DE1766184A1 - Device for withdrawing, collecting and returning body fluids - Google Patents

Description

679 013

Bio-Medical Syotems, Inc _v Panbury, Connecticut »USA *

Device for pulling off, sasaneln and returning of body fluids.

The invention relates to a device with which it is possible to a living body fluid such as blood or lymph, to refer to subject outside the body of a Bohandlung ", for example, a cleaning or decontamination, and then auzuführon the body by infusion. In the case of chronic Meren diseases, for example, it may be necessary to carry out the blood purification function normally performed by the kidneys artificially. Recent developments have shown that instead of the blood, the lymph can be aialyzed or otherwise purified with equally good results, since the toxins first accumulate in the lymph before they are released into the bloodstream. However, the lymph flows in the body of humans or animals at a much slower speed than the blood. If the blood of a patient is subjected to dialysis, then tolls in order not to endanger the blood circulation,

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any failure of the dialysis system within 3 minutes to be resolved while having a treatment 36 hours of lymph can elapse »before difficulties become noticeable to the patient. In addition, there is no risk of embolism, because lymph coagulates less easily than blood.

It requires treatment of the lymph instead of the blood but a very slow, sometimes intermittent withdrawal of body fluid with very little, practically negligible pressure, and this removal must still be absolutely reliable, and Speed and rhythm must meet the requirements can be customized.

The gate direction of the invention is a pumping device that can be adjusted to suit the body Withdraw liquid from one point and from another under the conditions required in each case Can feed place again »The device is working simple and safe, is not a nuisance for the patient and can be easily transported, eo that especially when using them to clean the lymph, the patient can go about his usual activity and not at home or in a clinic

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- 3 aas bed be careful.

The invention relates to a pumping device for taking a body fluid from a Place of a living body and infuse in another part of the body »the

a) a Sinlafl that connects to the body in the first place,

b) Send a diet to the Köx "by at the" wide point connecting outlet,

c) a elastißcl.e kollaMerbaxe chamber for receiving body fluid, the elasticity of which is such that when eie is compressed _f body fluid au outlet drives and to slacken the compression pressure expands again and thereby generates a negative pressure, through the liquid to is removed from the body at the point of the inlet and sucked into the chamber, valves being arranged at the inlet and outlet of the chamber,

d) means of compressing the elastic chamber,

e) Sinn drive for the means for compressing the Chamber such that the liquid with the required ? jraok is squeezed, and

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■ '' • ■ Λ

f) a control device that only drives the drive actuated when the chamber is in the expanded state *

having.

The pumping device according to the invention can auoh nor have means for injecting an anticoagulant into the body fluid the end

a) a storage container for a solution of the anticoagulant,

b) a wide elastic collapsible chamber next to it the first elastic chamber to accommodate the

L Solution from the storage container and expulsion the same when compressing and expanding when releasing the compression pressure due to them Elasticity such that liquid is sucked into it from the reservoir,

c) an outlet line that leads into the flowing body fluid near the point where it is taken Body leads,

d) gowns ium compressing the awaiten elastic Chamber in one of the Arbeitsrhyttau · the first Chamber adapted rhythm and

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β) means via the outside of the wide elastic chamber Expelled anticoagulants into the in to jump in body fluid flowing through the first electrical chamber.

In the drawings is:

FIG. 1 is an eohenatic view of a device GeatäS of the invention,

Figure 2 is a side view of a device according to the invention old entirely for the uakeasogenic bumper,

FIG. 3 shows a side view of a device according to FIG of the invention with an advanced bumper,

Figure 4 is a side view of the device of Figure 2, in which the bumper is pressed against the elastic barrel by adjustable means,

Figure 5 shows a switching system for a device according to the invention,

Figure 6 shows a device according to the invention with an associated pump for οin Ko & gullermittel,

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Figure 7 is a plan view of the bumpers of both β IaB ti ac hen chambers actuating ifoOcenfläohe and

Pigur Θ a plan view of a codification of a Pump device according to the invention with associated Pump device for an anticoagulant.

