DE19859586C1 - Thermocyclervorrichtung - Google Patents
ThermocyclervorrichtungInfo
- Publication number
- DE19859586C1 DE19859586C1 DE19859586A DE19859586A DE19859586C1 DE 19859586 C1 DE19859586 C1 DE 19859586C1 DE 19859586 A DE19859586 A DE 19859586A DE 19859586 A DE19859586 A DE 19859586A DE 19859586 C1 DE19859586 C1 DE 19859586C1
- Authority
- DE
- Germany
- Prior art keywords
- linear motor
- cover
- base body
- thermal cycler
- lid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006243 chemical reaction Methods 0.000 claims abstract description 51
- 239000000126 substance Substances 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 8
- 238000010438 heat treatment Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 6
- 230000002441 reversible effect Effects 0.000 claims description 3
- 238000007599 discharging Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 101150016193 fig gene Proteins 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50851—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
- B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Thermally Actuated Switches (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Heating, Cooling, Or Curing Plastics Or The Like In General (AREA)
- Confectionery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Glass Compositions (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19859586A DE19859586C1 (de) | 1998-12-22 | 1998-12-22 | Thermocyclervorrichtung |
| NO996187A NO996187L (no) | 1998-12-22 | 1999-12-14 | Termosyklusapparat |
| DE29925002U DE29925002U1 (de) | 1998-12-22 | 1999-12-16 | Thermocyclervorrichtung |
| EP99125152A EP1013342B1 (de) | 1998-12-22 | 1999-12-16 | Thermocyclervorrichtung |
| AT99125152T ATE263628T1 (de) | 1998-12-22 | 1999-12-16 | Thermocyclervorrichtung |
| DE59909106T DE59909106D1 (de) | 1998-12-22 | 1999-12-16 | Thermocyclervorrichtung |
| US09/467,322 US6153426A (en) | 1998-12-22 | 1999-12-20 | Thermocycler apparatus |
| AU65427/99A AU730946B2 (en) | 1998-12-22 | 1999-12-22 | Thermocycler apparatus |
| JP36367599A JP4578604B2 (ja) | 1998-12-22 | 1999-12-22 | 熱サイクル装置 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19859586A DE19859586C1 (de) | 1998-12-22 | 1998-12-22 | Thermocyclervorrichtung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE19859586C1 true DE19859586C1 (de) | 2000-07-13 |
Family
ID=7892332
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19859586A Expired - Lifetime DE19859586C1 (de) | 1998-12-22 | 1998-12-22 | Thermocyclervorrichtung |
| DE59909106T Revoked DE59909106D1 (de) | 1998-12-22 | 1999-12-16 | Thermocyclervorrichtung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE59909106T Revoked DE59909106D1 (de) | 1998-12-22 | 1999-12-16 | Thermocyclervorrichtung |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6153426A (enExample) |
| EP (1) | EP1013342B1 (enExample) |
| JP (1) | JP4578604B2 (enExample) |
| AT (1) | ATE263628T1 (enExample) |
| AU (1) | AU730946B2 (enExample) |
| DE (2) | DE19859586C1 (enExample) |
| NO (1) | NO996187L (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011011912B4 (de) * | 2011-02-21 | 2020-09-03 | Eppendorf Ag | Laborgerät mit Deckel und Pressanordnung und Verfahren zum Anpressen |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6238913B1 (en) * | 1999-11-23 | 2001-05-29 | Glaxo Wellcome Inc. | Apparatus for heating and cooling deep well pharmaceutical microplates |
| DE20006546U1 (de) * | 2000-04-08 | 2001-08-23 | MWG-BIOTECH AG, 85560 Ebersberg | Abdeckmatte |
