DE19748755A1 - Stabilisation of di:benzoyl-methane ultraviolet filters - Google Patents

Abstract

Use of cosmetically or dermatologically acceptable 1,1-dicyano-2,2-diphenylethene compounds (I) to stabilise cosmetically or dermatologically acceptable dibenzoylmethane compounds (II) against UV-induced degradation is new.

Description

The present invention relates to cosmetic and dermatological light protection preparations, in particular cosmetic and dermatological skin care products Sunscreen preparations.

The damaging effect of the ultraviolet part of solar radiation on the Skin is well known. While rays with a wavelength that is smaller than 290 nm (the so-called UVC range) from the ozone layer in the earth are absorbed in the atmosphere, causing rays in the range between 290 nm and 320 nm, the so-called UVB range, an erythema, a simple one Sunburn or even more or less severe burns.

As a maximum of the erythema effectiveness of sunlight, the narrower Be richly stated around 308 nm.

Numerous compounds are known for protection against UVB radiation, at which are mostly derivatives of the 3-benzylidene camphor, the 4-amina benzoic acid, cinnamic acid, salicylic acid, benzophenone and also 2-phenylbenzimidazole.

Also for the range between about 320 nm and about 400 nm, the so-called UVA range, it is important to have filter substances available as well whose rays can cause damage. It has been shown that UVA Radiation damages the elastic and collagen fibers of the bin  degewebes leads what causes the skin to age prematurely and that it pays as the cause rich phototoxic and photoallergic reactions can be seen. The beautiful The influence of UVB radiation can be increased by UVA radiation.

UV-A radiation can also cause skin damage by the skin egg gene keratin or elastin is damaged. This makes elasticity and what reduced skin storage capacity, d. H. the skin becomes less supple and tends to wrinkle. The strikingly high incidence of skin cancer in areas strong sunlight shows that apparently also damage to the heiress formations in the cells from sunlight, especially from UV-A radiation be called.

The UV radiation can also lead to photochemical reactions, whereby then insert the photochemical reaction products into the skin metabolism fen.

Such photochemical reaction products are predominantly radical compounds, e.g. B. hydroxyl radicals. Even undefined radicals Photo products that are created in the skin itself, due to their high Reactivity Show uncontrolled follow-up reactions. But also Singlet oxygen, a non-radical excited state of the oxygen mole Cool can occur with UV radiation, as can short-lived epoxies and many Other. Singlet oxygen, for example, stands out from the norma triplet oxygen (radical ground state) increased reactivity. However, there are also excited, reactive (radical Sche) triplet states of the oxygen molecule.

UV radiation also belongs to ionizing radiation. So there is a risk that ionic species also develop when exposed to UV, which in turn are able to intervene oxidatively in the biochemical processes.

A known and advantageous light protection filter substance is the 4- (tert-butyl) -4'-methoxydibenzoylmethane, which is characterized by the structure

and is sold by Givaudan under the Parsol® 1789 brand.

The main disadvantage of this substance is a certain instability towards UV radiation, so that it is expedient to incorporate certain UV stabilizers into preparations containing this substance. The photochemical decomposition of 4- (tert-butyl) -4'-methoxydibenzoylmethane - representative of all dibenzoylmethane derivatives absorbing in the UV range - follows a Norrish type I acyl cleavage according to the following reaction scheme:

The reaction products are no longer available as light protection filter substances addition. It was therefore an urgent need to show ways in which the  counteracted photolytic decomposition of dibenzoylmethane derivatives effectively can be.

For example, German Offenlegungsschrift DE-A-37 41 420 describes the combination of this light protection filter in a specific quantitative ratio to 4-Me thylbenzylidencampher, which is characterized by the structure

honored and sold by Merck under the Eusolex® 6300 brand. The a.a.O. The preparations described are distinguished by others Disadvantages, mainly of a technical formulation.

To remedy the disadvantages of the prior art was therefore the task of the present invention.

