserphase, auszustatten, um jeden löslichen Wirkstoff in einem Produkt kombi­ niert darreichen zu können. Dabei ist es unabhängig, ob die beiden Phasen diskret übereinandergeschichtet und damit organoleptisch unterscheidbar bestehen oder durch Emulgatoren miteinander ver­ mischt sind. Um größeren Spielraum bei der Kombination von Wirk­ stoffen zu haben, hat man bereits 3-Phasen-Emulsionsprodukte ent­ wickelt. Das Vorhandensein von 3 Phasen ist in dieser Produktform für den Anwender optisch nicht wahrnehmbar.Soluble drugs are determined by their structure either hy drophil or lipophilic. So far it is common and sufficient, Products with 2 phases, a fat phase and a water phase, to equip any soluble active ingredient in a product to be able to give it. It does not matter if the two Phases discretely stacked and thus organoleptic distinguishable or ver together by emulsifiers are mixed. To give greater latitude in the combination of Wirk already have 3-phase emulsion products ent wraps. The presence of 3 phases is in this product form optically imperceptible to the user.

Ziel der ErfindungObject of the invention

Wenn man 3 oder mehr Phasen in einem Produkt vereinigen könnte und dieses für den Anwender optisch nachvollziehbar machen wür­ de, hätte man folgende Vorteile in einem Produkt:
If you could combine 3 or more phases in one product and make it visually comprehensible for the user, you would have the following advantages in one product:

  • 1. Attraktivere optische Produkterscheinung1. More attractive optical product appearance
  • 2. Kombination nicht kombinierbarer Stoffe in verschiedenen Phasen2. Combination of non-combinable substances in different phases
  • 3. Depoteffekte3. Custodian effects
  • 4. Schutzeffekte4. Protective effects
  • 5. Andere Wirk- und Penetrations-Kinetik5. Other activity and penetration kinetics
Umsetzung des ErfindungszielesImplementation of the goal of the invention

Da alle Rohstoffe zunächst nur in lipophil und hydrophil unterteilbar sind, schien das Ziel unserer Erfindung nicht erreichbar. Erst das Angebot neuartiger Rohstoffe, die bei der Formulierungsarbeit kon­ ventioneller Produkte Probleme machen und Inkompartibilitäten mit üblichen Rohstoffen zeigen, wies den Weg zur Lösung der Aufgabe.Since all raw materials are initially subdividable only in lipophilic and hydrophilic are, the goal of our invention seemed unattainable. Only that Offer of novel raw materials that are used in the formulation work of conventional products cause problems and incompatibilities show usual resources, pointed the way to the solution of the problem.

So sind es dann unter anderen
Fluorierte Verbindungen (Fluorether, Perfluordekalin etc.)
Silikonderivate (Cyclomethicon, Dimethicon etc.)
die sich von einer Fettphase bestehend aus
Wachsestern und/oder
Paraffinölen und/oder
Pflanzenölen etc. abtrennen, auf Grund des spezifischen Gewichtes absetzen und mit einer Wasserphase zusammen 3 und mehr Phasen bilden, die sich in einem Produkt vereinigt anbieten lassen. Diese lassen sich durch Ausnutzung des Nernstschen Gesetzes und der damit verschiedenar­ tigen Löslichkeit von Farbstoffen in den einzelnen Phasen gut un­ terscheidbar anfärben. In den verschiedenen Phasen lassen sich die dort bevorzugt lösliche Wirkstoffe integrieren:
Wasserphase: wasserlösliche Wirkstoffe
Fettphase: fettlösliche Wirkstoffe
Perfluorierte Phase: Gase wie Sauerstoff, Stickstoff
Silikonderivatphase: SchutzkomponentenSo it is among others
Fluorinated compounds (fluoroether, perfluorodecalin, etc.)
Silicone derivatives (cyclomethicone, dimethicone etc.)
consisting of a fatty phase consisting of
Wax star and / or
Paraffin oils and / or
Separate vegetable oils, etc., settle on the basis of specific gravity and form together with a water phase 3 and more phases that can be combined in one product offered. By using Nernst's law and the resulting solubility of dyes in the individual phases, these can be stained well and distinctly. In the different phases, it is possible to integrate the active substances which are preferably soluble there:
Water phase: water-soluble active ingredients
Fat phase: fat-soluble active ingredients
Perfluorinated phase: gases such as oxygen, nitrogen
Silicone derivative phase: protective components

