DE1926373A1 - Mouthwash - Google Patents

Description

(US 754.54 * - prio June 5, 1968 - 6271)

Colgate-Palmolive Company

300 Park Avenue

New York. N.V. / V.St.Ao Hamburg, May 21, 1969 Mouthwash

The present invention relates to an aqueous, alcohol-containing one Mouthwash

The difficulties in the production of aqueous, Mouthwashes containing alcohol consists in adding the necessary flavorings to the other ingredients of the mouthwash are poorly tolerated and adversely affect the stability of the product «By adding from odoriferous substances you usually get unattractive mouthwashes or products that are stored for a long time become triibe. The addition of solubilizers or other additives leads to further »mostly undesirable side effects.

The present invention has set itself the task of "to propose a new type of mouthwash that softens out"

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has a marked aroma and also has other undesirable properties, namely good flushing * and has a cleaning effect »is bactericidal and can be stored for a long time without difficulty »

To solve this problem, an aqueous, alcohol-containing mouthwash is proposed, which is characterized by the fact that it contains 65 to 85% of water, 5 to 25 % of a compatible alcohol, 0.5 to 3% of a polymeric polyoxyethylene. containing nylon surfactant, wherein the polyoxyethylene comprises at least 40 pounds of the polymer and that a small amount of chloroform is present.

The addition of chloroform in combination with the particular Non-metallic surfactant gives an excellent one stimulating taste. The nonionic surfactant together with the chloroform influences the flavor and is also necessary to give a clear solution.

For example, a polyoxypropylene / polyoxyethylene Block polymer with a molecular weight of about 1750 uses · which contains 20Jf polyoxyethylene, one obtains instead of the nonionic, invention devices used Surfactants a dry mouthwash · which after some

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Standing in one or more oily phases separates.

The present invention is based on the fact that the aqueous «alcoholic mouthwash an effective amount Chloroform and between 0.5 and 5% of a polymeric polyoxyethylene containing non-ionic surface-active substance contains, the polyoxyethylene component makes up at least $ 40 of the polymer.

The mouthwashes contain 65 to 85 and preferably 68 to ? 8fv water and 5 to 25 and preferably 10 to 20Ji alcohol, furthermore the usual small amounts of flavoring substance «, the added Water used to dilute the mouthwash concentrate is preferably desalinated or distilled water

The alcohol component of the mouthwash is a non-toxic alcohol such as isopropanol or ethanol _p whereby flavoring substances such as anethole, anisole, bay oil, benzaldehyde, bergamot oil, bitter almond oil, camphor, cedar leaf oil, chlorothymol, cinnamic aldehyde, cinnamon oil, eucalyptus oil, cinnamon oil, cinnamon oil, cinnamon oil are preferably used for denaturing , Eugenol, guaiacol, lavender oil, menthol, peppermint oil, phenol, phenyl salioylate, spruce and spruce needle oil, rosemary oil, sassafras oil, spearmint oil. Spike lavender oil, Storax, ISiymlanöi, thymol, tolu balsam, turpentine oil and

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Wintergreen oil. The odorous substances should be present in the mouthwash in amounts of 1 to 2%, based on the total alcohol. The alcohol used preferably contains 90 to 9% ethanol, 1 to 2 _{% odorous substances or} substances to denature the alcohol and between 5 to 10 % water

The alcoholic watery mouthwashes with the stated chloroform content have an extremely refreshing and pungent aroma. The originally added aroma is enhanced by adding chloroform. Chloroform is used in amounts of 0.05 to 0.65Ji, with larger amounts of chloroform increasing the enhancement of the aroma. In general, the chloroform is added in amounts of 0.15 and 0.55 weight percent.

The polymeric nonionic surfactant with a content of at least 40 pounds of polyoxyethylene is used in amounts of 0.5 to 1½, based on the total mixture, in smaller amounts with a low chloroform content and in larger amounts with a higher chloroform content.

The polyoxyethylene containing nonionic surfactants are Copolymers of polyoxyethylene and polyoxypropylene, Furthermore, polyoxyethylene derivatives of sorbitan fatty acid esters and PolyoxyMthyienkondensaten Bit alkylphenols «such as

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w «li · nonylphenol, which condenses with 10 moles of ethylene oxide let.

Solid to pasty nonionic are particularly preferred Surfactants of the following kind «

1) Polyoxypropylene / polyoxyethylene copolymer of the general formula HO (CH ₂ CH ₂ OJa (CH (CH ₂ JCH ₂ OJb (CH ₃ CH ₂ O) CH, in which a, b and c are whole numbers) the corresponding polyethylene oxide units and polypropylene oxide units of the polymer. "The polyoxyethylene component of the block polymer is at least 40 mol of the block polymer. The polymer preferably has a molecular weight between 1000 and 4000. Although these polymers are effective at all chloroform concentrations, they are preferably used in amounts greater than 1 £ and in particular »between 2 and J% used if the chloroforacon consistency is above Q _f J% ,

2) Polyoxyethylene derivatives of sorbitan mono- and tri-Pettsltureeeter, in which the FettsMurekoeponente 12 to Has 84 carbon atoms. Preferred polyaxytethylene derivatives are sorbitan monolaurate. 3orbitanaonopalaiitat, Sorbltan monoetearm, sorbitan tristearate, sorbltanaonooleate and sorbitan trioleate. Contain the polyoxylethylene chains

■ '· BAD ORIGiWAL

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4 to 20 and preferably 20 xethylene oxide units. The sorbitan ester derivatives contain 1, 2 or 3 polyoxyethylene chains, depending on whether mono-, di- or tri-ester are used. These polyoxyethylene aorbitan derivatives are used in mouthwashes with a relatively low chloroform content of, for example, 0.05 to 0.2 pounds of chloroform in amounts of 0 * 6 to 1.5 and preferably 0.7 to 1.1 pounds.

