DE1617626A1 - Process for the production of durable, water-soluble vitamin B12 preparations - Google Patents

Description

Process for the production of durable, water-soluble vitamin B12 preparations Addition to DBt ... (German patent application M 62 496 IVa / 30h) Subject of the main patent is a process for the production of durable, water-soluble vitamin B12 preparations, because it consists in the fact that vitamin B12 is found in galactomannans obtained from the guar sohote embeds.

Vitamin B12 is known to be a very sensitive sub Medicines, especially in combination preparations and in feed and food 11 Generally in special preparation forms and with the addition of suitable stabilizers is used.

For example, there are already ansorbates of Vitsain B12 on ion exchangers, Complexes are made of peptides, embeddings in gelatin and similar preparations been. However, none of these preparations are satisfactory in practice. Addition In many cases it is necessary to add a stabilizer as well, for example cyanide, rhodanide or sulfite ions. Ze is worth striving for stranding such more or less non-physiological accessories.

It has now been found that vitamin B12 preparations are astonishing galenic stability can also be established if, instead of the Galactemannans obtained from guar pods Galactemannans from locust bean gum are used. Compared to the previously known stabilized preparations of vitamin B12 possesses the new preparation has the advantage that it can easily be compared to the usual Mills (special pin and hammer mills) machlen lä # t. YOU received - Depending on the vitamin B12 concentration, very or less pink tinted powder is finely divided and free-flowing. Another notable advantage of the new formulation is the ideal solubility in cold and warm water, so that # an addition # baz. the release of the embedded Vitawine in all cases both in the case of the physiolegiaohen Release in the body as well as in analytical contemplations is guaranteed.

The invention relates to a process for the production of durable, Vitamin B12 preparations according to DBP. . .

(German patent registration M 62 495 IVa / 30h), which consists in the fact that # vitamin B12 is embedded in galactomannans obtained from Johanna bread gum.

Jehanniebret kernel flour is made from the kernels of the shet of the Johnnisbrothaum, who is mainly at home in the Mediterranean region. These include Herne up to 50 9 plant gumnt (Hydrokolleide). Locust bean gum is its othemiqohen structure naoh a polysaccharide from the group of galactonannans. The molecules have a stretched main chain of mannose units. In the statistical mean every fourth manhose unit has a single branch made of galactose.

The hydrocolloids obtained from locust bean gum swell in cold Little water. When heated to about 85 °, the locust bean gum dissolves on the other hand almost complete. Even low concentrations can make very highly viscous colloids Provide solutions.

The new preparation is generally produced in the usual way, vorgugawaise by evaporation of an aqueous solution containing the Vita-Min B12 and the hydrocolloid contains. The evaporation to Trookne is expediently carried out under reduced pressure. The product obtained is crushed, mixed up by grinding, and given a trap sifted. Of course, other troubling methods can also be used for removal of the water, e.g. B. the usual spray drying method.

The end product. onthäls lin generally still about 0.5 bio 1.5 6 water; if necessary - o according to the storage conditions - higher water contents also come into play before. Depending on your needs and intended use, it contains the according to the procedure of the invention prepared preparation about i part of the vitaline to about 10 to 1000 part of the galactomannan to the currant flour.

The values given are not critical, however, and also in others Proportionally good stabilizing effects can be achieved.

The nous preparation is very durable and also when stored for a long time Stable at various, including elevated, temperatures.

In particular, no changes were made, if the new preparation take vitamin B12 sioh incompatible with Vitsmin B12 Contained substances, especially vitamin C. Auoh with the other vitamins and Their usual preparations proved the vitamin B12 embedding according to the invention as well tolerated.

The preparation produced by the method of the invention can because of the phy @ lological harmlessness of the natural hydrocolloid from com Locust bean gum not only in medicinal products, but also in the food sector oingcsotzt. It is thus more suitable for use in medicines in or for adding vitamins to feed and food, especially dietetic ones Nutrients. In principle, the new preparation can be used anywhere where an addition of vitamin B12 is desired.

Example t vitamin B12 galactomannan preparation 1: 1000 vitamin B12 (gyanocobalamin) 0.1 part Galahtomannan from locust bean gum 99.9 parts The galactomann polysaccharide from locust bean gum is poured into about 4 liters of water at room temperature and continuously Stir dispersed. The Gemisoh is allowed to soak overnight. The resulting Slime is added to the cyanocobalamin dissolved in 100 ml of cold water and mixed well.

The gel is then applied using a vacuum or spray method dried. For example, the Vitasin B12-containing gel is made in a layer thickness of t up to 2 cm poured out on enamel trays and placed in a vacuum tube tank at one temperature of 40 ° and a pressure of maximum 100 Torr. Finally there will. dry Product brought to the desired particle size in a mill.

Example a Vitamin B1 nitrate 100 mg Vitamin B6 hydrochloride 100 mg VitaMin B12 galactomannan preparation 1: 100 30 mg lactose 20 mg starch 20 mg talc ad 340 mg The vitamin B1 B12 galactomannan preparation is produced analogously to Example 1 and the other components are combined in a manner that is customary in itself.

Example 3 Iron (II) gluconate 250 Ig cobalt sulfate 5 mg manganese sulfate 0.2 mg copper sulfate 0.2 mg sorbitol 5 mg intrinsiofactor concentrate 15 mg vitamin C 50 mg vitamin B12 galactomann preparation 1: 1000 7.5 mg fola acid 1 mg lactose ad 380 mg The Vitemin B12-galactomannan preparation is made analogously to Example 1 and combined with the other components in the usual way.

Claims (1)

Method for the production of durable, water-soluble Vitamin B12 preparations according to DBP. . o (German patent application M 62 495 IVa / 30h), characterized in that vitamin 12 is obtained from locust bean gum Embeds Galectemannans.