DE1948111A1 - Sugar-free preparations - Google Patents

Description

DR. ILSE RUGH PATENT ADVOCATE ' REICHENBACHSTR. 51 I 9 4 8 1 1 I.

TEL «63151

Polio 14611

Joaeph Hodgson Briggs »London, England Jaok Sydney Pryor, London * England Gordon Robert Fryers »Place ed, England

Sugar-free PrJparata

The invention relates to suoker-free preparations and ins * special drinkable and injectable suoker-free preparations.

In certain pathological conditions, in particular some pins of diabetes, the patient must have one Low-suoker DiKt can be administered. The sugar can of course be made from synthetic sweeteners, such as Saccharin. Such a sweetener, however, is not a source of energy, so the patient has to change it Throwing suoker-free energy-yielding foods have to. Also, the patient's craving for candy is likely to persist, and consequently it is Sohon from a psychological point of view desirable to give him energy-giving and sweet-soothing foods administer.

Surprisingly, it has now been found that single patients advantageously use glycerol as an oleohmic substance Energy source can be administered. The usage of

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Glycerin and sweeteners have the particular advantage for diabetics that their processing by the body is independent of the presence or absence of insulin - it is rapidly absorbed and has a rapid effect. JU counteracts a ketosis caused by an insufficient amount of insulin in the blood and corrects hypoglycemia caused by or * jumps, for example neonatal hypoglycemia, the hypoglycemia that occurs as a concomitant symptom of prediabetes, the concomitant symptom of periodic hypoglycemia and idiopathic hypoglycemia in childhood. Glycerin invokes a feeling of satiety

and can therefore also be administered in a calorie-controlled DlKt to combat obesity. In addition, glycerine is a component of fats and is released from the digestive tract, so that it is a normal metabolic product, the administration of which cannot cause any organic disturbances. '..- ■■ \ \ _- ■■; -. ^;

The invention therefore relates to a sucker drink, the water, glycerin and a Geschmacksetoff, jedooh contains no pharsakologisch © of the therapeutically active compound _(.

The present Ixann any common in Oeti € nken used liquor flake, for example a Geraisoh of ^ itronensMure and lemon food, and Carbon dioxide can be injected in the usual way if a bubbly drink is unsuitable.

The addiction to glycerine can vary within a wide range and depends on the desired sweetness of the drink. Usually! Bit of a menga of less than IJl Glycerin get a drink »that is not enough»

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while using »more than 500 the 0« gives you a drink ■ Pecked texture. Preferably be about 10 to 40 ow.- £ glycerin used in des Oetr & nk

Lift water, Qlyoerin and Oesetaaoke can do the Beverages according to the invention also nooh other customarily Components used in OetrKnken «for example Parstoffs included. However, they do not contain a Zuoker or another phaxttakologisoh or therapeutisoh wlrksasie connection.

Another component of the invention is an injectable preparation in the form of a partially free, pyrogen-free, sterile "aqueous glycerin solution" whose concentration of aiyoerin is generally 1 to 10% by weight. As a precautionary measure , the concentration of the concentration is $ 2 because this is the isotonic concentration. Solo agents can be administered intravenously in the Ublloher manner. They have the same effect as the orally administered drinkable preparations described above and also have the advantages associated with intravenous administration.

The manufacture of the injectable preparations can be carried out in this Ublioher Welae made. Glycerin is the tibllohen Sterillization avetboden compared to good and better than belspeilswelse Olukoae continuously.

The following examples illustrate the invention.

example 1 3OO ■ 1 Olyoerin (995 <-ig) 700 al Wasaer 7.5 S. Zltronic acid q.s. Zltronenessen * U / U5 1 0098

Example 2

Glycerine (99 #) 30 ml Water 60 ml

Orange essence q «s. Both mixtures can be diluted as required.

In the treatment of diabetes me11itus, in particular those who have frequent spontaneous fluctuations in blood levels occur, 150 g of glycerine per day in three equal doses, for example, can be given to the patient can be administered in the form of any of the above drinkable preparations. The glycerin

is antiketogenic and provides an energy source for the intracellular metabolism. Its entry into cells does not depend on the presence or absence of insulin away.

All types of hypoglycemia can be oral or intravenous Administration of glycerin, when administered orally for example in a dosage of 50 g in the form a 25 # aqueous solution or intravenous 'Administration in a dosage of 1 1 10 # aqueous Solution to be administered over a period of 4 hours.

The same dosage can be used in ketotonic conditions as in the treatment of hypoglycemia. Glyoerin is of particular advantage here because it quickly supplies intracellular energy.

Glycerin can also be used in a weight loss diet, as it facilitates calorie control, does not cause hypoglycemia and gives a feeling of satiety.

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Claims (3)

Sponsorship claims 1. Energy donation of the sugar-free preparation in a Low-sugar diet can be used «characterized in that it contains olyoerin as an energy source. 2. Preparation according to claim 1, characterized in that that there are waaaer, glycerine and a carbon dioxide, but no pharmacological or contains therapeutically active compound. 3. preparation naoh claim 1, characterized that it is in the form of a particle-free, pyrogen-free sterile aqueous olcerol solution Has. 0 0 9 8 U / U 5 1