The sohematisch illustrated in Jigur 1 Pcmpvorrichtung, 12 grafts of the invention xur removal, collection and infusion can mensohlisohen a body fluid such as lymph, be verwendot * The fluid is at a location βλ dee body removed and su zurüokgoftthrt a Stolle 6B. The binflufi tube is connected at one end to the body, for example the thoracic lymph duct 6A, which has been severed, and at the other end it is connected to the supply end of a pump. The body fluid is removed under a bridge which corresponds to the pressure of the fluid in the thoracic duct . A removable container is connected directly to the pump © 12 in a liquid-tight manner, so that a collecting container 16 is formed. Beer can collect the lymph and drain it from the system for treatment purposes, or it can be infused at a point of the tank

Body, for example, the end of the bridge duct 6B f

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at the subclavian vein, to be transported further. The liquid is collected by turning valves B and C closes and valve A opens and the pump operated as described below. When the container 14 is filled and the pump is switched off, is The container is removed and the liquid can be subjected to any of the usual treatments including a Dialysis eut removal of impurities or a Irradiation, for example to eliminate lymphocytes, can be subjected.

After such a treatment, the body fluid becomes again in the concrete 14 or the same Recirculated container and this is, for example, by hook 15, connected to the pump. Then the treated liquid through the infusion portion of the device, shown here as the outlet tube 11 is, returned to the body, the infusion takes place by closing valves A and B and opening of the valve Q so that the pump 12 discharges the treated liquid from the container "H" into the subclave vein can lead.

The lines 10 and 11 can be connected via connection stttoke fluidly connected to the body lines

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will.

The in Figures 2 to 4 indicated in detail Pump device according to the invention comprises a Base plate 20, at one end of which an elastic collapsible chamber 21 is attached. From the chamber 21 an inlet conduit 23 and 23 extend an outlet duct 25, both with not shown Valves are provided. A parallel to the base plate 20 back and forth "movable bumper 27 eats slidingly mounted in two brackets 30. Through the Rotation of a neck surface 22 over a wool

is driven by a motor 24, the push rod 27 is moved to the left against the chamber 21. The cam surface 22 is created by cutting through at an angle θin2β cylinder and is turned by turning the Cylinder rotated around its longitudinal axis.

An adjustable power source, shown as a torsion spring 28, is mounted on a block 26 on the base plate 20. The spring 28 is U-shaped and has two arms on two. Hollen D ₁ which are arranged on opposite sides of the rod 27 and fastened in a block S which is fastened internally on the rod 27. In this way, the spring 28 is constantly pressing directly on the

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Bumper 27 and hall; this in contact with the elastic * chamber 21 »

On the rod 27, roughly a clamp 36 eats Era 32 adjustable mounted, and at the end of this arm 32 there is a magnet 34. When the magnet 24 above a normally open reed switch slides, the circuit of the motor »34 is disconnected (Figure 5) so that the motor 34 the cam surface 22 turns. By rotating the nook surface 22, the rod 27 is moved to the left so that it compresses the chamber 21, as shown in FIG. 3 * A second reed switch 40 is provided to the Keep the engine running until the cam surface 22 has completed one revolution. When the squat surface 22 completes one revolution, the normally closed one becomes second switch 40 opened by magnet 42 on cam fluid 22 (FIG. 4). Through this the power supply to the motor 24 is interrupted and the motor comes to a standstill almost instantaneously as a result of the braking effect of the signal lamps 44 (FIG. 5) The function of the signal lamps 44 is described in more detail below »

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The elastic chamber 21 may be in the form of a dome * The inlet line 23 and the outlet line 25 are normally closed «Both can be elastic. The lines 10 and 11 (FIG. 1) can be connected to these two lines The material from which the chamber 21 is made should have such elasticity that in it body fluid present is expelled when the chamber is compressed, and by the compression an elastic recovery force proportional to the degree of compression is generated. tuck The force must be so great that the chamber 21 expands again and thereby causes the liquid to escape is taken from the body and flows into it.