W The mouthwashes preferably contain quantities of glycerine

up to 15Jf, with compositions containing 8 to 12 pounds of olycerin are particularly suitable. The olycin, which is called "body substance" works, can be completely or partially replaced by other compounds such as sorbitol or propylene glycol *

The mouthwashes can also contain small amounts of bactericidal substances, such as, for example, quaternary aliphatic alloys and generally saturated aliphatic aliphatic alloys, which are preferably used in amounts of 0.05 to 0.1 % . Suitable examples of bactericides are, inter alia, BenzHthonluochlorid, Diisobutylphenoxyäthoxy-Hthyldi ^ thylbenzyl-aMeoniuachlorid, "-Alkylpyrldiniuewhlorid, N-Cetylpyridlnluabro, Matriueo-lauroyl-mycousarcosine, Matriue-Mauro-lauro-lauro-mycine, Matriue-M-lauro-lauro-lauro-sarcosine, Matriue-M-lauro-lauro-lauro-sarcosine, Nosauro-lauroyl-lauro-sarcosine, Nosauro-lauroylsarcosine, Nosauro-lauroylsarcosine, Nosauro-lauroylsarcosine, Nosauroyl-lauro-lauric acid

BATH ORIGINAL

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The mouthwashes usually contain other additives, such as colorings, sweeteners or flavorings or raw materials. Sacharine »preferably in amounts of 0, (A% added.

When preparing the mouthwash, the concerned Ingredients Added in water and diluted with water 100 * filled up. The order of addition is not essential »All components of the mouthwash can dissolve in water. Preferably the alcohol dissolves Components in the alcohol previously dissolved and then mixed with old water. The ingredients * which have greater solubility in water than in alcohol are preventive measures only added to the water before the aqueous solution is mixed with the alcohol «or they are added after addition of the water is added to the entire mixture.

The volatile chloroform is preferably added in excess to the desired amount. In order to reduce losses, the chloroform is preferably added last. The chloroform concentrations above 0.1 IJi given in the following examples can be added within a range of plus or minus 0.050. In ά · Λ following examples, all amounts are by Oewieht · besiehen -

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example 1

Ea a watery mouth waaaer was made by non-ionic Bensäthonlumohlorld and glycerine with one Alcohol containing aromatic substances is vermiaohteo Anaohliefiend became the necessary waaaern tightness and danaeh zacharin, Dye and chloroform added. The prepared mixture was crushed and filtered.

Beatand parts 22 * b £ Denatured alcohol 15 Desalinated water 72

Glycerin * 10

Benzethonium chloride 0.075

Saccharin 0.04

Dye 0.08

Chlorofora 0.55 Non-functional surfactant 2

The non-toxic surfactant was a polyoxypropylene / polyoxyethylene Blook polymer with a molecular weight of 1750 "in which the polyoxyethylene component 80 mol ^ of the total Molecule. The alcohol was a smell substance denatured ethyl alcohol. The mouth waaaer had an excellent aroma of stimulating effect, was found a clear, slightly bluish solution. These properties were not changed even after long periods of storage.

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Mouthwashes were used with other polyoxypropylene / Polyoxyttthylen block polymers * produced in which the polyoxymethylene content was 56 MoIjC, with that once Molecular weight was 1750 and the other was 3250. Further were compounds with a polyoxyethylene content of 40 MoIjC and a molecular weight of 1200 bsw, 1750 or 2 & 50 used «

The results were just as good. Example g

A mouthwash was produced just as Example 1, wherein Jedooh Jetst sus & tslloh xu the flavoring substances in the denatured Ethanol and other flavorings were added. Further became a polyoxypropylene / polyoxyethylene bloekpolymerlsat with about 80 NoI) C polyoxyethylene and a molecular weight from about 1750 used in an amount of 5jC. The watery one Mouthwash had excellent flavor characteristics and a slightly stronger aroma.

Example 3

A mouthwash was prepared according to Example 1, wherein However, the chlorofone concentration was now O * 359C. The appearance of this mouthwash corresponded to the product

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Example 1, however, it was less sharp with the same aesohmaaksriohtune. Welter · Mouthwashes were produced »whereby now polyoxypropylene / polyoxyethylene block polymers 80 moles of polyoxyethylene were used and had molecular weights of 2,750 and 3,250, respectively.