However, it was surprising and unforeseeable for the person skilled in the art that the use of cosmetically or dermatologically harmless substances, the chemical formula of which is the structural motif of 1,1-dicyano-2,2-diphenyl-ethene

contain, for the stabilization of cosmetic or dermatologically harmless substances, whose chemical formula is the structural motif of dibenzoylmethane

contain, against the decomposition induced by UV radiation, the disadvantages remedy the state of the art.

There are 1,1-dicyano-2,2-diphenyl-ethene derivatives in cosmetic or dermatola preparations in combination with dibenzoylmethane derivatives the latter against the decomposition induced by UV radiation in excellent Way protected.

Certain documents describe stable cosmetic cosmetic preparations in which dibenzoylmethane derivatives prior to photochemical decomposition should be protected, which is characterized by an optional content 1-cyano-2,2-diphenylethene derivatives, especially ethylhexyl-2-cyano-3,3-diphenyl acrylate Mark (octocrylene), e.g. B. EP-PS 514 491. The teaching of the invention is not even suggested by this document.

The document WO 97/17054 describes photostable UV-A filters containing cosmetic preparations. These UV-A filters are selected from the group of substances that have the generic structure

exhibit. R ¹ and R ² here are in the para and / or ortha position, identical or different straight-chain or branched-chain aliphatic or cycloaliphatic radicals having 1 to 18 carbon atoms, and where R ^{1 can} additionally be a hydrogen atom, and furthermore n denotes the numbers 1 or 2, provided that these compounds have their essential absorption in the range from 320 to 380 nm.

This document expressly refers to the already cited EP-PS 514 491 and the problematic UV stability of the dibenzoylmethane derivatives sen. However, this document does not give the slightest reference to the herewith given put invention.

Cosmetically or dermatologically safe substances to be used advantageously according to the invention, whose chemical formula contains the structural motif of 1,1-dicyano-2,2-diphenyl-ethene, can be selected from the group of substances which have the generic structure

exhibit. R ¹ and R ² here independently of one another represent hydrogen or the same or different straight-chain or branched-chain aliphatic or cycloaliphatic radicals having 1 to 18 carbon atoms or in the para and / or ortha position which are in the para and / or ortha position , same or different straight-chain or branched chain alkoxy radicals or cycloalkoxy radicals having 1 to 18 carbon atoms, where n and m independently of one another denote the numbers 1 or 2.

The following individual compounds are particularly preferred, in which R ¹ and / or R ^{2 are} in the para position and, independently of one another, n-propoxy-, n-butoxy, 2-methylpropoxy-, 1,1-dimethylpropoxy-, hexoxy-, heptoxy- , 2-ethylhexoxy, iso propoxy, 1-methylpropoxy, n-pentoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-methyl-1-ethylpropoxy and / or octoxy groups, where R ¹ and / or R ² can also mean hydrogen.

It is particularly advantageous for the purposes of the present invention that 1,1-dicyano 2,2-diphenylethene to use yourself.  

A very particularly advantageous substance that contains the structural motif of 1,1-dicyano-2,2-diphenyl-ethene is 1,1-dicyano-2-phenyl-2- (p-butoxy-phenyl) ethene, which through the chemical structural formula

distinguished.

Of the dibenzoylmethane derivatives are advantageously used:

If the teaching according to the invention is followed, light protection preparations are obtained Lich what higher stability, especially stability against decomposition under the Influence of light, especially UV light, have than the prior art should have been expected. In particular, the stability of 4- (tert-butyl) -4'-methoxydi Benzoylmethane against decomposition under UV light is drastically increased. All It was particularly surprising that the increase in the stability of Di  benzoylmethanes, especially 4- (tert-butyl) -4'-methoxydibenzoylmethane equally if this occurs in polar but also non-polar Ölkom components are available in solution.

The total amount of dibenzoylmethanes, especially 4- (tert-butyl) -4'-me thoxydibenzoylmethane in the finished cosmetic or dermatological Preparations from the range 0.1-10.0% by weight are preferred 0.5-6.0% by weight, based on the total weight of the preparations.