In its normal position, the chamber 21 is expanded, as shown in FIG. Duron moving the bumper 27 to the left will open the chamber compressed as shown in FIG. By the Squeezing chamber 21 closes the valve in line 23 and liquid becomes expelled from the chamber 21 through the discharge line 25. When the bumper 27 is pulled aurUokgö,

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can get the EartDcer 21 back up to its normal The mold expands and is only subject to the pressure from the inlet line 23 »the one with the liquid extraction point the body, for example the chest lymph " gang 6A, is connected. However, since the ÜJortionsfeder 28 the rod 27 over the rollers D against the chamber Proß, the chamber 21 is always under one adjustable back pressure that limits its expansion. This can reduce the pressure with which the Fluid removed from your body is regulated and pressure is exerted on the body Fluid can be adjusted for each patient.

The elastic recovery force of the chamber is greatest when it is completely compressed, like shown in FIG. For example, if the chamber is 3.2 cm in diameter, it can be filled with a Forward movement of the bumper about 0.8 cm has been fully compressed, with an elastic Rüokverfoznnungskrai't of about 0.1 kg / cm is generated. As the chamber 21 expands, this elastic flexural deformation force decreases and becomes equal to 0 when the Chamber 21 has resumed its original form (Figure 2).

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The squatting surface 22 pushes the rod © 27 forwards by a certain distance as it rotates, so that the chamber 21 is completely compressed and liquid is thereby squeezed out of it. The bumper 21 returns after finishing the rotation of the .Nockenfläch © 22 is not in its original position aurück but is held by the! Torsion spring 20 in contact with the chamber 21 and then returns β in the output distribution back _t when the chamber 21 again ' eats fully extended (Figure 2).

The baiden arms of the U-shaped spring 28 become an arch pushed backwards and lie on the two rollers D on, which are attached to block F by pins G are attached. The block P iot by means of a screw H. attached to the bumper 27. From the stentce yourself: in her: sucked-back position (Figure 2) is located, the arms of the spring 28 are bent back into a near-horizontal position and lie then at the bottom of rollers D. The spring force is then directed upwards, that practically none Component of the elastic recovery force of the Chamber 2Γ counteracts horizontally. If, on the other hand, the

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The bumper 27 is in its advanced position (Pigur 3), the arms of the spring 28 rest on the rollers D so that the spring force acts almost horizontally on the bumper 27 ure! opposes the elastic recovery force of the 4th chamber with the greatest possible force. That is, the horizontal component of the spring force reaches a maximum when the bumper 27 has advanced all the way to the left (FIG. 3) and decreases while the bumper is withdrawn, so that the elastic return deformation force of the chamber 2 t is always the same. * Opposed force »

It is essential that the counterforce exerted by the spring 28 can be adjusted so that the speed with which the chamber 21 expands and thus draws fluid from the body, the the pressure prevailing in the body can be adapted This makes it possible to divert the liquid from that Body to infer, that man or animal sustains no damage or damages the wall of the pipe from which the fluid is drawn will ►

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176618 «

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The tone of the every 28 -exerted counterforce can be changed by Ver-i Sohleben the support blocks 26 to the base plate 20 and bsw · or by moving the block carrying the hollies P BU of bumper 27 set «to earth.

The block 26 is known by threatening a Einutella earhrub E be shifted to red or left. If he naoh left, becomes veraohoben, becomes the peder for a bigger one Rope of the feed path of the bumper flaoh, whereby the the horizontal component of the spring force is reduced, while it is enlarged by moving the blocks.

By moving the block P after loosening the screw H (Figures 2 to 4) on the bumper near the left against the chamber is the horizontal component of the spring force increased, by moving this block to reohtβ against the cooking surface is reduced

The shift pattern shown in FIG. 5 inclines the oil side brackets 38 and 40, the motor 24 and the signal lamps 44 in their position to each other. Across Ubor the AneohlUaee the engine can be one odor eo can have several signal lamps,