Example "

Bs were further aqueous mouthwash gemäfl Example 1 with W lesser Chloroformkonxentratlon and lower concentration of nonionic surfactant · The chloro »formkonsentration was 0,15Ji while the Konsentration to the Bloekpolyaerisat 1 or 1 '5J <amounted to" Bs were in this case polymers "it 80 moles * of polyoxymethylene and a molecular weight of 1750 are used. Other mouthwashes have a content of 0.8, 1.0 and 1.5% polyoxypropylene / polyoxyethylene block polymer and a content of 70 mol polyoxyethylene and a molecular weight of 4000. showed just as good taste properties as the products in Examples 1 to 3, but were somewhat milder.

Example p

A mouthwash was prepared according to Example 1, wherein however, the chlorofora concentration was 0.15Ji and than nlchtlonleches surfactant is a polyethylene condensation product of the Sorbitaniwnooleate was used, which is about

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- ti -

Contained 20 moles of ethylene oxide. 01 · manufactured mouthwashes did the non-metallic surfactants contain 0.7, 0.8 and l »l £ · These mouthwashes had an excellent one Aroma and an extremely refreshing effect, but were a little milder than the mouthwashes according to example 1, 2 and? »

Xnliohe mouthwashes were made with 0.15 % chloroform and sorbitan monostearate or sorbitan monolaurate, each of which was condensed with 20 moles of ethylene oxide. Here too, the mouthwashes had excellent properties.

Example 6 ·. . ■

A mouthwash with a chloroform content of about 0 * 1% together with about 0.7 % of a PolyKthylenkondensate of Sorbltanmonoolöats old about 20 Hol Xthylenoxid was produced.

The mouthwashes were also made with benzethonium chloride Bactericidal or other bactericidal added and showed an excellent germicidal effect.

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BATH ORIGINAL

Claims (1)

- 12 claims 1 «wVesrlg · *, alcoholic mouthwash * characterized by daf ee 65 to W water, 5 to 25 * «Ines uneventful alcohol and 0.5 to 3ί * of a polyaeric, polyoxyethylene contains non-tonic surfactants », Its polyoxylethylene content is at least 400 dee polymers 1st and that the mouthwash still contains a small amount of chloroform » 2 · Mouthwash according to claim 1 »characterized in that that the alcohol is a denatured ethyl alcohol and that the chlorofora concentration is 0.05 to 0.55 and that it is Geruoheetoffe and also glycerine, Sorbitol and / or propylene glycol in amounts up to contains. Mouthwash according to Claims 1 to 2, characterized in that the polymer, polyoxyethylene-containing material is nonionic Tenaid a Polyoxypropylen / Polyoxyäthylen Blockpolyeerieat «with a molecular weight between 1000 and ^ 000 or a polyoxyethylene derivative of one 8orbitan fat8lturee8ter8 old of a fatty acid component is from 12 to 24 carbon atoms * , QBIQiNAL 909850 / 18.00- - JLj - 4. Mouthwash according to claim>, characterized in that » that there are 68 to? 8 pounds of water * 0.5 to 3Ji polyoxypropylene / Polyoxyethylene Blookpolyroeriaat with a molecular weight from 1000 to Λ00Ο and contains glycerine « 5 · Mouthwash according to claim t «characterized in that since there are 10 to 2Qrf of ethyl alcohol «8 to 12] 1QIy» erin and contains a small amount of saccharine " 6. Mouthwash according to claim 5, characterized in that there is more than 1> ί of the polyoxypropylene / polyoxyethylene Block polymer and contains more than 0.3Jl chloroform. T * mouthwash according to claim 6, characterized in that it contains 72 % water, 15% ethynol and about 10% glycerine. 8 · Mouthwash according to claim 6 and 7 # characterized in that that it is S to 3 $ polyoxypropylene / polyoxyethylene block » nischpolyaerisat and about 0.55 ^ Chlorofon · contains « 9- Mundwaeeer according to claim 6 umt 7 "characterized by the fact that there are 2 to J $ polyoxypropylene / polyoxyethylene block polymer and about 0.5 % & chloroform e" t- 10. Nunduaeaer according to Anepruoh 2, characterized in that dal M 68 to 7 & Waaaar, 0.6 to 1.5 * one «Polyox? - ithylcnderlvatea of a sorbitaner monofat kureester Up to 24 carbon atoms in the fatty acid component contains, and dal ee 0.05 to 0.20 chloroform and contains Ölywln. 11. Kuodwasser according to Anepruoh 10, characterized in that dal ea 10 bia 20Ji ethyl alcohol, 8 to 12 * glycerine and garlüca amounts of saccharine. 12 · Mundwaaaer according to Anapruoh 10 and 11, characterized by d & 0 es 0.7 to 1.1} ί polyoxyethylene derlvaite a SorbltAnexmo FettKureeatera «it 20 fetch ethylene oxide reveals. 15. Neadnaaaar according to claim 10 bia 12 »thereby gekennsaiehnat, dai dar sorbitan fatty acid ester ain sorbitan ■ onooiaat » «In sorbitan oil or a sorbitan «Ooolaurat is. ~~~ * ORiGINAL BATHROOM 90985β / t