| US6640891B1 (en) | 2000-09-05 | 2003-11-04 | Kevin R. Oldenburg | Rapid thermal cycling device |
| US7025120B2 (en) * | 2000-09-05 | 2006-04-11 | Oldenburg Kevin R | Rapid thermal cycling device |
| US6660232B1 (en) * | 2000-09-29 | 2003-12-09 | Promega Corporation | Multi-well assay plate and plate holder and method of assembling the same |
| US7459302B2 (en) * | 2001-10-02 | 2008-12-02 | Stratagene California | Side-wall heater for thermocycler device |
| DE20117661U1 (de) * | 2001-10-29 | 2003-03-13 | MWG-BIOTECH AG, 85560 Ebersberg | Thermocyclervorrichtung |
| US7373968B2 (en) * | 2002-01-08 | 2008-05-20 | Kevin R. Oldenburg | Method and apparatus for manipulating an organic liquid sample |
| US7614444B2 (en) | 2002-01-08 | 2009-11-10 | Oldenburg Kevin R | Rapid thermal cycling device |
| US6893613B2 (en) * | 2002-01-25 | 2005-05-17 | Bristol-Myers Squibb Company | Parallel chemistry reactor with interchangeable vessel carrying inserts |
| US7452712B2 (en) | 2002-07-30 | 2008-11-18 | Applied Biosystems Inc. | Sample block apparatus and method of maintaining a microcard on a sample block |
| US6730883B2 (en) * | 2002-10-02 | 2004-05-04 | Stratagene | Flexible heating cover assembly for thermal cycling of samples of biological material |
| US7507376B2 (en) * | 2002-12-19 | 2009-03-24 | 3M Innovative Properties Company | Integrated sample processing devices |
| US20040191831A1 (en) * | 2003-03-25 | 2004-09-30 | Council Of Scientific And Industrial Research | Rapid heat - mediated method for enzyme - linked immunosorbent assay procedure |
| US7570443B2 (en) * | 2003-09-19 | 2009-08-04 | Applied Biosystems, Llc | Optical camera alignment |
| US20050237528A1 (en) * | 2003-09-19 | 2005-10-27 | Oldham Mark F | Transparent heater for thermocycling |
| US20080118955A1 (en) * | 2004-04-28 | 2008-05-22 | International Business Machines Corporation | Method for precise temperature cycling in chemical / biochemical processes |
| US20050244933A1 (en) * | 2004-04-28 | 2005-11-03 | International Business Machines Corporation | Method and apparatus for precise temperature cycling in chemical/biochemical processes |
| US7311794B2 (en) | 2004-05-28 | 2007-12-25 | Wafergen, Inc. | Methods of sealing micro wells |
| US20050282270A1 (en) * | 2004-06-21 | 2005-12-22 | Applera Corporation | System for thermally cycling biological samples with heated lid and pneumatic actuator |
| US20060024204A1 (en) * | 2004-08-02 | 2006-02-02 | Oldenburg Kevin R | Well plate sealing apparatus and method |
| JP2008508533A (ja) * | 2004-08-05 | 2008-03-21 | イェーペーカー インストゥルメンツ アクチエンゲゼルシャフト | 検査試料の収容装置 |
| US8252581B2 (en) | 2007-01-22 | 2012-08-28 | Wafergen, Inc. | Apparatus for high throughput chemical reactions |
| US20080318280A1 (en) * | 2007-02-13 | 2008-12-25 | Eppendorf Ag | Cover for an array of reaction vessels for one-step operation modus |
| EP2359933B1 (en) | 2007-02-13 | 2017-11-08 | Eppendorf AG | Cover for sample with sample-size independent height adjustment |
| EP1961484B1 (en) * | 2007-02-13 | 2016-07-20 | Eppendorf Ag | Cover for sample with homogeneous pressure application |
| US8865457B2 (en) | 2007-03-15 | 2014-10-21 | Siemens Healthcare Diagnostics Inc. | Active, micro-well thermal control subsystem |
| CN102565441B (zh) * | 2007-05-15 | 2014-02-12 | 和光纯药工业株式会社 | 均衡集成式pcr-ce微流装置内的压力的压力歧管 |
| CN101952412B (zh) | 2008-02-15 | 2014-07-23 | 生物辐射实验室股份有限公司 | 具有自动调节盖的热循环仪 |
| US20110156090A1 (en) * | 2008-03-25 | 2011-06-30 | Lin Charles W C | Semiconductor chip assembly with post/base/post heat spreader and asymmetric posts |