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which serve a rapid stopping of the engine or ο, arranged For example, you can turn off power to the motor by opening the normally closed slide switch 40 is interrupted by the magnate 42, accelerate the lamps 44 plug the motor by inserting a generate dynamic braking effect. That means, the free-running excrement is currently acting as a generator, and that Signal lamps 44 consume the electrical energy, see above that the rotary energy consumes ras ch and the motor 24 is brought to a stand almost momentarily «The normally open switch 38 is closed when the magnet is pushed over it, while the second slide holder 40, which is normally closed is opened when the magnet 42 is pushed directly over it (Figure 2),

The pumping apparatus of the invention can be connected to any power source. However, a battery is preferred because the apparatus is intended to be carried by the patient. FIG. 6 illustrates a modification of a pumping device according to the invention. This modification contains an auxiliary device for the H ^ uptpumpvorrichtung. Injecting an anticoagulant into the body fluid immediately after it is removed from the body to cause it to clot

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the same uu prevent.

The pumping device of Figure 6 is similar to the rest of the in Figures 2 tie 5 illustrated, tie has a elastic collapsed chamber 51 with a pipe

50 between its inlet end R and the withdrawal part N of the body, its freely movable to and fro push rod 52 for compressing the chamber 51 to remove body fluid from it through the vent pipe B, and a pipe 57 between the chamber 51 and the infusion part N .. on * The ßteßetange 52 is operated by a rotating Rookenfläohe 54 "which is driven by a shaft 55 of a motor 56, as described in connection with Figures 2 to 4.

In addition, the device shown in FIG. 6 has gowns for injecting an anticoagulant into the gown Body fluid. These funds consist of one another »Wide elastic chamber 60 next to the elastic chamber

51 * ■ - the dassu. serves as an anti-coagulant on sunehmon and euszuetoßon. The solution arrives from an accumulator 62 via the pipe 65 to the inlet parts X of the chamber

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ftfflftAff this liquidity in the Kamer 60 i # äf <§ter «i dlaeer Kewä & r still your Bü Äeißt, the wall of the Karaaor 60 is au smiäB-tlzUm in our BeetrebU, your normal £ ri 'Hgaf 6 geesig-t ie4 _r nrusunehmon, Ba mmar 60 öin TTnteruicuclc poured out, because of the antkoaguliarunfiöiBittGl from the storeroom

in άί & βέ Mm ^ t ströüit, wäkrtöd it becomes at Kümprimierön Kaaüiör aoi * äieeer auageetoSdn.

Compression of _a K $ 0 miaer be coordinated mi of Koln ^ the 2aiamor 51 * In Figures 6 and 6 βίιΐί alternativo riaieitaie means for compressing the chamber 60 veranechaulichii. According to the Durohführungungeform of Figure 6, the chamber 60 by means of a lifting arm 64 of the main pushbutton 52, which is actuated by the cam surface 54, ait the chamber 51 cooperatively.

In the version shown in fig

the chamber 60 and the actuation of a Valves 66 in the outlet line 69 into the body fluid

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In dioeer Aoeführtneefurm let dtatf dör Iaitime 65 voraiifis ^ eiee gleioh dtm der 60 because the advice to the Auelufl Y atte dl? Karaae * # etoöene LöBtuie by dee Yentil ^ atfgomiWen ^ r lingers in the line 65 before aie au the # ^ M # P is penetrated into the body fluid '.

If it is in rigor 7, the shut-off valve is 66 lnern Angle iu and in έ £ & £ §β? Bntf irnung Tön dir & upteto3-

52 arranged. Ee will only catch one furiously the rotation of the nook surface 54 böüäUift and is therefore only for a short period of time after the equilateral Compression of the elaetieohen chamber 51 and the £ # i £ -ien eiastieohtn Kamaer 60 through the two hanging ones Butt rods 52 and 64 '

Operation de * in Wgur 6 angeiohaulioh-έβη Vdrriöhtune the K * maem 60 and 5t «became loyal Through the co-compression of air TUiimc4fBt Kaener 60 Otiri in the anticoagulant effect through the Auelofl Y dea J ^ biperr-7antil 66 ßugefle. The yontil 66 is also actuated by the button surface U in such a way that it is iaaer

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is closed with the exception of a short period of time immediately after the end of the travel of the push rods 52 and 64. During this time, the anticoagulant Through the valve 66 and from there through the AuelaSleitung 65 flow into the fluid taken from the body. Very soon after its opening, the shut-off valve 66 will be restored geaohlOBßon, in order to prevent the. olaatiochen Eckverforaunß the chamber 60 a negative pressure, is sucked, through which the anticoagulant solution directly Is sucked into the inflow tube 50 for the body fluid. As a result, when the shut-off valve 66 is closed, the elaotioohe recovery of the chamber 51 only depends on the flow of body fluid below that in the body prevailing pressure.