Beispiele für den Aufbau 3 oder mehr phasiger ProdukteExamples of the construction of 3 or more phased products Beispiel 1example 1 Phase 1Phase 1

Isooctylstearatisooctyl ad 100%ad 100% Paraffinum perliquidumParaffin perliquidum 20%20% Jojobaöljojoba oil 20%20% Farbe Rouge au grasColor rouge au gras 0,3%0.3% BergamottenölBergamot oil 0,2%0.2% Parabeneparabens 0,4%0.4%

Phase 2Phase 2

Cyclomethiconcyclomethicone ad 100%ad 100% Farbe Rouge au grasColor rouge au gras 0,002%0.002%

Phase 3Phase 3

Wasserwater ad 100%ad 100% Actyl TyrosinActyl tyrosine 0,1%0.1% Farbe C.I.10020Color C.I.10020 0,002%0.002% Kathon CGKathon CG 0,05%0.05%

Phase 4Phase 4

Perfluoroetherperfluoroether ad 100%ad 100% Sauerstoffoxygen 12%12%

Verhältnis der Phasen 1 : 2 : 3 : 4 wie 1 : 1 : 1 : 0,2 Ratio of phases 1: 2: 3: 4 as 1: 1: 1: 0.2  

Beispiel 2Example 2 Phase 1Phase 1

Paraffinum perliquidumParaffin perliquidum ad 100%ad 100% Isopropylpalmitatisopropyl palmitate 70%70% HagebuttenkernölRosehip seed oil 2%2% Farbe FD & C BlauColor FD & C blue 0,02%0.02% Vitamin E AcetatVitamin E acetate 1,5%1.5% Parabeneparabens 0,4%0.4%

Phase 2Phase 2

Dimethicondimethicone ad 100%ad 100% Farbe FD & C BlauColor FD & C blue 0,0002%0.0002%

Phase 3Phase 3

Wasserwater ad 100%ad 100% Glyceringlycerin 5%5% FeuchthaltefaktorMoisturizing factor 3%3% Hyaluronsäurehyaluronic acid 0,04%0.04% Kathon CGKathon CG 0.05%0.05%

Phase 4Phase 4

PerfluorodekalinPerfluorodekalin ad 100%ad 100% Sauerstoffoxygen 22%22%

Verhältnis der Phasen 1 : 2 : 3 : 4 wie 2 : 1 : 2 : 0.5Ratio of phases 1: 2: 3: 4 as 2: 1: 2: 0.5

Claims (1)

