DE187876C - - Google Patents

Description

IMPERIAL

PATENT OFFICE.

The invention relates to the production of a for administration in certain bone diseases, such as rickets, osteomalacia, and their accompanying symptoms serving phosphorus-containing preparation, which the The patient should supply the phosphorus as such.

Attempts have already been made to use such preparations as so-called phosphor pastilles or to produce phosphorous chocolate pastilles (see Pharmaceu.tische Centralhalle 1895, 36th year, p. 247 "Phosphorpastillen"); however, these lozenges do not offer any Guarantee that the phosphorus content is sufficiently uniform and reliable, for the phosphorus suffers with the a. a. O. mentioned method by heating and Oxidation in the air Changes and losses.

Total security for exactly the same dosage and perfect protection against that In contrast, the present one creates a change in the phosphorus during manufacture Process in that, according to him, the phosphorus and the carrier substances are avoided with a special supply of heat and with the exclusion of air, ideally in the presence of carbonic acid and under light, even, always controllable pressure is processed. Because the phosphorus cannot change here and it is more evenly absorbed Distribution containing and retaining mixture is obtained, the same amount of effective is obtained in each lozenge Phosphorus.

The presentation of the pastilles is done in the following way:

In a ratio corresponding to the phosphorus dose, on the one hand phosphorus oil, on the other hand couverture (coated chocolate, see Zipperer, Schokoladenfabrik. 1901, P. 191) and cream or just a couverture. The couverture is now for example kneaded in a soft, thin-walled, tight-fitting rubber bag, using only the warmth of the hands brought to blood temperature, processed into a thin, homogeneous paste. Under complete exclusion of air, preferably under a stream of carbonic acid that can be easily guided into the bag, the concentrated phosphor oil solution is then added to the couverture. Continued kneading, rolling, etc. a thoroughly even distribution of the phosphorus in the mass is achieved without that there is a loss of phosphorus. The mass obtained in this way becomes as quick as possible cooled, and as a result of the almost sudden solidification, the phosphorus in evenly distributed. In order to have a particularly durable, solid after solidification To achieve shape, one uses the couverture or a mixture of couverture and cream Even before processing, fruit varnishes, chocolate varnish or the like.

After cooling, the mass is removed from the mixing chamber in a suitable manner Formed into lozenges using special aids.

The essence of the new process is the processing under total Exclusion of air, avoiding increased heat input and using uniform, always through the eye and feeling of the

by kneading hand. Of course, these can be mechanical measures be modified accordingly when exercising the procedure.

Claims (1)

Patent claim: Process for the production of preparations containing phosphorus, characterized in that that one has phosphorus oils, couverture and cream, or phosphorus oils and couverture in the absence of air, preferably in the presence of carbonic acid, in thin-walled Rubber bags or the like kneaded together, the whole thing while cooling with fruit varnishes, chocolate varnishes and similar varnishes and turned the mixture into lozenges, tablets, pills, etc.