A potent anticoagulant is a "heparin ¹¹ solution. Heparin is a poljaacoharide sohwafic acid residue that occurs in the liver, lungs and other body tissues. In order for a Haparin solution to prevent the coagulation of body fluids, especially blood, small amounts of it must be continuous and proportional to." the amount of flowing body fluid is injected into it.

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There are of course various options for controlling the amount of Hepartite solution that is injected into the body fluid via the main beteage 52. For example, the size can be made larger or smaller, so that 3g advance of the push rod a larger or smaller amount of coagulation medium gets into the body fluid. A second possibility is to choose the diameter of the bumper 64 larger or smaller. This bumper has a large diameter of 64 let, more coagulant is added by a gate lift. A third possibility is to vary the length of the advance travel of the push rod 52. The longer the Vorsohubwog 1st, the very the chamber is 60 per verfornt Voraehubweg and more atehr heparin solution ^"in; geepritat the Körperflüssigkilt.

In the alternative published in Pigur 8, Ai'f guideoforra a device according to the invention the chamber 60 by a separately operated ttoßetango 69 actuated immediately after the first Kfcaaer 51 Itoiaprimiert is * The rod 69 is in its normal Position as shown above by solid lines is, by a spring 72 which is attached to a collar 79

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rests against this stango, held against the second chamber 60. Oils bumper 69 is actuated by the neck surface 54-, a Schwenkarn 74 and the spring 72 ', when the Hookenflächo 54 one revolution night _t 74 undergoes the pivot arm a small rash. This movement momentarily moves the bumper away from the chamber 60 so that the hammer 60 can suck the anticoagulant from the reservoir 62 (i * igur 6) the chamber 60 depresses and compresses it so that the anticoagulant amittol is expelled. In the embodiment shown in FIG. 8, the compression of the chamber 60 and the anti-co-regulation agent is injected into the flowing body fluid only by compressing the chamber 60.As shown in FIG P injected into the body fluid in the tube 50.

In the embodiment shown in FIG Bumper 69 slidably mounted on beams 68. The caterpillar bumper 52 is formed into a U-shaped spring

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70, whose two arms against each other 76 on one Block 78 on rod 52, jerk, on chamber 51 held. Me spring 70 is on a block Θ0 below the rod 52 is mounted. As described above, will the smaller rod 69 by the spring 72 resting on the collar 73 on this rod on the chamber 60 held «A rotatable about a pin 77 Pivot arm 74 is in contact with pin 75 on the bumper. The pivot arm 74 extends up to the area where the rock face turns 54 * When this weeding surface makes one turn, will the pivot arm 74 is pivoted out a short distance. This movement causes the bumper momentarily continued from the chamber, as shown in dashed lines, and thereby sucks anticoagulant from the reservoir 62 (Figure 6) as soon as the Kockenflache 54 has turned further, the Spring 72 pushes rod 69 back against the chamber until the next short deflection, so that the chamber 60 is almost always compressed and the anticoagulant agent is therefore not in or out of the chamber 60 streams: can. During 3 «of the cycle there will only be one low hengd of anticoagulants in the Body fluid injected.

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Ia of the designation form mentioned in iigur 8 combined the chamber 60 functions as both the chamber also άβΒ shut-off valve 66 from Jigur 6. That is, the Abeperrvöntil 66 can be omitted. The function of this valve is fulfilled in that die Ka ^ e * "60 for the greatest time of a cycle the! spring on the bumper 69 held koiaprimiart will.