| DE202008009556U1 (de) | 2008-07-16 | 2009-12-03 | Eppendorf Ag | Vorrichtung zum Temperieren wenigstens einer Probe |
| US20100279299A1 (en) * | 2009-04-03 | 2010-11-04 | Helixis, Inc. | Devices and Methods for Heating Biological Samples |
| EP2301666B1 (en) | 2009-09-09 | 2021-06-30 | Cole-Parmer Ltd. | Optical system for multiple reactions |
| DE102010019232B4 (de) * | 2010-05-03 | 2013-06-27 | Eppendorf Ag | Kondensatvermeidungshaube |
| GB201018624D0 (en) | 2010-11-04 | 2010-12-22 | Epistem Ltd | Reaction vessel |
| ES2854987T3 (es) | 2012-06-28 | 2021-09-23 | Fluoresentric Inc | Un dispositivo indicador químico |
| CN103725602B (zh) * | 2012-10-16 | 2015-05-27 | 常州福生生物技术有限公司 | 一种用于核酸扩增检测仪中的热盖板 |
| WO2014149268A1 (en) | 2013-03-19 | 2014-09-25 | Life Technologies Corporation | Thermal cycler cover |
| US9885862B2 (en) | 2013-05-01 | 2018-02-06 | Bio-Rad Laboratories, Inc. | Adjustable digital microscope display |
| WO2014179483A2 (en) * | 2013-05-02 | 2014-11-06 | Bio-Rad Laboratories, Inc. | Drawer handle mechanism |
| GB2591198B (en) * | 2014-04-04 | 2021-10-27 | It Is Int Ltd | Biochemical reaction system |
| RU2702577C2 (ru) * | 2015-02-06 | 2019-10-08 | Лайф Текнолоджиз Корпорейшн | Системы и способы для биологического анализа |
| JP6620160B2 (ja) | 2015-02-20 | 2019-12-11 | タカラ バイオ ユーエスエー, インコーポレイテッド | 単一細胞の迅速かつ正確な分注、視覚化及び解析のための方法 |
| EP3349903A4 (en) * | 2015-09-16 | 2019-03-13 | Fluoresentric, Inc. | APPARATUS, SYSTEMS AND METHODS FOR DYNAMIC FLOW AMPLIFICATION OF SAMPLES |
| WO2017098321A1 (en) * | 2015-12-11 | 2017-06-15 | Spartan Bioscience Inc. | Tube sealing system and methods for nucleic acid amplification |
| US11460405B2 (en) | 2016-07-21 | 2022-10-04 | Takara Bio Usa, Inc. | Multi-Z imaging and dispensing with multi-well devices |
| CN110157590A (zh) * | 2018-02-13 | 2019-08-23 | 光鼎生物科技(江苏)有限公司 | 热循环仪 |
| DE102018124412A1 (de) * | 2018-10-02 | 2020-04-02 | Biometra GmbH | Temperierblockmodul und Vorrichtung zur thermischen Behandlung von Proben |
| DE102018124408A1 (de) | 2018-10-02 | 2020-04-02 | Biometra GmbH | Vorrichtung zur thermischen Behandlung von Proben |
| DE102018131127A1 (de) * | 2018-12-06 | 2020-06-10 | Analytik Jena Ag | Automatisierbare Temperiervorrichtung |
| JP7492884B2 (ja) * | 2020-08-28 | 2024-05-30 | シスメックス株式会社 | 検体処理装置、測定装置および測定方法 |
| JP7327360B2 (ja) * | 2020-11-19 | 2023-08-16 | 横河電機株式会社 | 熱処理システム、核酸抽出システム、核酸分析システム |
| CN120322564A (zh) | 2022-12-08 | 2025-07-15 | 贝克顿·迪金森公司 | 全自动dPCR系统及其使用方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3316258C2 (enExample) * | 1983-05-04 | 1988-01-21 | Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt, De | |
| DE4116739C1 (enExample) * | 1991-05-23 | 1992-07-02 | Daimler-Benz Aktiengesellschaft, 7000 Stuttgart, De | |
| DE4331764C1 (de) * | 1993-09-18 | 1994-11-03 | Friwo Silberkraft Ges Fuer Bat | Elektrochemischer Aktor |
| DE4331763C1 (de) * | 1993-09-18 | 1994-11-10 | Friwo Silberkraft Ges Fuer Bat | Elektrochemischer Aktor |
| US5443791A (en) * | 1990-04-06 | 1995-08-22 | Perkin Elmer - Applied Biosystems Division | Automated molecular biology laboratory |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656493A (en) * | 1985-03-28 | 1997-08-12 | The Perkin-Elmer Corporation | System for automated performance of the polymerase chain reaction |
| SE9002579D0 (sv) * | 1990-08-07 | 1990-08-07 | Pharmacia Ab | Method and apparatus for carrying out biochemical reactions |
| JPH06327476A (ja) * | 1993-05-21 | 1994-11-29 | Hitachi Ltd | 遺伝子解析装置 |