The total amount of 1,1-dicyano-2,2-diphenyl-ethene derivatives, in particular 1,1-dicyano-2-phenyl-2- (p-butoxyphenyl) ethene, in the finished cosmetic or dermatological preparations will advantageously be in the range of 0.1-10.0 % By weight, preferably 0.5-6.0% by weight, based on the total weight of the preparations.

It is particularly advantageous to use weight ratios of 1,1-dicyano-2,2-diphenyl ethene derivatives to dibenzoylmethanes such as 8: 1 to 1: 5, preferably as 4: 1 to 1: 2, particularly preferably as 3: 1 to 1: 1 to choose.

Cosmetic and dermatological preparations according to the invention also advantageously, although not necessarily, contain inorganic pigments based on metal oxides and / or other metal compounds which are sparingly soluble or insoluble in water, in particular the oxides of titanium (TiO ₂ ), zinc (ZnO), iron (e.g. B. Fe ₂ O ₃ ), zirconium (ZrO ₂ ), silicon (SiO ₂ ), manganese (e.g. MnO), aluminum (Al ₂ O ₃ ), cerium (e.g. Ce ₂ O ₃ ), mixed oxides the corresponding metals and mixtures of such oxides. Pigments based on TiO _{2 are} particularly preferred.

According to the invention, the inorganic pigments are in hydrophobic form, d. that is, they are treated to be water-repellent on the surface. This surface Chen treatment can consist in that the pigments according to known Process can be provided with a thin hydrophobic layer.  

Such a method consists, for example, in that the hydrophobic surface layer according to a reaction

n TiO ₂ + m (RO) ₃ Si-R '→ n TiO ₂ (surface)

is produced. n and m are stoichiometric to be used at will Parameters, R and R 'the desired organic residues. For example in Analogy to DE-OS 33 14 742 shown hydrophobized pigments are from Advantage.

Advantageous TiO ₂ pigments are available, for example, from Degussa under the trade names T 805.

The total amount of inorganic pigments, especially hydrophobic organic micropigments in the finished cosmetic or dermatological Preparations from the range of 0.1-30% by weight are preferred 0.1-10.0, in particular 0.5-6.0% by weight, based on the total weight of the preparations.

According to the invention, the cosmetic and / or dermatological light protective formulations as usual and the cosmetic and / or dermatological light protection, also for treatment, care and cleaning the skin and / or hair and as a make-up product in the decorative cosmetics.

The cosmetic and dermatological preparations are used according to the invention in the usual manner for cosmetics on the skin and / or Hair applied in sufficient quantities.

Such cosmetic and dermatological preparations are particularly preferred conditions that are in the form of a sunscreen. Can be advantageous these additionally at least one further UVA filter and / or at least one further UVB filter and / or at least one inorganic pigment, preferred an inorganic micropigment.  

The cosmetic and dermatological preparations can according to the invention Contain cosmetic auxiliaries, as are usually found in such preparations are used, e.g. B. preservatives, bactericides, perfumes, substances to prevent foaming, dyes, pigments, a coloring Have effect thickeners, moisturizing and / or moisturizing Substances, fats, oils, waxes or other common components of one cosmetic or dermatological formulation such as alcohols, polyols, poly mers, foam stabilizers, electrolytes, organic solvents or silicone derivatives.

An additional level of antioxidants is generally preferred. Erfin In accordance with the invention, all of the cosmetic and / or dermatological applications of suitable or customary antioxidants be used.