The length of the preschool life of the rod 69 can be adjusted by changing the position of the pin 75 on this rod. If this pin is set further to the left (Sigur 8), the advance travel of the rod becomes longer. The spring force can be made divides ₉ by sliding the collar 72, on which the spring rests. If the collar 73 is shifted to the left * the spring force decreases.

Instead of heparin, fluffy anticoagulants can also be used. medium, e.g. solutions of sodium and potassium compounds, of fluorides and oritrates are used

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Claims (1)

- 24 P at ent an s ρ ρ ti ο h. e [1 ,) Pump device for taking a body fluid from one point of the living body and infusing it at another point a) an inlet (22) connecting to the body at the first point (6A) 2u, b) one with the body at the second point (6B) eu connecting outlet (25), c) an elaatiaohe collabiorbaro chamber (21, 51) to absorb body fluid, its elasticity is so dimensioned that when it is compressed it will flow body fluid to the outlet tjeej ^ j ^ and calibrate free slackening of the compression pressure again expands and thus sucks fluid out of the body, with valves at the sin and outflow of the chamber arranged and d) means (27t 52) for compressing the chamber, e). elaen drive (24, 56) for the means pum ffoajplaitrea 10982W0US dir Kftamer derert that the liquid under the required pressure is maintained, and f) a subdevice (22 »54) that only drives the engaged * call the Sauser in extended U «finds 2 ·! Pumping device according to claim!, Characterized ge "indicates that the Komprlmierungsaittel mm a freely reciprocating bumper (27 * 52) whose Onea end to the chamber (21, 51) abuts beetehen. 3 c pump device according to claim, characterized in that the control device el looktnfläohe, which rests on the other free end of the abutment, the footer surface is designed in such a way that it rotates during one revolution Push rod operated so that the chamber is compressed will. j 4 _# ^f 3? uBpvorriohtuDg according to claim 1, gekennieiohnet. { by adjustable means of maintaining a 1766114 Counterforce on the elastic laeaer in such a way that the Speed at which the chamber looks out of it while Plüssigkeit ana de «body is drinking, β« «pressure on the fluid in the living body is adapted. 5. Pump device according to Anepruoh 4, thereby marked that this "unites β Hb ar en." Gowns consist of a Toreion spring that is constantly a druok on the bump in the direction of the south elastic chamber exerts ao that this ateta in contact eteht with the elastic leaner and on this one Druok exercises, the etna de »through the elasticity of the Cashier generated recovery pressure si ei oh is. 6. Pump device according to Anepruoh 1, characterized by means of sun Einpriteen one Anticoafulants aittele in the body fluid, the the end a) a memory (62) for a solution of the Anfcikoa # ulierungBoittele, b) a second elastic collapsible chamber (60) next to the first chamber for receiving the solution compressing the memory and driving out the same boin 10982A / 044Ä BATH ORIGINAL and expanding according to their elasticity, such that Liquid from the memory into them in more detail will, o) an outlet line (65) which enters the flowing body fluid at the point of its withdrawal guides the body d) means for compressing the second elastic chamber (64) in a den- working rhythm of the first chamber adapted rhythm, e) means around the anticoagulant expelled from the second elastic chamber into the to inject flowing body fluid into the first elastic chamber, consists. 7 · pumping apparatus according to claim 6, daduroh in that the size of the second chamber that of the first chamber is adjusted so that the amount of anticoagulant which is injected into the body _fluid} the amount of 109824 / OUS BATH ORIGINAL 17 & 61S4 etrumender body fluid proportionally and εο large is "that" the curdling is prevented 8. Pump device according to claim 7, characterized marked that the smock buk compressing the second K & only one parallel ■ u the first bumper back and forth movable ■ wide bumper (64) exist, the aweit Bumper also from the calibrating loeken surface (54) but only during a »small feilee Rotary movement of the same is actuated. 9 "pumping device according to claim 8, characterized by means to hold the" wide bumper on the broadly elastic ^ aaeer au, so that the second Kaomer for the most part one turn of the squat surface remains compressed, with which the flow of the anti-coagulation agents Ib and controlled from the second chamber. 109824/0445 BAD ORIQINAt Blank page