| CA2130013C (en) * | 1993-09-10 | 1999-03-30 | Rolf Moser | Apparatus for automatic performance of temperature cycles |
| DE19646116A1 (de) * | 1996-11-08 | 1998-05-14 | Eppendorf Geraetebau Netheler | Temperierblock mit Aufnahmen |
| JP3552871B2 (ja) * | 1997-02-28 | 2004-08-11 | 独立行政法人 科学技術振興機構 | 全自動遺伝子解析システム |
| US5989499A (en) * | 1997-05-02 | 1999-11-23 | Biomerieux, Inc. | Dual chamber disposable reaction vessel for amplification reactions |
| US5851492A (en) * | 1997-09-30 | 1998-12-22 | Blattner; Frederick R. | Microtiter plate sealing system |
| ATE278471T1 (de) * | 1998-05-04 | 2004-10-15 | Hoffmann La Roche | Thermozyklierapparat mit einem automatisch positionierbaren deckel |
-
1998
- 1998-12-22 DE DE19859586A patent/DE19859586C1/de not_active Expired - Lifetime
-
1999
- 1999-12-14 NO NO996187A patent/NO996187L/no not_active Application Discontinuation
- 1999-12-16 DE DE59909106T patent/DE59909106D1/de not_active Revoked
- 1999-12-16 AT AT99125152T patent/ATE263628T1/de not_active IP Right Cessation
- 1999-12-16 EP EP99125152A patent/EP1013342B1/de not_active Revoked
- 1999-12-20 US US09/467,322 patent/US6153426A/en not_active Expired - Lifetime
- 1999-12-22 JP JP36367599A patent/JP4578604B2/ja not_active Expired - Lifetime
- 1999-12-22 AU AU65427/99A patent/AU730946B2/en not_active Ceased
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3316258C2 (enExample) * | 1983-05-04 | 1988-01-21 | Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt, De | |
| US5443791A (en) * | 1990-04-06 | 1995-08-22 | Perkin Elmer - Applied Biosystems Division | Automated molecular biology laboratory |
| DE4116739C1 (enExample) * | 1991-05-23 | 1992-07-02 | Daimler-Benz Aktiengesellschaft, 7000 Stuttgart, De | |
| DE4331764C1 (de) * | 1993-09-18 | 1994-11-03 | Friwo Silberkraft Ges Fuer Bat | Elektrochemischer Aktor |
| DE4331763C1 (de) * | 1993-09-18 | 1994-11-10 | Friwo Silberkraft Ges Fuer Bat | Elektrochemischer Aktor |
Non-Patent Citations (1)
| Title |
|---|
| Brüsewitz, Michael "Elektrochemische Aktoren" in: F&M (1988), 106, H.7-8 S.527-530 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102011011912B4 (de) * | 2011-02-21 | 2020-09-03 | Eppendorf Ag | Laborgerät mit Deckel und Pressanordnung und Verfahren zum Anpressen |
Also Published As
| Publication number | Publication date |
|---|---|
| NO996187L (no) | 2000-06-23 |
| EP1013342A3 (de) | 2001-01-10 |
| JP4578604B2 (ja) | 2010-11-10 |
| US6153426A (en) | 2000-11-28 |
| AU6542799A (en) | 2000-06-29 |
| DE59909106D1 (de) | 2004-05-13 |
| EP1013342B1 (de) | 2004-04-07 |
| AU730946B2 (en) | 2001-03-22 |
| EP1013342A2 (de) | 2000-06-28 |
| NO996187D0 (no) | 1999-12-14 |
| JP2000189152A (ja) | 2000-07-11 |
| ATE263628T1 (de) | 2004-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8100 | Publication of patent without earlier publication of application | ||
| D1 | Grant (no unexamined application published) patent law 81 | ||
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: APPLERA CORP. (N.D.GES.D. STAATES DELAWARE), FOSTE |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. VOLKER VOSSIUS, CORINNA VOSSIUS, TILMAN VOSSIU |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: APPLIED BIOSYSTEMS INC. (N.D.GES.D. STAATES DE, US |
|
| 8310 | Action for declaration of annulment | ||
| 8313 | Request for invalidation rejected/withdrawn | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LIFE TECHNOLOGIES CORP. (N.D.GES.D. STAATES DE, US |
|
| R071 | Expiry of right |