The antioxidants are advantageously selected from the group consisting of amino acids (e.g. glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (e.g. urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-camosin, L-carnosine and their derivatives (e.g. anserine), carotenoids, carotenes (e.g. α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and its derivatives ( e.g. dihydroliponic acid), Au rothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, Butyl and lauryl, palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and their derivatives (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and Sulfoximine compounds (e.g. buthionine sulfoximines, homocysteine sulfoximine, buthionine sulfones, penta-, hexa-, heptathioninsulfoximine) in very low tolerable doses (e.g. B. pmol to µmol / kg), further (metal) - chelators (e.g. α-hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (e.g. citric acid, lactic acid, malic acid), humic acid, gal lensic acid , Biliary extracts, bilirubin, biliverdin, EDTA, EGTA and their derivatives, unsaturated fatty acids and their derivatives (e.g. γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (e.g. ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoate of benzoin, rutinic acid and their derivatives , α-glycosyl rutin, ferulic acid, furfurylidene glucitol, carnosine, butylated hydroxytoluene, butylated hydroxyanisole, nordihydroguajak resin acid, nordihy droguajaretic acid, trihydroxybutyrophenone, uric acid and its derivatives, mannose and their derivatives, zinc and its derivatives (e.g. ZSO ₄ ) Selenium and its derivatives (e.g. B. selenomethionine), stilbenes and their derivatives (for example stilbene oxide, trans-stilbene oxide) and the derivatives suitable according to the invention (salts, esters, ethers, sugars, nucleotides, nucleosides, peptides and lipids) of these active substances.

The amount of the aforementioned antioxidants (one or more compounds) in the preparations are preferably 0.001 to 30% by weight, particularly preferably 0.05-20% by weight, in particular 1-10% by weight, based on the Total weight of the preparation.

If vitamin E and / or its derivatives represent the antioxidant (s), is advantageous whose respective concentrations range from 0.001-10 % By weight, based on the total weight of the formulation.

If vitamin A, or vitamin A derivatives, or carotenes or their derivatives, the or the antioxidants are advantageous, their respective concentrations from the range of 0.001-10% by weight, based on the total weight of the Wording to choose.

The lipid phase can advantageously be selected from the following group of substances:

• - mineral oils, mineral waxes;
• - Oils, such as triglycerides of capric or caprylic acid, but preferably Castor oil;
• - Fats, waxes and other natural and synthetic fat bodies preferably esters of fatty acids with alcohols of low C number, e.g. B. with  With isopropanol, propylene glycol or glycerin, or esters of fatty alcohols Low C number alkanoic acids or with fatty acids;
• - alkyl benzoates;
• - silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpoly siloxanes and mixed forms thereof.

The oil phase of the emulsions, oleogels or hydrodispersions or lipodispersi Ones in the sense of the present invention is advantageously selected from the group the ester of saturated and / or unsaturated, branched and / or uns branched alkane carboxylic acids with a chain length of 3 to 30 carbon atoms and sown saturated and / or unsaturated, branched and / or unbranched alcohols ner chain length of 3 to 30 carbon atoms, from the group of esters aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols with a chain length of 3 to 30 carbon atoms. Such ester oils can then advantageously be selected from the Isopro group pyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n- Hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2- Ethyl hexyl palmitate, 2-ethyl hexyl laurate, 2-hexyl decyl stearate, 2-oc tyldodecyl palmitate, oleyl oleate, olerlerucate, erucyl oleate, erucylerucate and synthe tables, semi-synthetic and natural mixtures of such esters, e.g. B. Jojoba oil.

Furthermore, the oil phase can advantageously be selected from the group of ver branched and unbranched hydrocarbons and waxes, the silicone oils, the Dialkyl ether, the group of saturated or unsaturated, branched or unbranched alcohols, as well as the fatty acid triglycerides, especially the triglyce pure esters of saturated and / or unsaturated, branched and / or unbranched Al can carboxylic acids with a chain length of 8 to 24, in particular 12-18 carbon atoms. The fatty acid triglycerides can, for example, advantageously be selected from the Group of synthetic, semi-synthetic and natural oils, e.g. B. olive oil, Sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil and the like.

Any mixtures of such oil and wax components are also advantageous liable to use in the sense of the present invention. There may also be  if advantageous, waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.

The oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyl dodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C _12-15 alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether.