Es wird Schutz für Produktformeln, deren Produktion und deren An­ wendung beantragt, die der allgemeinen Formel
<Phase 1 Ölkomponente ad 100% Fettlösliche Farbstoffe 0-100% Fettlösliche Wirkstoffe 0-100% Konservierungsmittel 0-100% AL=L<Phase 2 Nicht mit Phase 1 und 4 mischbare Komponenten ad 100% Fettlösliche Farben 0-100% AL=L<Phase 3 Wasser ad 100% Hydrophile Lösungsmittel 0-100% Wasserlösliche Wirkstoffe 0-100% Wasserlösliche Farbstoffe 0-100% Konservierung 0-100%
<Phase 4 Nicht mit Phase 1 und 2 mischbare Komponenten ad 100% Wirkstoffe 0-100%
Verhältnis der Phasen 1 : 2 : 3 : 4 wie 1 : 0,001-1 : 0,001-10 : 0-1, wobei
Phase 1 aus konventionellen Ölen
Phase 2 aus mit Phase 1 und 4 nicht kompatiblen lipophilen Komponenten mit einem spezifischen Gewicht kleiner 1
Phase 3 aus Wasser und hydrophilen Lösungsmitteln wie z. B. Propylenglykol, Glycerin etc.
Phase 4 aus mit Phase 1 und 2 nicht kompatiblen lipophilen Komponenten, mit einem spezifischen Gewicht größer 1
besteht, in die jeweils Wirkstoffe, Farben und Konservierung inte­ griert sind.Protection is requested for product formulas, their production and their application, those of the general formula
<Phase 1 oil component ad 100% Fat-soluble dyes 0-100% Fat-soluble active ingredients 0-100% preservative 0-100% AL = L <phase 2 Not mixable with phase 1 and 4 components ad 100% Fat-soluble colors 0-100% AL = L <phase 3 water ad 100% Hydrophilic solvents 0-100% Water-soluble active ingredients 0-100% Water-soluble dyes 0-100% preservation 0-100%
<Phase 4 Not mixable with phase 1 and 2 components ad 100% drugs 0-100%
Ratio of phases 1: 2: 3: 4 as 1: 0.001-1: 0.001-10: 0-1, wherein
Phase 1 from conventional oils
Phase 2 of lipophilic components not compatible with phase 1 and 4 and having a specific gravity less than 1
Phase 3 of water and hydrophilic solvents such. As propylene glycol, glycerol, etc.
Phase 4 of lipophilic components incompatible with Phase 1 and 2, with a specific gravity greater than 1
consisting of active ingredients, colors and preservatives.
DE19907305A 1999-02-22 1999-02-22 Products with three or more discrete and optically-distinguishable phases containing active substances, dyes and preservatives Withdrawn DE19907305A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19907305A DE19907305A1 (en) 1999-02-22 1999-02-22 Products with three or more discrete and optically-distinguishable phases containing active substances, dyes and preservatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19907305A DE19907305A1 (en) 1999-02-22 1999-02-22 Products with three or more discrete and optically-distinguishable phases containing active substances, dyes and preservatives

Publications (1)

Publication Number Publication Date
DE19907305A1 true DE19907305A1 (en) 2000-08-24

Family

ID=7898260

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19907305A Withdrawn DE19907305A1 (en) 1999-02-22 1999-02-22 Products with three or more discrete and optically-distinguishable phases containing active substances, dyes and preservatives

Country Status (1)

Country Link
DE (1) DE19907305A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005053636A2 (en) * 2003-12-08 2005-06-16 Coty B.V. Cosmetic and dermatological oxygen carrier system
FR2912656A1 (en) * 2007-02-15 2008-08-22 Dermaconcept Jmc Sarl Pharmaceutical composition of oil-in-oil emulsion, useful to manufacture product to treat vaginal dryness, comprises mixture of glycerin, paraffin gel and/or their derivatives, perfluorinated oils, gellfied lipids and polysaccharides

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005053636A2 (en) * 2003-12-08 2005-06-16 Coty B.V. Cosmetic and dermatological oxygen carrier system
WO2005053636A3 (en) * 2003-12-08 2005-07-28 Coty Bv Cosmetic and dermatological oxygen carrier system
JP2007513194A (en) * 2003-12-08 2007-05-24 コティ ビー．ヴィ． Cosmetic and dermatological oxygen carrier systems
CN1893916B (en) * 2003-12-08 2010-05-26 科蒂股份有限公司 Cosmetic and dermatologic oxygen carrier system
JP4726801B2 (en) * 2003-12-08 2011-07-20 コティ ビー．ヴィ． Cosmetic and dermatological oxygen carrier systems
US8252297B2 (en) 2003-12-08 2012-08-28 Coty B.V. Cosmetic and dermatologic oxygen carrier system
FR2912656A1 (en) * 2007-02-15 2008-08-22 Dermaconcept Jmc Sarl Pharmaceutical composition of oil-in-oil emulsion, useful to manufacture product to treat vaginal dryness, comprises mixture of glycerin, paraffin gel and/or their derivatives, perfluorinated oils, gellfied lipids and polysaccharides
WO2008129153A1 (en) * 2007-02-15 2008-10-30 Dermaconcept Jmc Oil-in-oil emulsion-type pharmaceutical composition

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