Mixtures of C _12-15 alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C _12-15 alkyl benzoate and isotridecyl isononanoate and mixtures of C _12-15 alkyl benzoate, 2-ethyl hexyl isostearate and isotridecyl isononanoate are particularly advantageous.

Of the hydrocarbons, paraffin oil, squalane and squalene are advantageous in To use the sense of the present invention.

The oil phase can also advantageously contain cyclic or linear sili have oils or consist entirely of such oils, although an additional one is preferred in addition to the silicone oil or the silicone oils Content of other oil phase components to use.

Cyclomethicone (octamethylcyclotetrasiloxane) is advantageous as according to the invention silicone oil to be used. But other silicone oils are also beneficial to use for the purposes of the present invention, for example hexamethylcy clotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

Mixtures of cyclomethicone and are also particularly advantageous Isotridecyl isononanoate, from cyclomethicone and 2-ethylhexyl isostearate.

The aqueous phase of the preparations according to the invention optionally advantageously contains

• - Alcohols, diols or polyols of low C number, and their ethers, preferred as ethanol, isopropanol, propylene glycol, glycerin, ethylene glycol, ethyl lenglycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or  monoethyl ether and analog products, furthermore alcohols with a low C number, e.g. As ethanol, isopropanol, 1,2-propanediol, glycerin and in particular a or more thickeners, which one or which is advantageously chosen can be from the group silicon dioxide, aluminum silicates, Polysac charide or its derivatives, e.g. B. hyaluronic acid, xanthan gum, hydroxy propylmethyl cellulose, particularly advantageous from the group of Polyacrylates, preferably a polyacrylate from the group of so-called Carbopoles, for example carbopoles of types 980, 981, 1382, 2984, 5984, individually or in combination.

It contains the cosmetic or dermatological sunscreen preparations inorganic pigments, in particular micropigments, advantageous according to the invention, e.g. B. in amounts of 0.1 wt .-% to 30 wt .-%, preferably in amounts of 0.5 % By weight to 10% by weight, but in particular 1% by weight to 6% by weight, based on the total weight of the preparations.

It is advantageous according to the invention, except for the combinations according to the invention further oil-soluble UVA filters and / or UVB filters in the lipid phase and / or additional water-soluble UVA filters and / or UVB filters in the aqueous phase clog.

According to the invention, the light protection formulations can advantageously further sub punches contain that absorb UV radiation in the UVB range, the Total amount of filter substances e.g. B. 0.1 wt .-% to 30 wt .-%, preferred as 0.5 to 10 wt .-%, in particular 1 to 6 wt .-%, based on the Total weight of the preparations available to cosmetic preparations to face the entire area of ultraviolet radiation protect. They can also serve as sunscreens.

The other UVB filters can be oil-soluble or water-soluble. Advantageous oil-soluble UVB filter substances are e.g. B .:

• 3-benzylidene camphor derivatives, preferably 3- (4-methylbenzylidene) camphor, 3-benzylidene camphor;  
• - 4-aminobenzoic acid derivatives, preferably 4- (dimethylamino) benzo acid (2-ethylhexyl) ester, 4- (dimethylamino) benzoic acid amyl ester;
• - 2,4,6-trianilina- (p-carbo-2'-ethyl-1'-hexyloxy) -1,3,5-triazine;
• - Esters of benzene malonic acid, preferably 4-methoxybenzenemonic acid di (2- ethylhexyl) ester;

Advantageous water-soluble UVB filter substances are e.g. B .:

• - Salts of 2-phenylbenzimidazole-5-sulfonic acid such as its sodium, potassium or their triethanolammonium salt, as well as the sulfonic acid itself;
• - Sulfonic acid derivatives of 3-benzylidene camphor, such as. B. 4- (2-Oxo-3-bornyli denmethyl) benzenesulfonic acid, 2-methyl-5- (2-oxo-3-bornylidenemethyl) sulfonic acid and their salts.

The list of UVB filters mentioned, which are also in the sense of the present inven of course, should not be limiting.

It can also be advantageous to use UVA filters, which have been commonly used in cosmetic preparations are included. It can be used for the UVB-Kombina tion used amounts are used.

It may also be advantageous according to the invention to provide the preparations with further UVA and / or UVB filters, for example certain salicylic acid derivatives such as

The total amount of one or more salicylic acid derivatives in the finished Cosmetic or dermatological preparations are advantageously made from the Range selected from 0.1-15.0% by weight, preferably 0.5-8.0% by weight, based on the total weight of the preparations. If ethylhexyl salicylate is chosen is it is advantageous whose total amount is in the range of 0.1-5.0% by weight, preferably 0.5-2.5 wt .-% to choose. If homomenthyl salicylate is chosen, it is advantageous, the total amount of which ranges from 0.1-10.0% by weight, preferably 0.5-5.0 wt .-% to choose.

Yet another additional light protection filter substance to be used advantageously according to the invention is ethylhexyl-2-cyano-3,3-diphenylacrylate (octocrylene), which is available from BASF under the name UVINUL® N 539 and is characterized by the following structure:

It has also proven advantageous in the sense of the present invention issued not to use any additional UV filter substances, which the Belong to the group of cinnamic acid derivatives.

The following examples are intended to illustrate the present invention without restrict them. All quantities, proportions and percentages are so far  not otherwise specified, on the weight and the total amount or on the Total weight of the preparations related.

example 1

Example 2

Example 3

Example 4

Example 5

Example 6

Example 7

Example 8

Claims (7)

1. Use of cosmetically or dermatologically harmless substances whose chemical formula is the structural motif of 1,1-dicyano-2,2-diphenyl-ethene
contain, for the stabilization of cosmetically or dermatologically harmless substances, whose chemical formula is the structural motif of dibenzoylmethane
contain, against the decomposition induced by UV radiation. 2. Use according to claim 1, characterized in that the substance or substances whose chemical formula contains the structural motif of 1,1-dicyano-2,2-diphenyl-ethene is selected or are selected from the group of substances which generic structure
have, where R ¹ and R ² independently of one another hydrogen or in the para and / or ortho position, identical or different straight-chain or branched chain aliphatic or cycloaliphatic radicals having 1 to 18 carbon atoms or in the para and / or ortho position represent standing, identical or different straight-chain or branched-chain alkoxy radicals or cycloalkoxy radicals having 1 to 18 carbon atoms, and furthermore n and m independently of one another denote the numbers 1 or 2. 3. Use according to claim 1, characterized in that as 1,1-dicyano 2,2-diphenyl-ethene derivative, 1,1-dicyano-2-phenyl-2- (p-butoxyphenyl) ethene and / or the 1,1-dicyano-2,2-diphenyl-ethene is selected. 4. Use according to claim 1, characterized in that the substances which have the structural motif of dibenzoylmethane can be selected from the Group 4-isopropyldibenzoylmethane, 4- (tert-butyl) -4'-methoxydibenzoylmethane. 5. Use according to claim 1, characterized in that the total amount of substances that have the structural motif of dibenzoylmethane, especially 4- (tert-butyl) -4'-methoxydibenzoylmethane, in the finished cosmetics human or dermatological preparations in the range of 0.1-10.0 % By weight, preferably 0.5-6.0% by weight, based on the total weight of the additives preparations is chosen. 6. Use according to claim 1, characterized in that the total amount of 1,1-dicyano-2,2-diphenyl-ethene derivatives in the finished cosmetic or dermatological preparations in the range of 0.1-10.0% by weight, preferably 0.5-6.0% by weight, based on the total weight of the preparations is chosen. 7. Use according to claim 1, characterized in that the weight ver Ratios of 1,1-dicyano-2,2-diphenyl-ethene derivatives to the substances that Structural motif of dibenzoylmethane have, such as 8: 1 to 1: 5, preferably as 4: 1 to 1: 2, particularly preferably selected as 3: 1 to 1: 1.